Abstract:
Background:Type 2 diabetes mellitus is usually related to vascular problems and is associated with impairment in endothelial function characterized by impaired endothelial-dependent vasodilation and increased platelet adhesion. There is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of endothelial dysfunction and adipokines dysregulation for obesity associated with type 2 diabetes mellitus. Objective:This study was designed to detect the effects of weight loss on insulin resistance, adhesive molecules and adipokines dysregulation in obese type 2 diabetic patients. Methods:Eighty obese patients with type 2 diabetes mellitus, their age ranged from 35-55 years and their body mass index ranged from 31-37 kg/m2 were equally assigned into 2 groups: the weight reduction group received aerobic exercises in addition to diet regimen, where the control group received medical treatment only for 12 weeks. Results:There was a 24.04%, 19.33%, 22.78% ,12.28%, 9.35%, 22.53% & 10.12 % reduction in mean values of Homeostasis Model Assessment-Insulin Resistance Index (HOMA-IR), Leptin, Adiponectin, Resistin, intercellular cell adhesion molecule -1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin & body mass index (BMI) respectively in addition to 26.20% & 24.58% increase in the mean values of adiponectin & the quantitative insulin-sensitivity check index (QUICKI) respectively in group (A) at the end of the study. The mean values of leptin, resistin, insulin, HOMA-IR, ICAM-1, VCAM-1, E-selectin & BMI were significantly decreased in addition to significant increase in the mean values of adiponectin & QUICKI in group (A) those that received aerobic exercise training in addition to diet regimen. While the results of group (B) those that received no treatment intervention were not significant. In addition, there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment (P<0.05). Conclusion:Within the limit of this study, 10% reduction in body mass index modulates insulin resistance, adhesive molecules and adipokines dysregulation among obese type 2 diabetic patients.
journal_name
Afr Health Scijournal_title
African health sciencesauthors
Abd El-Kader SM,Al-Jiffri OHdoi
10.4314/ahs.v18i4.5subject
Has Abstractpub_date
2018-12-01 00:00:00pages
873-883issue
4eissn
1680-6905issn
1729-0503pii
jAFHS.v18.i4.pg873journal_volume
18pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Patients with stroke experience a number of environmental barriers, limiting their re-integration. Information regarding the barriers experienced by patients with stroke in a specific setting such as the Musanze district in Rwanda would assist with the development of rehabilitation programmes that would take...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
abstract:Background:The risk of death from complications related to cancer of the cervix is a main health problem over the course of a woman's life in low income countries. It commonly affects women infected with HIV. Therefore, screening women infected with HIV should start in low income countries, including Ethiopia. Methods...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i1.46
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Coats' disease is an exudative retinal detachment with vascular telangiectasis occurring mostly in male children, the age group most affected by retinoblastoma. OBJECTIVES:Compare the differential diagnoses of Coats' disease Establish recommendation to early disease detection. MATERIALS AND METHODS:A 3-yea...
journal_title:African health sciences
pub_type: 杂志文章,评审
doi:10.4314/ahs.v14i3.37
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:The decoration of interior spaces can lead to dangerous levels of indoor formaldehyde pollution. Exposure to indoor air pollution may be responsible for nearly 2 million deaths per year in developing countries. OBJECTIVES:To assess the prevalence of indoor formaldehyde pollution caused by decoration and res...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i1.19
更新日期:2013-03-01 00:00:00
abstract:Objectives:Fungus Cordyceps militaris has been used as a herbal tonic in traditional Chinese medicine, which could be surface liquid-cultured for mycelia production. To evaluate the potential of polysaccharides obtained from mycelia of Cordyceps militaris (PS-MCM) for attenuation of side-effects of chemotherapy. Metho...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v19i2.40
更新日期:2019-06-01 00:00:00
abstract:Background:Prolonged corrected QT (QTc) has been identified as a risk factor for malignant arrhythmias and sudden cardiac death. Caucasian studies have shown a definite relationship between QTc prolongation and Cardiac Autonomic Neuropathy (CAN) in diabetic subjects. Objective:To determine the prevalence of prolonged ...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v17i4.17
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Caffeine one of the readily available stimulants consumed daily by more than 80% of the world's population, making it the most widely consumed drug in history. The objective of this study was to determine the effects of different doses (5, 10 &15 mg.kg(-1)) of caffeine per kilogram body weight on maximal aer...
journal_title:African health sciences
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2009-12-01 00:00:00
abstract:Background:Human Parvovirus (B19V) is a small, single-stranded, non-enveloped DNA virus which is pathogenic to humans causing a wide array of clinical complications which include erythema infectiosum, aplastic crisis and hydrops foetalis. It is generally harmless in healthy individuals but may be life threatening in im...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v18i3.5
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Uptake of HIV counseling and testing (HCT) among informal sector workers is not well documented. OBJECTIVE:To assess HCT practices among clients presenting for HIV services at a market HIV clinic in Kampala, Uganda. METHODS:Between August 1 and September 15, 2009, clients presenting for HIV services at a m...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v17i3.15
更新日期:2017-09-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2001-08-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone o...
journal_title:African health sciences
pub_type: 杂志文章,评审
doi:10.4314/ahs.v14i1.31
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Sonography is a valuable tool in the assessment of porto-systemic pathologies. This study aimed at determining the mean portal vein diameter based on age, gender and anthropometric variables. METHODS:A cross sectional study conducted among 201 apparently healthy adults in Bauchi Metropolis. Participants wer...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v16i4.35
更新日期:2016-12-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v17i4.27
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:The genotyping of Mycobacterium tuberculosis strains is important to have unique insights into the dissemination dynamics and evolutionary genetics of this pathogen and for TB control as it allows the detection of suspected outbreaks and the tracing of transmission chains. OBJECTIVE:To characterize M. tuber...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v12i3.15
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The progress in key maternal health indicators in the Eastern and Southern Africa Region (ESAR) over the past two decades has been slow. OBJECTIVE:This paper analyzed available information on nutrition programs and nutrition-specific interventions targeting maternal nutrition in the ESAR and proposes steps ...
journal_title:African health sciences
pub_type: 杂志文章,meta分析
doi:10.4314/ahs.v15i2.28
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Cancer can produce many different symptoms, some subtle and some not at all subtle. An increasingly important issue in oncology is to evaluate quality of life (QoL) in cancer patients. The cancer-specific QoL is related to all stages of this disease. OBJECTIVE:The aim of this study was to evaluate the QoL i...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract:BACKGROUND:Diabetes mellitus (DM) and essential hypertension are chronic medical conditions that place a lot of burden on patients. The presence of depression and suicidal behaviour may worsen the prognosis. OBJECTIVE:To assess the prevalence of depression and suicidal behaviour in subjects with diabetes mellitus and ...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i1.10
更新日期:2013-03-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章,多中心研究
doi:
更新日期:2003-08-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:There are limited reports on HIV-1 RNA load, CD4+ T-lymphocytes and antibody responses in relation to disease progression in HIV-1 infected untreated children in Africa. METHODS:To describe the relationships between these parameters, we conducted a longitudinal cohort study involving 51 perinatally HIV-1 in...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.5555/afhs.2006.6.1.3
更新日期:2006-03-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i2.17
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The plant, Parquetina nigrescens is used in folklore medicine to treat diabetes mellitus and its complications in several parts of West Africa. OBJECTIVE:To determine the effect of Parquetina nigrescens extract on fasting blood glucose in alloxan-induced diabetic rats. METHODS:The blood glucose levels, com...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:The morbid effects of urinary bilharziasis are becoming more evident with the advent of sophisticated diagnostics such as ultrasound. However, such diagnosis of Schistosoma haematobium morbidity is often hampered by lack of funds, proper equipment, or training. OBJECTIVE:We performed a cross-sectional inves...
journal_title:African health sciences
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract:Introduction:Glanzmann's Thrombasthenia (GT) is a rare autosomal recessive bleeding disorder due to defective platelet membrane glycoprotein GP IIb/IIIa (integrin αIIbβ3). The prevalence is estimated at 1:1,000,000 and it is commonly seen in areas where consanguinity is high. Case Presentation:The authors report a 12 ...
journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v20i2.27
更新日期:2020-06-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v13i2.37
更新日期:2013-06-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v15i2.18
更新日期:2015-06-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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journal_title:African health sciences
pub_type: 杂志文章
doi:10.4314/ahs.v14i4.9
更新日期:2014-12-01 00:00:00
abstract::Efforts to introduce and integrate the discipline of family medicine in sub-Saharan Africa have remained slow due to failure to understand what role and benefit such physicians can play in the existing health care systems in the region. An attempt is made here to explain reasons for this trend and suggest ways to over...
journal_title:African health sciences
pub_type: 信件
doi:10.5555/afhs.2007.7.2.120
更新日期:2007-06-01 00:00:00