当前位置： SCI文献检索 > Journal of Infection and Public Health期刊下所有文献 > Molecular insights of Carbapenem resistance Klebsiella pneumoniae isolates with focus on multidrug resistance from clinical samples.

Molecular insights of Carbapenem resistance Klebsiella pneumoniae isolates with focus on multidrug resistance from clinical samples.

Abstract：

BACKGROUND:Carbapenem are the last-line antibiotic, defence against Gram-negative extended spectrum ß-lactamases producers (ESBLs). Carbapenem resistance Enterobacteriaceae especially Carbapenem resistant-Klebsiella pneumoniae (CR-KP) is recognized as one of the well-known public health problem, which is increasingly being reported around the world. The present study was focused to analyse the prevalence and characterization of antibiotic resistance K. pneumoniae in centre region of Tamil Nadu, India. METHODOLOGY:Totally 145 suspected K. pneumoniae isolates [Urine, Pus, Sputum, Blood and Biopsy] obtained from hospitals of Central South India. The isolates were subjected to biochemical and molecular identification technique, following with antibiotic resistance pattern by standard antibiotic sensitivity test. Multidrug resistance (MDR) with β-lactamase producing Carbapenem resistant K. pneumoniae (CR-KP) strains were screened by classical sensitivity method and also drug resistance encoded gene. Also, molecular typing of the MDR strains were characterized by Pulsed-Field Gel Electrophoresis (PFGE). Further, the outer membrane protein (OmpK35 and 36) related Carbapenem resistance were characterized. RESULTS:Totally, 61% of isolates were confirmed as K. pneumoniae, 75 % of isolates were MDR including 58% carbapenem and 97% ESBL antibiotics and grouped into 17 distinct resistant patterns. The MDR KP isolates shows positive for blaCTXM-1 (92 %) gene followed by blaSHV (43 %), blaTEM (36 %), blaNDM-1 (26 %), blaGES (20 %) and blaIMP-1 (8 %). Moreover, 62 % CR-KP isolates loses OmpK36 and 33% isolates loses OmpK35. CONCLUSIONS:Loss of OmpK36 were highly an influence the cefoxitin and carbapenem resistance. Sixteen different PFGE patterns have been observed among the 18 MDR isolates. Eventually, ESBL as well as CR-KP were diverse in genetic makeup and often associated with hyper virulence hvKP should be of serious concern.

journal_name

J Infect Public Health

journal_title

Journal of infection and public health

authors

Indrajith S,Mukhopadhyay AK,Chowdhury G,Farraj DAA,Alkufeidy RM,Natesan S,Meghanathan V,Gopal S,Muthupandian S

doi

10.1016/j.jiph.2020.09.018

subject

Has Abstract

pub_date

2020-11-21 00:00:00

pages

131-138

issue

1

eissn

1876-0341

issn

1876-035X

pii

S1876-0341(20)30674-2

journal_volume

14

pub_type

杂志文章

相关文献

Journal of Infection and Public Health文献大全
  • Low prevalence, low immunization and low adherence to full hepatitis B vaccine scheme and high-risk behaviors among crack cocaine users in central Brazil.

    abstract：:Crack cocaine users represent a target group for hepatitis B vaccination. We evaluate the HBV epidemiology, immunization status and compliance with a super-accelerated vaccination schedule among in-treatment crack cocaine users in central Brazil. Six hundred in-treatment crack cocaine users were interviewed, and serum...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2016.02.010

    authors： da Silva LN,da Silva França DD,Del-Rio NHA,Dos Santos Carneiro MA,Martins RMB,Guimarães RA,Pinheiro RS,Junqueira ALN,Caetano KAA,Teles SA

    更新日期：2017-01-01 00:00:00

  • Towards an evaluation framework for Laboratory Information Systems.

    abstract：INTRODUCTION:Laboratory testing and reporting are error-prone and redundant due to repeated, unnecessary requests and delayed or missed reactions to laboratory reports. Occurring errors may negatively affect the patient treatment process and clinical decision making. Evaluation on laboratory testing and Laboratory Info...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2016.08.014

    authors： Yusof MM,Arifin A

    更新日期：2016-01-01 00:00:00

  • Serological and molecular analysis for brucellosis in selected swine herds from Southern India.

    abstract：BACKGROUND:Swine brucellosis is a zoonotic disease caused by Brucella suis. The study describes the occurrence of brucellosis in two organized piggeries in Southern India. METHODS:A total of 585 serum samples comprising 575 from pigs and 10 from animal handlers were collected and tested by serological tests and PCR. T...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2018.10.013

    authors： Shome R,Kalleshamurthy T,Natesan K,Jayaprakash KR,Byrareddy K,Mohandoss N,Sahay S,Shome BR,Hiremath J,Rahman H,Barbuddhe SB

    更新日期：2019-01-01 00:00:00

  • Demographic, laboratory and clinical characteristics of HIV-positive tuberculosis cases in Canada.

    abstract：BACKGROUND:Human immunodeficiency virus (HIV) is an important risk factor for the global incidence and mortality of tuberculosis (TB) and has had a tremendous impact on the epidemiology and the control of the disease. The purpose of this study was to determine the demographic, laboratory and clinical characteristics of...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2009.07.003

    authors： Wang GJ,Phypers M,Ellis E

    更新日期：2009-01-01 00:00:00

  • Forecast of the trend in incidence of acute hemorrhagic conjunctivitis in China from 2011-2019 using the Seasonal Autoregressive Integrated Moving Average (SARIMA) and Exponential Smoothing (ETS) models.

    abstract：BACKGROUND:This study aimed to explore the demographic and distributive features of acute hemorrhagic conjunctivitis (AHC). We constructed seasonal autoregressive integrated moving average (SARIMA) and exponential smoothing (ETS) models to predict its trend in incidence in mainland China and provided evidence for the g...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.12.008

    authors： Liu H,Li C,Shao Y,Zhang X,Zhai Z,Wang X,Qi X,Wang J,Hao Y,Wu Q,Jiao M

    更新日期：2020-02-01 00:00:00

  • Are the leading drugs against Staphylococcus aureus really toxic to cartilage?

    abstract：:Many studies have shown that the toxic effects of local antibiotics on bone and cartilage limit orthopedic surgeons. In this study, we evaluated three antibacterial agents used locally to treat highly mortal and morbid diseases in the field of orthopedics, such as septic arthritis. Are vancomycin, teicoplanin, and lin...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2015.10.004

    authors： Dogan M,Isyar M,Yilmaz I,Bilir B,Sirin DY,Cakmak S,Mahirogullari M

    更新日期：2016-05-01 00:00:00

  • Risk factors for dengue outbreaks in Odisha, India: A case-control study.

    abstract：BACKGROUND:Environmental and climatic risk factors of dengue outbreak has been studied in detail. However, the socio-epidemiological association with the disease is least explored. The study aims to identify the social and ecological factors associated with emerging dengue in Odisha, India. METHODS:A population-based ...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.08.015

    authors： Swain S,Bhatt M,Biswal D,Pati S,Soares Magalhaes RJ

    更新日期：2020-04-01 00:00:00

  • Cytomegalovirus viremia among pediatric oncology non-stem cell transplant patients with prolonged fever neutropenia.

    abstract：BACKGROUND:Cytomegalovirus (CMV) is a rare cause of prolonged febrile neutropenia (PFN) among pediatric oncology patients, especially in non-stem cell transplant setting (Non-SCTS). Infectious Diseases Society of America (IDSA) guidelines stated briefly that neutropenia is not considered as an indication of CMV re-acti...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2020.02.001

    authors： Al Talhi YM,Hariri B,Alsulaimani F,Almadani M,Abbas A,AlDabbagh M

    更新日期：2020-08-01 00:00:00

  • Genetic diversity and allelic variation in MSP3α gene of paired clinical Plasmodium vivax isolates from Delhi, India.

    abstract：BACKGROUND:Plasmodium vivax malaria accounts for 80% of the malaria cases in Delhi, India. The gene merozoite surface protein 3 alpha (MSP3α) is highly polymorphic and has been used as marker in many P. vivax population studies. METHODS:MSP3α has been used to assess the genetic diversity of P. vivax samples from Delhi...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.01.068

    authors： Kaul A,Bali P,Anwar S,Sharma AK,Gupta BK,Singh OP,Adak T,Sohail M

    更新日期：2019-01-01 00:00:00

  • Trauma-related infections due to cluster munitions.

    abstract：:Trauma-related infections remain a concerning and potentially avoidable complication of conflict-related injuries. During the Israeli conflict in South Lebanon, more than four million sub-munitions were dropped over South Lebanese soil. In this study, we will explore the different types of infection caused by sub-muni...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2013.05.006

    authors： Fares Y,El-Zaatari M,Fares J,Bedrosian N,Yared N

    更新日期：2013-12-01 00:00:00

  • Efficiency of two sewage treatment systems (activated sludge and natural lagoons) for helminth egg removal in Morocco.

    abstract：:Morocco is a country known for its vulnerability of water resources because of its arid and semi-arid climate. Thus, recycled wastewater has been suggested for agricultural activities, but contamination of these wastewaters is a major concern. The current study aims to determine the occurrence of helminth eggs in urba...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2017.07.026

    authors： Chaoua S,Boussaa S,Khadra A,Boumezzough A

    更新日期：2018-01-01 00:00:00

  • The demographic and clinical characteristics of leprosy in Saudi Arabia.

    abstract：:Leprosy is a chronic disease caused by Mycobacterium leprae. Although the occurrence of leprosy has declined in Saudi Arabia, it has not yet been eradicated. To our knowledge, this descriptive retrospective study is the first to assess the clinical presentation of leprosy at the time of diagnosis in Saudi Arabia. All ...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2015.12.015

    authors： Alotaibi MH,Bahammam SA,Ur Rahman S,Bahnassy AA,Hassan IS,Alothman AF,Alkayal AM

    更新日期：2016-09-01 00:00:00

  • Human saliva can be a diagnostic tool for Zika virus detection.

    abstract：:Zika virus (ZIKV), an Aedes mosquito-borne flavivirus, has captured public health attention worldwide. Initially, the virus was reported in Africa and Asia. However, the outbreak of ZIKV in Brazil and the United States of America demonstrated the global health risk. Symptoms of ZIKV infection vary from mild fever, ras...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2019.05.004

    authors： Khurshid Z,Zafar M,Khan E,Mali M,Latif M

    更新日期：2019-01-01 00:00:00

  • Prevalence and association of Panton-Valentine Leukocidin gene with the risk of sepsis in patients infected with Methicillin Resistant Staphylococcus aureus.

    abstract：BACKGROUND:Panton-Valentine Leukocidin (PVL), is one of the virulence gene expressed by Methicillin Resistant Staphylococcus aureus (MRSA) and is known to be associated with severe form of community acquired MRSA infection. The aim of this study is to investigate its prevalence in our setting and patient's clinical out...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2020.06.018

    authors： Ahmad NI,Yean Yean C,Foo PC,Mohamad Safiee AW,Hassan SA

    更新日期：2020-10-01 00:00:00

  • Evaluation of inter-pandemic influenza vaccine effectiveness during eight consecutive winter seasons in England and Wales in patients with cardiovascular risk factors.

    abstract：:We evaluated the effectiveness of inactivated influenza vaccine in persons aged ≥45 years with co-morbidities (including essential hypertension) likely to have prompted consideration of prophylactic statin therapy. Using case-control analyses, we measured the impact of vaccination on General Practitioner (GP) reported...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2010.09.007

    authors： Hashim AB,McKeever T,Kelly SJ,Nguyen-Van-Tam JS

    更新日期：2010-12-01 00:00:00

  • The seroprevalence of hepatitis C virus infection among children and their mothers attending for dental care in Glasgow, Scotland, United Kingdom.

    abstract：:This paper describes a voluntary anonymous survey to investigate the seroprevalence of Hepatitis C (HCV) in children in Glasgow, UK attending a Dental Hospital and the proportion of HCV positive mothers who have a child who is HCV seropositive. The study was undertaken among children and accompanying parents and house...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2016.08.001

    authors： O'Leary M,Bagg J,Welbury R,Hutchinson SJ,Hague R,Geary I,Roy KM

    更新日期：2017-01-01 00:00:00

  • Role of vitamin D in preventing of COVID-19 infection, progression and severity.

    abstract：:The outbreak of COVID-19 has created a global public health crisis. Little is known about the protective factors of this infection. Therefore, preventive health measures that can reduce the risk of infection, progression and severity are desperately needed. This review discussed the possible roles of vitamin D in redu...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2020.06.021

    authors： Ali N

    更新日期：2020-10-01 00:00:00

  • Seroprevalence study of HCV among hospitalized intravenous drug users in Ahvaz, Iran (2001-2006).

    abstract：BACKGROUND AND AIMS:Prevalence of hepatitis C virus (HCV) in intravenous drug users (IDU) varies in different areas according to socioeconomic and geographical circumstances. The present study was performed to determine seroprevalence of HCV in IDU individuals in Ahvaz, Iran. MATERIALS AND METHODS:142 IDU patients wer...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2009.01.001

    authors： Alavi SM,Alavi L

    更新日期：2009-01-01 00:00:00

  • The impact of the coexistence of mycobacterium avium with mycobacterium tuberculosis on the result of GeneXpert and MGIT susceptibility test.

    abstract：:Rapid tests to diagnose tuberculosis relies on molecular detection of the M. tuberculosis. GeneXpert MTB/RIF test identifies M. tuberculosis and rifampicin resistance. We present a case of simultaneous coinfection with M. tuberculosis and M. avium. M. tuberculosis was detected in the sputum by PCR GeneXpert method. Un...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2020.01.006

    authors： Bazzi AM,Abulhamayel Y,Rabaan AA,Al-Tawfiq JA

    更新日期：2020-05-01 00:00:00

  • Epidemiologic surveillance for controlling Covid-19 pandemic: types, challenges and implications.

    abstract：:The objectives of the study was to determine the types, challenges and implications of surveillance methods for controlling Covid-19 pandemic. An integrative article review was done. The source of data were documents from WHO, Euro-surveillance, CDC, Saudi CDC, MOH, and journals from PubMed, Medline, etc. The inclusio...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2020.07.019

    authors： Ibrahim NK

    更新日期：2020-11-01 00:00:00

  • What really affects surgical site infection rates in general surgery in a developing country?

    abstract：AIM:To assess the risk factors for surgical site infection and the effects of selected infection control measures on surgical site infection rates in a general surgery unit. METHODS:Surgical site infection rates and adherence to infection control measures were observed in a general surgery unit. RESULTS:In multivaria...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2013.11.006

    authors： Alp E,Altun D,Ulu-Kilic A,Elmali F

    更新日期：2014-09-01 00:00:00

  • Idiopathic granulomatous mastitis in a male breast following intravesical Bacille Calmette-Guerin treatment.

    abstract：:Idiopathic granulomatous mastitis (IGM) is a benign chronic inflammatory disorder of the breast tissue, with unknown etiology. IGM is extremely rare among male gender. In this case report, we present a male patient with superficial high grade bladder cancer, who was complaining of a palpable mass in his right breast f...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.09.006

    authors： Sahin C,Agridag Ucpinar B

    更新日期：2020-05-01 00:00:00

  • Salmonella osteomyelitis: A rare differential diagnosis in osteolytic lesions around the knee.

    abstract：:Salmonella osteomyelitis in immunocompetent adults is uncommon. It usually has a diaphyseal location or present as spondylitis. Metaphyseal affection is extremely rare. A 51-year-old male presented with refractory knee pain. Plain X-rays showed a rounded osteolytic lesion in the proximal tibia without marginal scleros...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2013.07.004

    authors： Salem KH

    更新日期：2014-02-01 00:00:00

  • Pseudomonas stutzeri prosthetic valve endocarditis: A case report and review of the literature.

    abstract：:We report a case of Pseudomonas stutzeri endocarditis in Lebanon. The patient had a recent history of prosthetic aortic valve replacement and presented to the emergency department with fever and chills. Transesophageal echocardiography confirmed the presence of a vegetation on the prosthetic valve and blood cultures y...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2018.07.004

    authors： Halabi Z,Mocadie M,El Zein S,Kanj SS

    更新日期：2019-01-01 00:00:00

  • Hantavirus infection among children hospitalized for febrile illness suspected to be dengue in Barbados.

    abstract：:Emerging picture of hantavirus infection in the South America is characterized by greater proportion of childhood infection and wider spectrum of disease from mild asymptomatic to lethal cardiopulmonary disease. Barbados is endemic for dengue and leptospirosis, both of which share clinical features with hantavirus inf...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2015.06.004

    authors： Kumar A,Krishnamurthy K,Nielsen AL

    更新日期：2016-01-01 00:00:00

  • A research on quality of life score (QOLS) of patients with trigeminal neuralgia (TN).

    abstract：BACKGROUND:To evaluate the clinic effect of treatment of trigeminal neuralgia (TN). METHODS:The current study aims to develop a multiple-scale characteristics quality of life (QOL) for patients with TN. After interview, the individual questionnaire was acquired. indicating the QOL has a good responsiveness and surveyi...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.03.011

    authors： Luo Y,He M,Li C,Yang H

    更新日期：2019-01-01 00:00:00

  • Prevalence, trend and antimicrobial susceptibility of Methicillin Resistant Staphylococcus aureus in Nigeria: a systematic review.

    abstract：BACKGROUND:Evidence to demonstrate the prevalence and trend of Methicillin Resistant Staphylococcus aureus (MRSA) infection in Nigeria is scarce. This review evaluates the prevalence, trend and antimicrobial susceptibility of clinical MRSA isolates reported in published studies. METHOD:Electronic search (PubMed, Scopu...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章,评审

    doi：10.1016/j.jiph.2018.05.013

    authors： Abubakar U,Sulaiman SAS

    更新日期：2018-01-01 00:00:00

  • Changes of intestinal microflora diversity in diarrhea model of KM mice and effects of Psidium guajava L. as the treatment agent for diarrhea.

    abstract：OBJECTIVES:This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. METHODS:Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose s...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2019.04.015

    authors： Lu J,Mao D,Li X,Ma Y,Luan Y,Cao Y,Luan Y

    更新日期：2020-01-01 00:00:00

  • The distribution of human papillomavirus genotypes in cervical cancer and intraepithelial neoplasia lesions among Chinese women in Yunnan Province.

    abstract：:This study was designed to explore baseline data about the prevalence and distribution of human papillomavirus (HPV) genotypes among Chinese women who had cervical intraepithelial lesions and cervical cancer. A total of 511 patients were recruited, and biopsy samples were collected from these patients. Polymerase chai...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2017.06.012

    authors： Yuanyue L,Baloch Z,Yasmeen N,Tao Y,Xiaomei W,Xueshan X

    更新日期：2018-01-01 00:00:00

  • Human visceral leishmaniasis: a picture from Italy.

    abstract：:The aim of our study was to describe the distribution of Visceral Leishmaniasis (VL) in Italy, focusing on HIV-infected patients, to estimate the burden of the disease and the public health actions that should be undertaken. A review of official notifications and hospitalization data has been performed. From 2006 to 2...

    journal_title：Journal of infection and public health

    pub_type： 杂志文章

    doi：10.1016/j.jiph.2013.03.004

    authors： Abdalmaula GH,Barbadoro P,Marigliano A,Illuminati D,Di Stanislao F,D'Errico MM,Prospero E

    更新日期：2013-12-01 00:00:00