Metagenome Proteins and Database Contamination.

abstract：:Bacterial small RNAs play a remarkable role in the regulation of functions involved in host-pathogen interaction. ErsA is a small RNA of Pseudomonas aeruginosa that contributes to the regulation of bacterial virulence traits such as biofilm formation and motility. Shown to take part in a regulatory circuit under the c...

journal_title：mSphere

authors： Ferrara S,Rossi A,Ranucci S,De Fino I,Bragonzi A,Cigana C,Bertoni G

更新日期：2020-10-14 00:00:00

abstract：:Many microbiologists exhibit a fascination with unculturable bacteria. This intrigue can be expressed through curiosity about nutrient needs, as well as about parameters such as optimal temperature, oxygen levels, minimum and optimal light, or other such environmental factors. Microbiologists study organisms' genetic ...

journal_title：mSphere

authors： Montgomery BL

更新日期：2020-10-28 00:00:00

abstract：:Candida albicans, a pervasive opportunistic pathogen, undergoes a unique phenotypic transition from a "white" phenotype to an "opaque" phenotype. The switch to opaque impacts gene expression, cell morphology, wall structure, metabolism, biofilm formation, mating, virulence, and colonization of the skin and gastrointes...

journal_title：mSphere

authors： Park YN,Pujol C,Wessels DJ,Soll DR

更新日期：2020-09-23 00:00:00

abstract：:Replication forks must respond to changes in nutrient conditions, especially in bacterial cells. By investigating the single-molecule dynamics of replicative helicase DnaC, DNA primase DnaG, and lagging-strand polymerase DnaE in the model bacterium Bacillus subtilis, we show that proteins react differently to stress c...

journal_title：mSphere

authors： Hernández-Tamayo R,Schmitz H,Graumann PL

更新日期：2021-01-27 00:00:00

abstract：:Control and eradication of foot-and-mouth disease (FMD) are impeded by the existence of a persistent, subclinical phase of infection in ruminants; animals with this status are referred to as carriers. However, the epidemiological significance of these FMD virus (FMDV) carriers is uncertain. In the current investigatio...

journal_title：mSphere

authors： Arzt J,Belsham GJ,Lohse L,Bøtner A,Stenfeldt C

更新日期：2018-09-12 00:00:00

abstract：:Malaria is a devastating illness that causes approximately 500,000 deaths annually. The malaria-causing parasite (Plasmodium genus) uses the process of translational repression to regulate its growth, development, and transmission. As poly(A)-binding proteins (PABP) have been identified as critical components of RNA m...

journal_title：mSphere

authors： Minns AM,Hart KJ,Subramanian S,Hafenstein S,Lindner SE

更新日期：2018-01-10 00:00:00

abstract：:The acquisition of genetic material conferring the arsenal necessary for host virulence is a prerequisite on the path to becoming a plant pathogen. More subtle mutations are also required for the perception of cues signifying the presence of the target host and optimal conditions for colonization. The decision to acti...

journal_title：mSphere

authors： Jourdan S,Francis IM,Deflandre B,Loria R,Rigali S

更新日期：2017-03-01 00:00:00

abstract：:Various Lactobacillus species have been reported to deconjugate bile acids in the gastrointestinal tract (GIT) through the action of bile salt hydrolase (BSH) proteins. This function contributes to altering the gut microbiota composition and bile metabolism and detoxification and to lowering cholesterol levels. Here, ...

journal_title：mSphere

authors： O'Flaherty S,Briner Crawley A,Theriot CM,Barrangou R

更新日期：2018-05-30 00:00:00

abstract：:Megan E. Spurgeon works in the field of viral oncology. In this mSphere of Influence article, she reflects on how the paper "Rescuing US biomedical research from its systemic flaws" by Bruce Alberts, Marc W. Kirschner, Shirley Tilghman, and Harold Varmus (Proc Natl Acad Sci U S A 111:5773-5777, 2014, https://doi.org/1...

journal_title：mSphere

authors： Spurgeon ME

更新日期：2019-07-03 00:00:00

abstract：:Melioidosis is an underreported infectious disease, caused by the Gram-negative bacterium Burkholderia pseudomallei. Understanding the disease susceptibility and pathogenesis is crucial for developing newer diagnostic and therapeutic strategies for this life-threatening infection. In this study, we aimed to analyze th...

journal_title：mSphere

authors： Krishnananthasivam S,Sathkumara HD,Corea E,Natesan M,De Silva AD

更新日期：2017-04-19 00:00:00

abstract：:Grf10, a homeodomain-containing transcription factor, regulates adenylate and one-carbon metabolism and morphogenesis in the human fungal pathogen Candida albicans Here, we identified functional domains and key residues involved in transcription factor activity using one-hybrid and mutational analyses. We localized ac...

journal_title：mSphere

authors： Wangsanut T,Tobin JM,Rolfes RJ

更新日期：2018-10-24 00:00:00

abstract：:Human adenoviruses (HAdV), species D in particular (HAdV-D), are frequently associated with epidemic keratoconjunctivitis (EKC). Although the infection originates at the ocular surface epithelium, the mechanisms by which HAdV-Ds bypass the membrane-associated mucin (MAM)-rich glycocalyx of the ocular surface epitheliu...

journal_title：mSphere

authors： Menon BB,Zhou X,Spurr-Michaud S,Rajaiya J,Chodosh J,Gipson IK

更新日期：2016-02-10 00:00:00

abstract：:Bacteria must sense alterations in their environment and respond with changes in function and/or structure in order to cope. Extracytoplasmic function sigma factors (ECF σs) modulate transcription in response to cellular and environmental signals. The symbiotic nitrogen-fixing alphaproteobacterium Sinorhizobium melilo...

journal_title：mSphere

authors： Lang C,Barnett MJ,Fisher RF,Smith LS,Diodati ME,Long SR

更新日期：2018-10-10 00:00:00

abstract：:Manipulation of the host cell is a crucial part of life for many intracellular organisms. We have recently come to appreciate the extent to which the intracellular pathogen Toxoplasma gondii reprograms its host cell, and this is illustrated by the marked upregulation of the central regulator c-Myc, an oncogene that co...

journal_title：mSphere

authors： Panas MW,Boothroyd JC

更新日期：2020-06-24 00:00:00

abstract：:Bordetella pertussis, B. parapertussis, and B. bronchiseptica cause respiratory infections, many of which are characterized by coughing of the infected hosts. The pathogenesis of the coughing remains to be analyzed, mainly because there were no convenient infection models of small animals that replicate coughing after...

journal_title：mSphere

authors： Nakamura K,Shinoda N,Hiramatsu Y,Ohnishi S,Kamitani S,Ogura Y,Hayashi T,Horiguchi Y

更新日期：2019-04-24 00:00:00

abstract：:Michael D. L. Johnson is a molecular microbiologist observing the role of metals in bacterial biology. In this mSphere of Influence article, he discusses the impact that the paper "Decoupling of the minority PhD talent pool and assistant professor hiring in medical school basic science departments in the US" by Kennet...

journal_title：mSphere

authors： Johnson MDL

更新日期：2019-09-18 00:00:00

abstract：:Huanglongbing disease (HLB; yellow shoot disease) is a severe worldwide infectious disease for citrus family plants. The pathogen "Candidatus Liberibacter asiaticus" is an alphaproteobacterium of the Rhizobiaceae family that has been identified as the causative agent of HLB. The virulence of "Ca. Liberibacter asiaticu...

journal_title：mSphere

authors： Dominguez-Mirazo M,Jin R,Weitz JS

更新日期：2019-11-13 00:00:00

abstract：:Buruli ulcer is a neglected tropical disease of skin and subcutaneous tissue caused by infection with the pathogen Mycobacterium ulcerans Many critical issues for disease control, such as understanding the mode of transmission and identifying source reservoirs of M. ulcerans, are still largely unknown. Here, we used g...

journal_title：mSphere

authors： Vandelannoote K,Phanzu DM,Kibadi K,Eddyani M,Meehan CJ,Jordaens K,Leirs H,Portaels F,Stinear TP,Harris SR,de Jong BC

更新日期：2019-02-06 00:00:00

abstract：:Glycine serves as a major source of single carbon units for biochemical reactions within bacterial cells. Utilization of glycine is tightly regulated and revolves around a key group of proteins known as the glycine cleavage system (GCS). Our lab previously identified the transcriptional regulator GcsR (PA2449) as bein...

journal_title：mSphere

authors： Sarwar Z,Lundgren BR,Grassa MT,Wang MX,Gribble M,Moffat JF,Nomura CT

更新日期：2016-04-27 00:00:00

abstract：:Brucella, the agent causing brucellosis, is a major zoonotic pathogen with worldwide distribution. Brucella resides and replicates inside infected host cells in membrane-bound compartments called Brucella-containing vacuoles (BCVs). Following uptake, Brucella resides in endosomal BCVs (eBCVs) that gradually mature fro...

journal_title：mSphere

authors： Casanova A,Low SH,Québatte M,Sedzicki J,Tschon T,Ketterer M,Smith K,Emmenlauer M,Ben-Tekaya H,Dehio C

更新日期：2019-06-26 00:00:00

abstract：:The stability of the Escherichia coli populations in the human gastrointestinal tract is not fully appreciated, and represents a significant knowledge gap regarding gastrointestinal community structure, as well as resistance to incoming pathogenic bacterial species and antibiotic treatment. The current study examines ...

journal_title：mSphere

authors： Richter TKS,Hazen TH,Lam D,Coles CL,Seidman JC,You Y,Silbergeld EK,Fraser CM,Rasko DA

更新日期：2018-11-07 00:00:00

abstract：:The facultative anaerobic polymorphic fungus Candida albicans and the strictly anaerobic Gram-positive bacterium Clostridium difficile are two opportunistic pathogens residing in the human gut. While a few studies have focused on the prevalence of C. albicans in C. difficile-infected patients, the nature of the intera...

journal_title：mSphere

authors： van Leeuwen PT,van der Peet JM,Bikker FJ,Hoogenkamp MA,Oliveira Paiva AM,Kostidis S,Mayboroda OA,Smits WK,Krom BP

更新日期：2016-11-09 00:00:00

abstract：:Botulinum neurotoxins (BoNTs), produced by neurotoxigenic clostridial species, are the cause of the severe disease botulism in humans and animals. Early research on BoNTs has led to their classification into seven serotypes (serotypes A to G) based upon the selective neutralization of their toxicity in mice by homolog...

journal_title：mSphere

authors： Pellett S,Tepp WH,Bradshaw M,Kalb SR,Dykes JK,Lin G,Nawrocki EM,Pier CL,Barr JR,Maslanka SE,Johnson EA

更新日期：2016-02-24 00:00:00

abstract：:Amino acids participate in several critical processes in the biology of trypanosomatids, such as osmoregulation, cell differentiation, and host cell invasion. Some of them provide reducing power for mitochondrial ATP synthesis. It was previously shown that alanine, which is formed mainly by the amination of pyruvate, ...

journal_title：mSphere

authors： Girard RMBM,Crispim M,Alencar MB,Silber AM

更新日期：2018-07-18 00:00:00

abstract：:Cryptococcus gattii R265 is a hypervirulent fungal strain responsible for the recent outbreak of cryptococcosis in Vancouver Island of British Columbia in Canada. It differs significantly from Cryptococcus neoformans in its natural environment, its preferred site in the mammalian host, and its pathogenesis. Our previo...

journal_title：mSphere

authors： Lam WC,Upadhya R,Specht CA,Ragsdale AE,Hole CR,Levitz SM,Lodge JK

更新日期：2019-10-09 00:00:00

abstract：:Enveloped viruses require viral fusion proteins to promote fusion of the viral envelope with a target cell membrane. To drive fusion, these proteins undergo large conformational changes that must occur at the right place and at the right time. Understanding the elements which control the stability of the prefusion sta...

journal_title：mSphere

authors： Webb SR,Smith SE,Fried MG,Dutch RE

更新日期：2018-04-18 00:00:00

abstract：:Virulence is a microbial property that is realized only in susceptible hosts. There is no absolute measurement for virulence, and consequently it is always measured relative to a standard, usually another microbe or host. This article introduces the concept of pathogenic potential, which provides a new approach to mea...

journal_title：mSphere

authors： Casadevall A

更新日期：2017-02-22 00:00:00

abstract：:Candida albicans is an opportunistic human fungal pathogen that causes superficial fungal infections and lethal systemic infections. To colonize and establish infections, C. albicans coordinates the expression of virulence and metabolic genes. Previous work showed that the homeodomain transcription factor Grf10 is req...

journal_title：mSphere

authors： Wangsanut T,Ghosh AK,Metzger PG,Fonzi WA,Rolfes RJ

更新日期：2017-08-02 00:00:00

abstract：:Opsonophagocytic assays are used to measure functional antibodies important in protection against pneumococcal capsular antigens. There have been efforts to standardize these methods, as the assays are commonly used to measure vaccine immunogenicity. We report here the results from three international laboratories usi...

journal_title：mSphere

authors： Balloch A,Roalfe L,Ekstrom N,Nguyen CD,Spry L,Marimla RA,Licciardi PV,Goldblatt D,Mulholland EK

更新日期：2018-04-25 00:00:00

abstract：:The azithromycin resistance conferred by phosphotransferase is encoded in the gene mph(A). This gene has been discovered in and reported for many bacterial species. We examined the prevalence of azithromycin resistance in Vibrio fluvialis (AR-VF) isolated during 2014 to 2015 from the hospitalized acute diarrheal patie...

journal_title：mSphere

authors： Chowdhury G,Ramamurthy T,Ghosh A,Dutta S,Takahashi E,Mukhopadhyay AK

更新日期：2019-06-12 00:00:00