Abstract:
:[This corrects the article DOI: 10.1128/mSphere.00393-18.].
journal_name
mSpherejournal_title
mSphereauthors
Foe IT,Onguka O,Amberg-Johnson K,Garner RM,Amara N,Beatty W,Yeh E,Bogyo Mdoi
10.1128/mSphere.00535-18subject
Has Abstractpub_date
2018-10-10 00:00:00issue
5issn
2379-5042pii
mSphere00535-18journal_volume
3pub_type
已发布勘误相关文献
mSphere文献大全abstract::Mary Lopez-Perez works on immunology and pathogenesis of malaria. In this mSphere of Influence article, she reflects on how the paper "Functional antibodies against VAR2CSA in nonpregnant populations from Colombia exposed to Plasmodium falciparum and Plasmodium vivax" by S. Gnidehou, J. Doritchamou, E. M. Arango, A. C...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00224-20
更新日期:2020-04-08 00:00:00
abstract::The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and their biological beha...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00450-19
更新日期:2019-09-04 00:00:00
abstract::The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of having an extremely high or l...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00575-18
更新日期:2019-01-30 00:00:00
abstract::Escherichia coli populations undergo repeated replacement of parental genotypes with fitter variants deep in stationary phase. We isolated one such variant, which emerged after 3 weeks of maintaining an E. coli K-12 population in stationary phase. This variant displayed a small colony phenotype and slow growth and was...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00092-20
更新日期:2020-04-15 00:00:00
abstract::Antibiotic resistance has become a major public health concern as bacteria evolve to evade drugs, leading to recurring infections and a decrease in antibiotic efficacy. Systematic efforts have revealed mechanisms involved in resistance. Yet, in many cases, how these specific mechanisms accelerate or slow the evolution...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.01056-20
更新日期:2020-12-16 00:00:00
abstract::We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00417-17
更新日期:2018-01-24 00:00:00
abstract::Current in vitro techniques for the culture of microorganisms, and particularly of delicate microbial biofilms, are still mostly limited to low-density plates and manual labor and are not amenable to automation and true high-throughput (HT) applications. We have developed a novel fully automated platform for the forma...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00247-17
更新日期:2017-06-28 00:00:00
abstract::Members of family Coronaviridae cause a variety of diseases in birds and mammals. Porcine hemagglutinating encephalomyelitis virus (PHEV), a lesser-researched coronavirus, can infect naive pigs of any age, but clinical disease is observed in pigs ≤4 weeks of age. No commercial PHEV vaccines are available, and neonatal...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00199-20
更新日期:2020-05-06 00:00:00
abstract::Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug susceptibility patterns, and genomic hypermutability. Pseudomonas aeruginosa isolates from CF patients have long been recognized for their overall r...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00615-17
更新日期:2018-03-14 00:00:00
abstract::Coxsackievirus typically infects humans via the gastrointestinal tract, which has a large number of microorganisms collectively referred to as the microbiota. To study how the intestinal microbiota influences enteric virus infection, several groups have used an antibiotic regimen in mice to deplete bacteria. These stu...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00632-18
更新日期:2019-02-20 00:00:00
abstract::Type I interferons (IFN) initiate an antiviral state through a signal transduction cascade that leads to the induction of hundreds of IFN-stimulated genes (ISGs) to restrict viral infection. Recently, RNA modifications on both host and viral RNAs have been described as regulators of infection. However, the impact of h...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00202-20
更新日期:2020-05-13 00:00:00
abstract::The fungal pathogen Candida glabrata can cause both mucosal and disseminated infections. Cell adhesion, a key step in colonization and infection, depends in C. glabrata primarily on the Epa family of cell adhesion proteins. While Epa proteins have been documented to mediate specific adhesion to host glycans, some of t...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00277-19
更新日期:2019-05-01 00:00:00
abstract::Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first r...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00016-16
更新日期:2016-02-17 00:00:00
abstract::Spores, the infectious agents of many Firmicutes, are remarkably resilient cell forms. Even distant relatives can have similar spore architectures although some display unique features; they all incorporate protective proteinaceous envelopes. We previously found that Bacillus spores can achieve these protective proper...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00424-20
更新日期:2020-07-01 00:00:00
abstract::Aspergillus species cause pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients at the greatest risk of developing life-threatening aspergillosis have weakened immune systems and/or various lung disorders. Patients are treated with antifungals such as amphotericin B (AmB), caspofungin...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00025-19
更新日期:2019-02-13 00:00:00
abstract::Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asi...
journal_title:mSphere
pub_type: 杂志文章,多中心研究
doi:10.1128/mSphere.00735-19
更新日期:2020-01-15 00:00:00
abstract::Commensal and generally harmless in healthy individuals, Enterococcus faecalis causes opportunistic infections in immunocompromised patients. Plasmid-cured E. faecalis strain VE14089, derived from sequenced reference strain V583, is widely used for functional studies due to its improved genetic amenability. Although s...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00310-19
更新日期:2019-07-10 00:00:00
abstract::Trichomonas vaginalis is the causative agent of trichomoniasis, the most prevalent nonviral sexually transmitted infection worldwide. Repetitive elements, including transposable elements (TEs) and virally derived repeats, comprise more than half of the ∼160-Mb T. vaginalis genome. An intriguing question is how the par...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.01061-20
更新日期:2021-01-06 00:00:00
abstract::The Anabaena organismic unit is a filament of communicating cells. Under conditions of nitrogen scarcity, some cells along the filament differentiate into heterocysts, which are specialized in the fixation of atmospheric N2 and provide the vegetative cells with N2 fixation products. At a certain stage, the differentia...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00188-20
更新日期:2020-05-20 00:00:00
abstract::Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitr...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00352-18
更新日期:2018-10-31 00:00:00
abstract::Clostridioides difficile is an obligately anaerobic, spore-forming, Gram-positive pathogenic bacterium that is considered the leading cause of nosocomial diarrhea worldwide. Recent studies have attempted to understand the biology of the outermost layer of C. difficile spores, the exosporium, which is believed to contr...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.01065-20
更新日期:2020-11-18 00:00:00
abstract::Opsonophagocytic assays are used to measure functional antibodies important in protection against pneumococcal capsular antigens. There have been efforts to standardize these methods, as the assays are commonly used to measure vaccine immunogenicity. We report here the results from three international laboratories usi...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00070-18
更新日期:2018-04-25 00:00:00
abstract::Molecular detection of biological agents in the field has traditionally relied on the use of quantitative real-time PCR (qPCR), which now includes commercially available instruments that can be used in the laboratory or field. Adapting this technology for field-forward applications necessitated innovation to minimize ...
journal_title:mSphere
pub_type: 杂志文章,评审
doi:10.1128/mSphere.00695-19
更新日期:2019-12-11 00:00:00
abstract::Skin and soft tissue infections (SSTIs) are common in the general population, with increased prevalence among military trainees. Previous research has revealed numerous nasal microbial signatures that correlate with SSTI development and Staphylococcus aureus colonization. Thus, we hypothesized that the ecology of the ...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00232-16
更新日期:2016-10-05 00:00:00
abstract::Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusive...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00157-20
更新日期:2020-03-18 00:00:00
abstract::Control and eradication of foot-and-mouth disease (FMD) are impeded by the existence of a persistent, subclinical phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers is uncertain. In the current investigatio...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00365-18
更新日期:2018-09-12 00:00:00
abstract::Streptococcus pneumoniae (the pneumococcus) carriage is commonly used to measure effects of pneumococcal vaccines. Based on findings from culture-based studies, the World Health Organization recommends both nasopharyngeal (NP) and oropharyngeal (OP) sampling for detecting adult carriage. Given evidence of potential co...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00478-20
更新日期:2020-07-29 00:00:00
abstract::CRISPR (clustered regularly interspaced short palindromic repeat)-Cas9 is a novel genome-editing system that has been successfully established in Aspergillus fumigatus. However, the current state of the technology relies heavily on DNA-based expression cassettes for delivering Cas9 and the guide RNA (gRNA) to the cell...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00446-17
更新日期:2017-11-22 00:00:00
abstract::The newly emerged Candida species Candida auris is associated with an exponential rise in life-threatening invasive disease in health care facilities worldwide. Unlike other species, C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in the environment, yet little is known about ...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00760-20
更新日期:2020-08-05 00:00:00
abstract::Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staphylococcus aureus. MIC and time-kill assays were employed to measure the activi...
journal_title:mSphere
pub_type: 杂志文章
doi:10.1128/mSphere.00119-16
更新日期:2016-07-27 00:00:00