The Antibiotic Neomycin Enhances Coxsackievirus Plaque Formation.

abstract：:Treponema pallidum subsp. pallidum is the causative agent of syphilis, a human-specific sexually transmitted infection that causes a multistage disease with diverse clinical manifestations. Treponema pallidum undergoes rapid vascular dissemination to penetrate tissue, placental, and blood-brain barriers and gain acces...

journal_title：mSphere

authors： Lithgow KV,Church B,Gomez A,Tsao E,Houston S,Swayne LA,Cameron CE

更新日期：2020-04-01 00:00:00

abstract：:Prebiotic oligosaccharides, such as fructooligosaccharides, are increasingly being used to modulate the composition and activity of the gut microbiota. However, carbohydrate utilization analyses and metagenomic studies recently revealed the ability of deleterious and uncultured human gut bacterial species to metaboliz...

journal_title：mSphere

authors： Wang Z,Tauzin AS,Laville E,Tedesco P,Létisse F,Terrapon N,Lepercq P,Mercade M,Potocki-Veronese G

更新日期：2020-01-08 00:00:00

abstract：:Cryptococcus neoformans and related species are encapsulated basidiomycetous fungi that cause meningoencephalitis in individuals with immune deficiency. This pathogen has a tractable genetic system; however, gene disruption via electroporation remains difficult, while biolistic transformation is often limited by lack ...

journal_title：mSphere

authors： Wang P

更新日期：2018-06-13 00:00:00

abstract：:Candida albicans, a pervasive opportunistic pathogen, undergoes a unique phenotypic transition from a "white" phenotype to an "opaque" phenotype. The switch to opaque impacts gene expression, cell morphology, wall structure, metabolism, biofilm formation, mating, virulence, and colonization of the skin and gastrointes...

journal_title：mSphere

authors： Park YN,Pujol C,Wessels DJ,Soll DR

更新日期：2020-09-23 00:00:00

abstract：:Clinical isolates of Pseudomonas aeruginosa from patients with cystic fibrosis (CF) are known to differ from those associated with non-CF hosts by colony morphology, drug susceptibility patterns, and genomic hypermutability. Pseudomonas aeruginosa isolates from CF patients have long been recognized for their overall r...

journal_title：mSphere

authors： Qin X,Zhou C,Zerr DM,Adler A,Addetia A,Yuan S,Greninger AL

更新日期：2018-03-14 00:00:00

abstract：:Shigella spp. are a major cause of diarrhea and dysentery in children under 5 years old in the developing world. The development of an effective vaccine remains a public health priority, necessitating improved understanding of immune responses to Shigella and identification of protective antigens. We report the develo...

journal_title：mSphere

authors： Ndungo E,Randall A,Hazen TH,Kania DA,Trappl-Kimmons K,Liang X,Barry EM,Kotloff KL,Chakraborty S,Mani S,Rasko DA,Pasetti MF

更新日期：2018-08-01 00:00:00

abstract：:Infections by malaria parasites can lead to very different clinical outcomes, ranging from mild symptoms to death. Differences in the ability of the spleen to deal with the infected red blood cells (iRBCs) are linked to differences in virulence. Using virulent and avirulent strains of the rodent malaria parasite Plasm...

journal_title：mSphere

authors： Huang X,Huang S,Ong LC,Lim JC,Hurst RJ,Mushunje AT,Matsudaira PT,Han J,Preiser PR

更新日期：2015-12-09 00:00:00

abstract：:We describe a novel genome integration system that enables the introduction of DNA fragments as large as 50 kbp into the chromosomes of recipient bacteria. This system, named BPI, comprises a bacterial artificial chromosome vector and phage-derived gene integration machinery. We introduced the wbm locus of Bordetella ...

journal_title：mSphere

authors： Ishigaki K,Shinzawa N,Nishikawa S,Suzuki K,Fukui-Miyazaki A,Horiguchi Y

更新日期：2018-01-24 00:00:00

abstract：:Lassa virus (LASV), a member of the family Arenaviridae, is the causative agent of Lassa fever. Lassa virus is endemic in West African countries, such as Nigeria, Guinea, Liberia, and Sierra Leone, and causes outbreaks annually. Lassa fever onset begins with "flu-like" symptoms and may develop into lethal hemorrhagic ...

journal_title：mSphere

authors： Maruyama J,Manning JT,Mateer EJ,Sattler R,Bukreyeva N,Huang C,Paessler S

更新日期：2019-09-25 00:00:00

abstract：:Bacteria must sense alterations in their environment and respond with changes in function and/or structure in order to cope. Extracytoplasmic function sigma factors (ECF σs) modulate transcription in response to cellular and environmental signals. The symbiotic nitrogen-fixing alphaproteobacterium Sinorhizobium melilo...

journal_title：mSphere

authors： Lang C,Barnett MJ,Fisher RF,Smith LS,Diodati ME,Long SR

更新日期：2018-10-10 00:00:00

abstract：:Parasitic protozoans of the genus Theileria are intracellular pathogens that induce the cellular transformation of leukocytes, causing uncontrolled proliferation of the infected host cell. The transforming stage of the parasite has a strictly intracellular lifestyle and ensures its distribution to both daughter cells ...

journal_title：mSphere

authors： Huber S,Bär A,Epp S,Schmuckli-Maurer J,Eberhard N,Humbel BM,Hemphill A,Woods K

更新日期：2020-02-05 00:00:00

abstract：:Arginine is an important pH-elevating agent in the oral cavity. It has been incorporated in oral hygiene formulations to mitigate sensitivity and to prevent caries. In this investigation, the effects of sustained arginine dosing of dental plaque microcosms on bacteriological composition and pH were evaluated under con...

journal_title：mSphere

authors： Ledder RG,Mistry H,Sreenivasan PK,Humphreys G,McBain AJ

更新日期：2017-08-23 00:00:00

abstract：:Polymyxin B and colistin are exclusively active against Gram-negative pathogens and have been used in the clinic as a last-line therapy. In this study, we investigated the antimicrobial activity of a novel polymyxin, FADDI-019, against Staphylococcus aureus. MIC and time-kill assays were employed to measure the activi...

journal_title：mSphere

authors： Zhao J,Cheah SE,Roberts KD,Nation RL,Thompson PE,Velkov T,Du Z,Johnson MD,Li J

更新日期：2016-07-27 00:00:00

abstract：:The stability of the Escherichia coli populations in the human gastrointestinal tract is not fully appreciated, and represents a significant knowledge gap regarding gastrointestinal community structure, as well as resistance to incoming pathogenic bacterial species and antibiotic treatment. The current study examines ...

journal_title：mSphere

authors： Richter TKS,Hazen TH,Lam D,Coles CL,Seidman JC,You Y,Silbergeld EK,Fraser CM,Rasko DA

更新日期：2018-11-07 00:00:00

abstract：:Staphylococcus aureus is a facultative intracellular pathogen that invades and replicates within many types of phagocytic and nonphagocytic cells. During intracellular infection, S. aureus is capable of subverting xenophagy and escaping to the cytosol of the host cell. Furthermore, drug-induced autophagy facilitates t...

journal_title：mSphere

authors： Bravo-Santano N,Ellis JK,Mateos LM,Calle Y,Keun HC,Behrends V,Letek M

更新日期：2018-08-08 00:00:00

abstract：:Pascale Guiton works in the field of parasitology at a primarily undergraduate institution. In this mSphere of Influence article, she reflects on her difficulties as a faculty of color to discuss socioscientific issues in her classrooms. T. D. Sadler's article "Situating socio-scientific issues in classrooms as a mean...

journal_title：mSphere

authors： Guiton PS

更新日期：2021-01-20 00:00:00

abstract：:Streptococcus pneumoniae two-component regulatory systems (TCS) enable adaptation and ensure its maintenance in host environments. This study deciphers the impact of TCS08 on pneumococcal gene expression and its role in metabolic and pathophysiological processes. Transcriptome analysis and real-time PCR demonstrated a...

journal_title：mSphere

authors： Gómez-Mejia A,Gámez G,Hirschmann S,Kluger V,Rath H,Böhm S,Voss F,Kakar N,Petruschka L,Völker U,Brückner R,Mäder U,Hammerschmidt S

更新日期：2018-05-16 00:00:00

abstract：:Periodontal disease induced by periodontopathic bacteria like Porphyromonas gingivalis is demonstrated to increase the risk of metabolic, inflammatory, and autoimmune disorders. Although precise mechanisms for this connection have not been elucidated, we have proposed mechanisms by which orally administered periodonto...

journal_title：mSphere

authors： Kato T,Yamazaki K,Nakajima M,Date Y,Kikuchi J,Hase K,Ohno H,Yamazaki K

更新日期：2018-10-17 00:00:00

abstract：:The chikungunya virus (CHIKV) is transmitted by female Aedes aegypti and Aedes albopictus mosquitoes, mostly present in (sub)tropical regions. No antivirals are available to treat CHIKV infections. If antiviral drugs are proven efficient to treat CHIKV-infected patients, it will be pivotal to determine whether drug-re...

journal_title：mSphere

authors： Delang L,Yen PS,Vallet T,Vazeille M,Vignuzzi M,Failloux AB

更新日期：2018-08-22 00:00:00

abstract：:The mechanisms underlying the rapidly reversible brain swelling described in patients with cerebral malaria (CM) are unknown. Using a 1.5-Tesla (T) magnetic resonance imaging (MRI) scanner, we undertook an observational study in Rourkela, India, of 11 Indian patients hospitalized with CM and increased brain volume. Am...

journal_title：mSphere

authors： Mohanty S,Benjamin LA,Majhi M,Panda P,Kampondeni S,Sahu PK,Mohanty A,Mahanta KC,Pattnaik R,Mohanty RR,Joshi S,Mohanty A,Turnbull IW,Dondorp AM,Taylor TE,Wassmer SC

更新日期：2017-06-07 00:00:00

abstract：:Zoonosis is the leading cause of emerging infectious diseases. In a recent article, R. S. Shabman et al. (mSphere 1[1]:e00070-15, 2016, http://dx.doi.org/10.1128/mSphere.00070-15) report the identification of a novel gammaherpesvirus in a cell line derived from the microbat Myotis velifer incautus. This is the first r...

journal_title：mSphere

authors： Host KM,Damania B

更新日期：2016-02-17 00:00:00

abstract：:Skin and soft tissue infections (SSTIs) are common in the general population, with increased prevalence among military trainees. Previous research has revealed numerous nasal microbial signatures that correlate with SSTI development and Staphylococcus aureus colonization. Thus, we hypothesized that the ecology of the ...

journal_title：mSphere

authors： Singh J,Johnson RC,Schlett CD,Elassal EM,Crawford KB,Mor D,Lanier JB,Law NN,Walters WA,Teneza-Mora N,Bennett JW,Hall ER,Millar EV,Ellis MW,Merrell DS

更新日期：2016-10-05 00:00:00

abstract：:Candida auris, an emerging multidrug-resistant yeast, has recently been associated with outbreaks of invasive infections in health care facilities worldwide. Its success as a nosocomial pathogen lies in its capability to sustain for prolonged periods in the intensive care unit (ICU), adeptly colonize skin, and spread ...

journal_title：mSphere

authors： Uppuluri P

更新日期：2020-01-22 00:00:00

abstract：:For enteroviruses such as poliovirus (PV), empty capsids, which are antigenically indistinguishable from mature virions, are produced naturally during viral infection. The production of such capsids recombinantly, in heterologous systems such as yeast, have great potential as virus-like particle (VLP) vaccine candidat...

journal_title：mSphere

authors： Sherry L,Grehan K,Snowden JS,Knight ML,Adeyemi OO,Rowlands DJ,Stonehouse NJ

更新日期：2020-03-11 00:00:00

abstract：:Clostridium difficile, also known as Clostridioides difficile, is a Gram-positive, spore-forming bacterium that is a leading cause of antibiotic-associated diarrhea. C. difficile infections begin when its metabolically dormant spores germinate to form toxin-producing vegetative cells. Successful spore germination depe...

journal_title：mSphere

authors： Diaz OR,Sayer CV,Popham DL,Shen A

更新日期：2018-06-27 00:00:00

abstract：:CRISPR-Cas (clustered regularly interspaced short palindromic repeat [CRISPR]-CRISPR-associated protein [Cas]) systems can provide protection against invading genetic elements by using CRISPR RNAs (crRNAs) as a guide to locate and degrade the target DNA. CRISPR-Cas systems have been classified into two classes and fiv...

journal_title：mSphere

authors： Guan J,Wang W,Sun B

更新日期：2017-11-15 00:00:00

abstract：:Bacterial small RNAs play a remarkable role in the regulation of functions involved in host-pathogen interaction. ErsA is a small RNA of Pseudomonas aeruginosa that contributes to the regulation of bacterial virulence traits such as biofilm formation and motility. Shown to take part in a regulatory circuit under the c...

journal_title：mSphere

authors： Ferrara S,Rossi A,Ranucci S,De Fino I,Bragonzi A,Cigana C,Bertoni G

更新日期：2020-10-14 00:00:00

abstract：:Human adenoviruses (HAdV), species D in particular (HAdV-D), are frequently associated with epidemic keratoconjunctivitis (EKC). Although the infection originates at the ocular surface epithelium, the mechanisms by which HAdV-Ds bypass the membrane-associated mucin (MAM)-rich glycocalyx of the ocular surface epitheliu...

journal_title：mSphere

authors： Menon BB,Zhou X,Spurr-Michaud S,Rajaiya J,Chodosh J,Gipson IK

更新日期：2016-02-10 00:00:00

abstract：:In fungi, most metabolic processes are subject to regulation by light. Trichoderma reesei is adapted to degradation of plant cell walls and regulates production of the required enzymes in a manner dependent on the nutrient source and the light status. Here we investigated the interrelated relevance of two regulation l...

journal_title：mSphere

authors： Stappler E,Dattenböck C,Tisch D,Schmoll M

更新日期：2017-05-10 00:00:00

abstract：:Vibrio cholerae is a noninvasive pathogen that colonizes the small intestine and produces cholera toxin, causing severe secretory diarrhea. Cholera results in long lasting immunity, and recent studies have improved our understanding of the antigenic repertoire of V. cholerae Interactions between the host, V. cholerae,...

journal_title：mSphere

authors： Weil AA,Becker RL,Harris JB

更新日期：2019-11-27 00:00:00