Abstract:
:Brucellosis is a common zoonotic disease throughout the world. Brucella spp. transmit to humans through contact with fluids of infected animals, especially sheep, cattle, and goats. It is also transmitted by ingestion of fluid-derived products of infected animals, such as unpasteurized milk and cheese. Brucella spp. changes pH level of intracellular environment, so the first treatment approach is to administer antibiotics that have activity in acidic conditions. Anti-brucellosis treatment regimens include doxycycline for children older than eight years old and rifampicin and trimethoprim/sulfamethoxazole (TMP-SMX) combination therapy for children under eight years old, which may be able to act intracellularly under acidic conditions. A TMP-SMX allergy causing anaphylaxis has been reported previously. No alternative anti-brucellosis treatments have been reported in the literature for patients under eight years old with a TMP-SMX allergy. Here, we report a case of a child with brucellosis and a TMP-SMX allergy who was under eight years old at the time of diagnosis and was successfully treated with rifampicin, ciprofloxacin, and gentamicin.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Teker D,Tanir G,Ozmen S,Teke TA,Keles S,Bostancı Idoi
10.1016/j.jiph.2014.07.004subject
Has Abstractpub_date
2014-11-01 00:00:00pages
553-6issue
6eissn
1876-0341issn
1876-035Xpii
S1876-0341(14)00104-Xjournal_volume
7pub_type
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