Understanding Participation in Genetic Research Among Patients With Multiple Sclerosis: The Influences of Ethnicity, Gender, Education, and Age.

abstract：:THE DIAGNOSIS OF A SUSPECTED TUMOR LESION FACES TWO BASIC PROBLEMS: detection and identification of the specific type of tumor. Radiological techniques are commonly used for the detection and localization of solid tumors. Prerequisite is a high intrinsic or enhanced contrast between normal and neoplastic tissue. Ident...

journal_title：Frontiers in genetics

authors： Dominietto M,Rudin M

更新日期：2014-01-13 00:00:00

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in re...

journal_title：Frontiers in genetics

authors： Onzima RB,Upadhyay MR,Doekes HP,Brito LF,Bosse M,Kanis E,Groenen MAM,Crooijmans RPMA

更新日期：2018-08-14 00:00:00

abstract：:The sustainable development of aquaculture has been impeded by infectious diseases worldwide. However, the genomic architecture and the genetic basis underlying the disease resistance remain poorly understood, which severely hampers both the understanding of the evolution of fish disease resistance traits and the prev...

journal_title：Frontiers in genetics

authors： Zhou Q,Su Z,Li Y,Liu Y,Wang L,Lu S,Wang S,Gan T,Liu F,Zhou X,Wei M,Liu G,Chen S

更新日期：2019-11-20 00:00:00

abstract：:In recent years, miRNAs have been verified to play an irreplaceable role in biological processes associated with human disease. Discovering potential disease-related miRNAs helps explain the underlying pathogenesis of the disease at the molecular level. Given the high cost and labor intensity of biological experiments...

journal_title：Frontiers in genetics

authors： Xu J,Cai L,Liao B,Zhu W,Wang P,Meng Y,Lang J,Tian G,Yang J

更新日期：2019-12-11 00:00:00

abstract：:In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory. We propose a strategy to employ the theoretical concept of UICC TNM classification in CRC. To reveal the critical transition of CRC, the DN...

journal_title：Frontiers in genetics

authors： Tong Y,Song Y,Xia C,Deng S

更新日期：2020-10-20 00:00:00

abstract：:The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study of centenarians to determine if centenarians could be a model of healthy human aging. Over time, the NECS along with other centenarian studies have demonstrated that the majority of centenarians markedly delay high mortality risk-asso...

journal_title：Frontiers in genetics

authors： Sebastiani P,Perls TT

更新日期：2012-11-30 00:00:00

abstract：:Lumbar disc degeneration (LDD) is age-related break-down in the fibrocartilaginous joints between lumbar vertebrae. It is a major cause of low back pain and is conventionally assessed by magnetic resonance imaging (MRI). Like most other complex traits, LDD is likely polygenic and influenced by both genetic and environ...

journal_title：Frontiers in genetics

authors： Zhou X,Cheung CL,Karasugi T,Karppinen J,Samartzis D,Hsu YH,Mak TS,Song YQ,Chiba K,Kawaguchi Y,Li Y,Chan D,Cheung KM,Ikegawa S,Cheah KS,Sham PC

更新日期：2018-08-03 00:00:00

abstract：:The phenotype of carcass traits in beef cattle are affected by random genetic and non-genetic effects, which both can be modulated by an environmental variable such as Temperature-Humidity Index (THI), a key environmental factor in cattle production. In this study, a multivariate reaction norm model (MRNM) was used to...

journal_title：Frontiers in genetics

authors： Chung Y,Lee SH,Lee HK,Lim D,van der Werf J,Lee SH

更新日期：2020-12-23 00:00:00

abstract：:In the last decades, genome-wide association studies (GWAS) have uncovered tens of thousands of associations between common genetic variants and complex diseases. However, these statistical associations can rarely be interpreted functionally and mechanistically. As the majority of the disease-associated variants are l...

journal_title：Frontiers in genetics

authors： Mariella E,Marotta F,Grassi E,Gilotto S,Provero P

更新日期：2019-08-16 00:00:00

abstract：:It is time to review all the available data and find the distinctive characteristics of actin that make it such an important cell molecule. The presented double-stranded organization of filamentous actin cannot explain the strong polymorphism of actin fibrils. In this work, we performed bioinformatics analysis of a se...

journal_title：Frontiers in genetics

authors： Glyakina AV,Galzitskaya OV

更新日期：2020-12-10 00:00:00

abstract：:Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in genera...

journal_title：Frontiers in genetics

authors： Hankey W,Zanghi N,Crow MM,Dow WH,Kratz A,Robinson AM,Robinson MR,Segarra VA

更新日期：2020-12-16 00:00:00

abstract：:Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a single network, which results in important temporal- or context-re...

journal_title：Frontiers in genetics

authors： Yu L,Yao S,Gao L,Zha Y

更新日期：2019-01-18 00:00:00

abstract：:Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and ob...

journal_title：Frontiers in genetics

authors： Cronin RM,Field JR,Bradford Y,Shaffer CM,Carroll RJ,Mosley JD,Bastarache L,Edwards TL,Hebbring SJ,Lin S,Hindorff LA,Crane PK,Pendergrass SA,Ritchie MD,Crawford DC,Pathak J,Bielinski SJ,Carrell DS,Crosslin DR,Ledbett

更新日期：2014-08-05 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. They are aberrantly expressed in many human cancers and are potential therapeutic targets and molecular biomarkers. METHODS:In this study, we for the first time validated the reported data on the entire set of published differential...

journal_title：Frontiers in genetics

authors： Zabolotneva AA,Zhavoronkov AA,Shegay PV,Gaifullin NM,Alekseev BY,Roumiantsev SA,Garazha AV,Kovalchuk O,Aravin A,Buzdin AA

更新日期：2013-11-15 00:00:00

abstract：:[This corrects the article on p. 102 in vol. 6, PMID: 25852744.]. ...

journal_title：Frontiers in genetics

authors： Brito S,Thompson K,Campistol J,Colomer J,Hardy SA,He L,Fernández-Marmiesse A,Palacios L,Jou C,Jiménez-Mallebrera C,Armstrong J,Montero R,Artuch R,Tischner C,Wenz T,McFarland R,Taylor RW

更新日期：2015-07-28 00:00:00

abstract：:Tolerance to infections is defined as the ability of a host to limit the impact of a given pathogen burden on host performance. Uncoupling resistance and tolerance is a challenge, and there is a need to be able to separate them using specific trait recording or statistical methods. We present three statistical methods...

journal_title：Frontiers in genetics

authors： Kause A,Odegård J

更新日期：2012-12-14 00:00:00

abstract：:Leprosy, an infectious disease caused by Mycobacterium leprae, affects millions of people worldwide. However, little is known regarding its molecular pathophysiological mechanisms. In this study, a comprehensive assessment of human mRNA was performed on leprosy skin lesions by using DNA chip microarrays, which include...

journal_title：Frontiers in genetics

authors： Belone Ade F,Rosa PS,Trombone AP,Fachin LR,Guidella CC,Ura S,Barreto JA,Pinilla MG,de Carvalho AF,Carraro DM,Soares FA,Soares CT

更新日期：2015-11-20 00:00:00

abstract：:Habitat loss and the illegal exploitation of natural resources are among the main drivers of species extinction around the world. These disturbances act at different scales, once changes in the landscape composition and configuration operate at large scales and exploitation of natural resources at local scales. Eviden...

journal_title：Frontiers in genetics

authors： Soares LASS,Cazetta E,Santos LR,França DS,Gaiotto FA

更新日期：2019-11-07 00:00:00

abstract：:Colitis-associated cancer (CAC) has been linked to microRNA (miRNA) aberrant expression elicited by inflammation. In this study, we used the AOM/DSS-induced CAC mice model to explore the ectopic expression of miRNAs in the precancerous stage of CAC. As a result, we found that miR-31-5p, miR-223-3p, and let-7f-5p were ...

journal_title：Frontiers in genetics

authors： Chen G,Feng Y,Li X,Jiang Z,Bei B,Zhang L,Han Y,Li Y,Li N

更新日期：2019-06-19 00:00:00

abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5' UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized...

journal_title：Frontiers in genetics

authors： Hoem G,Bowitz Larsen K,Øvervatn A,Brech A,Lamark T,Sjøttem E,Johansen T

更新日期：2019-03-28 00:00:00

abstract：:Myiopsitta monachus is a small Neotropical parrot (Psittaciformes: Arini Tribe) from subtropical and temperate regions of South America. It has a diploid chromosome number 2n = 48, different from other members of the Arini Tribe that have usually 70 chromosomes. The species has the lowest 2n within the Arini Tribe. In...

journal_title：Frontiers in genetics

authors： Furo IO,Kretschmer R,O'Brien PC,Pereira JC,Garnero ADV,Gunski RJ,O'Connor RE,Griffin DK,Gomes AJB,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-07-10 00:00:00

abstract：:Measuring facial traits by quantitative means is a prerequisite to investigate epidemiological, clinical, and forensic questions. This measurement process has received intense attention in recent years. We divided this process into the registration of the face, landmarking, morphometric quantification, and dimension r...

journal_title：Frontiers in genetics

authors： Böhringer S,de Jong MA

更新日期：2019-05-24 00:00:00

abstract：:Zeng et al. (2005) proposed a general two-allele (G2A) model to model bi-allelic quantitative trait loci (QTL). Comparing with the classical Fisher model, the G2A model can avoid using redundant parameters and be fitted directly using standard least square (LS) approach. In this study, we further extend the G2A model ...

journal_title：Frontiers in genetics

authors： Wang T

更新日期：2014-09-25 00:00:00

abstract：:Recently, a consanguineous family was identified in Israel with three children affected by Infantile Nystagmus and Foveal Hypoplasia, following an autosomal recessive mode of inheritance. A homozygous stop mutation c.1861C > T; p.Q621∗ in the aryl hydrocarbon receptor (AHR) gene (AHR; MIM 600253) was identified that c...

journal_title：Frontiers in genetics

authors： Borovok N,Weiss C,Sharkia R,Reichenstein M,Wissinger B,Azem A,Mahajnah M

更新日期：2020-09-24 00:00:00

abstract：:Recently, cancer has been characterized as a heterogeneous disease composed of many different subtypes. Early diagnosis of cancer subtypes is an important study of cancer research, which can be of tremendous help to patients after treatment. In this paper, we first extract a novel dataset, which contains gene expressi...

journal_title：Frontiers in genetics

authors： Li S,Jiang L,Tang J,Gao N,Guo F

更新日期：2020-09-10 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fgene.2018.00657.]. ...

journal_title：Frontiers in genetics

authors： Cheng L,Zhuang H,Yang S,Jiang H,Wang S,Zhang J

更新日期：2019-02-18 00:00:00

abstract：:HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry. It is reported that the HFE p.C282Y mutation is present in 1/10 people of northern European descent, resulting in one in two hundred people will be homozygous. However, the H...

journal_title：Frontiers in genetics

authors： Zhang W,Wang X,Duan W,Xu A,Zhao X,Huang J,You H,Brissot P,Ou X,Jia J

更新日期：2020-02-21 00:00:00

abstract：:The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood. Here, we performed integrated analysis of 195 deeply sequenced sRNA libraries of maize B73, represe...

journal_title：Frontiers in genetics

authors： Xu Y,Zhang T,Li Y,Miao Z

更新日期：2020-02-11 00:00:00

abstract：:Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures,...

journal_title：Frontiers in genetics

authors： Chen X,Han L,Yao H

更新日期：2020-04-17 00:00:00