Impact of weight reduction on insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.

Abstract:

Background:Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus. Objective:This study was designed to detect the effects of weight loss on insulin resistance, adhesive molecules and adipokines dysregulation in obese type 2 diabetic patients. Methods:Eighty obese patients with type 2 diabetes mellitus, their age ranged from 35-55 years and their body mass index ranged from 31-37 kg/m2 were equally assigned into 2 groups: the weight reduction group received aerobic exercises in addition to diet regimen, where the control group received medical treatment only for 12 weeks. Results:There was a 24.04%, 19.33%, 22.78% ,12.28%, 9.35%, 22.53% & 10.12 % reduction in mean values of Homeostasis Model Assessment-Insulin Resistance Index (HOMA-IR), Leptin, Adiponectin, Resistin, intercellular cell adhesion molecule -1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin & body mass index (BMI) respectively in addition to 26.20% & 24.58% increase in the mean values of adiponectin & the quantitative insulin-sensitivity check index (QUICKI) respectively in group (A) at the end of the study. The mean values of leptin, resistin, insulin, HOMA-IR, ICAM-1, VCAM-1, E-selectin & BMI were significantly decreased in addition to significant increase in the mean values of adiponectin & QUICKI in group (A) those that received aerobic exercise training in addition to diet regimen. While the results of group (B) those that received no treatment intervention were not significant. In addition, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment (P<0.05). Conclusion:Within the limit of this study, 10% reduction in body mass index modulates insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Abd El-Kader SM,Al-Jiffri OH

doi

10.4314/ahs.v18i4.5

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

873-883

issue

4

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v18.i4.pg873

journal_volume

18

pub_type

杂志文章,随机对照试验
  • Environmental barriers experienced by stroke patients in Musanze district in Rwanda: a descriptive qualitative study.

    abstract:BACKGROUND:Patients with stroke experience a number of environmental barriers, limiting their re-integration. Information regarding the barriers experienced by patients with stroke in a specific setting such as the Musanze district in Rwanda would assist with the development of rehabilitation programmes that would take...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Urimubenshi G,Rhoda A

    更新日期:2011-09-01 00:00:00

  • Precancerous lesions of cervix among women infected with HIV in Referral Hospitals of Amhara Region, Northwest Ethiopia: a cross sectional study.

    abstract:Background:The risk of death from complications related to cancer of the cervix is a main health problem over the course of a woman's life in low income countries. It commonly affects women infected with HIV. Therefore, screening women infected with HIV should start in low income countries, including Ethiopia. Methods...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i1.46

    authors: Kassa LS,Dile WM,Zenebe GK,Berta AM

    更新日期:2019-03-01 00:00:00

  • Coats' disease in Tanzania: first case report and literature review.

    abstract:BACKGROUND:Coats' disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma. OBJECTIVES:Compare the differential diagnoses of Coats' disease Establish recommendation to early disease detection. MATERIALS AND METHODS:A 3-yea...

    journal_title:African health sciences

    pub_type: 杂志文章,评审

    doi:10.4314/ahs.v14i3.37

    authors: Rugwizangoga B,Mwabili T,Scanlan T,Meyer P,Kitinya J

    更新日期:2014-09-01 00:00:00

  • Influence of indoor formaldehyde pollution on respiratory system health in the urban area of Shenyang, China.

    abstract:BACKGROUND:The decoration of interior spaces can lead to dangerous levels of indoor formaldehyde pollution. Exposure to indoor air pollution may be responsible for nearly 2 million deaths per year in developing countries. OBJECTIVES:To assess the prevalence of indoor formaldehyde pollution caused by decoration and res...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i1.19

    authors: Zhai L,Zhao J,Xu B,Deng Y,Xu Z

    更新日期:2013-03-01 00:00:00

  • Polysaccharides obtained from mycelia of Cordyceps militaris attenuated doxorubicin-induced cytotoxic effects in chemotherapy.

    abstract:Objectives:Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Metho...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v19i2.40

    authors: Lin RK,Choong CY,Hsu WH,Tai CJ,Tai CJ

    更新日期:2019-06-01 00:00:00

  • QTc prolongation in Black diabetic subjects with cardiac autonomic neuropathy.

    abstract:Background:Prolonged corrected QT (QTc) has been identified as a risk factor for malignant arrhythmias and sudden cardiac death. Caucasian studies have shown a definite relationship between QTc prolongation and Cardiac Autonomic Neuropathy (CAN) in diabetic subjects. Objective:To determine the prevalence of prolonged ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i4.17

    authors: Ukpabi OJ,Onwubere BJ

    更新日期:2017-12-01 00:00:00

  • Ergogenic effect of varied doses of coffee-caffeine on maximal aerobic power of young African subjects.

    abstract:BACKGROUND:Caffeine one of the readily available stimulants consumed daily by more than 80% of the world's population, making it the most widely consumed drug in history. The objective of this study was to determine the effects of different doses (5, 10 &15 mg.kg(-1)) of caffeine per kilogram body weight on maximal aer...

    journal_title:African health sciences

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Lamina S,Musa DI

    更新日期:2009-12-01 00:00:00

  • Seroprevalence of parvovirus B19 in blood donors: the risks and challenges of blood transfusion in Zambia in the era of HIV/AIDS at the Kitwe Central Hospital, blood bank.

    abstract:Background:Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be life threatening in im...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v18i3.5

    authors: Chirambo-Kalolekesha M,Kaile T,Mwaba F,Daka V,Simakando M,Kowa S

    更新日期:2018-09-01 00:00:00

  • HIV counseling and testing practices among clients presenting at a market HIV clinic in Kampala, Uganda: a cross-sectional study.

    abstract:BACKGROUND:Uptake of HIV counseling and testing (HCT) among informal sector workers is not well documented. OBJECTIVE:To assess HCT practices among clients presenting for HIV services at a market HIV clinic in Kampala, Uganda. METHODS:Between August 1 and September 15, 2009, clients presenting for HIV services at a m...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i3.15

    authors: Matovu JK,Bukuluki PW,Mafigiri DK,Mudondo H

    更新日期:2017-09-01 00:00:00

  • Empty sella syndrome: incidental findings at computerised tomography.

    abstract::A case is presented of a 43-year-old female patient who presented with severe dizziness, neck pain and headache. Clinical examination revealed diplopia with a horizontal gaze. Plain skull radiographs showed an enlarged sella turcica with no abnormal intracraial calcifications. Pre and post contrast axial and post cont...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Luutu I

    更新日期:2001-08-01 00:00:00

  • Comparison of Pulmonary TB DOTS clinic medication before and after the introduction of daily DOTS treatment and attitudes of treatment defaulters in the Western Division of the Gambia.

    abstract:BACKGROUND:Over a third of the world's population is infected with the tuberculin bacteria. In 1993 WHO launched the DOTS-strategy to enhance treatment compliance. Despite Gambia's adaption in 1985 it falls below WHO target of 85% cure rate. The defaulter rate was 14% in 2001, which reached 16% in the urban areas of th...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Sanneh AF,Pollock JI

    更新日期:2010-06-01 00:00:00

  • Review of the chemistry and pharmacology of 7-Methyljugulone.

    abstract:BACKGROUND:Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone o...

    journal_title:African health sciences

    pub_type: 杂志文章,评审

    doi:10.4314/ahs.v14i1.31

    authors: Mbaveng AT,Kuete V

    更新日期:2014-03-01 00:00:00

  • Sonographic assessment of the portal vein diameter in apparently healthy adults in a Northern Nigerian population.

    abstract:BACKGROUND:Sonography is a valuable tool in the assessment of porto-systemic pathologies. This study aimed at determining the mean portal vein diameter based on age, gender and anthropometric variables. METHODS:A cross sectional study conducted among 201 apparently healthy adults in Bauchi Metropolis. Participants wer...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v16i4.35

    authors: Luntsi G,Sani M,Zira JD,Ivor NC,Garba SH

    更新日期:2016-12-01 00:00:00

  • Intestinal candidiasis and antibiotic usage in children: case study of Nsukka, South Eastern Nigeria.

    abstract:Background:Overgrowth of candida results from factors that disrupt the intestinal microbial balance, such as the use of antibiotics. Unregulated antibiotic use and rampant practice of self-medication in Nigeria, is a cause for concern. Methods:A total of 314 stool specimens were collected from children <1 to 12 years ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v17i4.27

    authors: Ezeonu IM,Ntun NW,Ugwu KO

    更新日期:2017-12-01 00:00:00

  • Modern lineages of Mycobacterium tuberculosis in Addis Ababa, Ethiopia: implications for the tuberculosis control programe.

    abstract:BACKGROUND:The genotyping of Mycobacterium tuberculosis strains is important to have unique insights into the dissemination dynamics and evolutionary genetics of this pathogen and for TB control as it allows the detection of suspected outbreaks and the tracing of transmission chains. OBJECTIVE:To characterize M. tuber...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v12i3.15

    authors: Mihret A,Bekele Y,Aytenew M,Assefa Y,Abebe M,Wassie L,Loxton GA,Yamuah L,Aseffa A,Walzl G,Howe R

    更新日期:2012-09-01 00:00:00

  • Maternal nutrition: how is Eastern and Southern Africa faring and what needs to be done?

    abstract:BACKGROUND:The progress in key maternal health indicators in the Eastern and Southern Africa Region (ESAR) over the past two decades has been slow. OBJECTIVE:This paper analyzed available information on nutrition programs and nutrition-specific interventions targeting maternal nutrition in the ESAR and proposes steps ...

    journal_title:African health sciences

    pub_type: 杂志文章,meta分析

    doi:10.4314/ahs.v15i2.28

    authors: Salam RA,Syed B,Syed S,Das JK,Zagre NM,Rayco-Solon P,Bhutta ZA

    更新日期:2015-06-01 00:00:00

  • Factors affecting quality of life in cancer patients undergoing chemotherapy.

    abstract:BACKGROUND:Cancer can produce many different symptoms, some subtle and some not at all subtle. An increasingly important issue in oncology is to evaluate quality of life (QoL) in cancer patients. The cancer-specific QoL is related to all stages of this disease. OBJECTIVE:The aim of this study was to evaluate the QoL i...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Heydarnejad MS,Hassanpour DA,Solati DK

    更新日期:2011-06-01 00:00:00

  • Factors associated with depression and suicide among patients with diabetes mellitus and essential hypertension in a Nigerian teaching hospital.

    abstract:BACKGROUND:Diabetes mellitus (DM) and essential hypertension are chronic medical conditions that place a lot of burden on patients. The presence of depression and suicidal behaviour may worsen the prognosis. OBJECTIVE:To assess the prevalence of depression and suicidal behaviour in subjects with diabetes mellitus and ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i1.10

    authors: Igwe MN,Uwakwe R,Ahanotu CA,Onyeama GM,Bakare MO,Ndukuba AC

    更新日期:2013-03-01 00:00:00

  • Community pharmaceutical care: an 8-month critical review of two pharmacies in Kampala.

    abstract:BACKGROUND:The concept of pharmaceutical care is neither well developed nor adequately documented in Uganda. OBJECTIVES:This study is therefore an attempt to identify and quantify the various service components of community pharmacy practice in Kampala, Uganda's capital city. SETTING:Two pharmacies operating retail o...

    journal_title:African health sciences

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Anyama N,Adome RO

    更新日期:2003-08-01 00:00:00

  • The in vitro antimicrobial activity of fruit and leaf crude extracts of Momordica charantia: a Tanzania medicinal plant.

    abstract:OBJECTIVE:To evaluate the antimicrobial activity of Momordica charantia extracts on reference strains and microorganisms isolated from clinical specimens. METHOD:Petroleum ether and methanolic crude extracts of fruits and leaves of the plant were evaluated for antimicrobial activity using the disk diffusion method on ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Mwambete KD

    更新日期:2009-03-01 00:00:00

  • Viral load, CD4+ T-lymphocyte counts and antibody titres in HIV-1 infected untreated children in Kenya; implication for immunodeficiency and AIDS progression.

    abstract:BACKGROUND:There are limited reports on HIV-1 RNA load, CD4+ T-lymphocytes and antibody responses in relation to disease progression in HIV-1 infected untreated children in Africa. METHODS:To describe the relationships between these parameters, we conducted a longitudinal cohort study involving 51 perinatally HIV-1 in...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.5555/afhs.2006.6.1.3

    authors: Ochieng W,Ogoyi D,Mulaa FJ,Ogola S,Musoke R,Otsyula MG

    更新日期:2006-03-01 00:00:00

  • Exotic and indigenous problem plants species used, by the Bapedi, to treat sexually transmitted infections in Limpopo Province, South Africa.

    abstract:BACKGROUND:The ethnic usage of exotics and indigenous problem plants is a highly debated topic, as legislative requirements over-shadow their potential medicinal value, particularly to treat sexually transmitted infections (STIs). Limited information exists regarding their medicinal value among the Bapedi. OBJECTIVES:...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i2.17

    authors: Semenya SS,Potgieter MJ,Erasmus LJ

    更新日期:2013-06-01 00:00:00

  • Antidiabetic and haematinic effects of Parquetina nigrescens on alloxan induced type-1 diabetes and normocytic normochromic anaemia in Wistar rats.

    abstract:BACKGROUND:The plant, Parquetina nigrescens is used in folklore medicine to treat diabetes mellitus and its complications in several parts of West Africa. OBJECTIVE:To determine the effect of Parquetina nigrescens extract on fasting blood glucose in alloxan-induced diabetic rats. METHODS:The blood glucose levels, com...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Saba AB,Oyagbemi AA,Azeez OI

    更新日期:2010-09-01 00:00:00

  • Urinary schistosomiasis in Zimbabwean school children: predictors of morbidity.

    abstract:BACKGROUND:The morbid effects of urinary bilharziasis are becoming more evident with the advent of sophisticated diagnostics such as ultrasound. However, such diagnosis of Schistosoma haematobium morbidity is often hampered by lack of funds, proper equipment, or training. OBJECTIVE:We performed a cross-sectional inves...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:

    authors: Brouwer KC,Munatsi A,Ndhlovu PD,Wagatsuma Y,Shiff CJ

    更新日期:2004-08-01 00:00:00

  • Glanzmann's thrombasthenia: a rare bleeding disorder in a Nigerian girl.

    abstract:Introduction:Glanzmann's Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder due to defective platelet membrane glycoprotein GP IIb/IIIa (integrin αIIbβ3). The prevalence is estimated at 1:1,000,000 and it is commonly seen in areas where consanguinity is high. Case Presentation:The authors report a 12 ...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i2.27

    authors: Ezenwosu OU,Chukwu BF,Uwaezuoke NA,Ezenwosu IL,Ikefuna AN,Emodi IJ

    更新日期:2020-06-01 00:00:00

  • Commonly cited incentives in the community implementation of the emergency maternal and newborn care study in western Kenya.

    abstract:BACKGROUND:Mortality of mothers and newborns is an important public health problem in low-income countries. In the rural setting, implementation of community based education and mobilization are strategies that have sought to reduce these mortalities. Frequently such approaches rely on volunteers within each community....

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v13i2.37

    authors: Gisore P,Rono B,Marete I,Nekesa-Mangeni J,Tenge C,Shipala E,Mabeya H,Odhiambo D,Otieno K,Bucher S,Makokha C,Liechty E,Esamai F

    更新日期:2013-06-01 00:00:00

  • Musculoskeletal disorders among first-year Ghanaian students in a nursing college.

    abstract:OBJECTIVE:To estimate the prevalence and extent of MSDs among a sample of freshmen in a nursing college in Ghana. METHODS:A semi-structured self-reported questionnaire including the Nordic Musculoskeletal Questionnaire (NMQ) was used to collect information on age, gender and musculoskeletal complaints among a random s...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v15i2.18

    authors: Abledu JK,Offei EB

    更新日期:2015-06-01 00:00:00

  • Depression among medical students in Alexandria, Egypt.

    abstract:Background:Depression is a common illness worldwide with high rate among medical students. The objectives were to estimate the prevalence of depression among medical students in Alexandria, and identify its correlates. Methods:A cross-sectional study design was used. The study was conducted at the Faculty of Medicine,...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v20i3.47

    authors: Elsawy WIH,Sherif AAR,Attia MSED,El-Nimr NA

    更新日期:2020-09-01 00:00:00

  • The utility of the Helicobacter pylori stool antigen test in managing dyspepsia: an experience from a low resource setting.

    abstract:BACKGROUND:Dyspepsia is defined as a chronic or recurrent pain or discomfort centered in the upper abdomen. Endoscopy is the best strategy for confirming the cause of dyspepsia. Non- invasive strategies would be more appropriate in low resource countries where endoscopy is not readily available. However, there is conce...

    journal_title:African health sciences

    pub_type: 杂志文章

    doi:10.4314/ahs.v14i4.9

    authors: Segamwenge IL,Kagimu M,Ocama P,Opio K

    更新日期:2014-12-01 00:00:00

  • Family Medicine may be helpful in improving health care delivery in sub-Saharan Africa.

    abstract::Efforts to introduce and integrate the discipline of family medicine in sub-Saharan Africa have remained slow due to failure to understand what role and benefit such physicians can play in the existing health care systems in the region. An attempt is made here to explain reasons for this trend and suggest ways to over...

    journal_title:African health sciences

    pub_type: 信件

    doi:10.5555/afhs.2007.7.2.120

    authors: Ssenyonga R

    更新日期:2007-06-01 00:00:00