H3K36 Methylation in Neural Development and Associated Diseases.

abstract：:Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a key regulator in the development of the central nervous system, transcription factor 4 (TCF4) has been shown to be involved in the pathogenesis of schizophrenia. The aim of our study was to assay the association of TCF4 single nucleotide pol...

journal_title：Frontiers in genetics

authors： Yin J,Zhu D,Li Y,Lv D,Yu H,Liang C,Luo X,Xu X,Fu J,Yan H,Dai Z,Zhou X,Wen X,Xiong S,Lin Z,Lin J,Zhao B,Wang Y,Li K,Ma G

更新日期：2019-05-28 00:00:00

abstract：:Plant basic helix-loop-helix (bHLH) transcription factors are involved in the regulation of various biological processes in plant growth, development, and stress response. However, members of this important transcription factor family have not been systematically identified and analyzed in pepper (Capsicum annuum L.)....

journal_title：Frontiers in genetics

authors： Zhang Z,Chen J,Liang C,Liu F,Hou X,Zou X

更新日期：2020-09-25 00:00:00

abstract：:In recent years, miRNAs have been verified to play an irreplaceable role in biological processes associated with human disease. Discovering potential disease-related miRNAs helps explain the underlying pathogenesis of the disease at the molecular level. Given the high cost and labor intensity of biological experiments...

journal_title：Frontiers in genetics

authors： Xu J,Cai L,Liao B,Zhu W,Wang P,Meng Y,Lang J,Tian G,Yang J

更新日期：2019-12-11 00:00:00

abstract：:The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages. A fossil pollen record spanning the last 26,000 years from an upland bog ...

journal_title：Frontiers in genetics

authors： Collins AF,Bush MB,Sachs JP

更新日期：2013-12-03 00:00:00

abstract：:At the time of translation, nascent proteins are thought to be sorted into their final subcellular localization sites, based on the part of their amino acid sequences (i.e., sorting or targeting signals). Thus, it is interesting to computationally recognize these signals from the amino acid sequences of any given prot...

journal_title：Frontiers in genetics

authors： Imai K,Nakai K

更新日期：2020-11-25 00:00:00

abstract：:In the world of high-throughput sequencing there are numerous challenges to effective data quality control. There are no single quality metrics which are appropriate in all conditions. Here we detail the different open source software used at the Exeter Sequencing Service to provide generic quality control information...

journal_title：Frontiers in genetics

authors： Paszkiewicz KH,Farbos A,O'Neill P,Moore K

更新日期：2014-05-27 00:00:00

abstract：:Carcass weight, meat quality and muscle components are important traits economically and they underpin most of the commercial return to goat producers. In this study, the Longissimus dorsi muscle tissues were collected from five Liaoning cashmere (LC) goats and five Ziwuling black (ZB) goats with phenotypic difference...

journal_title：Frontiers in genetics

authors： Shen J,Hao Z,Wang J,Hu J,Liu X,Li S,Ke N,Song Y,Lu Y,Hu L,Qiao L,Wu X,Luo Y

更新日期：2021-01-13 00:00:00

abstract：:The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood. Here, we performed integrated analysis of 195 deeply sequenced sRNA libraries of maize B73, represe...

journal_title：Frontiers in genetics

authors： Xu Y,Zhang T,Li Y,Miao Z

更新日期：2020-02-11 00:00:00

abstract：:The arrangement of chromatin within interphase nuclei seems to be caused by topological constraints and related to gene expression depending on tissue and developmental stage. In yeast and animals it was found that homologous and heterologous chromatin association are required to realize faithful expression and DNA re...

journal_title：Frontiers in genetics

authors： Schubert V,Rudnik R,Schubert I

更新日期：2014-11-13 00:00:00

abstract：:Genome-wide association study (GWAS), exploring the historical and evolutionary recombinations at the population level, is a major method adopted to identify quantitative trait loci (QTL) for complex traits. However, to summarize GWAS results, gene structure, and linkage disequilibrium (LD) in a single view, multiple ...

journal_title：Frontiers in genetics

authors： He F,Ding S,Wang H,Qin F

更新日期：2020-03-20 00:00:00

abstract：:Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences (PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are revolutionizing the way transcriptomes are analyzed. These methods offer many advantages over most widely used high-throughput short-read RNA sequenci...

journal_title：Frontiers in genetics

authors： Zhao L,Zhang H,Kohnen MV,Prasad KVSK,Gu L,Reddy ASN

更新日期：2019-03-21 00:00:00

abstract：:Simple sequence repeats (SSRs) of short nucleotide motifs occur very frequently in the 5' untranslated coding region (5'-UTR) of genes and have been implicated in the regulation of gene expression. In this study, we identified an SSR with a variable number of CT repeats in the 5'-UTR of the Litopenaeus vannamei IRF (L...

journal_title：Frontiers in genetics

authors： Yin B,Wang H,Zhu P,Weng S,He J,Li C

更新日期：2019-12-06 00:00:00

abstract：:Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen rece...

journal_title：Frontiers in genetics

authors： Holwerda S,de Laat W

更新日期：2012-10-17 00:00:00

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Expanded newborn screening for inborn errors of metabolism (IEMs) by tandem mass spectrometry (MS/MS) could simultaneously analyze more than 40 metabolites and identify about 50 kinds of IEMs. Next generation sequencing (NGS) targeting hundreds of IMEs-associated genes as a follow-up test in expanded newborn screening...

journal_title：Frontiers in genetics

authors： Wang T,Ma J,Zhang Q,Gao A,Wang Q,Li H,Xiang J,Wang B

更新日期：2019-10-29 00:00:00

abstract：:Reliable phenotypes are paramount for meaningful quantification of genetic variation and for estimating individual breeding values on which genetic selection is based. In this paper, we assert that genetic improvement of host tolerance to disease, although desirable, may be first of all handicapped by the ability to o...

journal_title：Frontiers in genetics

authors： Doeschl-Wilson AB,Villanueva B,Kyriazakis I

更新日期：2012-12-14 00:00:00

abstract：:Genome-wide association studies (GWAS) have identified numerous associations between genetic loci and individual phenotypes; however, relatively few GWAS have attempted to detect pleiotropic associations, in which loci are simultaneously associated with multiple distinct phenotypes. We show that pleiotropic associatio...

journal_title：Frontiers in genetics

authors： Hartley SW,Monti S,Liu CT,Steinberg MH,Sebastiani P

更新日期：2012-09-11 00:00:00

abstract：:Bamboo is one of the fastest-growing non-timber forest plants. Moso bamboo (Phyllostachys edulis) is the most economically valuable bamboo in Asia, especially in China. With the release of the whole-genome sequence of moso bamboo, there are increasing demands for refined annotation of bamboo genes. Recently, large amo...

journal_title：Frontiers in genetics

authors： Ma X,Zhao H,Xu W,You Q,Yan H,Gao Z,Su Z

更新日期：2018-11-27 00:00:00

abstract：:Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available. Here we propose a novel normalization method for network propagation that is based ...

journal_title：Frontiers in genetics

authors： Biran H,Kupiec M,Sharan R

更新日期：2019-01-22 00:00:00

abstract：:The prophase of meiosis I ensures the correct segregation of chromosomes to each daughter cell. This includes the pairing, synapsis, and recombination of homologous chromosomes. A subset of chromosomal abnormalities, including translocation and inversion, disturbs these processes, resulting in the failure to complete ...

journal_title：Frontiers in genetics

authors： Kurahashi H,Kogo H,Tsutsumi M,Inagaki H,Ohye T

更新日期：2012-06-18 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies have identified over 50 new genetic loci for type 2 diabetes (T2D). Several studies conclude that higher dietary heme iron intake increases the risk of T2D. Therefore we assessed whether the relation between genetic loci and T2D is modified by dietary heme iron intake. M...

journal_title：Frontiers in genetics

authors： Pasquale LR,Loomis SJ,Aschard H,Kang JH,Cornelis MC,Qi L,Kraft P,Hu FB

更新日期：2013-01-30 00:00:00

abstract：:As one of the hotspot regions for sympatric speciation studies, Evolution Canyon (EC) became an ideal place for its high level of microclimatic divergence interslopes. In this study, to highlight the genetic mechanisms of sympatric speciation, phenotypic variation on flowering time and transcriptomic divergence were i...

journal_title：Frontiers in genetics

authors： Qian C,Yan X,Yin H,Fan X,Yin X,Sun P,Li Z,Nevo E,Ma XF

更新日期：2018-11-14 00:00:00

abstract：:Lin28 is a developmentally regulated RNA-binding protein that plays important roles in diverse physiological and pathological processes including oncogenesis and brain synaptic function. These pleiotropic roles of Lin28 are mechanistically linked both to its ability to directly stimulate translation of genes involved ...

journal_title：Frontiers in genetics

authors： Kallen AN,Ma J,Huang Y

更新日期：2012-11-16 00:00:00

abstract：:Extracellular vesicles (EVs) are abundant in most biological fluids and considered promising biomarker candidates, but the development of EV biomarker assays is hindered, in part, by their requirement for prior EV purification and the lack of standardized and reproducible EV isolation methods. We now describe a far-fi...

journal_title：Frontiers in genetics

authors： Amrollahi P,Rodrigues M,Lyon CJ,Goel A,Han H,Hu TY

更新日期：2019-12-17 00:00:00

abstract：:Environmental exposures vary by timing, severity, and frequency and may have a number of deleterious effects throughout the life course. The period of in utero development, for example, is one of the most crucial stages of development during which adverse environmental exposures can both alter the growth and developme...

journal_title：Frontiers in genetics

authors： Maccani MA,Knopik VS

更新日期：2012-04-09 00:00:00

abstract：:Multiple osteochondromas (MO), the most common type of benign bone tumor, is an autosomal dominant skeletal disorder characterized by multiple cartilage-capped bony protuberances. In most cases, EXT1 and EXT2, which encode glycosyltransferases involved in the biosynthesis of heparan sulfate, are the genes responsible....

journal_title：Frontiers in genetics

authors： Wang Y,Zhong L,Xu Y,Ding L,Ji Y,Schutz S,Férec C,Cooper DN,Xu C,Chen JM,Luo Y

更新日期：2020-12-22 00:00:00

abstract：:A complete and compelling evolutionary explanation for the origin of human menopause is wanting. Menopause onset is defined clinically as the final menses, confirmed after 1 year without menstruation. The theory proposed herein explains at multiple levels - ultimately genetic but involving (1) behavioral, (2) life his...

journal_title：Frontiers in genetics

authors： Takahashi M,Singh RS,Stone J

更新日期：2017-01-06 00:00:00

abstract：:Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be ...

journal_title：Frontiers in genetics

authors： Kinet V,Halkein J,Dirkx E,Windt LJ

更新日期：2013-11-12 00:00:00

abstract：:Recently, an increasing number of studies sequence multiple biopsies of primary tumors, and even paired metastatic tumors to understand heterogeneity and the evolutionary trajectory of cancer progression. Although several algorithms are available to infer the phylogeny, most tools rely on accurate measurements of muta...

journal_title：Frontiers in genetics

authors： Wu P,Hou L,Zhang Y,Zhang L

更新日期：2020-02-07 00:00:00

abstract：:A balanced pericentric inversion is normally without any clinical consequences for its carrier. However, there is a well-known risk of such inversions to lead to unbalanced offspring. Inversion-loop formation is the mechanism which may lead to duplication or deletion of the entire or parts of the inverted segment in t...

journal_title：Frontiers in genetics

authors： Liehr T,Weise A,Mrasek K,Ziegler M,Padutsch N,Wilhelm K,Al-Rikabi A

更新日期：2019-11-14 00:00:00