Abstract:
BACKGROUND:Natural products derived from marine microbes have more potential toward to treatment of various diseases. Among the microbes, the secondary metabolites recovered from the marine actinomycetes were more added values. OBJECTIVE:A promising antimicrobial metabolite producing filamentous actinomycete SCA-7 recovered from Alkhobar marine region was investigated for its potential to inhibit Gram positive Enterococcus sp. In addition to the chemical characterization, the polyketide gene cluster of the actinomycete SCA-7 was sequenced. RESULTS:Among the 8 actinomycetes isolated from the marine sample, the isolate SCA-7 produced significant antimicrobial activity against Enterococcus sp. The biochemical, physiological and morphological characteristics and fermentation assimilation pattern confirmed that the isolate belonged to the genus Streptomyces. The 16S rRNA gene amplification and sequencing results showed 99% sequence similarity to Streptomyces felleus. The antimicrobial activity of the crude ethyl acetate extract was performed by disc diffusion method. The spectral characterization was done by 13C NMR and 1H NMR. The compound was polyketide in nature. The Minimum Inhibitory Concentration (MIC) of the polyketide compound against Enterococcus sp. was 25μg/mL. Among the agro-industrial waste materials, wheat bran showed increased secondary metabolite production. Antibacterial activity was found to be high when the isolate SCA-7 was grown in wheat bran substrate and maximum zone of inhibition (22mm) was recorded in it. Among the carbon and nitrogen sources, lactose enhanced the production of secondary metabolites and the zone of inhibition against Enterococcus sp. was 25mm. The amplification and sequencing of the ketoacyl synthase gene clearly indicated that it was type I polyketide synthase (PKS) gene of Streptomyces species. CONCLUSION:Overall, the therapeutic drug molecule isolated from the marine Streptomyces species might be used for the treatment of disease causing microbial clinical pathogen.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Almalki MAdoi
10.1016/j.jiph.2019.07.002subject
Has Abstractpub_date
2020-01-01 00:00:00pages
125-130issue
1eissn
1876-0341issn
1876-035Xpii
S1876-0341(19)30235-7journal_volume
13pub_type
杂志文章abstract::Brucellosis is a common zoonotic disease throughout the world. Brucella spp. transmit to humans through contact with fluids of infected animals, especially sheep, cattle, and goats. It is also transmitted by ingestion of fluid-derived products of infected animals, such as unpasteurized milk and cheese. Brucella spp. c...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2014.07.004
更新日期:2014-11-01 00:00:00
abstract:INTRODUCTION:Despite the advancement in diagnostic modalities of sepsis, it is still a leading cause of morbidity and mortality. Differentiation between sepsis and non-infectious disease states remains a diagnostic challenge. Procalcitonin (PCT) is useful for the diagnosis of sepsis but it varies in cut-off ranges at d...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.11.004
更新日期:2019-01-01 00:00:00
abstract::A self-administered network-based questionnaire survey was conducted on 91 HIV-positive Chinese men having sex with men (MSM). Affiliation matrices were created to assess their networking pattern. The individuals' preferential use of venues for sex partnership before HIV infection has changed over three time periods o...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2009.09.002
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Swine brucellosis is a zoonotic disease caused by Brucella suis. The study describes the occurrence of brucellosis in two organized piggeries in Southern India. METHODS:A total of 585 serum samples comprising 575 from pigs and 10 from animal handlers were collected and tested by serological tests and PCR. T...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.10.013
更新日期:2019-01-01 00:00:00
abstract::Rapid tests to diagnose tuberculosis relies on molecular detection of the M. tuberculosis. GeneXpert MTB/RIF test identifies M. tuberculosis and rifampicin resistance. We present a case of simultaneous coinfection with M. tuberculosis and M. avium. M. tuberculosis was detected in the sputum by PCR GeneXpert method. Un...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2020.01.006
更新日期:2020-05-01 00:00:00
abstract::Mild encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome that can be related to infectious and non-infectious conditions. Patients present with mild neurological symptoms, and magnetic resonance imaging typically demonstrate a reversible lesion with transiently reduced diffusion ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2016.08.019
更新日期:2017-01-01 00:00:00
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2014.08.001
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Environmental and climatic risk factors of dengue outbreak has been studied in detail. However, the socio-epidemiological association with the disease is least explored. The study aims to identify the social and ecological factors associated with emerging dengue in Odisha, India. METHODS:A population-based ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.08.015
更新日期:2020-04-01 00:00:00
abstract::Nearly four months have passed since the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which caused the rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic. To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-1...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2020.04.016
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abstract::Patients in an intensive care unit (ICU) are frequently immunocompromised and might be highly susceptible to infection. Visitors to an ICU who do not adequately clean their hands could carry pathogenic organisms, resulting in risk to a vulnerable patient population. This observational study identifies pathogens carrie...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2015.04.027
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Evidence to demonstrate the prevalence and trend of Methicillin Resistant Staphylococcus aureus (MRSA) infection in Nigeria is scarce. This review evaluates the prevalence, trend and antimicrobial susceptibility of clinical MRSA isolates reported in published studies. METHOD:Electronic search (PubMed, Scopu...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2018.05.013
更新日期:2018-01-01 00:00:00
abstract::The purpose of this study was to analyze the characteristics of the diagnosis and treatment of female uterine fibroids based on data mining technology and the medication rule. Clinical literature related to the treatment of uterine fibroids by Chinese National Knowledge Infrastructure (CNKI) from 2004 to 2018 were sea...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.07.017
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Although the specific etiology of Henoch-Schonlein purpura (HSP) is still unknown, several kinds of infectious triggers have been proved to participate in its pathogenesis. The objectives of present study were to analyze the association of the infectious triggers with childhood HSP in Anhui province, China. ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.07.004
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Pseudomonas aeruginosa (member of ESKAPE group) is predominantly responsible for emerging nosocomial infections and poses serious health concern due to ever-increasing drug resistance trends. The current study investigates the prevalence of such highly resistant P. aeruginosa in major hospital settings and...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.08.019
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among wh...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2016.11.003
更新日期:2017-01-01 00:00:00
abstract::Morocco is a country known for its vulnerability of water resources because of its arid and semi-arid climate. Thus, recycled wastewater has been suggested for agricultural activities, but contamination of these wastewaters is a major concern. The current study aims to determine the occurrence of helminth eggs in urba...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.07.026
更新日期:2018-01-01 00:00:00
abstract:PURPOSES:The objective of the study was to identify the trends and relations between antimicrobial resistance (AMR) and antibiotic use in the Xinjiang Uyghur Autonomous Region in Western China from 2014 to 2016. METHODS:A retrospective, descriptive analysis of AMR prevalence, and trends and relations between AMR and a...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.09.021
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Respiratory viral infections (RVI) are a leading cause of mortality worldwide. We compared the epidemiology and severity of RVI in Ecuador during 2009-2016. METHODS:Respiratory specimens collected within the national surveillance system were tested for influenza viruses, respiratory syncytial virus (RSV), a...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.12.003
更新日期:2019-01-01 00:00:00
abstract::The World Alliance for Patient Safety is an evolving programme of the WHO, established to raise the profile of patient safety within the global health care agenda. The decision taken in 2004 to focus the effort and attention of the First Global Patient Safety Challenge on the problem of health care-associated infectio...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2008.08.006
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:The study was done experimentally to test the effect of diabetes on body mass index (BMI), low-density lipoprotein (LDL), high-density lipoprotein (HDL), systolic blood pressure, diastolic blood pressure, fasting blood glucose and postprandial blood glucose. METHODS:In the randomization performed, with 80 p...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2020.03.008
更新日期:2020-12-01 00:00:00
abstract::In the last few years, Cryptococcus laurentii infections have increased, particularly in immunocompromised patients. Here we report the first case of C. laurentii fungemia in low birth weight preterm infant from India. A preterm neonate was admitted for feeding intolerance and respiratory distress. Blood culture ascer...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.04.012
更新日期:2018-01-01 00:00:00
abstract::The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ATP; viral RNA polymerases incorporate...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2016.04.002
更新日期:2016-05-01 00:00:00
abstract::HPV is the sexually transmitted agent most common among young people, like college students. The aim of study was to associate sexual behavior characteristics of women with HPV, detected in genital samples taken before the introduction of the HPV vaccine. Female students during 2001-2005 donated genital samples and th...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.08.014
更新日期:2018-01-01 00:00:00
abstract::Zika virus (ZIKV), an Aedes mosquito-borne flavivirus, has captured public health attention worldwide. Initially, the virus was reported in Africa and Asia. However, the outbreak of ZIKV in Brazil and the United States of America demonstrated the global health risk. Symptoms of ZIKV infection vary from mild fever, ras...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2019.05.004
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Spontaneous bacterial peritonitis (SBP) is a potentially lethal complication of cirrhosis. It is probably the most characteristic infectious complication of cirrhosis. AIM:The aim of this study was to evaluate the bacterial and fungal causes of SBP in Egyptian population. Furthermore to predict the occurren...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2011.06.002
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:Few studies have reported the uptake of health preventive measures among Hajj pilgrims from Saudi Arabia. Yet, none of these studies have explored their perceptions of health risks at Hajj or pretravel health-advice-seeking behavior. METHODS:A cross-sectional survey conducted among Hajj pilgrims from Saudi ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.04.007
更新日期:2019-01-01 00:00:00
abstract::Toxocarosis is a zoonotic parasitic disease transmitted from companion animals to humans. Environmental contamination with Toxocara eggs is considered to be the main source of human infections. In Portugal, knowledge regarding the current situation, including density, distribution and environmental contamination by To...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.05.002
更新日期:2018-01-01 00:00:00
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.06.023
更新日期:2020-12-01 00:00:00
abstract::MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.11.016
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Nowadays, there is a paradigm shift in medical education. This shift occurred following the Covid-19 crisis. The world uses digital e-learning to support the public health response to this pandemic. The study's objective was to determine the medical students' acceptance and perceptions of e-learning during t...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2020.11.007
更新日期:2020-12-05 00:00:00