Abstract:
OBJECTIVE:This study aimed to describe the experience with a protocol of therapeutic hypothermia (TH) in southern Brazil. STUDY DESIGN:Newborns with gestational age > 35 weeks with evidence of perinatal asphyxia plus moderate or severe encephalopathy were recruited between March 2011 and November 2017. Whole-body hypothermia for 72 hours, starting within the first 6 hours of life was used. Survivors underwent magnetic resonance imaging (MRI) and electroencephalogram (EEG). The primary outcome was death during hospitalization and neurodevelopment assessed using the Bayley Scales of Infant Development III (BSID III) at 12 months of age. RESULTS:A total of 72 newborns were treated (41 with moderate encephalopathy and 31 with severe encephalopathy), of whom 16 died. MRI was performed in 56 patients, and 24 presented some alterations. Fifty-three patients had an EEG: 11 normal, 20 mildly altered, 12 moderately altered, and 10 severely altered. Forty patients were evaluated through BSID III: 45% presented with some delay in neurodevelopment, 8 (20%) had motor retardation, 15 (37.5%) had language delay, and 13 (32.5%) had a delay in cognitive development. CONCLUSION:Mortality and adverse events were similar to those described in large randomized controlled trials. TH is a safe and an effective method of neurologic protection in asphyxiated newborns in a developing country when performed adequately.
journal_name
Am J Perinatoljournal_title
American journal of perinatologyauthors
Procianoy RS,Corso AL,Schoenardie BO,de Oliveira GPF,Longo MG,Silveira RCdoi
10.1055/s-0039-1692388subject
Has Abstractpub_date
2020-07-01 00:00:00pages
955-961issue
9eissn
0735-1631issn
1098-8785journal_volume
37pub_type
杂志文章abstract::With more than 20,000 fetal deaths occurring annually in the United States, accurate epidemiological data concerning fetal death offer the potential to develop interventions aimed at saving a considerable number of fetuses. Currently, fetal death rates are determined by dividing the number of deaths by total births. T...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994589
更新日期:1994-07-01 00:00:00
abstract::Our purpose was to evaluate the impact of intravenous and oral tocolysis on prolongation of gestation for women with preterm uterine contractions and/or labor. Candidates for evaluation and treatment including women with contractions between 24 and 35 weeks. Two hundred women (group I) without cervical changes met the...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章
doi:10.1055/s-2007-994169
更新日期:1997-08-01 00:00:00
abstract::A randomized clinical trial (RCT) noted that sonographic examination in the third trimester, in conjunction with delivery at term for abnormalities of fetal growth, significantly decreased the likelihood of small-for-gestational-age (SGA) neonates in uncomplicated pregnancies. We identified 15 characteristics of scree...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0032-1321497
更新日期:2013-01-01 00:00:00
abstract::Periventricular leukomalacia (PVL) is a complication of prematurity that carries a high risk of long-term neurologic morbidity. We report the first case, to our knowledge, of unexpected PVL associated with in utero methamphetamine exposure in a 30-week gestation premature infant with a benign hospital course, who subs...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-970079
更新日期:2007-02-01 00:00:00
abstract::Background Association studies of various gene variants in neonatal sepsis show conflicting results. Objective We performed a systematic review of candidate gene association studies in neonatal sepsis to provide pooled estimates of risk for selected gene variants. Methods We performed a search using MeSH terms "infect...
journal_title:American journal of perinatology
pub_type: 杂志文章,meta分析,评审
doi:10.1055/s-0036-1597132
更新日期:2017-06-01 00:00:00
abstract::Twenty-five patients undergoing nipple stimulation contraction stress tests were enrolled in this study. Plasma 13,14-dihydro, 15-keto prostaglandin F2 alpha and plasma prolactin concentrations were analyzed before and during the contraction stress tests. Prolactin concentrations were significantly higher (p less than...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999444
更新日期:1990-01-01 00:00:00
abstract::We studied 16 women, at 32 weeks' or more gestation who required magnesium sulfate (MgSO4) therapy for preterm labor or preeclampsia. A 60-minute Doppler fetal heart rate (FHR) tracing, analyzed by the Oxford Sonicaid System 8000, was obtained for 1 hour before and 2 hours after each patient received intravenous MgSO4...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994468
更新日期:1995-07-01 00:00:00
abstract::The Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommends influenza vaccination for women who will be in the second or third trimester of pregnancy during the influenza season. We analyzed hospital admissions with principal diagnoses of influenza or pneumonia and inf...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2004-831888
更新日期:2004-08-01 00:00:00
abstract::This study was performed at University Medical Center, Lubbock, Texas, from July 1989 to June 1990. We obtained serum gentamicin peak and trough levels in 23 pregnant women with pyelonephritis. The patients were given a loading dose of 2 mg/kg gentamicin, followed by 1.5 mg/kg gentamicin adjusted for obesity every 8 h...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994533
更新日期:1994-01-01 00:00:00
abstract::Conventional interval dosing (CID) and extended interval dosing (EID) of gentamicin were compared in preterm infants. Gentamicin peak and trough levels, serum creatinine, urine output, and hearing screens were obtained in 40 preterm infants. Results suggest that EID is safe, provides gentamicin levels in desirable ran...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2004-820515
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:The Apgar score has been shown to have utility in predicting mortality in the extremely preterm infant in delivery hospital populations, where most mortality occurs within 12 hours of birth. We tested the hypothesis that the 5 minute Apgar score would remain associated with mortality in extremely preterm infa...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0035-1554803
更新日期:2015-11-01 00:00:00
abstract::Objective The aim of this article is to examine characteristics of birth tourism (BT) neonates admitted to a neonatal intensive care unit (NICU). Methods This was a retrospective review over 3 years; BT cases were identified, and relevant perinatal, medical, social, and financial data were collected and compared with ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1584139
更新日期:2016-12-01 00:00:00
abstract::We studied the relationships between fetal hemoglobin concentration, acid base status, and lactate concentration in umbilical venous and fetal heart blood in 157 fetuses affected by blood group incompatibility who had been exposed for 214 fetal blood sampling procedures (cordocentesis in 153 and intracardiac puncture ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994524
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE: New treatments are needed for multidrug-resistant (MDR) gram-negative infections in neonates. Ceftolozane/tazobactam is a β-lactam/β-lactamase inhibitor combination that has broad-spectrum activity against most common gram-negative bacteria, including MDR strains. We evaluated pharmacokinetics (PK) and safet...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-3402719
更新日期:2020-01-07 00:00:00
abstract::Four cases of transient polyhydramnios are reviewed. It is proposed that by taking note of changes in amniotic fluid volume, one can more accurately assess a fetal-maternal unit that is affected by a number of specific disease processes. ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999656
更新日期:1988-01-01 00:00:00
abstract::Cardiovascular disease (CVD) is the leading cause of death and disability among women, with more than half occurring in individuals with hypertension. New blood pressure criteria for the diagnosis of hypertension from the American College of Cardiology/American Heart Association recognize that there is no specific blo...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1669441
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Neonatal presentation of vein of Galen aneurysmal malformations (VGAMs) complicated by cardiac failure and pulmonary hypertension is frequently associated with a poor prognosis. Interventional neuroradiology with embolization can offer a chance for survival, although neurological damage can represent a limit...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1666813
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:We hypothesized that surgical energy could be used to create hysterotomies in open fetal surgery. STUDY DESIGN:Initial studies compared the LigaSure Impact and Harmonic ACE + 7 Shears in the efficiency of hysterotomy and thermal damage. Pregnant ewes at an estimated gestational age (EGA) of 116 to 120 days (te...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1673664
更新日期:2019-06-01 00:00:00
abstract::Elevated serum transaminase levels can have many different etiologies, especially in the pregnant patient. Hypoxic hepatitis is a distinct syndrome caused by decreased hepatic blood flow that presents with a marked, but transient, increase in liver enzymes. A 28-year-old woman, gravida 3, para 2 with history of gastri...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0028-1085065
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE: The study aims to assess the impact on neurodevelopmental outcomes of a prolonged hemodynamically significant patent ductus arteriosus (PDA) after a conservative treatment. STUDY DESIGN: This involves the study of two cohorts of preterm infants 23 to 29 weeks gestation, before (n = 29) and after (n = 54) a ...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1697674
更新日期:2019-10-10 00:00:00
abstract:OBJECTIVE:To develop a model to predict cesarean-associated red blood cell transfusion. STUDY DESIGN:Secondary analysis of all cesarean deliveries in the Maternal-Fetal Medicine Units Network Cesarean Registry. Using a split-sample technique, the derivation group was used to identify associated factors and build predi...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0039-1678604
更新日期:2019-07-01 00:00:00
abstract::The objective of this paper is to determine whether acyclovir suppression provides a greater cost savings over no medical therapy in the management of recurrent genital herpes (HSV) in pregnancy. Estimates of the risk of HSV recurrence and cesarean delivery rates in acyclovir-treated and -untreated patients and freque...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-993900
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of pretreatment with obestatin (OB), an endogenous hormone also found in mother's milk, in experimental necrotizing enterocolitis (NEC). STUDY DESIGN:Pups were randomized into four groups: control, OB-control, NEC, and OB-NEC. NEC was induced by asphyxia and hypothermia in the NEC a...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0038-1676491
更新日期:2019-09-01 00:00:00
abstract::Classically, genetically decreased bilirubin conjugation and/or hemolysis account for the mechanisms contributing to neonatal hyperbilirubinemia associated with glucose-6-phosphate dehydrogenase (G6PD) deficiency. However, these mechanisms are not involved in most cases of this hyperbilirubinemia. Additional plausible...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-0036-1585465
更新日期:2017-02-01 00:00:00
abstract::Objective To determine if mandatory online training in electronic fetal monitoring (EFM) improved agreement in documentation between obstetric care providers and nurses on labor and delivery. Methods Health care professionals working in obstetrics at our institution were required to complete a course on EFM interpreta...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1572540
更新日期:2016-07-01 00:00:00
abstract::Although values for cardiac output in the newborn infant have been reported previously, the methods utilized have been invasive. To assess if cardiac output could be determined noninvasively in the neonate, we measured mean ascending aortic blood flow velocity (VAo) in well newborns using a portable 5MHz, range gated,...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-999991
更新日期:1984-01-01 00:00:00
abstract::Studies of the effect of body position during and after bolus feeding upon gastric emptying or gastric residual have not had consistent results. We tested the hypotheses that right lateral decubitus leads to less gastric residual than left lateral decubitus and that the prone position leads to less gastric residual th...
journal_title:American journal of perinatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2004-823778
更新日期:2004-04-01 00:00:00
abstract::We present a case of a premature infant with early-onset necrotizing enterocolitis as the presenting symptom of familial dysautonomia. The diagnosis of familial dysautonomia in the neonatal period is usually rare and difficult, because many of the symptoms may be mild or nonspecific, whereas other characteristic signs...
journal_title:American journal of perinatology
pub_type: 杂志文章,评审
doi:10.1055/s-2005-871525
更新日期:2005-10-01 00:00:00
abstract::Objective To assess the additive value of prenatal chromosomal microarray analysis (CMA) for all indications and the likelihood of detecting pathologic copy number variations (CNVs) based on specific indications. Methods A retrospective analysis was performed on amniocentesis and chorionic villi sampling results obtai...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-0036-1586501
更新日期:2017-03-01 00:00:00
abstract::Premature closure of the foramen ovale is a rare cardiac anomaly. Severe right-sided heart failure accounts for the hepatomegaly, ascites, pleural and pericardial effusions, and generalized edema of these hydropic fetuses. Premature closure of the foramen ovale should be a part of the differential diagnosis when unexp...
journal_title:American journal of perinatology
pub_type: 杂志文章
doi:10.1055/s-2007-994616
更新日期:1994-11-01 00:00:00