The anti-miR21 antagomir, a therapeutic tool for colorectal cancer, has a potential synergistic effect by perturbing an angiogenesis-associated miR30.

abstract：:While substantial progress has been made in finding genetic variants associated with nicotine dependence (ND), a large proportion of the genetic variants remain undiscovered. The current research focuses have shifted toward uncovering rare variants, gene-gene/gene-environment interactions, and structural variations pr...

journal_title：Frontiers in genetics

authors： Zhang X,Lan T,Wang T,Xue W,Tong X,Ma T,Liu G,Lu Q

更新日期：2019-05-17 00:00:00

abstract：:Resistant Starch (RS), plays a crucial role in human health and nutrition by controlling glucose metabolism. RS or dietary fibre content in rice is low because it goes through a variety of process before it is ready for cooking and consumption. Hence, this study was carried out to develop a rice mutant with increased ...

journal_title：Frontiers in genetics

authors： Gurunathan S,Ramadoss BR,Mudili V,Siddaiah C,Kalagatur NK,Bapu JRK,Mohan CD,Alqarawi AA,Hashem A,Abd Allah EF

更新日期：2019-11-15 00:00:00

abstract：:The formation mechanism underlying the blue eggshell characteristic has been discovered in birds, and SLCO1B3 is the key gene that regulates the blue eggshell color. Insertion of an endogenous retrovirus, EAV-HP, in the SLCO1B3 5' flanking region promotes SLCO1B3 expression in the chicken shell gland, and this express...

journal_title：Frontiers in genetics

authors： Li Z,Ren T,Li W,Zhou Y,Han R,Li H,Jiang R,Yan F,Sun G,Liu X,Tian Y,Kang X

更新日期：2019-02-26 00:00:00

abstract：:Obesity has become a major public health issue which is caused by a combination of genetic and environmental factors. Genome-wide DNA methylation studies have identified that DNA methylation at Cytosine-phosphate-Guanine (CpG) sites are associated with obesity. However, subsequent functional validation of the results ...

journal_title：Frontiers in genetics

authors： Guo Q,Zheng R,Huang J,He M,Wang Y,Guo Z,Sun L,Chen P

更新日期：2018-12-19 00:00:00

abstract：:Background: Genomic regions associated with divergent livestock feed efficiency have been found predominantly outside protein coding sequences. Long non-coding RNAs (lncRNA) can modulate chromatin accessibility, gene expression and act as important metabolic regulators in mammals. By integrating phenotypic, transcript...

journal_title：Frontiers in genetics

authors： Nolte W,Weikard R,Brunner RM,Albrecht E,Hammon HM,Reverter A,Kühn C

更新日期：2019-11-22 00:00:00

abstract：:The factors behind genome size evolution have been of great interest, considering that eukaryotic genomes vary in size by more than three orders of magnitude. Using a model of two wild peanut relatives, Arachis duranensis and Arachis ipaensis, in which one genome experienced large rearrangements, we find that the main...

journal_title：Frontiers in genetics

authors： Ren L,Huang W,Cannon EKS,Bertioli DJ,Cannon SB

更新日期：2018-10-09 00:00:00

abstract：OBJECTIVES:Using a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans. METHODS:  We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are mo...

journal_title：Frontiers in genetics

authors： Jacobs DI,Walsh KM,Wrensch M,Wiencke J,Jenkins R,Houlston RS,Bondy M,Simon M,Sanson M,Gousias K,Schramm J,Labussière M,Di Stefano AL,Wichmann HE,Müller-Nurasyid M,Schreiber S,Franke A,Moebus S,Eisele L,Dewan AT,Du

更新日期：2012-10-12 00:00:00

abstract：:HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry. It is reported that the HFE p.C282Y mutation is present in 1/10 people of northern European descent, resulting in one in two hundred people will be homozygous. However, the H...

journal_title：Frontiers in genetics

authors： Zhang W,Wang X,Duan W,Xu A,Zhao X,Huang J,You H,Brissot P,Ou X,Jia J

更新日期：2020-02-21 00:00:00

abstract：:Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla) is the primary cause of Phomopsis seed decay (PSD) in soybean, Glycine max (L.) Merrill. This disease results in poor seed quality and is one of the most economically important seed diseases in soybean. The objectives of this study were to infer protein-prot...

journal_title：Frontiers in genetics

authors： Li S,Musungu B,Lightfoot D,Ji P

更新日期：2018-04-03 00:00:00

abstract：:Binge drinking is a widespread problem linked to increased risk for alcohol-related complications, including development of alcohol use disorders. In the last decade, binge drinking has increased significantly, specifically in women. Clinically, sexually dimorphic effects of alcohol are well-characterized, however, th...

journal_title：Frontiers in genetics

authors： Rhinehart EM,Nentwig TB,Wilson DE,Leonard KT,Chaney BN,Grisel JE

更新日期：2018-11-29 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is one of the malignancies in women, which has the highest mortality. However, the microlevel mechanism has not been discussed in detail. The expression profiles GSE27651, GSE38666, GSE40595, and GSE66957 including 188 tumor and 52 nontumor samples were downloaded from the Gene Expressi...

journal_title：Frontiers in genetics

authors： Liu J,Meng H,Li S,Shen Y,Wang H,Shan W,Qiu J,Zhang J,Cheng W

更新日期：2019-10-24 00:00:00

abstract：:Organ size and architecture of plants are important traits affecting crop yield and agronomic practices. An induced mutant, multiple-organ gigantism (MOG), of black gram (Vigna mungo) has been obtained, which shows gigantic leaves, fruit, seed, and architecture (plant height) but lower number of pods per plant. These ...

journal_title：Frontiers in genetics

authors： Somta P,Chen J,Yimram T,Yundaeng C,Yuan X,Tomooka N,Chen X

更新日期：2020-06-30 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：BACKGROUND:Non-synonymous single-nucleotide polymorphisms (nsSNPs) within the coding regions of genes causing amino acid substitutions (AASs) may have a large impact on protein function. The possibilities to identify nsSNPs across genomes have increased notably with the advent of next-generation sequencing technologies...

journal_title：Frontiers in genetics

authors： Li X,Kierczak M,Shen X,Ahsan M,Carlborg O,Marklund S

更新日期：2013-03-06 00:00:00

abstract：:The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated an...

journal_title：Frontiers in genetics

authors： Kovina MV,Karnaukhov AV,Krasheninnikov ME,Kovin AL,Gazheev ST,Sergievich LA,Karnaukhova EV,Bogdanenko EV,Balyasin MV,Khodarovich YM,Dyuzheva TG,Lyundup AV

更新日期：2019-04-12 00:00:00

abstract：:Pharmacogenomics is the study of how genes affect a person's response to drugs. Thus, understanding the effect of drug at the molecular level can be helpful in both drug discovery and personalized medicine. Over the years, transcriptome data upon drug treatment has been collected and several databases compiled before ...

journal_title：Frontiers in genetics

authors： Oh M,Park S,Lee S,Lee D,Lim S,Jeong D,Jo K,Jung I,Kim S

更新日期：2020-11-12 00:00:00

abstract：:Hexavalent chromium [Cr(VI)] is a well-known occupational carcinogen, but the mechanisms contributing to DNA damage and cell cycle alternation have not been fully characterized. To study the dose-response effects of Cr(VI) on transcription, we exposed BEAS-2B cells to Cr(VI) at concentrations of 0.2, 0.6, and 1.8 μmol...

journal_title：Frontiers in genetics

authors： Zheng P,Kang Y,Han S,Feng H,Ha F,Long C,Zhou D,Hu G,Chen Z,Wang Z,Wang T,Jia G

更新日期：2021-01-13 00:00:00

abstract：:Homologous recombination (HR) is an evolutionarily conserved process that plays a pivotal role in the equilibrium between genetic stability and diversity. HR is commonly considered to be error-free, but several studies have shown that HR can be error-prone. Here, we discuss the actual accuracy of HR. First, we present...

journal_title：Frontiers in genetics

authors： Guirouilh-Barbat J,Lambert S,Bertrand P,Lopez BS

更新日期：2014-06-11 00:00:00

abstract：:In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element LINE-1, MEST, P16, H19, and GNAS in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quantitative DNA methyla...

journal_title：Frontiers in genetics

authors： Zhang W,Li M,Sun F,Xu X,Zhang Z,Liu J,Sun X,Zhang A,Shen Y,Xu J,Miao M,Wu B,Yuan Y,Huang X,Shi H,Du J

更新日期：2019-10-18 00:00:00

abstract：:Large-scale tumor genome sequencing projects have revealed a complex landscape of genomic mutations in multiple cancer types. A major goal of these projects is to characterize somatic mutations and discover cancer drivers, thereby providing important clues to uncover diagnostic or therapeutic targets for clinical trea...

journal_title：Frontiers in genetics

authors： Chen L,Miao Y,Liu M,Zeng Y,Gao Z,Peng D,Hu B,Li X,Zheng Y,Xue Y,Zuo Z,Xie Y,Ren J

更新日期：2018-07-17 00:00:00

abstract：:For datasets of gastric cancer collected by TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) repositories, we applied a bioinformatics approach to obtain expression data for the ISLR (immunoglobulin superfamily containing leucine-rich repeat) gene, which is highly expressed in gastric cancer tissues an...

journal_title：Frontiers in genetics

authors： Li S,Zhao W,Sun M

更新日期：2020-06-16 00:00:00

abstract：:The new class of rare variant tests has usually been evaluated assuming perfect genotype information. In reality, rare variant genotypes may be incorrect, and so rare variant tests should be robust to imperfect data. Errors and uncertainty in SNP genotyping are already known to dramatically impact statistical power fo...

journal_title：Frontiers in genetics

authors： Cook K,Benitez A,Fu C,Tintle N

更新日期：2014-04-01 00:00:00

abstract：:Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expression of genetic inform...

journal_title：Frontiers in genetics

authors： Ni Z,Zhou XY,Aslam S,Niu DK

更新日期：2019-12-04 00:00:00

abstract：:Sorting of individual chromosomes by Flow Cytometry (flow-sorting) is an enrichment method to potentially simplify genome assembly by isolating chromosomes from the context of the genome. We have recently developed a workflow to sequence native, unamplified DNA and applied it to the smallest human chromosome, the Y ch...

journal_title：Frontiers in genetics

authors： Kuderna LFK,Solís-Moruno M,Batlle-Masó L,Julià E,Lizano E,Anglada R,Ramírez E,Bote A,Tormo M,Marquès-Bonet T,Fornas Ò,Casals F

更新日期：2020-01-09 00:00:00

abstract：:A case-control study was used to explore the association between the methylation status in the promoter regions of the cGAS, MAVS, and TRAF3 genes and the diseases of cervical precancerous lesions (CPL) and cervical cancer (CC) in a Southern Chinese population, and to further explore their interaction effects with hig...

journal_title：Frontiers in genetics

authors： Huang S,Li R,Huang X,Zheng S,Wang L,Wen Z,Zou X,Wu J,Liu Y,Liu D,Wang Y,Dong S,Chen X,Zhu K,Du X,Zhou Z,Han Y,Ye X,Zeng C,Zhang B,Yang G,Jing C

更新日期：2019-11-14 00:00:00

abstract：:Drought alone or in combination with other stresses forms the major crop production constraint worldwide. Sorghum, one of the most important cereal crops is affected by drought alone or in combination with co-occurring stresses; notwithstanding, sorghum has evolved adaptive responses to combined stresses. Furthermore,...

journal_title：Frontiers in genetics

authors： Woldesemayat AA,Ntwasa M

更新日期：2018-11-20 00:00:00

abstract：:Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the development of biological markers. With this aim, several RNA-seq studies have been devoted to the characterization of the transcriptome of ejaculated spermatozoa in relation to sperm quality and fertility. Semen quality foll...

journal_title：Frontiers in genetics

authors： Gòdia M,Estill M,Castelló A,Balasch S,Rodríguez-Gil JE,Krawetz SA,Sánchez A,Clop A

更新日期：2019-04-16 00:00:00

abstract：:Various patterns of multi-phenotype associations (MPAs) exist in the results of Genome Wide Association Studies (GWAS) involving different topologies of single nucleotide polymorphism (SNP)-phenotype associations. These can provide interesting information about the different impacts of a gene on closely related phenot...

journal_title：Frontiers in genetics

authors： Weighill D,Jones P,Bleker C,Ranjan P,Shah M,Zhao N,Martin M,DiFazio S,Macaya-Sanz D,Schmutz J,Sreedasyam A,Tschaplinski T,Tuskan G,Jacobson D

更新日期：2019-05-10 00:00:00

abstract：:Mechanotransduction is an essential mechanism of transforming external mechanical stimulus to biochemical response. In cardiomyocytes mechanotransduction plays an important role in contraction, stretch sensing and homeostasis regulation. One of the major mechanosensitive area in cardiomyocytes, the Z-disk, consists of...

journal_title：Frontiers in genetics

authors： Knyazeva A,Krutikov A,Golovkin A,Mishanin A,Pavlov G,Smolina N,Hushkina A,Sejersen T,Sjoberg G,Galagudza M,Kostareva A

更新日期：2019-01-07 00:00:00

abstract：:Recent population declines to the high elevation western North America foundation species whitebark pine, have been driven by the synergistic effects of the invasive blister rust pathogen, mountain pine beetle (MPB), fire exclusion, and climate change. This has led to consideration for listing whitebark pine (WBP) as ...

journal_title：Frontiers in genetics

authors： Landguth EL,Holden ZA,Mahalovich MF,Cushman SA

更新日期：2017-02-10 00:00:00