Single Nucleotide Polymorphisms in Starch Biosynthetic Genes Associated With Increased Resistant Starch Concentration in Rice Mutant.

abstract：:Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavor, p...

journal_title：Frontiers in genetics

authors： Walker AJ,Ressurreição M,Rothermel R

更新日期：2014-07-31 00:00:00

abstract：:Cytotoxicity assays of immortalized lymphoblastoid cell lines (LCLs) represent a promising new in vitro approach in pharmacogenomics research. However, previous studies employing LCLs in gene mapping have used simple association methods, which may not adequately capture the true differences in non-linear response prof...

journal_title：Frontiers in genetics

authors： Brown C,Havener TM,Everitt L,McLeod H,Motsinger-Reif AA

更新日期：2011-12-14 00:00:00

abstract：:The primary cilium is able to maintain a specific protein composition, which is critical for its function as a signaling organelle. Here we introduce a system to synchronize biosynthetic trafficking of ciliary proteins that is based on conditional aggregation domains (CADs). This approach enables to create a wave of c...

journal_title：Frontiers in genetics

authors： Stroukov W,Rösch A,Schwan C,Jeney A,Römer W,Thuenauer R

更新日期：2019-03-08 00:00:00

abstract：:Cell secretion is an important physiological process that ensures smooth metabolic activities and tissue repair as well as growth and immunological functions in the body. Apocrine secretion occurs when the secretory process is accomplished with a partial loss of cell cytoplasm. The secretory materials are contained wi...

journal_title：Frontiers in genetics

authors： Ishikawa T,Toyoda Y,Yoshiura K,Niikawa N

更新日期：2013-01-02 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：:Glioblastoma, also called glioblastoma multiform (GBM), is the most aggressive cancer that initiates within the brain. GBM is produced in the central nervous system. Cancer cells in GBM are similar to stem cells. Several different schemes for GBM stratification exist. These schemes are based on intertumoral molecular ...

journal_title：Frontiers in genetics

authors： Zhang YH,Li Z,Zeng T,Pan X,Chen L,Liu D,Li H,Huang T,Cai YD

更新日期：2020-11-24 00:00:00

abstract：:Several authors have acknowledged that testing mediational hypotheses between treatments, genes, physiological measures, and behaviors may substantially advance our understanding of how these associations operate. In psychiatric research, the costs of measuring the putative mediator or the outcome can be prohibitive. ...

journal_title：Frontiers in genetics

authors： Makowsky R,Beasley TM,Gadbury GL,Albert JM,Kennedy RE,Allison DB

更新日期：2011-10-31 00:00:00

abstract：:A variety of statistical methods, such as admixture models, have been used to estimate genomic breed composition (GBC). These methods, however, tend to produce non-zero components to reference breeds that shared some genomic similarity with a test animal. These non-essential GBC components, in turn, offset the estimat...

journal_title：Frontiers in genetics

authors： Wang Y,Wu XL,Li Z,Bao Z,Tait RG Jr,Bauck S,Rosa GJM

更新日期：2020-06-11 00:00:00

abstract：:Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality, and reproductive efficiency. Natural mutat...

journal_title：Frontiers in genetics

authors： Tellam RL,Cockett NE,Vuocolo T,Bidwell CA

更新日期：2012-08-29 00:00:00

abstract：:Recently, an increasing number of studies sequence multiple biopsies of primary tumors, and even paired metastatic tumors to understand heterogeneity and the evolutionary trajectory of cancer progression. Although several algorithms are available to infer the phylogeny, most tools rely on accurate measurements of muta...

journal_title：Frontiers in genetics

authors： Wu P,Hou L,Zhang Y,Zhang L

更新日期：2020-02-07 00:00:00

abstract：:To gain a detailed understanding of how plant microbes evolve and adapt to hosts, pesticides, and other factors, knowledge of the population dynamics and evolutionary history of populations is crucial. Plant pathogen populations are often clonal or partially clonal which requires different analytical tools. With the a...

journal_title：Frontiers in genetics

authors： Kamvar ZN,Brooks JC,Grünwald NJ

更新日期：2015-06-10 00:00:00

abstract：:MicroRNAs (miRNAs) undergo high levels of regulation in skeletal muscle development and control skeletal muscle mass, function and metabolism over the lifespan. More recently, the role of long non-coding RNAs (lncRNAs) in skeletal muscle regulation has started to emerge. Following up on our recent study describing the...

journal_title：Frontiers in genetics

authors： Mikovic J,Sadler K,Butchart L,Voisin S,Gerlinger-Romero F,Della Gatta P,Grounds MD,Lamon S

更新日期：2018-11-16 00:00:00

abstract：:Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by a CGG-repeat expansion in the 5' UTR of the FMR1 gene on the X-chromosome. Both elevated levels of the expanded FMR1 mRNA and aberrant expression of a polyglycine protein (FMRpolyG) from the CGG-repeat region are hypothesized...

journal_title：Frontiers in genetics

authors： Hoem G,Bowitz Larsen K,Øvervatn A,Brech A,Lamark T,Sjøttem E,Johansen T

更新日期：2019-03-28 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common histological subtypes of renal cancer, with a poor prognosis. Our study aimed to identify a biomarker that is significantly associated with ccRCC prognosis and novel immunotherapeutic targets, as well as some novel molecular drugs for ccRCC. Based on th...

journal_title：Frontiers in genetics

authors： Xiao GF,Yan X,Chen Z,Zhang RJ,Liu TZ,Hu WL

更新日期：2020-08-18 00:00:00

abstract：:Technological advances over the past decade have unraveled the remarkable complexity of RNA. The identification of small peptides encoded by long non-coding RNAs (lncRNAs) as well as regulatory functions mediated by non-coding regions of mRNAs have further complicated our understanding of the multifaceted functions of...

journal_title：Frontiers in genetics

authors： Li J,Liu C

更新日期：2019-05-22 00:00:00

abstract：:Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the development of biological markers. With this aim, several RNA-seq studies have been devoted to the characterization of the transcriptome of ejaculated spermatozoa in relation to sperm quality and fertility. Semen quality foll...

journal_title：Frontiers in genetics

authors： Gòdia M,Estill M,Castelló A,Balasch S,Rodríguez-Gil JE,Krawetz SA,Sánchez A,Clop A

更新日期：2019-04-16 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in improving cancer prognostic, predictive, diagnostic and therapeutic approaches, they have become an area of intense research focus in recent yea...

journal_title：Frontiers in genetics

authors： Macharia LW,Wanjiru CM,Mureithi MW,Pereira CM,Ferrer VP,Moura-Neto V

更新日期：2019-02-20 00:00:00

abstract：:Livestock conservation practice is changing rapidly in light of policy developments, climate change and diversifying market demands. The last decade has seen a step change in technology and analytical approaches available to define, manage and conserve Farm Animal Genomic Resources (FAnGR). However, these rapid change...

journal_title：Frontiers in genetics

authors： Bruford MW,Ginja C,Hoffmann I,Joost S,Orozco-terWengel P,Alberto FJ,Amaral AJ,Barbato M,Biscarini F,Colli L,Costa M,Curik I,Duruz S,Ferenčaković M,Fischer D,Fitak R,Groeneveld LF,Hall SJ,Hanotte O,Hassan FU,Helsen

更新日期：2015-10-21 00:00:00

abstract：:I present here an in-depth, although non-exhaustive, review of two topics in molecular dating. Clock models, which describe the evolution of the rate of evolution, are considered first. Some of the shortcomings of popular approaches-uncorrelated clock models in particular-are presented and discussed. Autocorrelated mo...

journal_title：Frontiers in genetics

authors： Guindon S

更新日期：2020-05-27 00:00:00

abstract：:The unique structure of the X chromosome shaped by evolution has led to the present gender-specific genetic differences, which are not shared by its counterpart, the Y chromosome, and neither by the autosomes. In males, recombination between the X and Y chromosomes is limited to the pseudoautosomal regions, PAR1 and P...

journal_title：Frontiers in genetics

authors： Gomes I,Pinto N,Antão-Sousa S,Gomes V,Gusmão L,Amorim A

更新日期：2020-09-17 00:00:00

abstract：:It is broadly expected that next generation sequencing will ultimately generate a complete genome as is the latest goat reference genome (ARS1), which is considered to be one of the most continuous assemblies in livestock. However, the rich diversity of worldwide goat breeds indicates that a genome from one individual...

journal_title：Frontiers in genetics

authors： Li R,Fu W,Su R,Tian X,Du D,Zhao Y,Zheng Z,Chen Q,Gao S,Cai Y,Wang X,Li J,Jiang Y

更新日期：2019-11-15 00:00:00

abstract：:One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These ...

journal_title：Frontiers in genetics

authors： Fejes AP,Jones MJ,Kobor MS

更新日期：2014-09-18 00:00:00

abstract：:The development of whole-genome bisulfite sequencing (WGBS) has resulted in a number of exciting discoveries about the role of DNA methylation leading to a plethora of novel testable hypotheses. Methods for constructing sodium bisulfite-converted and amplified libraries have recently advanced to the point that the bot...

journal_title：Frontiers in genetics

authors： Ji L,Sasaki T,Sun X,Ma P,Lewis ZA,Schmitz RJ

更新日期：2014-10-21 00:00:00

abstract：:Fast growth is one of the most desired traits for all food animals, which affects the profitability of animal production. The Pacific oyster, Crassostrea gigas, is an important aquaculture shellfish around the world with the largest annual production. Growth of the Pacific oyster has been greatly improved by artificia...

journal_title：Frontiers in genetics

authors： Zhang F,Hu B,Fu H,Jiao Z,Li Q,Liu S

更新日期：2019-06-28 00:00:00

abstract：:Exosomes are biomolecular nanostructures released from cells. They carry specific biomolecular information and are mainly researched for their exquisite properties as a biomarker source and delivery system. We introduce exosomes in the context of other extracellular vesicles, describe their biophysical isolation and c...

journal_title：Frontiers in genetics

authors： de la Torre Gomez C,Goreham RV,Bech Serra JJ,Nann T,Kussmann M

更新日期：2018-03-27 00:00:00

abstract：:Muscle weakness is a common consequence of both aging (sarcopenia) and neuromuscular disorders (NMD). Whilst genome-wide association (GWA) studies have identified genetic variants associated with grip strength (GS; measure of muscle strength/weakness) and NMDs, including multiple sclerosis (MS), myasthenia gravis (MG)...

journal_title：Frontiers in genetics

authors： Gokuladhas S,Schierding W,Cameron-Smith D,Wake M,Scotter EL,O'Sullivan J

更新日期：2020-04-24 00:00:00

abstract：:The New England Centenarian Study (NECS) was founded in 1994 as a longitudinal study of centenarians to determine if centenarians could be a model of healthy human aging. Over time, the NECS along with other centenarian studies have demonstrated that the majority of centenarians markedly delay high mortality risk-asso...

journal_title：Frontiers in genetics

authors： Sebastiani P,Perls TT

更新日期：2012-11-30 00:00:00

abstract：:Two chaperonopathies have been linked to mutations in the human hsp60 (hHsp60; HSPD1) gene, but other existing variants might cause diseases, even if there is no comprehensive information about this possibility. To fill this vacuum, which might be at the basis of misdiagnoses or simply ignorance of chaperonopathies in...

journal_title：Frontiers in genetics

authors： Vitale AM,Conway de Macario E,Alessandro R,Cappello F,Macario AJL,Marino Gammazza A

更新日期：2020-08-18 00:00:00

abstract：:Communication disorders have complex genetic origins, with constellations of relevant gene markers that vary across individuals. Some genetic variants are present in healthy individuals as well as those affected by developmental disorders. Growing evidence suggests that some variants may increase susceptibility to the...

journal_title：Frontiers in genetics

authors： Centanni TM,Green JR,Iuzzini-Seigel J,Bartlett CW,Hogan TP

更新日期：2015-08-24 00:00:00