Abstract:
BACKGROUND:Panton-Valentine Leukocidin (PVL), is one of the virulence gene expressed by Methicillin Resistant Staphylococcus aureus (MRSA) and is known to be associated with severe form of community acquired MRSA infection. The aim of this study is to investigate its prevalence in our setting and patient's clinical outcome. METHODS:A cross sectional study involve retrospective record review were done involving 90 MRSA positive isolates between November 2016 and October 2017. Multiplex PCR was performed to detect femA, mecA and PVL genes. Clinical presentation and outcomes of patients were reviewed and presented as descriptive analysis. RESULTS:All of the 90 MRSA isolates included in this study were positive for femA and mecA genes following PCR. PVL gene was detected in 20% (n = 18) of the isolates of which 61.1% (n = 11) were community acquired infections and 38.8% (n = 7) were hospital acquired. Case distribution from community acquired infections include patients with skin and soft tissue infections (33.3%, n = 6), infected diabetic foot ulcers (16.7%, n = 3), and one patient each (5.5%, n = 1) for community acquired pneumonia and meningitis. Half of the PVL positive MRSA cases (50%, n = 9) were having sepsis and four of them succumbed to death due to severe infection. CONCLUSION:This study shows a high prevalence of PVL positive MRSA infection in our population. Skin and soft tissue infections accounting for the major sources. In addition, the presence of the PVL gene is associated with increased risk for developing sepsis.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Ahmad NI,Yean Yean C,Foo PC,Mohamad Safiee AW,Hassan SAdoi
10.1016/j.jiph.2020.06.018subject
Has Abstractpub_date
2020-10-01 00:00:00pages
1508-1512issue
10eissn
1876-0341issn
1876-035Xpii
S1876-0341(20)30528-1journal_volume
13pub_type
杂志文章abstract::HPV is the sexually transmitted agent most common among young people, like college students. The aim of study was to associate sexual behavior characteristics of women with HPV, detected in genital samples taken before the introduction of the HPV vaccine. Female students during 2001-2005 donated genital samples and th...
journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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abstract::Nearly four months have passed since the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which caused the rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic. To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-1...
journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2013.02.006
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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abstract::Zika virus (ZIKV), an Aedes mosquito-borne flavivirus, has captured public health attention worldwide. Initially, the virus was reported in Africa and Asia. However, the outbreak of ZIKV in Brazil and the United States of America demonstrated the global health risk. Symptoms of ZIKV infection vary from mild fever, ras...
journal_title:Journal of infection and public health
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abstract::Diagnosis of MERS-Cov still a major concern in most of daignostic laboratories. To date the Real-time Polymerase Chain reaction (RT-PCR) is the mainstay for diagnosis of MERS-CoV. RT-PCR has limitations, including a long turnaround time and lack of common measurements and correlations with Viral Load (VL). It is recom...
journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2016.04.005
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abstract::We evaluated the effectiveness of inactivated influenza vaccine in persons aged ≥45 years with co-morbidities (including essential hypertension) likely to have prompted consideration of prophylactic statin therapy. Using case-control analyses, we measured the impact of vaccination on General Practitioner (GP) reported...
journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2010.09.007
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Prevalence of hepatitis C virus (HCV) in intravenous drug users (IDU) varies in different areas according to socioeconomic and geographical circumstances. The present study was performed to determine seroprevalence of HCV in IDU individuals in Ahvaz, Iran. MATERIALS AND METHODS:142 IDU patients wer...
journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2009.01.001
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abstract::Carbapenemase-producing Enterobacteriaceae have been steadily spreading worldwide during the last decade. Nine patients were identified prospectively and were followed during their hospitalization course to identify the epidemiology, clinical profiles and outcomes. These patients had one or more cultures positive for ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.05.004
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often describ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.03.014
更新日期:2019-01-01 00:00:00
abstract::Morocco is a country known for its vulnerability of water resources because of its arid and semi-arid climate. Thus, recycled wastewater has been suggested for agricultural activities, but contamination of these wastewaters is a major concern. The current study aims to determine the occurrence of helminth eggs in urba...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.07.026
更新日期:2018-01-01 00:00:00
abstract::MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to ...
journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2019.11.016
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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doi:10.1016/j.jiph.2013.02.002
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journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
doi:10.1016/j.jiph.2016.04.002
更新日期:2016-05-01 00:00:00
abstract::This paper describes a voluntary anonymous survey to investigate the seroprevalence of Hepatitis C (HCV) in children in Glasgow, UK attending a Dental Hospital and the proportion of HCV positive mothers who have a child who is HCV seropositive. The study was undertaken among children and accompanying parents and house...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2016.08.001
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:MBL acts as a binding protein that enables uptake of mycobacteria into macrophages. And, TNF-alpha is an important cytokine that is involved in control of mycobacterial infections both in-vivo and in-vitro. A large number of genetic factors exerting susceptibility to tuberculosis has been identified, among wh...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2016.11.003
更新日期:2017-01-01 00:00:00
abstract::Leprosy is a chronic disease caused by Mycobacterium leprae. Although the occurrence of leprosy has declined in Saudi Arabia, it has not yet been eradicated. To our knowledge, this descriptive retrospective study is the first to assess the clinical presentation of leprosy at the time of diagnosis in Saudi Arabia. All ...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2015.12.015
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. METHODS:Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose s...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.04.015
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Norovirus (NoV) is recognized as a leading global cause of viral acute gastroenteritis (AGE). To better understand the prevalence and genotypic patterns of NoV infection in Southeast China, we conducted a retrospective study of diarrheal syndrome surveillance of NoV and analyzed the epidemiological character...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.06.006
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Middle East respiratory syndrome coronavirus (MERS-CoV) belongs to the family Coronaviridae, and is named for the crown-like spikes on its surface. The clinical presentation of MERS-CoV infection ranges from asymptomatic to very severe disease, and the classical presentation includes fever, cough chills, s...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.02.001
更新日期:2018-01-01 00:00:00
abstract:INTRODUCTION:Pseudomonas aeruginosa (member of ESKAPE group) is predominantly responsible for emerging nosocomial infections and poses serious health concern due to ever-increasing drug resistance trends. The current study investigates the prevalence of such highly resistant P. aeruginosa in major hospital settings and...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2019.08.019
更新日期:2020-04-01 00:00:00
abstract::Listeria monocytogenes is among the most important foodborne pathogens, which can be isolated from bird feces. The aim of this study was to examine the prevalence, genotypes, virulence factors and drug-resistance characteristics of L. monocytogenes isolated from the black-headed gull in Kunming, China. Serotypes and v...
journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.03.003
更新日期:2018-01-01 00:00:00