Abstract：
:The adenosine nucleoside analog BCX4430 is a direct-acting antiviral drug under investigation for the treatment of serious and life-threatening infections from highly pathogenic viruses, such as the Ebola virus. Cellular kinases phosphorylate BCX4430 to a triphosphate that mimics ATP; viral RNA polymerases incorporate the drug's monophosphate nucleotide into the growing RNA chain, causing premature chain termination. BCX4430 is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV and SARS-CoV. In vivo, BCX4430 is active after intramuscular, intraperitoneal, and oral administration in a variety of experimental infections. In nonclinical studies involving lethal infections with Ebola virus, Marburg virus, Rift Valley fever virus, and Yellow Fever virus, BCX4430 has demonstrated pronounced efficacy. In experiments conducted in several models, both a reduction in the viral load and an improvement in survival were found to be related to the dose of BCX4430. A Phase 1 clinical trial of intramuscular administration of BCX4430 in healthy subjects is currently ongoing.
journal_name
J Infect Public Healthjournal_title
Journal of infection and public healthauthors
Taylor R,Kotian P,Warren T,Panchal R,Bavari S,Julander J,Dobo S,Rose A,El-Kattan Y,Taubenheim B,Babu Y,Sheridan WPdoi
10.1016/j.jiph.2016.04.002subject
Has Abstractpub_date
2016-05-01 00:00:00pages
220-6issue
3eissn
1876-0341issn
1876-035Xpii
S1876-0341(16)30019-3journal_volume
9pub_type
杂志文章,评审abstract：OBJECTIVES:Incidence of tuberculosis (TB) is greatest among patients with impaired immunity. India is experiencing a double epidemic of HIV and diabetes mellitus (DM), both of which are strongly associated with immuno-suppression. This study aimed to discover the prevalence of HIV and DM in both the pulmonary and extra...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2011.03.005
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Little is known about epidemiology of carbapenemase-producing Enterobacteriaceae (CPE) in children. Aim of this study was to describe CPE epidemiology in a tertiary care pediatric hospital in Italy that admits patients coming from geographic areas with high diffusion of CPE. METHODS:Prospective evaluation o...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2018.11.003
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Identified in 2001, Human Metapneumovirus (HMPV) is a Pneumovirus associated with acute lower and upper respiratory infections in all age groups and especially in newborns, elderly and immunocompromised subjects. Data are still limited in sub-Saharan African countries genetic characterization of this respira...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.08.018
更新日期：2020-04-01 00:00:00
abstract：:The purpose of this study was to evaluate the observed incidence of acute kidney injury (AKI) in adult patients receiving either piperacillin-tazobactam (PT) and vancomycin or meropenem and vancomycin for at least 48h. In this retrospective cohort study, we included adult patients with no known renal dysfunction who r...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.11.007
更新日期：2017-01-01 00:00:00
abstract：:We report a case of Listeria meningitis related to mantle cell lymphoma. A clinical pharmacist adjusted repeatedly the patient's anti-infective therapeutic regimen by analyzing the pharmacologic and pharmacokinetic characteristics of antibacterial drugs (such as cefotaxime, meropenem, etc.) due to the patient's repeat...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.04.010
更新日期：2019-01-01 00:00:00
abstract：INTRODUCTION:Despite the advancement in diagnostic modalities of sepsis, it is still a leading cause of morbidity and mortality. Differentiation between sepsis and non-infectious disease states remains a diagnostic challenge. Procalcitonin (PCT) is useful for the diagnosis of sepsis but it varies in cut-off ranges at d...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2018.11.004
更新日期：2019-01-01 00:00:00
abstract：:The human stomach is colonized by diverse bacterial species. The presence of non-Helicobacter pylori bacteria in urease-positive biopsies of individuals has been reported. Bacteria belonging to the Ochrobactrum genus have been documented in the human gastric niche. The co-occurrence of Ochrobactrum spp. with H. pylori...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.04.013
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Healthcare-associated infections (HCAIs) are an important public health problem. It is estimated that approximately 1 out of every 20 hospitalized patients will contract an HCAI. The risk is substantial not only to patients but also to healthcare workers, who may contract deadly blood-borne infectious diseas...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2013.02.006
更新日期：2013-08-01 00:00:00
abstract：:Tubercular osteomyelitis of zygomatic bone is extremely rare. Here we have reported a rarest case of primary tuberculosis (TB) of zygomatic bone in a 20 year male who presented with discharging sinus over right zygomatic region. Anti-tubercular chemotherapy given and patient improved well. ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.10.008
更新日期：2020-05-01 00:00:00
abstract：:This paper describes a voluntary anonymous survey to investigate the seroprevalence of Hepatitis C (HCV) in children in Glasgow, UK attending a Dental Hospital and the proportion of HCV positive mothers who have a child who is HCV seropositive. The study was undertaken among children and accompanying parents and house...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.08.001
更新日期：2017-01-01 00:00:00
abstract：:Today, because systemic infections such as urinary tract infection (UTI) affect even pediatric patients, antibiotic resistant bacteria have become a constant clinical challenge. In the present study, a total of 1054 urine samples were collected from pediatric patients over 18 months. From these samples, 510 isolates o...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2015.10.002
更新日期：2016-05-01 00:00:00
abstract：:This study compares the factors, which influence individuals from the countries of China, Japan and South Korea to obtain any type of influenza vaccines and their perceived concerns about the new strain of the influenza - pandemic (H1N1) 2009. The data analyzed was from the East Asian Social Survey (EASS), Cross-Natio...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.06.004
更新日期：2017-01-01 00:00:00
abstract：:Mild encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome that can be related to infectious and non-infectious conditions. Patients present with mild neurological symptoms, and magnetic resonance imaging typically demonstrate a reversible lesion with transiently reduced diffusion ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2016.08.019
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often describ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.03.014
更新日期：2019-01-01 00:00:00
abstract：:Nearly four months have passed since the emergence of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which caused the rapidly spreading Coronavirus Disease 2019 (COVID-19) pandemic. To date, there have been more than 2.3 million confirmed cases and more than 160,000 deaths globally caused by COVID-1...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2020.04.016
更新日期：2020-06-01 00:00:00
abstract：:Myiasis-the feeding of fly larvae on living mammals, may have various clinical presentations depending on the tissues or organs involved. Myiasis is a common travel associated skin disorder as a consequence of short visits to developing countries. It is the fourth most common travel associated disease. The most common...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2009.08.001
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Panton-Valentine Leukocidin (PVL), is one of the virulence gene expressed by Methicillin Resistant Staphylococcus aureus (MRSA) and is known to be associated with severe form of community acquired MRSA infection. The aim of this study is to investigate its prevalence in our setting and patient's clinical out...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2020.06.018
更新日期：2020-10-01 00:00:00
abstract：:To study the nursing effects of different CT angiography (CTA) technology-based nursing methods on patients with coronary artery heart diseases (CHD), CHD patients treated in Dongying People's Hospital were selected as the research objects and were divided into the control group and the observation group. Different co...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.06.023
更新日期：2020-12-01 00:00:00
abstract：:We report the case of a 10-year-old girl who presented to the emergency department with acute abdominal pain. She was diagnosed as having extrapulmonary tuberculosis (TB) with multifocal osteomyelitis of the spine and ribs, peritonitis and intestinal involvement. We describe the clinical presentation of this unusual c...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2011.11.005
更新日期：2012-04-01 00:00:00
abstract：:Salmonella osteomyelitis in immunocompetent adults is uncommon. It usually has a diaphyseal location or present as spondylitis. Metaphyseal affection is extremely rare. A 51-year-old male presented with refractory knee pain. Plain X-rays showed a rounded osteolytic lesion in the proximal tibia without marginal scleros...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2013.07.004
更新日期：2014-02-01 00:00:00
abstract：:To evaluate the efficacy and safety of a new domestic dacron patch in the surgical treatment of congenital heart disease (CHD) with infective endocarditis (IE), a clinical controlled trial is conducted. 48 patients with CHD complicated with IE are selected and randomly divided into two groups. 26 patients in the exper...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.08.009
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Carbapenem are the last-line antibiotic, defence against Gram-negative extended spectrum ß-lactamases producers (ESBLs). Carbapenem resistance Enterobacteriaceae especially Carbapenem resistant-Klebsiella pneumoniae (CR-KP) is recognized as one of the well-known public health problem, which is increasingly b...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2020.09.018
更新日期：2020-11-21 00:00:00
abstract：:MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31months period from June 6, 2012 to ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.11.016
更新日期：2020-05-01 00:00:00
abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic respiratory virus with mechanisms that may be driven by innate immune responses. Despite the effort of scientific studies related to this virus, Middle East Respiratory Syndrome (MERS) is still a public health concern. MERS-CoV infection ha...
journal_title：Journal of infection and public health
pub_type： 杂志文章,评审
doi：10.1016/j.jiph.2017.08.009
更新日期：2018-01-01 00:00:00
abstract：:Leprosy is a chronic disease caused by Mycobacterium leprae. Although the occurrence of leprosy has declined in Saudi Arabia, it has not yet been eradicated. To our knowledge, this descriptive retrospective study is the first to assess the clinical presentation of leprosy at the time of diagnosis in Saudi Arabia. All ...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2015.12.015
更新日期：2016-09-01 00:00:00
abstract：:The World Alliance for Patient Safety is an evolving programme of the WHO, established to raise the profile of patient safety within the global health care agenda. The decision taken in 2004 to focus the effort and attention of the First Global Patient Safety Challenge on the problem of health care-associated infectio...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2008.08.006
更新日期：2008-01-01 00:00:00
abstract：:Dengue hemorrhagic fever is transmitted through a bite by a dengue -infected Aedes aegypti mosquito. It was first reported in the mid -20th century in Thailand, and since then its epidemiology has been of great concern and has spread all across the country. The alarming incidence of dengue posed a serious threat to hu...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2017.01.016
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVES:This study aimed to explore the effects of Psidium guajava L. extracts on mice diarrhea model and changes in their intestinal microflora diversity. METHODS:Mice diarrhea model was constructed with Folium Sennae. and The therapeutic effects of Psidium guajava L. extracts on diarrhea were evaluated by loose s...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.04.015
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:The MERS-CoV was identified for the first time from Jeddah, Saudi Arabia in 2012 from a hospitalized patient. This virus has now been spread to 27 countries with a total of 858 deaths and 2494 confirmed cases and has become a serious concern for the human population. Camels are well known for the transmissio...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2020.12.018
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:Escherichia coli sequence type 131 is an important multidrug resistant clone responsible from more than half of ESBL-producing E.coli isolates. Aim of this study was to investigate the presence of O25b-ST131 clone, CTX-M-15 and CTX-M-1 genes in the E. coli strains isolated from both hospital and community ac...
journal_title：Journal of infection and public health
pub_type： 杂志文章
doi：10.1016/j.jiph.2019.02.017
更新日期：2019-01-01 00:00:00
