Review of the chemistry and pharmacology of 7-Methyljugulone.

Abstract:

BACKGROUND:Naphthoquinone is a class of phenolic compounds derived from naphthalene. 7-Methyljuglone (7-MJ) is a naphthoquinone also known as ramentaceone or 6-Methyl-8-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-1,4-naphthoquinone or 7-Methyl-5-hydroxy-1,4-naphthoquinone or 5-Hydroxy-7-methyl-,1,4-naphtoquinone or 7-Methyl-5-hydroxynaphthalene-1,4-dione. This compound is a biologically active naphtoquinone, with a molecular weight of 188 g/mol mostly isolated in the genus Diospyros and Euclea. OBJECTIVES:This review was aimed at providing available chemically and pharmacological data on 7-MJ. METHODS:The chemical and pharmacological data were retrieved from the well-known scientific websites such as Pubmed, Google Scholar, Reaxys, Scirus, Scopus, Sciencedirect, Web-of-knowledge and Scifinder. RESULTS:7-MJ was reported to have a variety of pharmacological activities such as antibacterial, antifungal, anticancer, antitubercular, anti-inflammatory and antiviral activities. The hemi-synthesis of the compound have been described. CONCLUSIONS:The present review pooled out together the knowledge on 7-MJ, and can serve as the start point for future research and valorization accomplishments.

journal_name

Afr Health Sci

journal_title

African health sciences

authors

Mbaveng AT,Kuete V

doi

10.4314/ahs.v14i1.31

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

201-5

issue

1

eissn

1680-6905

issn

1729-0503

pii

jAFHS.v14.i1.pg201

journal_volume

14

pub_type

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