Co-expression Gene Network Analysis and Functional Module Identification in Bamboo Growth and Development.

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:RNA binding proteins (RBPs) play a key role in post-transcriptional gene regulation. They have been shown to be dysfunctional in a variety of cancers and are closely related to the occurrence and progression of cancers. However, the biological function and clinical significance of RBPs in clear cell renal carcinoma (c...

journal_title：Frontiers in genetics

authors： Wu Y,Wei X,Feng H,Hu B,Liu B,Luan Y,Ruan Y,Liu X,Liu Z,Wang S,Liu J,Wang T

更新日期：2021-01-07 00:00:00

abstract：:Animal models are invaluable for biomedical research, especially in the context of rare diseases, which have a very low prevalence and are often complex. Concretely mouse models provide key information on rare disease mechanisms and therapeutic strategies that cannot be obtained by using only alternative methods, and ...

journal_title：Frontiers in genetics

authors： Murillo-Cuesta S,Artuch R,Asensio F,de la Villa P,Dierssen M,Enríquez JA,Fillat C,Fourcade S,Ibáñez B,Montoliu L,Oliver E,Pujol A,Salido E,Vallejo M,Varela-Nieto I

更新日期：2020-10-14 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:Classification of DNA sequences is an important issue in the bioinformatics study, yet most existing methods for phylogenetic analysis including Multiple Sequence Alignment (MSA) are time-consuming and computationally expensive. The alignment-free methods are popular nowadays, whereas the manual intervention in those ...

journal_title：Frontiers in genetics

authors： Dong R,He L,He RL,Yau SS

更新日期：2019-04-09 00:00:00

abstract：:In genome wide association studies (GWAS), family-based studies tend to have less power to detect genetic associations than population-based studies, such as case-control studies. This can be an issue when testing if genes in a family-based GWAS have a direct effect on the phenotype of interest over and above their po...

journal_title：Frontiers in genetics

authors： Lutz SM,Vansteelandt S,Lange C

更新日期：2013-11-21 00:00:00

abstract：:Encephalomyopathic mitochondrial DNA (mtDNA) depletion syndrome 13 (MTDPS13) is a rare genetic disorder caused by defects in F-box leucine-rich repeat protein 4 (FBXL4). Although FBXL4 is essential for the bioenergetic homeostasis of the cell, the precise role of the protein remains unknown. In this study, we report t...

journal_title：Frontiers in genetics

authors： Emperador S,Garrido-Pérez N,Amezcua-Gil J,Gaudó P,Andrés-Sanz JA,Yubero D,Fernández-Marmiesse A,O'Callaghan MM,Ortigoza-Escobar JD,Iriondo M,Ruiz-Pesini E,García-Cazorla A,Gil-Campos M,Artuch R,Montoya J,Bayona-Bafaluy MP

更新日期：2020-01-08 00:00:00

abstract：:Our understanding of the mechanisms governing the response to DNA damage in higher eucaryotes crucially depends on our ability to dissect the temporal and spatial organization of the cellular machinery responsible for maintaining genomic integrity. To achieve this goal, we need experimental tools to inflict DNA lesion...

journal_title：Frontiers in genetics

authors： Ferrando-May E,Tomas M,Blumhardt P,Stöckl M,Fuchs M,Leitenstorfer A

更新日期：2013-07-16 00:00:00

abstract：:The fragile X premutation (PM) allele contains a CGG expansion of 55-200 repeats in the FMR1 gene's promoter. Male PM carriers have an elevated risk of developing neurological and psychiatric changes, including an approximately 50% risk of the fragile X-associated tremor/ataxia syndrome (FXTAS). The aim of this study ...

journal_title：Frontiers in genetics

authors： Loesch DZ,Trost N,Bui MQ,Hammersley E,Lay ST,Annesley SJ,Sanislav O,Allan CY,Tassone F,Chen ZP,Ngoei KRW,Kemp BE,Francis D,Fisher PR,Storey E

更新日期：2018-11-12 00:00:00

abstract：:As a conserved protein family, WRKY has been shown to be involved in multiple biological processes in plants. However, the mechanism of functional diversity for WRKYs in pepper has not been well elucidated. Here, a total of 223 WRKY members from solanaceae crops including pepper, tomato and potato, were analyzed using...

journal_title：Frontiers in genetics

authors： Cheng Y,Ahammed GJ,Yao Z,Ye Q,Ruan M,Wang R,Li Z,Zhou G,Wan H

更新日期：2019-05-28 00:00:00

abstract：:Goats (Capra hircus) are an economically important livestock species providing meat and milk across the globe. They are of particular importance in tropical agri-systems contributing to sustainable agriculture, alleviation of poverty, social cohesion, and utilisation of marginal grazing. There are excellent genetic an...

journal_title：Frontiers in genetics

authors： Muriuki C,Bush SJ,Salavati M,McCulloch MEB,Lisowski ZM,Agaba M,Djikeng A,Hume DA,Clark EL

更新日期：2019-11-04 00:00:00

abstract：:Cereals are a staple food for many people around the world; however, they are also a major dietary source of toxic metal(loid)s. Many agricultural regions throughout the world are contaminated with toxic metal(loid)s, which can accumulate to high levels in the grains of cereals cultivated in these regions, posing seri...

journal_title：Frontiers in genetics

authors： Deng F,Yu M,Martinoia E,Song WY

更新日期：2019-04-09 00:00:00

abstract：:A lot of studies indicated that aberrant expression of long non-coding RNA genes (lncRNAs) is closely related to human diseases. Identifying disease-related lncRNAs (disease lncRNAs) is critical for understanding the pathogenesis and etiology of diseases. Most of the previous methods focus on prioritizing the potentia...

journal_title：Frontiers in genetics

authors： Xuan P,Cao Y,Zhang T,Kong R,Zhang Z

更新日期：2019-05-03 00:00:00

abstract：BACKGROUND:Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of 0.5-1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating evidence indicates that DNA methylation, which is the addition of a methyl group to the cytosine in a CpG dinucleotide, might play an important ...

journal_title：Frontiers in genetics

authors： Numata S,Ye T,Herman M,Lipska BK

更新日期：2014-08-26 00:00:00

abstract：:von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease and the underlying me...

journal_title：Frontiers in genetics

authors： Wang J,Peng X,Chen C,Ning X,Peng S,Li T,Liu S,Hong B,Zhou J,Ma K,Cai L,Gong K

更新日期：2019-04-24 00:00:00

abstract：:MicroRNAs are a class of noncoding RNAs that can be involved in the regulation of gene expression in cancers, including lung cancer. Our previous research has shown that miR-486-5p is one of the most downregulated microRNAs in tissue and serum samples of lung cancer as a good diagnostic biomarker. The objective of thi...

journal_title：Frontiers in genetics

authors： Tian F,Wang J,Ouyang T,Lu N,Lu J,Shen Y,Bai Y,Xie X,Ge Q

更新日期：2019-07-26 00:00:00

abstract：:Transcriptome analyses have increased our understanding of the molecular mechanisms underlying human diseases. Most approaches aim to identify significant genes by comparing their expression values between healthy subjects and a group of patients with a certain disease. Given that studies normally contain few samples,...

journal_title：Frontiers in genetics

authors： Gonçalves ANA,Lever M,Russo PST,Gomes-Correia B,Urbanski AH,Pollara G,Noursadeghi M,Maracaja-Coutinho V,Nakaya HI

更新日期：2019-10-24 00:00:00

abstract：:Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes. The vast majority of adult CMs (ACMs) do not reenter cell...

journal_title：Frontiers in genetics

authors： Oyama K,El-Nachef D,Zhang Y,Sdek P,MacLellan WR

更新日期：2014-11-04 00:00:00

abstract：:Colon cancer has the third highest incidence and mortality among cancers in the United States. MicroRNA-21 (miR21) has been described as an oncomir that is highly overexpressed in tumor tissue from colorectal cancer. Recent studies showed that silencing of miR21 through use of a miR21 inhibitor (anti-miR21) affected v...

journal_title：Frontiers in genetics

authors： Song MS,Rossi JJ

更新日期：2014-01-02 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington's Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associated with a mutant, ag...

journal_title：Frontiers in genetics

authors： Ohkuni K,Pasupala N,Peek J,Holloway GL,Sclar GD,Levy-Myers R,Baker RE,Basrai MA,Kerscher O

更新日期：2018-09-18 00:00:00

abstract：:Leprosy, an infectious disease caused by Mycobacterium leprae, affects millions of people worldwide. However, little is known regarding its molecular pathophysiological mechanisms. In this study, a comprehensive assessment of human mRNA was performed on leprosy skin lesions by using DNA chip microarrays, which include...

journal_title：Frontiers in genetics

authors： Belone Ade F,Rosa PS,Trombone AP,Fachin LR,Guidella CC,Ura S,Barreto JA,Pinilla MG,de Carvalho AF,Carraro DM,Soares FA,Soares CT

更新日期：2015-11-20 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:The codon redundancy ("degeneracy") found in protein-coding regions of mRNA also prescribes Translational Pausing (TP). When coupled with the appropriate interpreters, multiple meanings and functions are programmed into the same sequence of configurable switch-settings. This additional layer of Ontological Prescriptiv...

journal_title：Frontiers in genetics

authors： D'Onofrio DJ,Abel DL

更新日期：2014-05-20 00:00:00

abstract：:Exosomes are biomolecular nanostructures released from cells. They carry specific biomolecular information and are mainly researched for their exquisite properties as a biomarker source and delivery system. We introduce exosomes in the context of other extracellular vesicles, describe their biophysical isolation and c...

journal_title：Frontiers in genetics

authors： de la Torre Gomez C,Goreham RV,Bech Serra JJ,Nann T,Kussmann M

更新日期：2018-03-27 00:00:00

abstract：:The goal of any plant breeding program is to improve quality of a target crop. Crop quality is a comprehensive feature largely determined by biological background. To improve the quality parameters of crops grown for the production of fiber, a functional approach was used to search for genes suitable for the effective...

journal_title：Frontiers in genetics

authors： Galinousky D,Mokshina N,Padvitski T,Ageeva M,Bogdan V,Kilchevsky A,Gorshkova T

更新日期：2020-11-12 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are an emerging class of RNA species that may play a critical regulatory role in gene expression. However, the association between lncRNAs and atrial fibrillation (AF) is still not fully understood. In this study, we used RNA sequencing data to identify and quantify the both protein codi...

journal_title：Frontiers in genetics

authors： Wu DM,Zhou ZK,Fan SH,Zheng ZH,Wen X,Han XR,Wang S,Wang YJ,Zhang ZF,Shan Q,Li MQ,Hu B,Lu J,Chen GQ,Hong XW,Zheng YL

更新日期：2019-10-02 00:00:00

abstract：:Vitamin D receptor (VDR) gene polymorphisms were reported to influence blood lead levels (BLL) and the response of subjects to the symptoms of lead toxicity. However, no studies have been conducted in the Saudi Arabian population which has unique ethnicity and socio-demographic features. This study examined the polymo...

journal_title：Frontiers in genetics

authors： Shaik AP,Alsaeed AH,Faiyaz-Ul-Haque M,Alsaeed MA,Alyousef AA,Bammidi VK,Shaik AS

更新日期：2019-04-26 00:00:00

abstract：Background:This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method:We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cervical cancer patients from The Cancer Genome Atlas database and the Molec...

journal_title：Frontiers in genetics

authors： Chen Q,Hu L,Huang D,Chen K,Qiu X,Qiu B

更新日期：2020-10-14 00:00:00

abstract：Background:Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junction proteins (GJA) m...

journal_title：Frontiers in genetics

authors： Horn T,Ludwig M,Eickmeier O,Neerinex AH,Maitland-van der Zee AH,Smaczny C,Wagner TOF,Schubert R,Zielen S,Majoor C,Bos LD,Schmitt-Grohé S

更新日期：2020-10-28 00:00:00