Abstract：
INTRODUCTION:Despite the advancement in diagnostic modalities of sepsis, it is still a leading cause of morbidity and mortality. Differentiation between sepsis and non-infectious disease states remains a diagnostic challenge. Procalcitonin (PCT) is useful for the diagnosis of sepsis but it varies in cut-off ranges at different clinical settings. The aim of this study was to correlate serum PCT levels with cultures and to evaluate the best cut-off values with high sensitivity and specificity for PCT. METHODOLOGY:This prospective study included 305 patients from different medical wards; the patients were classified into group I: controls (n=46), group II: culture-negative sepsis (n=76) and group III: culture-positive sepsis (n=196). Mean p value <0.05 was considered significant. RESULTS:PCT levels were significantly higher in group II and group III as compared with group I. In group II, the best cut-off point for PCT was 1.3ng/ml with 87.30% sensitivity and 78.26% specificity (area under curve 0.86). In group III, the best cut-off value of 2.20ng/ml with 98.47% sensitivity and 89.13% specificity was found (AUC 0.96). CONCLUSION:Procalcitonin can accurately differentiate culture-negative and culture-positive sepsis from non-infectious diseases, thus making it a promising biomarker in diagnosis of bacterial sepsis.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Gupta S,Jaswani P,Sharma RK,Agrawal S,Prasad N,Sahu C,Gupta A,Prasad KNdoi
10.1016/j.jiph.2018.11.004subject
Has Abstractpub_date
2019-01-01 00:00:00pages
323-329issue
3eissn
1876-0341issn
1876-035Xpii
S1876-0341(18)30312-5journal_volume
12pub_type
杂志文章abstract：OBJECTIVE:MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among wh...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the family Coronaviridae, and is named for the crown-like spikes on its surface. The clinical presentation of MERS-CoV infection ranges from asymptomatic to very severe disease, and the classical presentation includes fever, cough chills, s...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2018.02.001
更新日期：2018-01-01 00:00:00
abstract：:This paper describes a voluntary anonymous survey to investigate the seroprevalence of Hepatitis C (HCV) in children in Glasgow, UK attending a Dental Hospital and the proportion of HCV positive mothers who have a child who is HCV seropositive. The study was undertaken among children and accompanying parents and house...
journal_title：Journal of infection and public health
pub_type： 杂志文章
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abstract：BACKGROUND:Although the specific etiology of Henoch-Schonlein purpura (HSP) is still unknown, several kinds of infectious triggers have been proved to participate in its pathogenesis. The objectives of present study were to analyze the association of the infectious triggers with childhood HSP in Anhui province, China. ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.07.004
更新日期：2020-01-01 00:00:00
abstract：:The World Alliance for Patient Safety is an evolving programme of the WHO, established to raise the profile of patient safety within the global health care agenda. The decision taken in 2004 to focus the effort and attention of the First Global Patient Safety Challenge on the problem of health care-associated infectio...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2008.08.006
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVES:Incidence of tuberculosis (TB) is greatest among patients with impaired immunity. India is experiencing a double epidemic of HIV and diabetes mellitus (DM), both of which are strongly associated with immuno-suppression. This study aimed to discover the prevalence of HIV and DM in both the pulmonary and extra...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2011.03.005
更新日期：2011-08-01 00:00:00
abstract：:Brucellosis is an ancient disease that still remains a significant threat to humans and is typically linked to exposure to infected animals and/or consumption of unpasteurized animal products. Despite this history, we have a relatively limited understanding of the host characteristics of this disease; consequently, fu...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2012.03.006
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abstract：BACKGROUND:Carbapenem are the last-line antibiotic, defence against Gram-negative extended spectrum ß-lactamases producers (ESBLs). Carbapenem resistance Enterobacteriaceae especially Carbapenem resistant-Klebsiella pneumoniae (CR-KP) is recognized as one of the well-known public health problem, which is increasingly b...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2020.09.018
更新日期：2020-11-21 00:00:00
abstract：BACKGROUND AND AIMS:Prevalence of hepatitis C virus (HCV) in intravenous drug users (IDU) varies in different areas according to socioeconomic and geographical circumstances. The present study was performed to determine seroprevalence of HCV in IDU individuals in Ahvaz, Iran. MATERIALS AND METHODS:142 IDU patients wer...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2009.01.001
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:While performing the Hajj, hajjis face different risks related to the environment, their behaviors and their health conditions that can result in a variety of diseases. The objective of this study was to determine the pattern of diseases among pilgrims seeking medical services in Mina primary health care cen...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2011.10.003
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Patient-professional interactions and adherence to infection control measures are central to the quality of care and patient safety in healthcare. Persons colonized with methicillin-resistant Staphylococcus aureus (MRSA) describe insufficient support and unprofessional behavior among healthcare personnel. M...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2014.02.004
更新日期：2014-09-01 00:00:00
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journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2018.08.011
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Relative to adults, children have a higher risk of influenza-related illnesses, and they play a major role in the spread of infections through a household. Because the primary caregiver is responsible for the overall health of the child, it is important to analyze the relationship between caregiver character...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2012.12.001
更新日期：2013-04-01 00:00:00
abstract：:Rapid tests to diagnose tuberculosis relies on molecular detection of the M. tuberculosis. GeneXpert MTB/RIF test identifies M. tuberculosis and rifampicin resistance. We present a case of simultaneous coinfection with M. tuberculosis and M. avium. M. tuberculosis was detected in the sputum by PCR GeneXpert method. Un...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2020.01.006
更新日期：2020-05-01 00:00:00
abstract：:Zika virus (ZIKV), an Aedes mosquito-borne flavivirus, has captured public health attention worldwide. Initially, the virus was reported in Africa and Asia. However, the outbreak of ZIKV in Brazil and the United States of America demonstrated the global health risk. Symptoms of ZIKV infection vary from mild fever, ras...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2019.05.004
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Natural products derived from marine microbes have more potential toward to treatment of various diseases. Among the microbes, the secondary metabolites recovered from the marine actinomycetes were more added values. OBJECTIVE:A promising antimicrobial metabolite producing filamentous actinomycete SCA-7 rec...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.07.002
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Due to the increasing availability of antiretroviral treatment, HIV infected children are living longer which points out the necessity of disclosure. And which is important to support the uptake and adherence to treatment. Disclosure is an important measure to prevent secondary transmission when children are...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.05.018
更新日期：2019-01-01 00:00:00
abstract：:Myiasis-the feeding of fly larvae on living mammals, may have various clinical presentations depending on the tissues or organs involved. Myiasis is a common travel associated skin disorder as a consequence of short visits to developing countries. It is the fourth most common travel associated disease. The most common...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2009.08.001
更新日期：2010-01-01 00:00:00
abstract：:This study compares the factors, which influence individuals from the countries of China, Japan and South Korea to obtain any type of influenza vaccines and their perceived concerns about the new strain of the influenza - pandemic (H1N1) 2009. The data analyzed was from the East Asian Social Survey (EASS), Cross-Natio...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.06.004
更新日期：2017-01-01 00:00:00
abstract：:We report a case of Pseudomonas stutzeri endocarditis in Lebanon. The patient had a recent history of prosthetic aortic valve replacement and presented to the emergency department with fever and chills. Transesophageal echocardiography confirmed the presence of a vegetation on the prosthetic valve and blood cultures y...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2018.07.004
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abstract：BACKGROUND:Healthcare-associated infections (HCAIs) are an important public health problem. It is estimated that approximately 1 out of every 20 hospitalized patients will contract an HCAI. The risk is substantial not only to patients but also to healthcare workers, who may contract deadly blood-borne infectious diseas...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2013.02.006
更新日期：2013-08-01 00:00:00
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journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2017.05.004
更新日期：2017-01-01 00:00:00
abstract：:Brucellosis is a common zoonotic disease throughout the world. Brucella spp. transmit to humans through contact with fluids of infected animals, especially sheep, cattle, and goats. It is also transmitted by ingestion of fluid-derived products of infected animals, such as unpasteurized milk and cheese. Brucella spp. c...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2014.07.004
更新日期：2014-11-01 00:00:00
abstract：:A man, 26years-old, presented fever, mental confusion and a progressively worsening headache 6days prior to admission. The CSF study was suggestive of meningoencephalitis, the PCR study revealed presence of HSV-1 and ZIKV, while other immunology tests were negative. ZIKV was also identified in serum. The MRI showed te...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2018.04.010
更新日期：2019-01-01 00:00:00
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journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2011.06.002
更新日期：2011-09-01 00:00:00
abstract：:The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ATP; viral RNA polymerases incorporate...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2016.04.002
更新日期：2016-05-01 00:00:00
abstract：:We evaluated the effectiveness of inactivated influenza vaccine in persons aged ≥45 years with co-morbidities (including essential hypertension) likely to have prompted consideration of prophylactic statin therapy. Using case-control analyses, we measured the impact of vaccination on General Practitioner (GP) reported...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2010.09.007
更新日期：2010-12-01 00:00:00
abstract：:The purpose of this study was to analyze the characteristics of the diagnosis and treatment of female uterine fibroids based on data mining technology and the medication rule. Clinical literature related to the treatment of uterine fibroids by Chinese National Knowledge Infrastructure (CNKI) from 2004 to 2018 were sea...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.07.017
更新日期：2020-10-01 00:00:00
abstract：:The outbreak of COVID-19 has created a global public health crisis. Little is known about the protective factors of this infection. Therefore, preventive health measures that can reduce the risk of infection, progression and severity are desperately needed. This review discussed the possible roles of vitamin D in redu...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2020.06.021
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to evaluate the microbial quality of the well water used as a drinking source in urban and rural households. METHODS:A total of 80 household well water samples were analyzed by the multiple fermentation tube method to determine the presumptive coliform count/most probable numb...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2012.03.004
更新日期：2012-06-01 00:00:00
