Tracking the Subtle Mutations Driving Host Sensing by the Plant Pathogen Streptomyces scabies.

abstract：:The major surface lipophosphoglycan (LPG) of Leishmania parasites is critical to vector competence in restrictive sand fly vectors in mediating Leishmania attachment to the midgut epithelium, considered essential to parasite survival and development. However, the relevance of LPG for sand flies that harbor multiple sp...

journal_title：mSphere

authors： Coutinho-Abreu IV,Oristian J,de Castro W,Wilson TR,Meneses C,Soares RP,Borges VM,Descoteaux A,Kamhawi S,Valenzuela JG

更新日期：2020-09-09 00:00:00

abstract：:Mary Lopez-Perez works on immunology and pathogenesis of malaria. In this mSphere of Influence article, she reflects on how the paper "Functional antibodies against VAR2CSA in nonpregnant populations from Colombia exposed to Plasmodium falciparum and Plasmodium vivax" by S. Gnidehou, J. Doritchamou, E. M. Arango, A. C...

journal_title：mSphere

authors： Lopez-Perez M

更新日期：2020-04-08 00:00:00

abstract：:Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota. However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metaboliz...

journal_title：mSphere

authors： Wang Z,Tauzin AS,Laville E,Tedesco P,Létisse F,Terrapon N,Lepercq P,Mercade M,Potocki-Veronese G

更新日期：2020-01-08 00:00:00

abstract：:Periodontal disease induced by periodontopathic bacteria like Porphyromonas gingivalis is demonstrated to increase the risk of metabolic, inflammatory, and autoimmune disorders. Although precise mechanisms for this connection have not been elucidated, we have proposed mechanisms by which orally administered periodonto...

journal_title：mSphere

authors： Kato T,Yamazaki K,Nakajima M,Date Y,Kikuchi J,Hase K,Ohno H,Yamazaki K

更新日期：2018-10-17 00:00:00

abstract：:Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread ...

journal_title：mSphere

authors： Uppuluri P

更新日期：2020-01-22 00:00:00

abstract：:This study was carried out to evaluate hypotheses generated by fundamental cause theory regarding the socioeconomic status (SES) gradient in colonization with Staphylococcus aureus among Hispanic and non-Hispanic adults living in a border community. Participants (n = 613) recruited in naturally occurring small groups ...

journal_title：mSphere

authors： Barger SD,Lininger MR,Trotter RT 2nd,Wayment HA,Mbegbu M,Kyman S,Pearson T

更新日期：2020-09-30 00:00:00

abstract：:The gut microbiota has a key role in determining susceptibility to Clostridioides difficile infections (CDIs). However, much of the mechanistic work examining CDIs in mouse models uses animals obtained from a single source. We treated mice from 6 sources (2 University of Michigan colonies and 4 commercial vendors) wit...

journal_title：mSphere

authors： Tomkovich S,Stough JMA,Bishop L,Schloss PD

更新日期：2020-10-21 00:00:00

abstract：:Streptococcus pneumoniae two-component regulatory systems (TCS) enable adaptation and ensure its maintenance in host environments. This study deciphers the impact of TCS08 on pneumococcal gene expression and its role in metabolic and pathophysiological processes. Transcriptome analysis and real-time PCR demonstrated a...

journal_title：mSphere

authors： Gómez-Mejia A,Gámez G,Hirschmann S,Kluger V,Rath H,Böhm S,Voss F,Kakar N,Petruschka L,Völker U,Brückner R,Mäder U,Hammerschmidt S

更新日期：2018-05-16 00:00:00

abstract：:The cell-to-cell heterogeneity in a bacterial population provides a rich response to environmental changes and robust survival of an isogenic population. Especially, the rare, extreme phenotypes can be important for survival under transient lethal conditions. We analyze the probability of having an extremely high or l...

journal_title：mSphere

authors： Svenningsen MS,Semsey S,Mitarai N

更新日期：2019-01-30 00:00:00

abstract：:Shigella spp. are a major cause of diarrhea and dysentery in children under 5 years old in the developing world. The development of an effective vaccine remains a public health priority, necessitating improved understanding of immune responses to Shigella and identification of protective antigens. We report the develo...

journal_title：mSphere

authors： Ndungo E,Randall A,Hazen TH,Kania DA,Trappl-Kimmons K,Liang X,Barry EM,Kotloff KL,Chakraborty S,Mani S,Rasko DA,Pasetti MF

更新日期：2018-08-01 00:00:00

abstract：:Toxoplasma gondii can infect and replicate in vascular endothelial cells prior to entering host tissues. However, little is known about the molecular interactions at the parasite-endothelial cell interface. We demonstrate that T. gondii infection of primary human umbilical vein endothelial cells (HUVEC) altered cell m...

journal_title：mSphere

authors： Franklin-Murray AL,Mallya S,Jankeel A,Sureshchandra S,Messaoudi I,Lodoen MB

更新日期：2020-01-29 00:00:00

abstract：:The rhoptry organelle is critical for the invasion of an erythrocyte by the malaria parasite Plasmodium falciparum. Despite their critical roles, the mechanisms behind their biogenesis are still poorly defined. Our earlier work had suggested that the interaction between the glycosylphosphatidylinositol (GPI)-anchored ...

journal_title：mSphere

authors： Hallée S,Boddey JA,Cowman AF,Richard D

更新日期：2018-01-03 00:00:00

abstract：:Oxalate, broadly found in both dietary and endogenous sources, is a primary constituent in 80% of kidney stones, an affliction that has tripled in prevalence over the last 40 years. Oxalate-degrading bacteria within the gut microbiota can mitigate the effects of oxalate and are negatively correlated with kidney stone ...

journal_title：mSphere

authors： Miller AW,Dale C,Dearing MD

更新日期：2017-10-18 00:00:00

abstract：:Antibiotic resistance is a global crisis that threatens our ability to treat bacterial infections, such as tuberculosis, caused by Mycobacterium tuberculosis Of the 10 million cases of tuberculosis in 2017, approximately 19% of new cases and 43% of previously treated cases were caused by strains of M. tuberculosis res...

journal_title：mSphere

authors： Harrison GA,Mayer Bridwell AE,Singh M,Jayaraman K,Weiss LA,Kinsella RL,Aneke JS,Flentie K,Schene ME,Gaggioli M,Solomon SD,Wildman SA,Meyers MJ,Stallings CL

更新日期：2019-09-11 00:00:00

abstract：:To design immune interventions that can synergize with antiretroviral therapy (ART) to reduce the rate of HIV mother-to-child transmission (MTCT), it is essential to characterize maternal immune responses in the setting of ART during pregnancy and breastfeeding and define their effect on MTCT. Prior studies reported a...

journal_title：mSphere

authors： Hompe ED,Jacobson DL,Eudailey JA,Butler K,Edwards W,Pollara J,Brummel SS,Fouda GG,Chinula L,Kamanga M,Kinikar A,Moodley D,Owor M,Fowler MG,Permar SR

更新日期：2019-10-23 00:00:00

abstract：:We are exposed daily to many glycans from bacteria and food plants. Bacterial glycans are generally antigenic and elicit antibody responses. It is unclear if food glycans' sharing of antigens with bacterial glycans influences our immune responses to bacteria. We studied 14 different plant foods for cross-reactivity wi...

journal_title：mSphere

authors： Nahm MH,Yu J,Vlach J,Bar-Peled M

更新日期：2020-04-08 00:00:00

abstract：:Sepsis caused by Gram-negative bacteria is the consequence of an unrestrained infection that continuously releases lipopolysaccharide (LPS) into the bloodstream, which triggers an uncontrolled systemic inflammatory response leading to multiorgan failure and death. After scrutinizing the immune modulation exerted by a ...

journal_title：mSphere

authors： Ramos-Benitez MJ,Ruiz-Jimenez C,Rosado-Franco JJ,Ramos-Pérez WD,Mendez LB,Osuna A,Espino AM

更新日期：2018-12-19 00:00:00

abstract：:Melioidosis is an underreported infectious disease, caused by the Gram-negative bacterium Burkholderia pseudomallei. Understanding the disease susceptibility and pathogenesis is crucial for developing newer diagnostic and therapeutic strategies for this life-threatening infection. In this study, we aimed to analyze th...

journal_title：mSphere

authors： Krishnananthasivam S,Sathkumara HD,Corea E,Natesan M,De Silva AD

更新日期：2017-04-19 00:00:00

abstract：:Toxoplasma gondii is a ubiquitous, intracellular protozoan that extensively modifies infected host cells through secreted effector proteins. Many such effectors must be translocated across the parasitophorous vacuole (PV), in which the parasites replicate, ultimately ending up in the host cytosol or nucleus. This tran...

journal_title：mSphere

authors： Cygan AM,Theisen TC,Mendoza AG,Marino ND,Panas MW,Boothroyd JC

更新日期：2020-02-19 00:00:00

abstract：:Parasitic protozoans of the genus Theileria are intracellular pathogens that induce the cellular transformation of leukocytes, causing uncontrolled proliferation of the infected host cell. The transforming stage of the parasite has a strictly intracellular lifestyle and ensures its distribution to both daughter cells ...

journal_title：mSphere

authors： Huber S,Bär A,Epp S,Schmuckli-Maurer J,Eberhard N,Humbel BM,Hemphill A,Woods K

更新日期：2020-02-05 00:00:00

abstract：:Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitr...

journal_title：mSphere

authors： Bhatt K,Machado H,Osório NS,Sousa J,Cardoso F,Magalhães C,Chen B,Chen M,Kim J,Singh A,Ferreira CM,Castro AG,Torrado E,Jacobs WR Jr,Bhatt A,Saraiva M

更新日期：2018-10-31 00:00:00

abstract：:Streptococcus pneumoniae (the pneumococcus) carriage is commonly used to measure effects of pneumococcal vaccines. Based on findings from culture-based studies, the World Health Organization recommends both nasopharyngeal (NP) and oropharyngeal (OP) sampling for detecting adult carriage. Given evidence of potential co...

journal_title：mSphere

authors： Boelsen LK,Dunne EM,Gould KA,Ratu FT,Vidal JE,Russell FM,Mulholland EK,Hinds J,Satzke C

更新日期：2020-07-29 00:00:00

abstract：:Amino acids participate in several critical processes in the biology of trypanosomatids, such as osmoregulation, cell differentiation, and host cell invasion. Some of them provide reducing power for mitochondrial ATP synthesis. It was previously shown that alanine, which is formed mainly by the amination of pyruvate, ...

journal_title：mSphere

authors： Girard RMBM,Crispim M,Alencar MB,Silber AM

更新日期：2018-07-18 00:00:00

abstract：:Felipe Santiago-Tirado studies the cell biology of cryptococcal infections. In this mSphere of Influence article, he reflects on how the papers "Systematic Genetic Analysis of Virulence in the Human Fungal Pathogen Cryptococcus neoformans" (https://doi.org/10.1016/j.cell.2008.07.046) and "Unraveling the Biology of a F...

journal_title：mSphere

authors： Santiago-Tirado FH

更新日期：2019-10-02 00:00:00

abstract：:Disruption of the histone-like nucleoid structuring protein (H-NS) was shown to affect the ability of Gram-negative bacteria to regulate genes associated with virulence, persistence, stress response, quorum sensing, biosynthesis pathways, and cell adhesion. Here, we used the expression of metallo-β-lactamases (MBLs), ...

journal_title：mSphere

authors： Huang F,Fitchett N,Razo-Gutierrez C,Le C,Martinez J,Ra G,Lopez C,Gonzalez LJ,Sieira R,Vila AJ,Bonomo RA,Ramirez MS

更新日期：2020-08-26 00:00:00

abstract：:Glycine serves as a major source of single carbon units for biochemical reactions within bacterial cells. Utilization of glycine is tightly regulated and revolves around a key group of proteins known as the glycine cleavage system (GCS). Our lab previously identified the transcriptional regulator GcsR (PA2449) as bein...

journal_title：mSphere

authors： Sarwar Z,Lundgren BR,Grassa MT,Wang MX,Gribble M,Moffat JF,Nomura CT

更新日期：2016-04-27 00:00:00

abstract：:Members of family Coronaviridae cause a variety of diseases in birds and mammals. Porcine hemagglutinating encephalomyelitis virus (PHEV), a lesser-researched coronavirus, can infect naive pigs of any age, but clinical disease is observed in pigs ≤4 weeks of age. No commercial PHEV vaccines are available, and neonatal...

journal_title：mSphere

authors： Mora-Díaz JC,Magtoto R,Houston E,Baum D,Carrillo-Ávila JA,Temeeyasen G,Zimmerman J,Piñeyro P,Giménez-Lirola L

更新日期：2020-05-06 00:00:00

abstract：:As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread around the world, there is an urgent need for new assay formats to characterize the humoral response to infection. Here, we present an efficient, competitive serological assay that can simultaneously determine an individual's seroreact...

journal_title：mSphere

authors： Byrnes JR,Zhou XX,Lui I,Elledge SK,Glasgow JE,Lim SA,Loudermilk RP,Chiu CY,Wang TT,Wilson MR,Leung KK,Wells JA

更新日期：2020-09-16 00:00:00

abstract：:The azithromycin resistance conferred by phosphotransferase is encoded in the gene mph(A). This gene has been discovered in and reported for many bacterial species. We examined the prevalence of azithromycin resistance in Vibrio fluvialis (AR-VF) isolated during 2014 to 2015 from the hospitalized acute diarrheal patie...

journal_title：mSphere

authors： Chowdhury G,Ramamurthy T,Ghosh A,Dutta S,Takahashi E,Mukhopadhyay AK

更新日期：2019-06-12 00:00:00

abstract：:This study examines the pharmacodynamics of antimicrobials that are used to treat Salmonella with each other and with key components of the innate immune system. Antimicrobial synergy was assessed using time-kill and checkerboard assays. Antimicrobial interactions with innate immunity were studied by employing catheli...

journal_title：mSphere

authors： Sakoulas G,Kumaraswamy M,Kousha A,Nizet V

更新日期：2017-12-06 00:00:00