The aging-disease false dichotomy: understanding senescence as pathology.

abstract：:Purpose: The present study examines the role of Sox11 in the initial response of retinal ganglion cells (RGCs) to axon damage and in optic nerve regeneration in mouse. Methods: Markers of retinal injury were identified using the normal retina database and optic nerve crush (ONC) database on GeneNetwork2 (www.genenetwo...

journal_title：Frontiers in genetics

authors： Li Y,Struebing FL,Wang J,King R,Geisert EE

更新日期：2018-12-18 00:00:00

abstract：AIMS/HYPOTHESIS:Genome-wide association studies have identified over 50 new genetic loci for type 2 diabetes (T2D). Several studies conclude that higher dietary heme iron intake increases the risk of T2D. Therefore we assessed whether the relation between genetic loci and T2D is modified by dietary heme iron intake. M...

journal_title：Frontiers in genetics

authors： Pasquale LR,Loomis SJ,Aschard H,Kang JH,Cornelis MC,Qi L,Kraft P,Hu FB

更新日期：2013-01-30 00:00:00

abstract：:Erythropoiesis of human hematopoietic stem cells (HSCs) maintains generation of red blood cells throughout life. However, little is known how human erythropoiesis is regulated by long non-coding RNAs (lncRNAs). By using ChIRP-seq, we report here that the lncRNA steroid receptor RNA activator (SRA) occupies chromatin, ...

journal_title：Frontiers in genetics

authors： Sawaengdee W,Cui K,Zhao K,Hongeng S,Fucharoen S,Wongtrakoongate P

更新日期：2020-08-11 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures,...

journal_title：Frontiers in genetics

authors： Chen X,Han L,Yao H

更新日期：2020-04-17 00:00:00

abstract：:ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale. Although it is ubiqu...

journal_title：Frontiers in genetics

authors： Ye B,Yang G,Li Y,Zhang C,Wang Q,Yu G

更新日期：2020-04-07 00:00:00

abstract：:Human T-lymphotropic virus 1 (HTLV-1) was the first human retrovirus to be discovered and is the causative agent of adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The importance of microRNA (miRNA) in the replicative cycle of ...

journal_title：Frontiers in genetics

authors： Sampey GC,Van Duyne R,Currer R,Das R,Narayanan A,Kashanchi F

更新日期：2012-12-17 00:00:00

abstract：:Recently, cancer has been characterized as a heterogeneous disease composed of many different subtypes. Early diagnosis of cancer subtypes is an important study of cancer research, which can be of tremendous help to patients after treatment. In this paper, we first extract a novel dataset, which contains gene expressi...

journal_title：Frontiers in genetics

authors： Li S,Jiang L,Tang J,Gao N,Guo F

更新日期：2020-09-10 00:00:00

abstract：:I present here an in-depth, although non-exhaustive, review of two topics in molecular dating. Clock models, which describe the evolution of the rate of evolution, are considered first. Some of the shortcomings of popular approaches-uncorrelated clock models in particular-are presented and discussed. Autocorrelated mo...

journal_title：Frontiers in genetics

authors： Guindon S

更新日期：2020-05-27 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:Amphibians are important vertebrates in toxicology often representing both aquatic and terrestrial forms within the life history of the same species. Of the thousands of species, only two have substantial genomics resources: the recently published genome of the Pipid, Xenopus (Silurana) tropicalis, and transcript info...

journal_title：Frontiers in genetics

authors： Helbing CC

更新日期：2012-03-14 00:00:00

abstract：:Carcass weight, meat quality and muscle components are important traits economically and they underpin most of the commercial return to goat producers. In this study, the Longissimus dorsi muscle tissues were collected from five Liaoning cashmere (LC) goats and five Ziwuling black (ZB) goats with phenotypic difference...

journal_title：Frontiers in genetics

authors： Shen J,Hao Z,Wang J,Hu J,Liu X,Li S,Ke N,Song Y,Lu Y,Hu L,Qiao L,Wu X,Luo Y

更新日期：2021-01-13 00:00:00

abstract：:In recent years, miRNAs have been verified to play an irreplaceable role in biological processes associated with human disease. Discovering potential disease-related miRNAs helps explain the underlying pathogenesis of the disease at the molecular level. Given the high cost and labor intensity of biological experiments...

journal_title：Frontiers in genetics

authors： Xu J,Cai L,Liao B,Zhu W,Wang P,Meng Y,Lang J,Tian G,Yang J

更新日期：2019-12-11 00:00:00

abstract：:Recent studies have revealed that the RNA N6-methyladenosine (m6A) modification plays a critical role in a variety of biological processes and associated with multiple diseases including cancers. Till this day, transcriptome-wide m6A RNA methylation sites have been identified by high-throughput sequencing technique co...

journal_title：Frontiers in genetics

authors： Tang Y,Chen K,Wu X,Wei Z,Zhang SY,Song B,Zhang SW,Huang Y,Meng J

更新日期：2019-04-03 00:00:00

abstract：:Shotgun metagenomics has greatly advanced our understanding of microbial communities over the last decade. Metagenomic analyses often include assembly and genome binning, computationally daunting tasks especially for big data from complex environments such as soil and sediments. In many studies, however, only a subset...

journal_title：Frontiers in genetics

authors： Guo J,Quensen JF,Sun Y,Wang Q,Brown CT,Cole JR,Tiedje JM

更新日期：2019-10-15 00:00:00

abstract：:Cereals are a staple food for many people around the world; however, they are also a major dietary source of toxic metal(loid)s. Many agricultural regions throughout the world are contaminated with toxic metal(loid)s, which can accumulate to high levels in the grains of cereals cultivated in these regions, posing seri...

journal_title：Frontiers in genetics

authors： Deng F,Yu M,Martinoia E,Song WY

更新日期：2019-04-09 00:00:00

abstract：:The comet assay is a simple and cost effective technique, commonly used to analyze and quantify DNA damage in individual cells. The versatility of the comet assay allows introduction of various modifications to the basic technique. The difference in the methylation sensitivity of the isoschizomeric restriction enzymes...

journal_title：Frontiers in genetics

authors： Lewies A,Van Dyk E,Wentzel JF,Pretorius PJ

更新日期：2014-07-07 00:00:00

abstract：:Fragile X-associated primary ovarian insufficiency (FXPOI) occurs in about 20% of women who carry a premutation allele (55-200 CGG repeats). These women develop hypergonadotropic hypogonadism and have secondary amenorrhea before age 40. A non-linear association with repeat size and risk for FXPOI has been seen in mult...

journal_title：Frontiers in genetics

authors： Allen EG,Glicksman A,Tortora N,Charen K,He W,Amin A,Hipp H,Shubeck L,Nolin SL,Sherman SL

更新日期：2018-08-03 00:00:00

abstract：:Software which simulates, infers, or analyzes ancestral recombination graphs (ARGs) faces the problem of communicating them. Existing formats omit information either about the location of recombinations along the chromosome or the position of recombinations relative to the branching topology. We present a specializati...

journal_title：Frontiers in genetics

authors： McGill JR,Walkup EA,Kuhner MK

更新日期：2013-08-07 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. They are aberrantly expressed in many human cancers and are potential therapeutic targets and molecular biomarkers. METHODS:In this study, we for the first time validated the reported data on the entire set of published differential...

journal_title：Frontiers in genetics

authors： Zabolotneva AA,Zhavoronkov AA,Shegay PV,Gaifullin NM,Alekseev BY,Roumiantsev SA,Garazha AV,Kovalchuk O,Aravin A,Buzdin AA

更新日期：2013-11-15 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fgene.2018.00657.]. ...

journal_title：Frontiers in genetics

authors： Cheng L,Zhuang H,Yang S,Jiang H,Wang S,Zhang J

更新日期：2019-02-18 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are recognized as an important class of regulatory molecules involved in a variety of biological functions. However, the regulatory mechanisms of long non-coding genes expression are still poorly understood. The characterization of the genomic features of lncRNAs is crucial to get insigh...

journal_title：Frontiers in genetics

authors： Abou Alezz M,Celli L,Belotti G,Lisa A,Bione S

更新日期：2020-05-15 00:00:00

abstract：:The aging brain undergoes a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons and circuits due to age-associated neurodegenerativ...

journal_title：Frontiers in genetics

authors： Hermann PM,Watson SN,Wildering WC

更新日期：2014-12-04 00:00:00

abstract：:Transcriptomics technologies such as next-generation sequencing and microarray platforms provide exciting opportunities for improving diagnosis and treatment of complex diseases. Transcriptomics studies often share similar hypotheses, but are carried out on different platforms, in different conditions, and with differ...

journal_title：Frontiers in genetics

authors： Wu C,Huang BE,Chen G,Lovenberg TW,Pocalyko DJ,Yao X

更新日期：2019-04-30 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNA molecules that play key regulatory roles in cancer acting as both oncogenes and tumor suppressors. Due to their potential roles in improving cancer prognostic, predictive, diagnostic and therapeutic approaches, they have become an area of intense research focus in recent yea...

journal_title：Frontiers in genetics

authors： Macharia LW,Wanjiru CM,Mureithi MW,Pereira CM,Ferrer VP,Moura-Neto V

更新日期：2019-02-20 00:00:00

abstract：:Through linkage and candidate gene screening, many breast cancer (BC) predisposition genes have been identified in the past 20 years. However, the majority of genetic risks that contribute to familial BC remains undetermined. In this study, we revisited whole exome sequencing datasets from non-BRCA1/2 familial BC pati...

journal_title：Frontiers in genetics

authors： Yin J,Wu K,Ma Q,Dong H,Zhu Y,Hu L,Kong X

更新日期：2019-06-04 00:00:00

abstract：:The genetic predisposition to chronic kidney disease (CKD) has been widely evaluated especially using the genome-wide association studies, which highlighted some novel genetic susceptibility variants in many genes, and estimated glomerular filtration rate to diagnose and stage CKD. Of these variants, rs7805747 in PRKA...

journal_title：Frontiers in genetics

authors： Wang E,Zhao H,Zhao D,Li L,Du L

更新日期：2018-12-03 00:00:00

abstract：Background:Cross-sectional observational studies have reported obesity and cardiometabolic co-morbidities as important predictors of coronavirus disease 2019 (COVID-19) hospitalization. The causal impact of these risk factors is unknown at present. Methods:We conducted multivariable logistic regression to evaluate the...

journal_title：Frontiers in genetics

authors： Aung N,Khanji MY,Munroe PB,Petersen SE

更新日期：2020-11-11 00:00:00