Bioinformatics Analysis of Actin Molecules: Why Quantity Does Not Translate Into Quality?

abstract：:Habitat loss and the illegal exploitation of natural resources are among the main drivers of species extinction around the world. These disturbances act at different scales, once changes in the landscape composition and configuration operate at large scales and exploitation of natural resources at local scales. Eviden...

journal_title：Frontiers in genetics

authors： Soares LASS,Cazetta E,Santos LR,França DS,Gaiotto FA

更新日期：2019-11-07 00:00:00

abstract：:The aging of the population represents one of the largest healthcare challenges facing the world today. The available scientific evidence shows that interventions are available now that can target fundamental "aging" processes or pathways. Sufficient economic evidence is available to argue convincingly that this appro...

journal_title：Frontiers in genetics

authors： Faragher RG

更新日期：2015-07-14 00:00:00

abstract：:The termites evolved eusociality and complex societies before the ants, but have been studied much less. The recent publication of the first two termite genomes provides a unique comparative opportunity, particularly because the sequenced termites represent opposite ends of the social complexity spectrum. Zootermopsis...

journal_title：Frontiers in genetics

authors： Korb J,Poulsen M,Hu H,Li C,Boomsma JJ,Zhang G,Liebig J

更新日期：2015-03-04 00:00:00

abstract：UNLABELLED:The PIMMS (Pragmatic Insertional Mutation Mapping System) pipeline has been developed for simple conditionally essential genome discovery experiments in bacteria. Capable of using raw sequence data files alongside a FASTA sequence of the reference genome and GFF file, PIMMS will generate a tabulated output o...

journal_title：Frontiers in genetics

authors： Blanchard AM,Leigh JA,Egan SA,Emes RD

更新日期：2015-04-09 00:00:00

abstract：:A rapidly increasing number of reports on dysregulated long intergenic non-coding RNA (lincRNA) expression across numerous types of cancers indicates that aberrant lincRNA expression may be a major contributor to tumorigenesis. Marek's disease (MD) is a T cell lymphoma of chickens induced by Marek's disease virus (MDV...

journal_title：Frontiers in genetics

authors： He Y,Han B,Ding Y,Zhang H,Chang S,Zhang L,Zhao C,Yang N,Song J

更新日期：2019-11-14 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in genera...

journal_title：Frontiers in genetics

authors： Hankey W,Zanghi N,Crow MM,Dow WH,Kratz A,Robinson AM,Robinson MR,Segarra VA

更新日期：2020-12-16 00:00:00

abstract：:The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning properties of basilar membrane. We present the current evidence supporting...

journal_title：Frontiers in genetics

authors： Booth KT,Azaiez H,Jahan I,Smith RJH,Fritzsch B

更新日期：2018-05-08 00:00:00

abstract：:Inverted repeat (IR) regions in the plastomes from land plants induce homologous recombination, generating isomeric plastomes. While the plastomes of Taxaceae species often lose one of the IR regions, considerable isomeric plastomes were created in Taxaceae species with a hitherto unclarified mechanism. To investigate...

journal_title：Frontiers in genetics

authors： Zhang Y,Xu Y,Chen H,Wang L,Yin K,Du FK

更新日期：2020-01-14 00:00:00

abstract：:From a biological perspective aging (senescence) appears to be a form of complex disease syndrome, though this is not the traditional view. This essay aims to foster a realistic understanding of aging by scrutinizing ideas old and new. The conceptual division between aging-related diseases and an underlying, non-patho...

journal_title：Frontiers in genetics

authors： Gems D

更新日期：2015-06-16 00:00:00

abstract：:Keratinocyte differentiation requires intricately coordinated spatiotemporal expression changes that specify epidermis structure and function. This article utilizes single-cell RNA-seq data from 22,338 human foreskin keratinocytes to reconstruct the transcriptional regulation of skin development and homeostasis genes,...

journal_title：Frontiers in genetics

authors： Finnegan A,Cho RJ,Luu A,Harirchian P,Lee J,Cheng JB,Song JS

更新日期：2019-09-03 00:00:00

abstract：:Through linkage and candidate gene screening, many breast cancer (BC) predisposition genes have been identified in the past 20 years. However, the majority of genetic risks that contribute to familial BC remains undetermined. In this study, we revisited whole exome sequencing datasets from non-BRCA1/2 familial BC pati...

journal_title：Frontiers in genetics

authors： Yin J,Wu K,Ma Q,Dong H,Zhu Y,Hu L,Kong X

更新日期：2019-06-04 00:00:00

abstract：:Cyprinids are the most important group of farmed fish globally in terms of production volume, with common carp (Cyprinus carpio) being one of the most valuable species of the group. The use of modern selective breeding methods in carp is at a formative stage, implying a large scope for genetic improvement of key produ...

journal_title：Frontiers in genetics

authors： Palaiokostas C,Kocour M,Prchal M,Houston RD

更新日期：2018-03-13 00:00:00

abstract：:The aging brain undergoes a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons and circuits due to age-associated neurodegenerativ...

journal_title：Frontiers in genetics

authors： Hermann PM,Watson SN,Wildering WC

更新日期：2014-12-04 00:00:00

abstract：:Liver is the main organ of lipid metabolism in chicken, especially for laying hens. To explore the molecular mechanism of lipid metabolism in chicken, five novel genes discovered in chicken liver tissue were systematically studied. Bioinformatic analysis was used to analyze the gene characteristics. The expression pat...

journal_title：Frontiers in genetics

authors： Li H,Li Y,Yang L,Zhang D,Liu Z,Wang Y,Han R,Li G,Li Z,Tian Y,Kang X,Liu X

更新日期：2020-03-31 00:00:00

abstract：:A biochemical activity, that is, enzymatic reaction or molecular interaction, frequently involves a molecule, for example, an enzyme, capable of interacting with numerous substrates or partners. Specificity is a fundamental property of biochemical activities, and relative specificity refers to the situation whereby a ...

journal_title：Frontiers in genetics

authors： Zeng Y

更新日期：2011-09-20 00:00:00

abstract：:The genetic diversity of the sheep breeds in the Arab countries might be considered to be a mirror of the ecology of the region. In this study, the genetic structure and diversity of sheep breeds from Saudi Arabia (Harri, Najdi, Naemi, Arb, and Rufidi) and Awassi sheep from Jordan as an out-group were investigated usi...

journal_title：Frontiers in genetics

authors： Al-Atiyat RM,Aljumaah RS,Alshaikh MA,Abudabos AM

更新日期：2018-09-25 00:00:00

abstract：:While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In ...

journal_title：Frontiers in genetics

authors： Marshall JM,Raban RR,Kandul NP,Edula JR,León TM,Akbari OS

更新日期：2019-10-30 00:00:00

abstract：:Late blight of potato (Solanum tuberosum L.) caused by the oomycete Phytophthora infestans (Mont.) de Bary, is one of the most important bottlenecks of potato production worldwide. Cultivars with high levels of durable, race unspecific, quantitative resistance are part of a solution to this problem. However, breeding ...

journal_title：Frontiers in genetics

authors： Muktar MS,Lübeck J,Strahwald J,Gebhardt C

更新日期：2015-09-23 00:00:00

abstract：:Recruitment of diverse populations and subjects living in Medically Underserved Areas and Populations (MUA/P's) into clinical trials is a considerable challenge. Likewise, representation of African-Americans in pharmacogenetic trials is often inadequate, but critical for identifying genetic variation within and betwee...

journal_title：Frontiers in genetics

authors： Shah-Williams E,Levy KD,Zang Y,Holmes AM,Stoughton C,Dexter P,Skaar TC

更新日期：2020-06-25 00:00:00

abstract：Background:This study aimed to investigate the genetic causes of hypohidrotic ectodermal dysplasia (HED) in two families and elucidate the molecular pathogenesis of HED in Chinese Han patients. Methods:Whole-exome sequencing (WES) was used to screen HED-related genes in two family members, followed by confirmatory San...

journal_title：Frontiers in genetics

authors： Han Y,Wang X,Zheng L,Zhu T,Li Y,Hong J,Xu C,Wang P,Gao M

更新日期：2020-02-04 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC). Patients diagnosed with EGFR-mutant NSCLC have good initial clinical response to EGFR tyrosine kinase inhibitors (EGFR TKIs), yet tumor rec...

journal_title：Frontiers in genetics

authors： Shaurova T,Zhang L,Goodrich DW,Hershberger PA

更新日期：2020-03-27 00:00:00

abstract：:For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challe...

journal_title：Frontiers in genetics

authors： Mamoshina P,Volosnikova M,Ozerov IV,Putin E,Skibina E,Cortese F,Zhavoronkov A

更新日期：2018-07-12 00:00:00

abstract：:Inference of absolute copy numbers in tumor genomes is one of the key points in the study of tumor genesis. However, the mixture of tumor and normal cells poses a big challenge to this task. Accurate estimation of tumor purity (i.e., the fraction of tumor cells) is a necessary step to solve this problem. In this paper...

journal_title：Frontiers in genetics

authors： Yuan X,Li Z,Zhao H,Bai J,Zhang J

更新日期：2020-04-30 00:00:00

abstract：:Mesopelagic fish are largely abundant poorly studied fish that are still intact, but which, due to their potentially great added value, will be imminently exploited by humans. Therefore, studies that provide information to anticipate the anthropogenic impact on this important resource are urgently needed. In particula...

journal_title：Frontiers in genetics

authors： Rodriguez-Ezpeleta N,Álvarez P,Irigoien X

更新日期：2017-11-28 00:00:00

abstract：:Transcription is a tightly regulated process ensuring the proper expression of numerous genes regulating all aspects of cellular behavior. Transcription factors regulate multiple genes including other transcription factors that together control a highly complex gene network. The transcriptional machinery can be "hijac...

journal_title：Frontiers in genetics

authors： Faridi F,Ponnusamy K,Quagliano-Lo Coco I,Chen-Wichmann L,Grez M,Henschler R,Wichmann C

更新日期：2013-11-28 00:00:00

abstract：:Recent population declines to the high elevation western North America foundation species whitebark pine, have been driven by the synergistic effects of the invasive blister rust pathogen, mountain pine beetle (MPB), fire exclusion, and climate change. This has led to consideration for listing whitebark pine (WBP) as ...

journal_title：Frontiers in genetics

authors： Landguth EL,Holden ZA,Mahalovich MF,Cushman SA

更新日期：2017-02-10 00:00:00

abstract：:Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavor, p...

journal_title：Frontiers in genetics

authors： Walker AJ,Ressurreição M,Rothermel R

更新日期：2014-07-31 00:00:00

abstract：:The Xichuan black-bone chicken, which is a rare local chicken species in China, is an important genetic resource of black-bone chickens. Tyrosine can affect melanin production, but the molecular mechanism underlying tyrosine-induced melanin deposition in Xichuan black-bone chickens is poorly understood. Here, the blac...

journal_title：Frontiers in genetics

authors： Li D,Wang X,Fu Y,Zhang C,Cao Y,Wang J,Zhang Y,Li Y,Chen Y,Li Z,Li W,Jiang R,Sun G,Tian Y,Li G,Kang X

更新日期：2019-05-15 00:00:00