Chromosomal Evolution in the Phylogenetic Context: A Remarkable Karyotype Reorganization in Neotropical Parrot Myiopsitta monachus (Psittacidae).

abstract：:A livestock population can be characterized by different population genetic parameters, such as linkage disequilibrium and recombination rate between pairs of genetic markers. The population structure, which may be caused by family stratification, has an influence on the estimates of these parameters. An expectation m...

journal_title：Frontiers in genetics

authors： Hampel A,Teuscher F,Gomez-Raya L,Doschoris M,Wittenburg D

更新日期：2018-06-05 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:Motivation:Arabidopsis thaliana is a well-established model system for the analysis of the basic physiological and metabolic pathways of plants. Nevertheless, the system is not yet fully understood, although many mechanisms are described, and information for many processes exists. However, the combination and interpre...

journal_title：Frontiers in genetics

authors： Koch I,Nöthen J,Schleiff E

更新日期：2017-06-30 00:00:00

abstract：:Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in genera...

journal_title：Frontiers in genetics

authors： Hankey W,Zanghi N,Crow MM,Dow WH,Kratz A,Robinson AM,Robinson MR,Segarra VA

更新日期：2020-12-16 00:00:00

abstract：Objective:This study reports a Chinese patient with a Congenital Disorder of Glycosylation (CDG) caused by compound-heterozygous mutations in the Conserved Oligomeric Golgi 5 (COG5) gene and thereby offers concrete evidence for early diagnosis. Methods:The clinical manifestations, the results of laboratory examination...

journal_title：Frontiers in genetics

authors： Wang X,Han L,Wang XY,Wang JH,Li XM,Jin CH,Wang L

更新日期：2020-02-27 00:00:00

abstract：BACKGROUND:Non-synonymous single-nucleotide polymorphisms (nsSNPs) within the coding regions of genes causing amino acid substitutions (AASs) may have a large impact on protein function. The possibilities to identify nsSNPs across genomes have increased notably with the advent of next-generation sequencing technologies...

journal_title：Frontiers in genetics

authors： Li X,Kierczak M,Shen X,Ahsan M,Carlborg O,Marklund S

更新日期：2013-03-06 00:00:00

abstract：:Leaf rust, caused by Puccinia triticina (Pt), is one of the most devastating diseases of wheat, affecting production in nearly all wheat-growing regions worldwide. Despite its economic importance, genomic resources for Pt are very limited. In the present study, we have used long-read sequencing (LRS) and the pipeline ...

journal_title：Frontiers in genetics

authors： Wu JQ,Dong C,Song L,Park RF

更新日期：2020-06-04 00:00:00

abstract：:Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. The mechanisms leading to the progression of CRC are involved in both genetic and epigenetic regulations. In this study, we applied systems biology methods to identify potential biomarkers and conduct drug discovery in a computation...

journal_title：Frontiers in genetics

authors： Yeh SJ,Chen SW,Chen BS

更新日期：2020-03-06 00:00:00

abstract：:Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is...

journal_title：Frontiers in genetics

authors： Zaghi M,Broccoli V,Sessa A

更新日期：2020-01-09 00:00:00

abstract：:Background:NKX2-1 related disorders (also known as brain-lung-thyroid syndrome or benign hereditary chorea 1) are associated with a wide spectrum of symptoms. The core features are various movement disorders, characteristically chorea, less frequently myoclonus, dystonia, ataxia; thyroid disease; and lung involvement....

journal_title：Frontiers in genetics

authors： Balicza P,Grosz Z,Molnár V,Illés A,Csabán D,Gézsi A,Dézsi L,Zádori D,Vécsei L,Molnár MJ

更新日期：2018-08-22 00:00:00

abstract：:Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and tissue concentrations...

journal_title：Frontiers in genetics

authors： Matthaei J,Bonat WH,Kerb R,Tzvetkov MV,Strube J,Brunke S,Sachse-Seeboth C,Sehrt D,Hofmann U,von Bornemann Hjelmborg J,Schwab M,Brockmöller J

更新日期：2020-08-21 00:00:00

abstract：:Satellite DNA is a class of repetitive sequences that are organized in long arrays of tandemly repeated units in most eukaryotes. Long considered as selfish DNA, satellite sequences are now proposed to contribute to genome integrity. Despite their potential impact on the architecture and evolution of the genome, satel...

journal_title：Frontiers in genetics

authors： Panabières F,Rancurel C,da Rocha M,Kuhn ML

更新日期：2020-06-05 00:00:00

abstract：:Simple sequence repeats (SSRs) of short nucleotide motifs occur very frequently in the 5' untranslated coding region (5'-UTR) of genes and have been implicated in the regulation of gene expression. In this study, we identified an SSR with a variable number of CT repeats in the 5'-UTR of the Litopenaeus vannamei IRF (L...

journal_title：Frontiers in genetics

authors： Yin B,Wang H,Zhu P,Weng S,He J,Li C

更新日期：2019-12-06 00:00:00

abstract：:Vibrio cholerae, a gram-negative bacterium that causes cholera, has already caused seven major pandemics across the world and infects roughly 1.3-4 million people every year. Cholera treatment primarily involves oral rehydration therapy supplemented with antibiotics. But recently, multidrug-resistant strains of V. cho...

journal_title：Frontiers in genetics

authors： Shankar U,Jain N,Majee P,Kodgire P,Sharma TK,Kumar A

更新日期：2020-09-25 00:00:00

abstract：:From a biological perspective aging (senescence) appears to be a form of complex disease syndrome, though this is not the traditional view. This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new. The conceptual division between aging-related diseases and an underlying, non-patho...

journal_title：Frontiers in genetics

authors： Gems D

更新日期：2015-06-16 00:00:00

abstract：:Background: Porcine respiratory and reproductive syndrome virus (PRRSV) is a single-stranded RNA virus member that infects pigs and causes losses to the commercial industry reaching upward of a billion dollars annually in combined direct and indirect costs. The virus can be separated into etiologies that contain multi...

journal_title：Frontiers in genetics

authors： Fleming DS,Miller LC

更新日期：2019-08-02 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative therapies worldwide, with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinson's disease, spinal cord injuries, and type 1 ...

journal_title：Frontiers in genetics

authors： Henry MP,Hawkins JR,Boyle J,Bridger JM

更新日期：2019-01-21 00:00:00

abstract：:Colon cancer has the third highest incidence and mortality among cancers in the United States. MicroRNA-21 (miR21) has been described as an oncomir that is highly overexpressed in tumor tissue from colorectal cancer. Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected v...

journal_title：Frontiers in genetics

authors： Song MS,Rossi JJ

更新日期：2014-01-02 00:00:00

abstract：:Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expression of genetic inform...

journal_title：Frontiers in genetics

authors： Ni Z,Zhou XY,Aslam S,Niu DK

更新日期：2019-12-04 00:00:00

abstract：:A balanced pericentric inversion is normally without any clinical consequences for its carrier. However, there is a well-known risk of such inversions to lead to unbalanced offspring. Inversion-loop formation is the mechanism which may lead to duplication or deletion of the entire or parts of the inverted segment in t...

journal_title：Frontiers in genetics

authors： Liehr T,Weise A,Mrasek K,Ziegler M,Padutsch N,Wilhelm K,Al-Rikabi A

更新日期：2019-11-14 00:00:00

abstract：:Common carp is a major aquaculture species worldwide, commonly sold alive but also as processed headless carcass or filets. However, recording of processing yields is impossible on live breeding candidates, and alternatives for genetic improvement are either sib selection based on slaughtered fish, or indirect selecti...

journal_title：Frontiers in genetics

authors： Prchal M,Bugeon J,Vandeputte M,Kause A,Vergnet A,Zhao J,Gela D,Genestout L,Bestin A,Haffray P,Kocour M

更新日期：2018-07-30 00:00:00

abstract：:Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and ...

journal_title：Frontiers in genetics

authors： Murillo-Cuesta S,Artuch R,Asensio F,de la Villa P,Dierssen M,Enríquez JA,Fillat C,Fourcade S,Ibáñez B,Montoliu L,Oliver E,Pujol A,Salido E,Vallejo M,Varela-Nieto I

更新日期：2020-10-14 00:00:00

abstract：:Homozygous and compound heterozygous mutations in GNB5 gene have been associated with a wide spectrum of clinical presentations, ranging from neurodevelopmental issues with or without cardiac arrhythmia (LADCI) to severe developmental delay with epileptic encephalopathy, retinal dystrophy, and heart rhythm abnormaliti...

journal_title：Frontiers in genetics

authors： Sciacca FL,Ciaccio C,Fontana F,Strano C,Gilardoni F,Pantaleoni C,D'Arrigo S

更新日期：2020-05-13 00:00:00

abstract：:The fragile X premutation (PM) allele contains a CGG expansion of 55-200 repeats in the FMR1 gene's promoter. Male PM carriers have an elevated risk of developing neurological and psychiatric changes, including an approximately 50% risk of the fragile X-associated tremor/ataxia syndrome (FXTAS). The aim of this study ...

journal_title：Frontiers in genetics

authors： Loesch DZ,Trost N,Bui MQ,Hammersley E,Lay ST,Annesley SJ,Sanislav O,Allan CY,Tassone F,Chen ZP,Ngoei KRW,Kemp BE,Francis D,Fisher PR,Storey E

更新日期：2018-11-12 00:00:00

abstract：:Successful seedling establishment depends on the optimum depth of seed placement especially in drought-prone conditions, providing an opportunity to exploit subsoil water and increase winter survival in winter wheat. Coleoptile length is a key determinant for the appropriate depth at which seed can be sown. Thus, unde...

journal_title：Frontiers in genetics

authors： Sidhu JS,Singh D,Gill HS,Brar NK,Qiu Y,Halder J,Al Tameemi R,Turnipseed B,Sehgal SK

更新日期：2020-02-05 00:00:00

abstract：:Using genomic information, local ruminant populations can be better characterized and compared to selected ones. Genetic relationships between animals can be established even without systematic pedigree recording, provided a budget is available for genotyping. Genomic selection (GS) can rely on a subset of the total p...

journal_title：Frontiers in genetics

authors： Ducrocq V,Laloe D,Swaminathan M,Rognon X,Tixier-Boichard M,Zerjal T

更新日期：2018-07-13 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies have identified over 50 new genetic loci for type 2 diabetes (T2D). Several studies conclude that higher dietary heme iron intake increases the risk of T2D. Therefore we assessed whether the relation between genetic loci and T2D is modified by dietary heme iron intake. M...

journal_title：Frontiers in genetics

authors： Pasquale LR,Loomis SJ,Aschard H,Kang JH,Cornelis MC,Qi L,Kraft P,Hu FB

更新日期：2013-01-30 00:00:00

abstract：:Autosomal dwarfism (adw) in chickens is a growth deficiency caused by a recessive mutation. Characteristic for adw is an approximately 30% growth reduction with short shank. The adw variant was first recognized in the Cornell K-strain of White Leghorns, but the genetic causal variant remained unknown. To identify the ...

journal_title：Frontiers in genetics

authors： Wu Z,Derks MFL,Dibbits B,Megens HJ,Groenen MAM,Crooijmans RPMA

更新日期：2018-06-07 00:00:00

abstract：:The study of microorganisms that pervade each and every part of this planet has encountered many challenges through time such as the discovery of unknown organisms and the understanding of how they interact with their environment. The aim of this review is to take the reader along the timeline and major milestones tha...

journal_title：Frontiers in genetics

authors： Escobar-Zepeda A,Vera-Ponce de León A,Sanchez-Flores A

更新日期：2015-12-17 00:00:00

abstract：Background:Cross-sectional observational studies have reported obesity and cardiometabolic co-morbidities as important predictors of coronavirus disease 2019 (COVID-19) hospitalization. The causal impact of these risk factors is unknown at present. Methods:We conducted multivariable logistic regression to evaluate the...

journal_title：Frontiers in genetics

authors： Aung N,Khanji MY,Munroe PB,Petersen SE

更新日期：2020-11-11 00:00:00