The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes.

abstract：:Methane-oxidizing microorganisms perform an important role in reducing emissions of the greenhouse gas methane to the atmosphere. To date, known bacterial methanotrophs belong to the Proteobacteria, Verrucomicrobia, and NC10 phyla. Within the Proteobacteria phylum, they can be divided into type Ia, type Ib, and type I...

journal_title：mSphere

authors： Ghashghavi M,Belova SE,Bodelier PLE,Dedysh SN,Kox MAR,Speth DR,Frenzel P,Jetten MSM,Lücker S,Lüke C

更新日期：2019-06-05 00:00:00

abstract：:Human norovirus interacts with the polymorphic human histo-blood group antigens (HBGAs), and this interaction is thought to be important for infection. The genogroup II genotype 4 (GII.4) noroviruses are the dominant cluster, evolve every other year, and are thought to modify their binding interactions with different ...

journal_title：mSphere

authors： Singh BK,Leuthold MM,Hansman GS

更新日期：2016-03-30 00:00:00

abstract：:The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored ...

journal_title：mSphere

authors： Hallée S,Boddey JA,Cowman AF,Richard D

更新日期：2018-01-03 00:00:00

abstract：:We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...

journal_title：mSphere

authors： Ishigaki K,Shinzawa N,Nishikawa S,Suzuki K,Fukui-Miyazaki A,Horiguchi Y

更新日期：2018-01-24 00:00:00

abstract：:The newly emerged Candida species Candida auris is associated with an exponential rise in life-threatening invasive disease in health care facilities worldwide. Unlike other species, C. auris exhibits a high level of transmissibility, multidrug resistance, and persistence in the environment, yet little is known about ...

journal_title：mSphere

authors： Vila T,Montelongo-Jauregui D,Ahmed H,Puthran T,Sultan AS,Jabra-Rizk MA

更新日期：2020-08-05 00:00:00

abstract：:The mechanisms underlying the rapidly reversible brain swelling described in patients with cerebral malaria (CM) are unknown. Using a 1.5-Tesla (T) magnetic resonance imaging (MRI) scanner, we undertook an observational study in Rourkela, India, of 11 Indian patients hospitalized with CM and increased brain volume. Am...

journal_title：mSphere

authors： Mohanty S,Benjamin LA,Majhi M,Panda P,Kampondeni S,Sahu PK,Mohanty A,Mahanta KC,Pattnaik R,Mohanty RR,Joshi S,Mohanty A,Turnbull IW,Dondorp AM,Taylor TE,Wassmer SC

更新日期：2017-06-07 00:00:00

abstract：:Shigella spp. are a major cause of diarrhea and dysentery in children under 5 years old in the developing world. The development of an effective vaccine remains a public health priority, necessitating improved understanding of immune responses to Shigella and identification of protective antigens. We report the develo...

journal_title：mSphere

authors： Ndungo E,Randall A,Hazen TH,Kania DA,Trappl-Kimmons K,Liang X,Barry EM,Kotloff KL,Chakraborty S,Mani S,Rasko DA,Pasetti MF

更新日期：2018-08-01 00:00:00

abstract：:Many microbiologists exhibit a fascination with unculturable bacteria. This intrigue can be expressed through curiosity about nutrient needs, as well as about parameters such as optimal temperature, oxygen levels, minimum and optimal light, or other such environmental factors. Microbiologists study organisms' genetic ...

journal_title：mSphere

authors： Montgomery BL

更新日期：2020-10-28 00:00:00

abstract：:Parasitic protozoans of the genus Theileria are intracellular pathogens that induce the cellular transformation of leukocytes, causing uncontrolled proliferation of the infected host cell. The transforming stage of the parasite has a strictly intracellular lifestyle and ensures its distribution to both daughter cells ...

journal_title：mSphere

authors： Huber S,Bär A,Epp S,Schmuckli-Maurer J,Eberhard N,Humbel BM,Hemphill A,Woods K

更新日期：2020-02-05 00:00:00

abstract：:Coxsackievirus typically infects humans via the gastrointestinal tract, which has a large number of microorganisms collectively referred to as the microbiota. To study how the intestinal microbiota influences enteric virus infection, several groups have used an antibiotic regimen in mice to deplete bacteria. These stu...

journal_title：mSphere

authors： Woods Acevedo MA,Erickson AK,Pfeiffer JK

更新日期：2019-02-20 00:00:00

abstract：:Globally, more antimicrobials are used in food-producing animals than in humans, and the extensive use of medically important human antimicrobials poses a significant public health threat in the face of rising antimicrobial resistance (AMR). The development of novel ionophores, a class of antimicrobials used exclusive...

journal_title：mSphere

authors： Harbison-Price N,Ferguson SA,Heikal A,Taiaroa G,Hards K,Nakatani Y,Rennison D,Brimble MA,El-Deeb IM,Bohlmann L,McDevitt CA,von Itzstein M,Walker MJ,Cook GM

更新日期：2020-03-18 00:00:00

abstract：:Père David's deer (Elaphurus davidianus or milu) is an endangered species, and the prevalence of antimicrobial resistance (AMR) such as mcr-1-positive strains among them has been unknown. In this study, we aimed to investigate the genomic characterizations of mcr-1-positive strains and provide insight into the dissemi...

journal_title：mSphere

authors： Lu X,Xiao X,Liu Y,Huang S,Li R,Wang Z

更新日期：2020-12-23 00:00:00

abstract：:Staphylococcus aureus diseases affect ~500,000 individuals per year in the United States. Worldwide, the USA100, USA200, USA400, and USA600 lineages cause many of the life-threatening S. aureus infections, such as bacteremia, infective endocarditis, pneumonia, toxic shock syndrome, and surgical site infections. Howeve...

journal_title：mSphere

authors： King JM,Kulhankova K,Stach CS,Vu BG,Salgado-Pabón W

更新日期：2016-06-08 00:00:00

abstract：:Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug susceptibility patterns, and genomic hypermutability. Pseudomonas aeruginosa isolates from CF patients have long been recognized for their overall r...

journal_title：mSphere

authors： Qin X,Zhou C,Zerr DM,Adler A,Addetia A,Yuan S,Greninger AL

更新日期：2018-03-14 00:00:00

abstract：:Neal Hammer works in the field of bacterial pathogenesis, metabolism, and antibiotic resistance. In this mSphere of Influence article, he reflects on how "Gut inflammation provides a respiratory electron acceptor for Salmonella" by Winter and colleagues (S. E. Winter, P. Thiennimitr, M. G. Winter, B. P. Butler, et al....

journal_title：mSphere

authors： Hammer ND

更新日期：2020-02-26 00:00:00

abstract：:Acinetobacter baumannii ATCC 19606 can grow without lipid A, the major component of lipooligosaccharide. However, we previously reported that depletion of LpxH (the fourth enzyme in the lipid A biosynthetic pathway) prevented growth of this strain due to toxic accumulation of lipid A pathway intermediates. Here, we ex...

journal_title：mSphere

authors： Wei JR,Richie DL,Mostafavi M,Metzger LE 4th,Rath CM,Sawyer WS,Takeoka KT,Dean CR

更新日期：2017-07-26 00:00:00

abstract：:Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations. Treponema pallidum undergoes rapid vascular dissemination to penetrate tissue, placental, and blood-brain barriers and gain acces...

journal_title：mSphere

authors： Lithgow KV,Church B,Gomez A,Tsao E,Houston S,Swayne LA,Cameron CE

更新日期：2020-04-01 00:00:00

abstract：:The azithromycin resistance conferred by phosphotransferase is encoded in the gene mph(A). This gene has been discovered in and reported for many bacterial species. We examined the prevalence of azithromycin resistance in Vibrio fluvialis (AR-VF) isolated during 2014 to 2015 from the hospitalized acute diarrheal patie...

journal_title：mSphere

authors： Chowdhury G,Ramamurthy T,Ghosh A,Dutta S,Takahashi E,Mukhopadhyay AK

更新日期：2019-06-12 00:00:00

abstract：:Aspergillus species cause pulmonary invasive aspergillosis resulting in nearly 100,000 deaths each year. Patients at the greatest risk of developing life-threatening aspergillosis have weakened immune systems and/or various lung disorders. Patients are treated with antifungals such as amphotericin B (AmB), caspofungin...

journal_title：mSphere

authors： Ambati S,Ferarro AR,Kang SE,Lin J,Lin X,Momany M,Lewis ZA,Meagher RB

更新日期：2019-02-13 00:00:00

abstract：:Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first r...

journal_title：mSphere

authors： Host KM,Damania B

更新日期：2016-02-17 00:00:00

abstract：:Continued influx of metagenome-derived proteins with misannotated taxonomy into conventional databases, including RefSeq, threatens to eliminate the value of taxonomy identifiers. To prevent this, urgent efforts should be undertaken by submitters of metagenomic data sets as well as by database managers. ...

journal_title：mSphere

authors： Arkhipova IR

更新日期：2020-11-04 00:00:00

abstract：:Lassa virus (LASV), a member of the family Arenaviridae, is the causative agent of Lassa fever. Lassa virus is endemic in West African countries, such as Nigeria, Guinea, Liberia, and Sierra Leone, and causes outbreaks annually. Lassa fever onset begins with "flu-like" symptoms and may develop into lethal hemorrhagic ...

journal_title：mSphere

authors： Maruyama J,Manning JT,Mateer EJ,Sattler R,Bukreyeva N,Huang C,Paessler S

更新日期：2019-09-25 00:00:00

abstract：:Most observation of human respiratory virus carriage is derived from medical surveillance; however, the infections documented by this surveillance represent only a symptomatic fraction of the total infected population. As the role of asymptomatic infection in respiratory virus transmission is still largely unknown and...

journal_title：mSphere

authors： Birger R,Morita H,Comito D,Filip I,Galanti M,Lane B,Ligon C,Rosenbloom D,Shittu A,Ud-Dean M,Desalle R,Planet P,Shaman J

更新日期：2018-07-11 00:00:00

abstract：:Felipe Santiago-Tirado studies the cell biology of cryptococcal infections. In this mSphere of Influence article, he reflects on how the papers "Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans" (https://doi.org/10.1016/j.cell.2008.07.046) and "Unraveling the Biology of a F...

journal_title：mSphere

authors： Santiago-Tirado FH

更新日期：2019-10-02 00:00:00

abstract：:Chikungunya virus (CHIKV) and Zika virus (ZIKV) emerged in the Americas in 2013. Limited antigenic variability of CHIKV and ZIKV may restrict urban transmission cycles due to population protective immunity. In Africa, sylvatic transmission cycles involving nonhuman primates (NHP) are known for CHIKV and ZIKV, causing ...

journal_title：mSphere

authors： Moreira-Soto A,Carneiro IO,Fischer C,Feldmann M,Kümmerer BM,Silva NS,Santos UG,Souza BFCD,Liborio FA,Valença-Montenegro MM,Laroque PO,da Fontoura FR,Oliveira AVD,Drosten C,de Lamballerie X,Franke CR,Drexler JF

更新日期：2018-01-31 00:00:00

abstract：:A maternal vaccine capable of boosting neutralizing antibody (NAb) responses directed against circulating viruses in HIV-infected pregnant women could effectively decrease mother-to-child transmission of HIV. However, it is not known if an HIV envelope (Env) vaccine administered to infected pregnant women could enhanc...

journal_title：mSphere

authors： Hompe ED,Mangold JF,Kumar A,Eudailey JA,McGuire E,Haynes BF,Moody MA,Wright PF,Fouda GG,Giorgi EE,Gao F,Permar SR

更新日期：2020-06-03 00:00:00

abstract：:Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas9 genome modification systems have greatly facilitated the genetic analysis of fungal pathogens. In CRISPR-Cas9 genome editing methods designed for use in Candida albicans, DNAs that encode the necessary components are expressed in the target cells. ...

journal_title：mSphere

authors： Grahl N,Demers EG,Crocker AW,Hogan DA

更新日期：2017-06-21 00:00:00

abstract：:Glycine serves as a major source of single carbon units for biochemical reactions within bacterial cells. Utilization of glycine is tightly regulated and revolves around a key group of proteins known as the glycine cleavage system (GCS). Our lab previously identified the transcriptional regulator GcsR (PA2449) as bein...

journal_title：mSphere

authors： Sarwar Z,Lundgren BR,Grassa MT,Wang MX,Gribble M,Moffat JF,Nomura CT

更新日期：2016-04-27 00:00:00

abstract：:The fungal cell wall is a complex and dynamic entity essential for the development of fungi. It is composed mainly of polysaccharides that are synthetized by protein complexes. At the cell wall level, enzyme activities are involved in postsynthesis polysaccharide modifications such as cleavage, elongation, branching, ...

journal_title：mSphere

authors： Muszkieta L,Fontaine T,Beau R,Mouyna I,Vogt MS,Trow J,Cormack BP,Essen LO,Jouvion G,Latgé JP

更新日期：2019-07-31 00:00:00

abstract：:Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During intracellular infection, S. aureus is capable of subverting xenophagy and escaping to the cytosol of the host cell. Furthermore, drug-induced autophagy facilitates t...

journal_title：mSphere

authors： Bravo-Santano N,Ellis JK,Mateos LM,Calle Y,Keun HC,Behrends V,Letek M

更新日期：2018-08-08 00:00:00