Procalcitonin as a diagnostic biomarker of sepsis: A tertiary care centre experience.

Abstract:

INTRODUCTION:Despite the advancement in diagnostic modalities of sepsis, it is still a leading cause of morbidity and mortality. Differentiation between sepsis and non-infectious disease states remains a diagnostic challenge. Procalcitonin (PCT) is useful for the diagnosis of sepsis but it varies in cut-off ranges at different clinical settings. The aim of this study was to correlate serum PCT levels with cultures and to evaluate the best cut-off values with high sensitivity and specificity for PCT. METHODOLOGY:This prospective study included 305 patients from different medical wards; the patients were classified into group I: controls (n=46), group II: culture-negative sepsis (n=76) and group III: culture-positive sepsis (n=196). Mean p value <0.05 was considered significant. RESULTS:PCT levels were significantly higher in group II and group III as compared with group I. In group II, the best cut-off point for PCT was 1.3ng/ml with 87.30% sensitivity and 78.26% specificity (area under curve 0.86). In group III, the best cut-off value of 2.20ng/ml with 98.47% sensitivity and 89.13% specificity was found (AUC 0.96). CONCLUSION:Procalcitonin can accurately differentiate culture-negative and culture-positive sepsis from non-infectious diseases, thus making it a promising biomarker in diagnosis of bacterial sepsis.

journal_name

J Infect Public Health

authors

Gupta S,Jaswani P,Sharma RK,Agrawal S,Prasad N,Sahu C,Gupta A,Prasad KN

doi

10.1016/j.jiph.2018.11.004

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

323-329

issue

3

eissn

1876-0341

issn

1876-035X

pii

S1876-0341(18)30312-5

journal_volume

12

pub_type

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