mSphere of Influence: a Controlled Burn-Pathogen Manipulation of the Dynamic Chemistry That Results from Inflammation.

abstract：:Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During intracellular infection, S. aureus is capable of subverting xenophagy and escaping to the cytosol of the host cell. Furthermore, drug-induced autophagy facilitates t...

journal_title：mSphere

authors： Bravo-Santano N,Ellis JK,Mateos LM,Calle Y,Keun HC,Behrends V,Letek M

更新日期：2018-08-08 00:00:00

abstract：:Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis Of the 10 million cases of tuberculosis in 2017, approximately 19% of new cases and 43% of previously treated cases were caused by strains of M. tuberculosis res...

journal_title：mSphere

authors： Harrison GA,Mayer Bridwell AE,Singh M,Jayaraman K,Weiss LA,Kinsella RL,Aneke JS,Flentie K,Schene ME,Gaggioli M,Solomon SD,Wildman SA,Meyers MJ,Stallings CL

更新日期：2019-09-11 00:00:00

abstract：:Cryptococcus neoformans is a pathogenic yeast that causes lethal cryptococcal meningitis in immunocompromised patients. One of the challenges in treating cryptococcosis is the development of resistance to azole antifungals. Previous studies linked azole resistance to elevated numbers of copies of critical resistance g...

journal_title：mSphere

authors： Altamirano S,Fang D,Simmons C,Sridhar S,Wu P,Sanyal K,Kozubowski L

更新日期：2017-06-14 00:00:00

abstract：:Buruli ulcer is a neglected tropical disease of skin and subcutaneous tissue caused by infection with the pathogen Mycobacterium ulcerans Many critical issues for disease control, such as understanding the mode of transmission and identifying source reservoirs of M. ulcerans, are still largely unknown. Here, we used g...

journal_title：mSphere

authors： Vandelannoote K,Phanzu DM,Kibadi K,Eddyani M,Meehan CJ,Jordaens K,Leirs H,Portaels F,Stinear TP,Harris SR,de Jong BC

更新日期：2019-02-06 00:00:00

abstract：:Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations. Treponema pallidum undergoes rapid vascular dissemination to penetrate tissue, placental, and blood-brain barriers and gain acces...

journal_title：mSphere

authors： Lithgow KV,Church B,Gomez A,Tsao E,Houston S,Swayne LA,Cameron CE

更新日期：2020-04-01 00:00:00

abstract：:Brucella, the agent causing brucellosis, is a major zoonotic pathogen with worldwide distribution. Brucella resides and replicates inside infected host cells in membrane-bound compartments called Brucella-containing vacuoles (BCVs). Following uptake, Brucella resides in endosomal BCVs (eBCVs) that gradually mature fro...

journal_title：mSphere

authors： Casanova A,Low SH,Québatte M,Sedzicki J,Tschon T,Ketterer M,Smith K,Emmenlauer M,Ben-Tekaya H,Dehio C

更新日期：2019-06-26 00:00:00

abstract：:Elizabethkingia anophelis is an emerging global multidrug-resistant opportunistic pathogen. We assessed the diversity among 13 complete genomes and 23 draft genomes of E. anophelis strains derived from various environmental settings and human infections from different geographic regions around the world from 1950s to ...

journal_title：mSphere

authors： Xu J,Pei D,Nicholson A,Lan Y,Xia Q

更新日期：2019-04-03 00:00:00

abstract：:To design immune interventions that can synergize with antiretroviral therapy (ART) to reduce the rate of HIV mother-to-child transmission (MTCT), it is essential to characterize maternal immune responses in the setting of ART during pregnancy and breastfeeding and define their effect on MTCT. Prior studies reported a...

journal_title：mSphere

authors： Hompe ED,Jacobson DL,Eudailey JA,Butler K,Edwards W,Pollara J,Brummel SS,Fouda GG,Chinula L,Kamanga M,Kinikar A,Moodley D,Owor M,Fowler MG,Permar SR

更新日期：2019-10-23 00:00:00

abstract：:Cryptococcus gattii R265 is a hypervirulent fungal strain responsible for the recent outbreak of cryptococcosis in Vancouver Island of British Columbia in Canada. It differs significantly from Cryptococcus neoformans in its natural environment, its preferred site in the mammalian host, and its pathogenesis. Our previo...

journal_title：mSphere

authors： Lam WC,Upadhya R,Specht CA,Ragsdale AE,Hole CR,Levitz SM,Lodge JK

更新日期：2019-10-09 00:00:00

abstract：:Feedback mechanisms are fundamental to the control of physiological responses. One important example in gene regulation, termed negative autoregulation (NAR), occurs when a transcription factor (TF) inhibits its own production through transcriptional repression. This enables more-rapid homeostatic control of gene expr...

journal_title：mSphere

authors： Kozuch BC,Shaffer MG,Culyba MJ

更新日期：2020-08-19 00:00:00

abstract：:The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored ...

journal_title：mSphere

authors： Hallée S,Boddey JA,Cowman AF,Richard D

更新日期：2018-01-03 00:00:00

abstract：:The role of the gut microbiome in critical illness is being actively investigated, but the optimal sampling methods for sequencing studies of gut microbiota remain unknown. Stool samples are generally considered the reference standard but are not practical to obtain in the intensive care unit (ICU), and thus, rectal s...

journal_title：mSphere

authors： Fair K,Dunlap DG,Fitch A,Bogdanovich T,Methé B,Morris A,McVerry BJ,Kitsios GD

更新日期：2019-07-24 00:00:00

abstract：:Hypervirulent Klebsiella pneumoniae (hvKp) is an emerging pathogen of increasing concern due to its ability to cause serious organ and life-threatening infections in healthy individuals and its increasing acquisition of antimicrobial resistance determinants. Identification of hvKp is critical for patient care and epid...

journal_title：mSphere

authors： Russo TA,MacDonald U

更新日期：2020-01-08 00:00:00

abstract：:Grf10, a homeodomain-containing transcription factor, regulates adenylate and one-carbon metabolism and morphogenesis in the human fungal pathogen Candida albicans Here, we identified functional domains and key residues involved in transcription factor activity using one-hybrid and mutational analyses. We localized ac...

journal_title：mSphere

authors： Wangsanut T,Tobin JM,Rolfes RJ

更新日期：2018-10-24 00:00:00

abstract：:The Enterobacterales order of Gram-negative bacteria includes the common nosocomial pathogens Klebsiella pneumoniae, Escherichia coli, Serratia marcescens, and Enterobacter species. Intestinal domination by some colonizing bacterial taxa is associated with subsequent infection, but 16S rRNA gene sequencing is too cost...

journal_title：mSphere

authors： Rao K,Seekatz A,Bassis C,Sun Y,Mantlo E,Bachman MA

更新日期：2020-07-22 00:00:00

abstract：:Various Lactobacillus species have been reported to deconjugate bile acids in the gastrointestinal tract (GIT) through the action of bile salt hydrolase (BSH) proteins. This function contributes to altering the gut microbiota composition and bile metabolism and detoxification and to lowering cholesterol levels. Here, ...

journal_title：mSphere

authors： O'Flaherty S,Briner Crawley A,Theriot CM,Barrangou R

更新日期：2018-05-30 00:00:00

abstract：:Influenza D virus (IDV) is unique among four types of influenza viruses in that it utilizes cattle as a primary reservoir. The thermal and acid stability of IDV were examined and directly compared with those of influenza A virus (IAV), influenza B virus (IBV), and influenza C virus (ICV). The results of our experiment...

journal_title：mSphere

authors： Yu J,Hika B,Liu R,Sheng Z,Hause BM,Li F,Wang D

更新日期：2017-08-09 00:00:00

abstract：:Chlamydia trachomatis delivers multiple type 3 secreted effector proteins to host epithelial cells to manipulate cytoskeletal functions, membrane dynamics, and signaling pathways. TepP is the most abundant effector protein secreted early in infection, but its molecular function is poorly understood. In this report, we...

journal_title：mSphere

authors： Carpenter V,Chen YS,Dolat L,Valdivia RH

更新日期：2017-07-19 00:00:00

abstract：:We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...

journal_title：mSphere

authors： Ishigaki K,Shinzawa N,Nishikawa S,Suzuki K,Fukui-Miyazaki A,Horiguchi Y

更新日期：2018-01-24 00:00:00

abstract：:The emergence of Cryptococcus gattii, previously regarded as a predominantly tropical pathogen, in the temperate climate of the North American Pacific Northwest (PNW) in 1999 prompted several questions. The most prevalent among these was the timing of the introduction of this pathogen to this novel environment. Here, ...

journal_title：mSphere

authors： Roe CC,Bowers J,Oltean H,DeBess E,Dufresne PJ,McBurney S,Overy DP,Wanke B,Lysen C,Chiller T,Meyer W,Thompson GR 3rd,Lockhart SR,Hepp CM,Engelthaler DM

更新日期：2018-01-17 00:00:00

abstract：:Type I interferons (IFN) initiate an antiviral state through a signal transduction cascade that leads to the induction of hundreds of IFN-stimulated genes (ISGs) to restrict viral infection. Recently, RNA modifications on both host and viral RNAs have been described as regulators of infection. However, the impact of h...

journal_title：mSphere

authors： Williams GD,Gokhale NS,Snider DL,Horner SM

更新日期：2020-05-13 00:00:00

abstract：:We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans' sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity wi...

journal_title：mSphere

authors： Nahm MH,Yu J,Vlach J,Bar-Peled M

更新日期：2020-04-08 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) carriage is commonly used to measure effects of pneumococcal vaccines. Based on findings from culture-based studies, the World Health Organization recommends both nasopharyngeal (NP) and oropharyngeal (OP) sampling for detecting adult carriage. Given evidence of potential co...

journal_title：mSphere

authors： Boelsen LK,Dunne EM,Gould KA,Ratu FT,Vidal JE,Russell FM,Mulholland EK,Hinds J,Satzke C

更新日期：2020-07-29 00:00:00

abstract：:The genomes of Leishmania and trypanosomes encode six paralogs of the eIF4E cap-binding protein, known in other eukaryotes to anchor the translation initiation complex. In line with the heteroxenous nature of these parasites, the different LeishIF4E paralogs vary in their biophysical features and their biological beha...

journal_title：mSphere

authors： Shrivastava R,Tupperwar N,Drory-Retwitzer M,Shapira M

更新日期：2019-09-04 00:00:00

abstract：:The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America. To examine the genome evolution and the diversity of Paracoccidioides spp., we conducted whole-genome sequencing of 31 isolates...

journal_title：mSphere

authors： Muñoz JF,Farrer RA,Desjardins CA,Gallo JE,Sykes S,Sakthikumar S,Misas E,Whiston EA,Bagagli E,Soares CM,Teixeira MM,Taylor JW,Clay OK,McEwen JG,Cuomo CA

更新日期：2016-09-28 00:00:00

abstract：:CRISPR-Cas (clustered regularly interspaced short palindromic repeat [CRISPR]-CRISPR-associated protein [Cas]) systems can provide protection against invading genetic elements by using CRISPR RNAs (crRNAs) as a guide to locate and degrade the target DNA. CRISPR-Cas systems have been classified into two classes and fiv...

journal_title：mSphere

authors： Guan J,Wang W,Sun B

更新日期：2017-11-15 00:00:00

abstract：:The fungal cell wall is a complex and dynamic entity essential for the development of fungi. It is composed mainly of polysaccharides that are synthetized by protein complexes. At the cell wall level, enzyme activities are involved in postsynthesis polysaccharide modifications such as cleavage, elongation, branching, ...

journal_title：mSphere

authors： Muszkieta L,Fontaine T,Beau R,Mouyna I,Vogt MS,Trow J,Cormack BP,Essen LO,Jouvion G,Latgé JP

更新日期：2019-07-31 00:00:00

abstract：:Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing ...

journal_title：mSphere

authors： Moreira-Soto A,Carneiro IO,Fischer C,Feldmann M,Kümmerer BM,Silva NS,Santos UG,Souza BFCD,Liborio FA,Valença-Montenegro MM,Laroque PO,da Fontoura FR,Oliveira AVD,Drosten C,de Lamballerie X,Franke CR,Drexler JF

更新日期：2018-01-31 00:00:00

abstract：:Molecular detection of biological agents in the field has traditionally relied on the use of quantitative real-time PCR (qPCR), which now includes commercially available instruments that can be used in the laboratory or field. Adapting this technology for field-forward applications necessitated innovation to minimize ...

journal_title：mSphere

authors： Yeh KB,Wood H,Scullion M,Russell JA,Parker K,Gnade BT,Jones AR,Whittier C,Mereish K

更新日期：2019-12-11 00:00:00

abstract：:Increased knowledge about the role of horizontal gene transfer is key to improve our understanding of the spread of antimicrobial resistance (AMR) in human populations. We therefore studied the dissemination of the blaCTX-M-15 extended-spectrum-β-lactamase (ESBL) gene in Klebsiella pneumoniae isolates obtained from st...

journal_title：mSphere

authors： Pedersen T,Tellevik MG,Kommedal Ø,Lindemann PC,Moyo SJ,Janice J,Blomberg B,Samuelsen Ø,Langeland N

更新日期：2020-07-15 00:00:00