Identifying Potential miRNAs-Disease Associations With Probability Matrix Factorization.

abstract：:p73 transcription factor belongs to one of the most important gene families in vertebrate biology, the p53-family. Trp73 gene, like the other family members, generates multiple isoforms named TA and DNp73, with different and, sometimes, antagonist functions. Although p73 shares many biological functions with p53, it a...

journal_title：Frontiers in genetics

authors： Marques MM,Villoch-Fernandez J,Maeso-Alonso L,Fuertes-Alvarez S,Marin MC

更新日期：2019-03-15 00:00:00

abstract：:The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinc...

journal_title：Frontiers in genetics

authors： Palstra RJ,Grosveld F

更新日期：2012-09-28 00:00:00

abstract：:Tools for genomic island prediction use strategies for genomic comparison analysis and sequence composition analysis. The goal of comparative analysis is to identify unique regions in the genomes of related organisms, whereas sequence composition analysis evaluates and relates the composition of specific regions with ...

journal_title：Frontiers in genetics

authors： da Silva Filho AC,Raittz RT,Guizelini D,De Pierri CR,Augusto DW,Dos Santos-Weiss ICR,Marchaukoski JN

更新日期：2018-12-12 00:00:00

abstract：:Autosomal recessive non-syndromic hearing loss (ARNSHL) is a highly heterogeneous disease involving more than 70 pathogenic genes. However, most ARNSHL families have small-sized pedigrees with limited genetic information, rendering challenges for the molecular diagnosis of these patients. Therefore, we attempted to es...

journal_title：Frontiers in genetics

authors： Sang S,Ling J,Liu X,Mei L,Cai X,Li T,Li W,Li M,Wen J,Liu X,Liu J,Liu Y,Chen H,He C,Feng Y

更新日期：2019-07-17 00:00:00

abstract：:The Flavivirus genus comprises many viruses (including dengue, Zika, West Nile and yellow fever viruses) which constitute important public health concerns worldwide. For several of these pathogens, neither antivirals nor vaccines are currently available. In addition to this unmet medical need, flaviviruses are of part...

journal_title：Frontiers in genetics

authors： Mazeaud C,Freppel W,Chatel-Chaix L

更新日期：2018-12-04 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. They constitute a major, but still poorly characterized part of human transcriptome, however, evidence is growing that they are important regulatory molecules involved...

journal_title：Frontiers in genetics

authors： Yarmishyn AA,Kurochkin IV

更新日期：2015-04-23 00:00:00

abstract：:In this study, we used pan RNA-seq analysis to reveal the ubiquitous existence of both 5' and 3' end small RNAs (5' and 3' sRNAs). 5' and 3' sRNAs alone can be used to annotate nuclear non-coding and mitochondrial genes at 1-bp resolution and identify new steady RNAs, which are usually transcribed from functional gene...

journal_title：Frontiers in genetics

authors： Xu X,Ji H,Jin X,Cheng Z,Yao X,Liu Y,Zhao Q,Zhang T,Ruan J,Bu W,Chen Z,Gao S

更新日期：2019-02-14 00:00:00

abstract：:Sertoli cells are central and essential coordinators of spermatogenesis. Accumulating evidence has demonstrated that miRNAs participate in the regulation of Sertoli cell growth. However, the functions and the regulatory mechanisms of miRNAs in Sertoli cells of domestic animals remain largely unknown. Here we report th...

journal_title：Frontiers in genetics

authors： Luo H,Peng F,Weng B,Tang X,Chen Y,Yang A,Chen B,Ran M

更新日期：2020-10-29 00:00:00

abstract：:Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and ...

journal_title：Frontiers in genetics

authors： Murillo-Cuesta S,Artuch R,Asensio F,de la Villa P,Dierssen M,Enríquez JA,Fillat C,Fourcade S,Ibáñez B,Montoliu L,Oliver E,Pujol A,Salido E,Vallejo M,Varela-Nieto I

更新日期：2020-10-14 00:00:00

abstract：:The aging brain undergoes a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons and circuits due to age-associated neurodegenerativ...

journal_title：Frontiers in genetics

authors： Hermann PM,Watson SN,Wildering WC

更新日期：2014-12-04 00:00:00

abstract：Background:Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junction proteins (GJA) m...

journal_title：Frontiers in genetics

authors： Horn T,Ludwig M,Eickmeier O,Neerinex AH,Maitland-van der Zee AH,Smaczny C,Wagner TOF,Schubert R,Zielen S,Majoor C,Bos LD,Schmitt-Grohé S

更新日期：2020-10-28 00:00:00

abstract：:Advances in the field of sequencing techniques have resulted in the greatly accelerated production of huge sequence datasets. This presents immediate challenges in database maintenance at datacenters. It provides additional computational challenges in data mining and sequence analysis. Together these represent a signi...

journal_title：Frontiers in genetics

authors： Thakur RS,Bandopadhyay R,Chaudhary B,Chatterjee S

更新日期：2012-12-11 00:00:00

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00

abstract：:Mutations in CHD7 have been shown to be a major cause of CHARGE syndrome, which presents many symptoms and features common to other syndromes making its diagnosis difficult. Next generation sequencing (NGS) of a panel of intellectual disability related genes was performed in an adult patient without molecular diagnosi...

journal_title：Frontiers in genetics

authors： Villate O,Ibarluzea N,Fraile-Bethencourt E,Valenzuela A,Velasco EA,Grozeva D,Raymond FL,Botella MP,Tejada MI

更新日期：2018-01-26 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：:In recent years, studies have shown that phytopathogenic fungi possess the ability of cross-kingdom regulation of host plants through small RNAs (sRNAs). Magnaporthe oryzae, a causative agent of rice blast, introduces disease by penetrating the rice tissues through appressoria. However, little is known about the trans...

journal_title：Frontiers in genetics

authors： Zhang H,Liu S,Chang H,Zhan M,Qin QM,Zhang B,Li Z,Liu Y

更新日期：2019-03-29 00:00:00

abstract：:Sucrose transporters (SUTs) play key roles in allocating the translocation of assimilates from source to sink tissues. Although the characteristics and biological roles of SUTs have been intensively investigated in higher plants, this gene family has not been functionally characterized in cotton. In this study, we per...

journal_title：Frontiers in genetics

authors： Li W,Sun K,Ren Z,Song C,Pei X,Liu Y,Wang Z,He K,Zhang F,Zhou X,Ma X,Yang D

更新日期：2018-10-23 00:00:00

abstract：:Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide. The mechanisms leading to the progression of CRC are involved in both genetic and epigenetic regulations. In this study, we applied systems biology methods to identify potential biomarkers and conduct drug discovery in a computation...

journal_title：Frontiers in genetics

authors： Yeh SJ,Chen SW,Chen BS

更新日期：2020-03-06 00:00:00

abstract：:The prophase of meiosis I ensures the correct segregation of chromosomes to each daughter cell. This includes the pairing, synapsis, and recombination of homologous chromosomes. A subset of chromosomal abnormalities, including translocation and inversion, disturbs these processes, resulting in the failure to complete ...

journal_title：Frontiers in genetics

authors： Kurahashi H,Kogo H,Tsutsumi M,Inagaki H,Ohye T

更新日期：2012-06-18 00:00:00

abstract：:Background:NKX2-1 related disorders (also known as brain-lung-thyroid syndrome or benign hereditary chorea 1) are associated with a wide spectrum of symptoms. The core features are various movement disorders, characteristically chorea, less frequently myoclonus, dystonia, ataxia; thyroid disease; and lung involvement....

journal_title：Frontiers in genetics

authors： Balicza P,Grosz Z,Molnár V,Illés A,Csabán D,Gézsi A,Dézsi L,Zádori D,Vécsei L,Molnár MJ

更新日期：2018-08-22 00:00:00

abstract：:There is evidence of a purifying filter acting in the female germline to prevent the expansion of deleterious mutations in the mitochondrial DNA (mtDNA). Given our poor understanding of this filter, here we investigate the competence of the mouse embryo to eliminate dysfunctional mitochondria. Toward that, mitochondri...

journal_title：Frontiers in genetics

authors： Machado TS,Macabelli CH,Collado MD,Meirelles FV,Guimarães FEG,Chiaratti MR

更新日期：2020-07-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fgene.2018.00657.]. ...

journal_title：Frontiers in genetics

authors： Cheng L,Zhuang H,Yang S,Jiang H,Wang S,Zhang J

更新日期：2019-02-18 00:00:00

abstract：:Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is...

journal_title：Frontiers in genetics

authors： Zaghi M,Broccoli V,Sessa A

更新日期：2020-01-09 00:00:00

abstract：:Few studies have been conducted to explore the influence of the catechol-o-methyltransferase (COMT) genotype on the severity of and treatment efficacy on auditory verbal hallucination (AVH) symptoms in healthy individuals with AVHs (Hi-AVHs). We hypothesized that the efficacy of dopamine antagonist treatment on AVHs i...

journal_title：Frontiers in genetics

authors： Zhuo C,Xu Y,Zhang L,Jing R,Zhou C

更新日期：2019-03-06 00:00:00

abstract：:The codon redundancy ("degeneracy") found in protein-coding regions of mRNA also prescribes Translational Pausing (TP). When coupled with the appropriate interpreters, multiple meanings and functions are programmed into the same sequence of configurable switch-settings. This additional layer of Ontological Prescriptiv...

journal_title：Frontiers in genetics

authors： D'Onofrio DJ,Abel DL

更新日期：2014-05-20 00:00:00

abstract：:In this case report, we characterize a novel inherited frameshift mutation c.4700_4701del (p.Phe1567Cysfs*221) in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered fr...

journal_title：Frontiers in genetics

authors： Micaglio E,Monasky MM,Ciconte G,Vicedomini G,Conti M,Mecarocci V,Giannelli L,Giordano F,Pollina A,Saviano M,Pozzi PR,Di Resta C,Benedetti S,Ferrari M,Santinelli V,Pappone C

更新日期：2019-06-06 00:00:00

abstract：:In recent years, there has been an explosive increase in the amount of bioinformatics data produced, but data are not information. The purpose of bioinformatics research is to obtain information with biological significance from large amounts of data. Multiple sequence alignment is widely used in sequence homology det...

journal_title：Frontiers in genetics

authors： Shi H,Zhang X

更新日期：2020-02-27 00:00:00

abstract：:Gene copy-number differences due to gene duplications and deletions are rampant in natural populations and play a crucial role in the evolution of genome complexity. Per-locus analyses of gene duplication rates in the pre-genomic era revealed that gene duplication rates are much higher than the per nucleotide substitu...

journal_title：Frontiers in genetics

authors： Katju V,Bergthorsson U

更新日期：2013-12-10 00:00:00

abstract：:Telomeres are important for maintaining genomic stability. Telomere length has been associated with aging, disease, and mortality and is highly heritable (∼82%). In this study, we aimed to identify rare genetic variants associated with telomere length using whole-exome sequence data. We studied 1,303 participants of t...

journal_title：Frontiers in genetics

authors： van der Spek A,Warner SC,Broer L,Nelson CP,Vojinovic D,Ahmad S,Arp PP,Brouwer RWW,Denniff M,van den Hout MCGN,van Rooij JGJ,Kraaij R,van IJcken WFJ,Samani NJ,Ikram MA,Uitterlinden AG,Codd V,Amin N,van Duijn CM

更新日期：2020-04-30 00:00:00

abstract：:Cyprinids are the most important group of farmed fish globally in terms of production volume, with common carp (Cyprinus carpio) being one of the most valuable species of the group. The use of modern selective breeding methods in carp is at a formative stage, implying a large scope for genetic improvement of key produ...

journal_title：Frontiers in genetics

authors： Palaiokostas C,Kocour M,Prchal M,Houston RD

更新日期：2018-03-13 00:00:00