A Common Food Glycan, Pectin, Shares an Antigen with Streptococcus pneumoniae Capsule.

abstract：:The emergence of Cryptococcus gattii, previously regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest (PNW) in 1999 prompted several questions. The most prevalent among these was the timing of the introduction of this pathogen to this novel environment. Here, ...

journal_title：mSphere

authors： Roe CC,Bowers J,Oltean H,DeBess E,Dufresne PJ,McBurney S,Overy DP,Wanke B,Lysen C,Chiller T,Meyer W,Thompson GR 3rd,Lockhart SR,Hepp CM,Engelthaler DM

更新日期：2018-01-17 00:00:00

abstract：:The major surface lipophosphoglycan (LPG) of Leishmania parasites is critical to vector competence in restrictive sand fly vectors in mediating Leishmania attachment to the midgut epithelium, considered essential to parasite survival and development. However, the relevance of LPG for sand flies that harbor multiple sp...

journal_title：mSphere

authors： Coutinho-Abreu IV,Oristian J,de Castro W,Wilson TR,Meneses C,Soares RP,Borges VM,Descoteaux A,Kamhawi S,Valenzuela JG

更新日期：2020-09-09 00:00:00

abstract：:Glycine serves as a major source of single carbon units for biochemical reactions within bacterial cells. Utilization of glycine is tightly regulated and revolves around a key group of proteins known as the glycine cleavage system (GCS). Our lab previously identified the transcriptional regulator GcsR (PA2449) as bein...

journal_title：mSphere

authors： Sarwar Z,Lundgren BR,Grassa MT,Wang MX,Gribble M,Moffat JF,Nomura CT

更新日期：2016-04-27 00:00:00

abstract：:The extraintestinal pathogenic Escherichia coli (ExPEC) H30 subclone of sequence type 131 (ST131-H30) has emerged abruptly as a dominant lineage of ExPEC responsible for human disease. The ST131-H30 lineage has been well described phylogenetically, yet its plasmid complement is not fully understood. Here, single-molec...

journal_title：mSphere

authors： Johnson TJ,Danzeisen JL,Youmans B,Case K,Llop K,Munoz-Aguayo J,Flores-Figueroa C,Aziz M,Stoesser N,Sokurenko E,Price LB,Johnson JR

更新日期：2016-06-29 00:00:00

abstract：:Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen of increasing concern due to its ability to cause serious organ and life-threatening infections in healthy individuals and its increasing acquisition of antimicrobial resistance determinants. Identification of hvKp is critical for patient care and epid...

journal_title：mSphere

authors： Russo TA,MacDonald U

更新日期：2020-01-08 00:00:00

abstract：:Various Lactobacillus species have been reported to deconjugate bile acids in the gastrointestinal tract (GIT) through the action of bile salt hydrolase (BSH) proteins. This function contributes to altering the gut microbiota composition and bile metabolism and detoxification and to lowering cholesterol levels. Here, ...

journal_title：mSphere

authors： O'Flaherty S,Briner Crawley A,Theriot CM,Barrangou R

更新日期：2018-05-30 00:00:00

abstract：:Immunity to Toxoplasma gondii at early stages of infection in C57BL/6 mice depends on gamma interferon (IFN-γ) production by NK cells, while at later stages it is primarily mediated by CD8 T cells. We decided to explore the requirement for CD4 T cells during T. gondii infection in Batf3-/- mice, which lack CD8α+ dendr...

journal_title：mSphere

authors： Tussiwand R,Behnke MS,Kretzer NM,Grajales-Reyes GE,Murphy TL,Schreiber RD,Murphy KM,Sibley LD

更新日期：2020-07-15 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), produced by neurotoxigenic clostridial species, are the cause of the severe disease botulism in humans and animals. Early research on BoNTs has led to their classification into seven serotypes (serotypes A to G) based upon the selective neutralization of their toxicity in mice by homolog...

journal_title：mSphere

authors： Pellett S,Tepp WH,Bradshaw M,Kalb SR,Dykes JK,Lin G,Nawrocki EM,Pier CL,Barr JR,Maslanka SE,Johnson EA

更新日期：2016-02-24 00:00:00

abstract：:Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which provides a new approach to mea...

journal_title：mSphere

authors： Casadevall A

更新日期：2017-02-22 00:00:00

abstract：:Brucella, the agent causing brucellosis, is a major zoonotic pathogen with worldwide distribution. Brucella resides and replicates inside infected host cells in membrane-bound compartments called Brucella-containing vacuoles (BCVs). Following uptake, Brucella resides in endosomal BCVs (eBCVs) that gradually mature fro...

journal_title：mSphere

authors： Casanova A,Low SH,Québatte M,Sedzicki J,Tschon T,Ketterer M,Smith K,Emmenlauer M,Ben-Tekaya H,Dehio C

更新日期：2019-06-26 00:00:00

abstract：:Members of family Coronaviridae cause a variety of diseases in birds and mammals. Porcine hemagglutinating encephalomyelitis virus (PHEV), a lesser-researched coronavirus, can infect naive pigs of any age, but clinical disease is observed in pigs ≤4 weeks of age. No commercial PHEV vaccines are available, and neonatal...

journal_title：mSphere

authors： Mora-Díaz JC,Magtoto R,Houston E,Baum D,Carrillo-Ávila JA,Temeeyasen G,Zimmerman J,Piñeyro P,Giménez-Lirola L

更新日期：2020-05-06 00:00:00

abstract：:Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the ability of Gram-negative bacteria to regulate genes associated with virulence, persistence, stress response, quorum sensing, biosynthesis pathways, and cell adhesion. Here, we used the expression of metallo-β-lactamases (MBLs), ...

journal_title：mSphere

authors： Huang F,Fitchett N,Razo-Gutierrez C,Le C,Martinez J,Ra G,Lopez C,Gonzalez LJ,Sieira R,Vila AJ,Bonomo RA,Ramirez MS

更新日期：2020-08-26 00:00:00

abstract：:Michael D. L. Johnson is a molecular microbiologist observing the role of metals in bacterial biology. In this mSphere of Influence article, he discusses the impact that the paper "Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US" by Kennet...

journal_title：mSphere

authors： Johnson MDL

更新日期：2019-09-18 00:00:00

abstract：:Microsporidia are obligate intracellular parasites that infect a wide variety of host organisms, including humans. The sporoplasm is the initial stage of microsporidian infection and proliferation, but its morphological and molecular characteristics are poorly understood. In this study, the sporoplasm of Nosema bombyc...

journal_title：mSphere

authors： He Q,Luo J,Xu JZ,Wang CX,Meng XZ,Pan GQ,Li T,Zhou ZY

更新日期：2020-02-12 00:00:00

abstract：:Outbreaks of infection occur more often than they are reported in most developing countries, largely due to poor diagnostic services. A Klebsiella species bacteremia outbreak in a newborn unit with high mortality was recently encountered at a location being surveilled for childhood bacteremia. These surveillance effor...

journal_title：mSphere

authors： Brinkac LM,White R,D'Souza R,Nguyen K,Obaro SK,Fouts DE

更新日期：2019-03-13 00:00:00

abstract：:Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread ...

journal_title：mSphere

authors： Uppuluri P

更新日期：2020-01-22 00:00:00

abstract：:Megan E. Spurgeon works in the field of viral oncology. In this mSphere of Influence article, she reflects on how the paper "Rescuing US biomedical research from its systemic flaws" by Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus (Proc Natl Acad Sci U S A 111:5773-5777, 2014, https://doi.org/1...

journal_title：mSphere

authors： Spurgeon ME

更新日期：2019-07-03 00:00:00

abstract：:Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent strains of the rodent malaria parasite Plasm...

journal_title：mSphere

authors： Huang X,Huang S,Ong LC,Lim JC,Hurst RJ,Mushunje AT,Matsudaira PT,Han J,Preiser PR

更新日期：2015-12-09 00:00:00

abstract：:Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory infections, many of which are characterized by coughing of the infected hosts. The pathogenesis of the coughing remains to be analyzed, mainly because there were no convenient infection models of small animals that replicate coughing after...

journal_title：mSphere

authors： Nakamura K,Shinoda N,Hiramatsu Y,Ohnishi S,Kamitani S,Ogura Y,Hayashi T,Horiguchi Y

更新日期：2019-04-24 00:00:00

abstract：:Cryptococcus neoformans and related species are encapsulated basidiomycetous fungi that cause meningoencephalitis in individuals with immune deficiency. This pathogen has a tractable genetic system; however, gene disruption via electroporation remains difficult, while biolistic transformation is often limited by lack ...

journal_title：mSphere

authors： Wang P

更新日期：2018-06-13 00:00:00

abstract：:The Anabaena organismic unit is a filament of communicating cells. Under conditions of nitrogen scarcity, some cells along the filament differentiate into heterocysts, which are specialized in the fixation of atmospheric N2 and provide the vegetative cells with N2 fixation products. At a certain stage, the differentia...

journal_title：mSphere

authors： Valladares A,Velázquez-Suárez C,Herrero A

更新日期：2020-05-20 00:00:00

abstract：:Candida albicans is an opportunistic human fungal pathogen that causes superficial fungal infections and lethal systemic infections. To colonize and establish infections, C. albicans coordinates the expression of virulence and metabolic genes. Previous work showed that the homeodomain transcription factor Grf10 is req...

journal_title：mSphere

authors： Wangsanut T,Ghosh AK,Metzger PG,Fonzi WA,Rolfes RJ

更新日期：2017-08-02 00:00:00

abstract：:We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...

journal_title：mSphere

authors： Ishigaki K,Shinzawa N,Nishikawa S,Suzuki K,Fukui-Miyazaki A,Horiguchi Y

更新日期：2018-01-24 00:00:00

abstract：:A maternal vaccine capable of boosting neutralizing antibody (NAb) responses directed against circulating viruses in HIV-infected pregnant women could effectively decrease mother-to-child transmission of HIV. However, it is not known if an HIV envelope (Env) vaccine administered to infected pregnant women could enhanc...

journal_title：mSphere

authors： Hompe ED,Mangold JF,Kumar A,Eudailey JA,McGuire E,Haynes BF,Moody MA,Wright PF,Fouda GG,Giorgi EE,Gao F,Permar SR

更新日期：2020-06-03 00:00:00

abstract：:Neal Hammer works in the field of bacterial pathogenesis, metabolism, and antibiotic resistance. In this mSphere of Influence article, he reflects on how "Gut inflammation provides a respiratory electron acceptor for Salmonella" by Winter and colleagues (S. E. Winter, P. Thiennimitr, M. G. Winter, B. P. Butler, et al....

journal_title：mSphere

authors： Hammer ND

更新日期：2020-02-26 00:00:00

abstract：:The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored ...

journal_title：mSphere

authors： Hallée S,Boddey JA,Cowman AF,Richard D

更新日期：2018-01-03 00:00:00

abstract：:The etiology of bacterial meningitis in Turkey changed after the implementation of conjugated vaccines against Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) in the Turkish National Immunization Program (NIP). Administration of Hib vaccine and PCV-7 (7-valent pneumococcal conjugate vaccine) was imple...

journal_title：mSphere

authors： Ceyhan M,Ozsurekci Y,Tanır Basaranoglu S,Gurler N,Sali E,Keser Emiroglu M,Oz FN,Belet N,Duman M,Ulusoy E,Kurugol Z,Tezer H,Ozkaya Parlakay A,Dinleyici EC,Celik U,Celebi S,Oner AF,Solmaz MA,Karbuz A,Hatipoglu N,Dev

更新日期：2020-03-25 00:00:00

abstract：:The facultative anaerobic polymorphic fungus Candida albicans and the strictly anaerobic Gram-positive bacterium Clostridium difficile are two opportunistic pathogens residing in the human gut. While a few studies have focused on the prevalence of C. albicans in C. difficile-infected patients, the nature of the intera...

journal_title：mSphere

authors： van Leeuwen PT,van der Peet JM,Bikker FJ,Hoogenkamp MA,Oliveira Paiva AM,Kostidis S,Mayboroda OA,Smits WK,Krom BP

更新日期：2016-11-09 00:00:00

abstract：:Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitr...

journal_title：mSphere

authors： Bhatt K,Machado H,Osório NS,Sousa J,Cardoso F,Magalhães C,Chen B,Chen M,Kim J,Singh A,Ferreira CM,Castro AG,Torrado E,Jacobs WR Jr,Bhatt A,Saraiva M

更新日期：2018-10-31 00:00:00

abstract：:Sepsis caused by Gram-negative bacteria is the consequence of an unrestrained infection that continuously releases lipopolysaccharide (LPS) into the bloodstream, which triggers an uncontrolled systemic inflammatory response leading to multiorgan failure and death. After scrutinizing the immune modulation exerted by a ...

journal_title：mSphere

authors： Ramos-Benitez MJ,Ruiz-Jimenez C,Rosado-Franco JJ,Ramos-Pérez WD,Mendez LB,Osuna A,Espino AM

更新日期：2018-12-19 00:00:00