Discovery of a Novel Bat Gammaherpesvirus.

abstract：:The major surface lipophosphoglycan (LPG) of Leishmania parasites is critical to vector competence in restrictive sand fly vectors in mediating Leishmania attachment to the midgut epithelium, considered essential to parasite survival and development. However, the relevance of LPG for sand flies that harbor multiple sp...

journal_title：mSphere

authors： Coutinho-Abreu IV,Oristian J,de Castro W,Wilson TR,Meneses C,Soares RP,Borges VM,Descoteaux A,Kamhawi S,Valenzuela JG

更新日期：2020-09-09 00:00:00

abstract：:Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory infections, many of which are characterized by coughing of the infected hosts. The pathogenesis of the coughing remains to be analyzed, mainly because there were no convenient infection models of small animals that replicate coughing after...

journal_title：mSphere

authors： Nakamura K,Shinoda N,Hiramatsu Y,Ohnishi S,Kamitani S,Ogura Y,Hayashi T,Horiguchi Y

更新日期：2019-04-24 00:00:00

abstract：:Increasing evidence shows that exosomes are key regulators in cancer cell-to-cell communication. Several reports on Epstein-Barr virus (EBV)-related malignancies demonstrate that latent membrane protein 1 (LMP1) secreted by exosomes derived from EBV- or LMP1-positive cells can promote cancer progression and metastasis...

journal_title：mSphere

authors： Kobayashi E,Aga M,Kondo S,Whitehurst C,Yoshizaki T,Pagano JS,Shackelford J

更新日期：2018-02-07 00:00:00

abstract：:We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...

journal_title：mSphere

authors： Ishigaki K,Shinzawa N,Nishikawa S,Suzuki K,Fukui-Miyazaki A,Horiguchi Y

更新日期：2018-01-24 00:00:00

abstract：:Trichomonas vaginalis is the causative agent of trichomoniasis, the most prevalent nonviral sexually transmitted infection worldwide. Repetitive elements, including transposable elements (TEs) and virally derived repeats, comprise more than half of the ∼160-Mb T. vaginalis genome. An intriguing question is how the par...

journal_title：mSphere

authors： Warring SD,Blow F,Avecilla G,Orosco JC,Sullivan SA,Carlton JM

更新日期：2021-01-06 00:00:00

abstract：:Periodontal disease induced by periodontopathic bacteria like Porphyromonas gingivalis is demonstrated to increase the risk of metabolic, inflammatory, and autoimmune disorders. Although precise mechanisms for this connection have not been elucidated, we have proposed mechanisms by which orally administered periodonto...

journal_title：mSphere

authors： Kato T,Yamazaki K,Nakajima M,Date Y,Kikuchi J,Hase K,Ohno H,Yamazaki K

更新日期：2018-10-17 00:00:00

abstract：:The extraintestinal pathogenic Escherichia coli (ExPEC) H30 subclone of sequence type 131 (ST131-H30) has emerged abruptly as a dominant lineage of ExPEC responsible for human disease. The ST131-H30 lineage has been well described phylogenetically, yet its plasmid complement is not fully understood. Here, single-molec...

journal_title：mSphere

authors： Johnson TJ,Danzeisen JL,Youmans B,Case K,Llop K,Munoz-Aguayo J,Flores-Figueroa C,Aziz M,Stoesser N,Sokurenko E,Price LB,Johnson JR

更新日期：2016-06-29 00:00:00

abstract：:Continued influx of metagenome-derived proteins with misannotated taxonomy into conventional databases, including RefSeq, threatens to eliminate the value of taxonomy identifiers. To prevent this, urgent efforts should be undertaken by submitters of metagenomic data sets as well as by database managers. ...

journal_title：mSphere

authors： Arkhipova IR

更新日期：2020-11-04 00:00:00

abstract：:Molecular detection of biological agents in the field has traditionally relied on the use of quantitative real-time PCR (qPCR), which now includes commercially available instruments that can be used in the laboratory or field. Adapting this technology for field-forward applications necessitated innovation to minimize ...

journal_title：mSphere

authors： Yeh KB,Wood H,Scullion M,Russell JA,Parker K,Gnade BT,Jones AR,Whittier C,Mereish K

更新日期：2019-12-11 00:00:00

abstract：:The Amazon River watershed and its associated plume comprise a vast continental and oceanic area. The microbial activities along this continuum contribute substantially to global carbon and nutrient cycling, and yet there is a dearth of information on the diversity, abundance, and possible roles of viruses in this glo...

journal_title：mSphere

authors： Silva BSO,Coutinho FH,Gregoracci GB,Leomil L,de Oliveira LS,Fróes A,Tschoeke D,Soares AC,Cabral AS,Ward ND,Richey JE,Krusche AV,Yager PL,de Rezende CE,Thompson CC,Thompson FL

更新日期：2017-10-04 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) carriage is commonly used to measure effects of pneumococcal vaccines. Based on findings from culture-based studies, the World Health Organization recommends both nasopharyngeal (NP) and oropharyngeal (OP) sampling for detecting adult carriage. Given evidence of potential co...

journal_title：mSphere

authors： Boelsen LK,Dunne EM,Gould KA,Ratu FT,Vidal JE,Russell FM,Mulholland EK,Hinds J,Satzke C

更新日期：2020-07-29 00:00:00

abstract：:Parasitic protozoans of the genus Theileria are intracellular pathogens that induce the cellular transformation of leukocytes, causing uncontrolled proliferation of the infected host cell. The transforming stage of the parasite has a strictly intracellular lifestyle and ensures its distribution to both daughter cells ...

journal_title：mSphere

authors： Huber S,Bär A,Epp S,Schmuckli-Maurer J,Eberhard N,Humbel BM,Hemphill A,Woods K

更新日期：2020-02-05 00:00:00

abstract：:The role of the gut microbiome in critical illness is being actively investigated, but the optimal sampling methods for sequencing studies of gut microbiota remain unknown. Stool samples are generally considered the reference standard but are not practical to obtain in the intensive care unit (ICU), and thus, rectal s...

journal_title：mSphere

authors： Fair K,Dunlap DG,Fitch A,Bogdanovich T,Methé B,Morris A,McVerry BJ,Kitsios GD

更新日期：2019-07-24 00:00:00

abstract：:The genetic stability of every living organism depends on accurate DNA replication and repair systems. Here, we investigated the Aspergillus fumigatusMSH2 mismatch repair (MMR) gene MshA and how it impacts virulence and the evolution of azole resistance. We examined mshA gene variation in 62 environmental and clinical...

journal_title：mSphere

authors： Dos Reis TF,Silva LP,de Castro PA,do Carmo RA,Marini MM,da Silveira JF,Ferreira BH,Rodrigues F,Lind AL,Rokas A,Goldman GH

更新日期：2019-08-07 00:00:00

abstract：:Campylobacter jejuni is a leading cause of bacterial diarrhea worldwide and is associated with high rates of mortality and growth stunting in children inhabiting low- to middle-resource countries. To better understand the impact of breastfeeding on Campylobacter infection in infants in sub-Saharan Africa and South Asi...

journal_title：mSphere

authors： Bian X,Garber JM,Cooper KK,Huynh S,Jones J,Mills MK,Rafala D,Nasrin D,Kotloff KL,Parker CT,Tennant SM,Miller WG,Szymanski CM

更新日期：2020-01-15 00:00:00

abstract：:Neal Hammer works in the field of bacterial pathogenesis, metabolism, and antibiotic resistance. In this mSphere of Influence article, he reflects on how "Gut inflammation provides a respiratory electron acceptor for Salmonella" by Winter and colleagues (S. E. Winter, P. Thiennimitr, M. G. Winter, B. P. Butler, et al....

journal_title：mSphere

authors： Hammer ND

更新日期：2020-02-26 00:00:00

abstract：:The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored ...

journal_title：mSphere

authors： Hallée S,Boddey JA,Cowman AF,Richard D

更新日期：2018-01-03 00:00:00

abstract：:Although the role of high-risk human papillomaviruses (hrHPVs) as etiological agents in cancer development has been intensively studied during the last decades, there is still the necessity of understanding the impact of the HPV E6 and E7 oncogenes on host cells, ultimately leading to malignant transformation. Here, w...

journal_title：mSphere

authors： Yang R,Klimentová J,Göckel-Krzikalla E,Ly R,Gmelin N,Hotz-Wagenblatt A,Řehulková H,Stulík J,Rösl F,Niebler M

更新日期：2019-03-27 00:00:00

abstract：:Buruli ulcer is a neglected tropical disease of skin and subcutaneous tissue caused by infection with the pathogen Mycobacterium ulcerans Many critical issues for disease control, such as understanding the mode of transmission and identifying source reservoirs of M. ulcerans, are still largely unknown. Here, we used g...

journal_title：mSphere

authors： Vandelannoote K,Phanzu DM,Kibadi K,Eddyani M,Meehan CJ,Jordaens K,Leirs H,Portaels F,Stinear TP,Harris SR,de Jong BC

更新日期：2019-02-06 00:00:00

abstract：:The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was imple...

journal_title：mSphere

authors： Ceyhan M,Ozsurekci Y,Tanır Basaranoglu S,Gurler N,Sali E,Keser Emiroglu M,Oz FN,Belet N,Duman M,Ulusoy E,Kurugol Z,Tezer H,Ozkaya Parlakay A,Dinleyici EC,Celik U,Celebi S,Oner AF,Solmaz MA,Karbuz A,Hatipoglu N,Dev

更新日期：2020-03-25 00:00:00

abstract：:Coxsackievirus typically infects humans via the gastrointestinal tract, which has a large number of microorganisms collectively referred to as the microbiota. To study how the intestinal microbiota influences enteric virus infection, several groups have used an antibiotic regimen in mice to deplete bacteria. These stu...

journal_title：mSphere

authors： Woods Acevedo MA,Erickson AK,Pfeiffer JK

更新日期：2019-02-20 00:00:00

abstract：:Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing ...

journal_title：mSphere

authors： Moreira-Soto A,Carneiro IO,Fischer C,Feldmann M,Kümmerer BM,Silva NS,Santos UG,Souza BFCD,Liborio FA,Valença-Montenegro MM,Laroque PO,da Fontoura FR,Oliveira AVD,Drosten C,de Lamballerie X,Franke CR,Drexler JF

更新日期：2018-01-31 00:00:00

abstract：:Pseudomonas aeruginosa is an opportunistic pathogen that causes severe health problems. Despite intensive investigation, many aspects of microbial virulence remain poorly understood. We used a high-throughput, high-content, whole-organism, phenotypic screen to identify small molecules that inhibit P. aeruginosa virule...

journal_title：mSphere

authors： Kirienko DR,Revtovich AV,Kirienko NV

更新日期：2016-08-24 00:00:00

abstract：:Clostridioides difficile is an obligately anaerobic, spore-forming, Gram-positive pathogenic bacterium that is considered the leading cause of nosocomial diarrhea worldwide. Recent studies have attempted to understand the biology of the outermost layer of C. difficile spores, the exosporium, which is believed to contr...

journal_title：mSphere

authors： Romero-Rodríguez A,Troncoso-Cotal S,Guerrero-Araya E,Paredes-Sabja D

更新日期：2020-11-18 00:00:00

abstract：:Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusive...

journal_title：mSphere

authors： Harbison-Price N,Ferguson SA,Heikal A,Taiaroa G,Hards K,Nakatani Y,Rennison D,Brimble MA,El-Deeb IM,Bohlmann L,McDevitt CA,von Itzstein M,Walker MJ,Cook GM

更新日期：2020-03-18 00:00:00

abstract：:We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans' sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity wi...

journal_title：mSphere

authors： Nahm MH,Yu J,Vlach J,Bar-Peled M

更新日期：2020-04-08 00:00:00

abstract：:Syndiniales are a ubiquitous group of protist parasites that infect and kill a wide range of hosts, including harmful bloom-forming dinoflagellates. Despite the importance of parasitism as an agent of plankton mortality, parasite-host dynamics remain poorly understood, especially over time, hindering the inclusion of ...

journal_title：mSphere

authors： Anderson SR,Harvey EL

更新日期：2020-05-27 00:00:00

abstract：:A maternal vaccine capable of boosting neutralizing antibody (NAb) responses directed against circulating viruses in HIV-infected pregnant women could effectively decrease mother-to-child transmission of HIV. However, it is not known if an HIV envelope (Env) vaccine administered to infected pregnant women could enhanc...

journal_title：mSphere

authors： Hompe ED,Mangold JF,Kumar A,Eudailey JA,McGuire E,Haynes BF,Moody MA,Wright PF,Fouda GG,Giorgi EE,Gao F,Permar SR

更新日期：2020-06-03 00:00:00

abstract：:Female Hawaiian bobtail squid, Euprymna scolopes, harbor a symbiotic bacterial community in a reproductive organ, the accessory nidamental gland (ANG). This community is known to be stable over several generations of wild-caught bobtail squid but has, to date, been examined for only one population in Maunalua Bay, Oah...

journal_title：mSphere

authors： Kerwin AH,Nyholm SV

更新日期：2018-03-28 00:00:00

abstract：:The stability of the Escherichia coli populations in the human gastrointestinal tract is not fully appreciated, and represents a significant knowledge gap regarding gastrointestinal community structure, as well as resistance to incoming pathogenic bacterial species and antibiotic treatment. The current study examines ...

journal_title：mSphere

authors： Richter TKS,Hazen TH,Lam D,Coles CL,Seidman JC,You Y,Silbergeld EK,Fraser CM,Rasko DA

更新日期：2018-11-07 00:00:00