Abstract:
:The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of having an extremely high or low protein level in a stochastic model of gene expression. The fraction of rare state cells defined as the cells in the tails of distributions is found to be highly sensitive to small changes of the mean protein level. The result highlights the importance of relatively weak changes to the mean for the occurrence of rare phenotypes.
journal_name
mSpherejournal_title
mSphereauthors
Svenningsen MS,Semsey S,Mitarai Ndoi
10.1128/mSphere.00575-18subject
Has Abstractpub_date
2019-01-30 00:00:00issue
1issn
2379-5042pii
4/1/e00575-18journal_volume
4pub_type
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