Long noncoding RNAs: a potential novel class of cancer biomarkers.

abstract：OBJECTIVES:Using a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans. METHODS:  We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are mo...

journal_title：Frontiers in genetics

authors： Jacobs DI,Walsh KM,Wrensch M,Wiencke J,Jenkins R,Houlston RS,Bondy M,Simon M,Sanson M,Gousias K,Schramm J,Labussière M,Di Stefano AL,Wichmann HE,Müller-Nurasyid M,Schreiber S,Franke A,Moebus S,Eisele L,Dewan AT,Du

更新日期：2012-10-12 00:00:00

abstract：:Detection of differentially expressed genes is a common task in single-cell RNA-seq (scRNA-seq) studies. Various methods based on both bulk-cell and single-cell approaches are in current use. Due to the unique distributional characteristics of single-cell data, it is important to compare these methods with rigorous st...

journal_title：Frontiers in genetics

authors： Mou T,Deng W,Gu F,Pawitan Y,Vu TN

更新日期：2020-01-17 00:00:00

abstract：:Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a single network, which results in important temporal- or context-re...

journal_title：Frontiers in genetics

authors： Yu L,Yao S,Gao L,Zha Y

更新日期：2019-01-18 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. They are aberrantly expressed in many human cancers and are potential therapeutic targets and molecular biomarkers. METHODS:In this study, we for the first time validated the reported data on the entire set of published differential...

journal_title：Frontiers in genetics

authors： Zabolotneva AA,Zhavoronkov AA,Shegay PV,Gaifullin NM,Alekseev BY,Roumiantsev SA,Garazha AV,Kovalchuk O,Aravin A,Buzdin AA

更新日期：2013-11-15 00:00:00

abstract：:In situ adaptation to climate change will be critical for the persistence of many ectotherm species due to their relative lack of dispersal capacity. Climate change is causing increases in both the mean and the variance of environmental temperature, each of which may act as agents of selection on different traits. Imp...

journal_title：Frontiers in genetics

authors： Logan ML,Cox CL

更新日期：2020-09-18 00:00:00

abstract：:The primary cilium is able to maintain a specific protein composition, which is critical for its function as a signaling organelle. Here we introduce a system to synchronize biosynthetic trafficking of ciliary proteins that is based on conditional aggregation domains (CADs). This approach enables to create a wave of c...

journal_title：Frontiers in genetics

authors： Stroukov W,Rösch A,Schwan C,Jeney A,Römer W,Thuenauer R

更新日期：2019-03-08 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies have identified over 50 new genetic loci for type 2 diabetes (T2D). Several studies conclude that higher dietary heme iron intake increases the risk of T2D. Therefore we assessed whether the relation between genetic loci and T2D is modified by dietary heme iron intake. M...

journal_title：Frontiers in genetics

authors： Pasquale LR,Loomis SJ,Aschard H,Kang JH,Cornelis MC,Qi L,Kraft P,Hu FB

更新日期：2013-01-30 00:00:00

abstract：:HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry. It is reported that the HFE p.C282Y mutation is present in 1/10 people of northern European descent, resulting in one in two hundred people will be homozygous. However, the H...

journal_title：Frontiers in genetics

authors： Zhang W,Wang X,Duan W,Xu A,Zhao X,Huang J,You H,Brissot P,Ou X,Jia J

更新日期：2020-02-21 00:00:00

abstract：:Predicting how species interactions evolve requires that we understand the mechanistic basis of coevolution, and thus the functional genotype-by-genotype interactions (G × G) that drive reciprocal natural selection. Theory on host-parasite coevolution provides testable hypotheses for empiricists, but depends upon mode...

journal_title：Frontiers in genetics

authors： Heath KD,Nuismer SL

更新日期：2014-04-11 00:00:00

abstract：BACKGROUND:Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of 0.5-1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating evidence indicates that DNA methylation, which is the addition of a methyl group to the cytosine in a CpG dinucleotide, might play an important ...

journal_title：Frontiers in genetics

authors： Numata S,Ye T,Herman M,Lipska BK

更新日期：2014-08-26 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:Classification of DNA sequences is an important issue in the bioinformatics study, yet most existing methods for phylogenetic analysis including Multiple Sequence Alignment (MSA) are time-consuming and computationally expensive. The alignment-free methods are popular nowadays, whereas the manual intervention in those ...

journal_title：Frontiers in genetics

authors： Dong R,He L,He RL,Yau SS

更新日期：2019-04-09 00:00:00

abstract：:The adaptation of the yeast Saccharomyces cerevisiae to man-made environments for the fermentation of foodstuffs and beverages illustrates the scientific, social, and economic relevance of microbe domestication. Here we address a yet unexplored aspect of S. cerevisiae domestication, that of the emergence of lineages h...

journal_title：Frontiers in genetics

authors： Pontes A,Čadež N,Gonçalves P,Sampaio JP

更新日期：2019-05-29 00:00:00

abstract：:With the availability of high-throughput sequencing data, identification of genetic causal variants accurately requires the efficient incorporation of function annotation data into the optimization routine. This motivates the need for development of novel methods for genome wide association studies with special focus ...

journal_title：Frontiers in genetics

authors： Sundar VS,Fan CC,Holland D,Dale AM

更新日期：2018-03-05 00:00:00

abstract：:Bovine leukemia virus (BLV) affects cattle health and productivity worldwide, causing abnormal immune function and immunosuppression. Transfer RNA fragments (tRFs) are known to be involved in inhibition of gene expression and have been associated with stress and immune response, tumor growth, and viral infection. The ...

journal_title：Frontiers in genetics

authors： Taxis TM,Kehrli ME Jr,D'Orey-Branco R,Casas E

更新日期：2018-07-04 00:00:00

abstract：:The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood. Here, we performed integrated analysis of 195 deeply sequenced sRNA libraries of maize B73, represe...

journal_title：Frontiers in genetics

authors： Xu Y,Zhang T,Li Y,Miao Z

更新日期：2020-02-11 00:00:00

abstract：:Molybdenum cofactor deficiency (MoCD) is an autosomal recessive disorder belonging to the large family of inborn errors in metabolism. Patients typically present with encephalopathy and seizures early after birth and develop severe neurodegeneration within the first few weeks of life. The main pathomechanism underlyin...

journal_title：Frontiers in genetics

authors： Mellis AT,Roeper J,Misko AL,Kohl J,Schwarz G

更新日期：2021-01-07 00:00:00

abstract：:Myiopsitta monachus is a small Neotropical parrot (Psittaciformes: Arini Tribe) from subtropical and temperate regions of South America. It has a diploid chromosome number 2n = 48, different from other members of the Arini Tribe that have usually 70 chromosomes. The species has the lowest 2n within the Arini Tribe. In...

journal_title：Frontiers in genetics

authors： Furo IO,Kretschmer R,O'Brien PC,Pereira JC,Garnero ADV,Gunski RJ,O'Connor RE,Griffin DK,Gomes AJB,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-07-10 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterized by a...

journal_title：Frontiers in genetics

authors： Kim JE,Leung E,Baguley BC,Finlay GJ

更新日期：2013-05-31 00:00:00

abstract：:Purpose: The present study examines the role of Sox11 in the initial response of retinal ganglion cells (RGCs) to axon damage and in optic nerve regeneration in mouse. Methods: Markers of retinal injury were identified using the normal retina database and optic nerve crush (ONC) database on GeneNetwork2 (www.genenetwo...

journal_title：Frontiers in genetics

authors： Li Y,Struebing FL,Wang J,King R,Geisert EE

更新日期：2018-12-18 00:00:00

abstract：:Sucrose transporters (SUTs) play key roles in allocating the translocation of assimilates from source to sink tissues. Although the characteristics and biological roles of SUTs have been intensively investigated in higher plants, this gene family has not been functionally characterized in cotton. In this study, we per...

journal_title：Frontiers in genetics

authors： Li W,Sun K,Ren Z,Song C,Pei X,Liu Y,Wang Z,He K,Zhang F,Zhou X,Ma X,Yang D

更新日期：2018-10-23 00:00:00

abstract：:In recent years, studies have shown that phytopathogenic fungi possess the ability of cross-kingdom regulation of host plants through small RNAs (sRNAs). Magnaporthe oryzae, a causative agent of rice blast, introduces disease by penetrating the rice tissues through appressoria. However, little is known about the trans...

journal_title：Frontiers in genetics

authors： Zhang H,Liu S,Chang H,Zhan M,Qin QM,Zhang B,Li Z,Liu Y

更新日期：2019-03-29 00:00:00

abstract：:Influenza A virus (IAV) is a segmented negative-stranded RNA virus that brings a potentially serious threat to public health and animal husbandry. Mast cells play an important role in both the inherent and adaptive immune response. Previous studies have indicated that mast cells support the productive replication of H...

journal_title：Frontiers in genetics

authors： Huo C,Wu H,Xiao J,Meng D,Zou S,Wang M,Qi P,Tian H,Hu Y

更新日期：2019-06-21 00:00:00

abstract：:Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal role in the equilibrium between genetic stability and diversity. HR is commonly considered to be error-free, but several studies have shown that HR can be error-prone. Here, we discuss the actual accuracy of HR. First, we present...

journal_title：Frontiers in genetics

authors： Guirouilh-Barbat J,Lambert S,Bertrand P,Lopez BS

更新日期：2014-06-11 00:00:00

abstract：:There are associations between DNA methylation and the expression of long non-coding RNA (lncRNA), also known as lncRNA expression quantitative trait methylations (lnc-eQTMs). Lnc-eQTMs may induce a wide range of carcinogenesis pathways. However, lnc-eQTMs have not been globally identified and studied, and their roles...

journal_title：Frontiers in genetics

authors： Wu X,Gao Y,Bu J,Deng L,Zhang P,Chi M,Jiang L,Shi X,Ning S,Wang G

更新日期：2020-12-09 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes. This study explored potential prognostic markers in CRC via the construction and in-depth analysis of a competing endogenous RNA (ceRNA) network, which was gene...

journal_title：Frontiers in genetics

authors： Guo L,Yang G,Kang Y,Li S,Duan R,Shen L,Jiang W,Qian B,Yin Z,Liang T

更新日期：2020-05-08 00:00:00

abstract：:The development of whole-genome bisulfite sequencing (WGBS) has resulted in a number of exciting discoveries about the role of DNA methylation leading to a plethora of novel testable hypotheses. Methods for constructing sodium bisulfite-converted and amplified libraries have recently advanced to the point that the bot...

journal_title：Frontiers in genetics

authors： Ji L,Sasaki T,Sun X,Ma P,Lewis ZA,Schmitz RJ

更新日期：2014-10-21 00:00:00

abstract：:People want to live long, healthy lives. Previous surveys suggest very limited interest in much longer lifespans, but we show that stipulating good health changes responses to favor longer lives by an order of magnitude. Advances in aging research hold out hope for greatly slowed aging with associated good health. Und...

journal_title：Frontiers in genetics

authors： Donner Y,Fortney K,Calimport SR,Pfleger K,Shah M,Betts-LaCroix J

更新日期：2016-01-20 00:00:00

abstract：:Mutations in mitochondrial (mt) DNA determine important human diseases. The majority of the known pathogenic mutations are located in transfer RNA (tRNA) genes and are responsible for a wide range of currently untreatable disorders. Experimental evidence both in yeast and in human cells has shown that the detrimental ...

journal_title：Frontiers in genetics

authors： Giordano C,Morea V,Perli E,d'Amati G

更新日期：2015-03-23 00:00:00