Abstract:
BACKGROUND:Identified in 2001, Human Metapneumovirus (HMPV) is a Pneumovirus associated with acute lower and upper respiratory infections in all age groups and especially in newborns, elderly and immunocompromised subjects. Data are still limited in sub-Saharan African countries genetic characterization of this respiratory virus. This study reports the genetic variability of HMPV strains in Cameroonian children for 3 consecutive epidemic seasons (September 2011-October 2014). METHODS:A prospective surveillance was conducted to identify inpatient and outpatient children less than 15 years with respiratory symptoms ≤5 days. The nasopharyngeal samples were tested for HMPV using a multiplex polymerase chain reaction. Viral distribution and demographic data were analyzed statistically. Positive samples for HMPV were amplified by semi-nested polymerize chain reaction and then partially sequenced at the G gene. Phylogenetic analyzes were performed on the partial nucleotide and protein sequences of the G gene. RESULTS:From September 2011 to October 2014, 822 children under 15 years were enrolled in the study. HMPV was identified in each of 3.9% (32/822) of children. HMPV were detected throughout the year. HMPV-A (73.3%; 11/15) was predominant compared to HMPV-B (26.7; 4/15). Cameroonian HMPV strains are grouped among the members of genotype A2b (for HMPV-A), B1 and B2 (for HMPV-B). CONCLUSION:This study suggests that about 4% of ARI recorded in children in Cameroon are caused by HMPV. The present study is also the first report on the genetic variability of the G gene of HMPV strains in the region. Although this work partially fills gaps for some information, additional studies are required to clarify the molecular epidemiology and evolutionary pattern of HMPV in sub-Saharan Africa in general and more particularly in Cameroon.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Kenmoe S,Vernet MA,Penlap Beng V,Vabret A,Njouom Rdoi
10.1016/j.jiph.2019.08.018subject
Has Abstractpub_date
2020-04-01 00:00:00pages
606-612issue
4eissn
1876-0341issn
1876-035Xpii
S1876-0341(19)30298-9journal_volume
13pub_type
杂志文章abstract::Many studies have shown that the toxic effects of local antibiotics on bone and cartilage limit orthopedic surgeons. In this study, we evaluated three antibacterial agents used locally to treat highly mortal and morbid diseases in the field of orthopedics, such as septic arthritis. Are vancomycin, teicoplanin, and lin...
journal_title:Journal of infection and public health
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abstract:AIM:To assess the risk factors for surgical site infection and the effects of selected infection control measures on surgical site infection rates in a general surgery unit. METHODS:Surgical site infection rates and adherence to infection control measures were observed in a general surgery unit. RESULTS:In multivaria...
journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.05.004
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2017.08.014
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章,多中心研究
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2018.02.001
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journal_title:Journal of infection and public health
pub_type: 杂志文章
doi:10.1016/j.jiph.2013.08.004
更新日期:2014-07-01 00:00:00
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章,多中心研究
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
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journal_title:Journal of infection and public health
pub_type: 杂志文章,评审
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journal_title:Journal of infection and public health
pub_type: 杂志文章
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