Single-Cell Transcriptomics Reveals Spatial and Temporal Turnover of Keratinocyte Differentiation Regulators.

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00

abstract：:Across species and tissues and especially in the mammalian brain, production of gene isoforms is widespread. While gene expression coordination has been previously described as a scale-free coexpression network, the properties of transcriptome-wide isoform production coordination have been less studied. Here we evalua...

journal_title：Frontiers in genetics

authors： Iancu OD,Colville A,Oberbeck D,Darakjian P,McWeeney SK,Hitzemann R

更新日期：2015-05-13 00:00:00

abstract：:Gene copy-number differences due to gene duplications and deletions are rampant in natural populations and play a crucial role in the evolution of genome complexity. Per-locus analyses of gene duplication rates in the pre-genomic era revealed that gene duplication rates are much higher than the per nucleotide substitu...

journal_title：Frontiers in genetics

authors： Katju V,Bergthorsson U

更新日期：2013-12-10 00:00:00

abstract：:Myiopsitta monachus is a small Neotropical parrot (Psittaciformes: Arini Tribe) from subtropical and temperate regions of South America. It has a diploid chromosome number 2n = 48, different from other members of the Arini Tribe that have usually 70 chromosomes. The species has the lowest 2n within the Arini Tribe. In...

journal_title：Frontiers in genetics

authors： Furo IO,Kretschmer R,O'Brien PC,Pereira JC,Garnero ADV,Gunski RJ,O'Connor RE,Griffin DK,Gomes AJB,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-07-10 00:00:00

abstract：:RNA binding proteins (RBPs) play a key role in post-transcriptional gene regulation. They have been shown to be dysfunctional in a variety of cancers and are closely related to the occurrence and progression of cancers. However, the biological function and clinical significance of RBPs in clear cell renal carcinoma (c...

journal_title：Frontiers in genetics

authors： Wu Y,Wei X,Feng H,Hu B,Liu B,Luan Y,Ruan Y,Liu X,Liu Z,Wang S,Liu J,Wang T

更新日期：2021-01-07 00:00:00

abstract：:[This corrects the article on p. 23 in vol. 9, PMID: 29456554.]. ...

journal_title：Frontiers in genetics

authors： Yang L,Banerjee S,Cao J,Bai X,Peng Z,Chen H,Huang H,Han P,Feng S,Yi N,Song X,Wu J

更新日期：2018-04-04 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：:Human T-lymphotropic virus 1 (HTLV-1) was the first human retrovirus to be discovered and is the causative agent of adult T-cell leukemia/lymphoma (ATL) and the neurodegenerative disease HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The importance of microRNA (miRNA) in the replicative cycle of ...

journal_title：Frontiers in genetics

authors： Sampey GC,Van Duyne R,Currer R,Das R,Narayanan A,Kashanchi F

更新日期：2012-12-17 00:00:00

abstract：:The genetic resources available for the commercially important fish species Yellowtail kingfish (YTK) (Seriola lalandi) are relative sparse. To overcome this, we aimed (1) to develop a linkage map for this species, and (2) to identify markers/variants associated with economically important traits in kingfish (with an ...

journal_title：Frontiers in genetics

authors： Nguyen NH,Rastas PMA,Premachandra HKA,Knibb W

更新日期：2018-04-17 00:00:00

abstract：:Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways. Elucidating shared biologic processes and overlapping gene networks will help to bett...

journal_title：Frontiers in genetics

authors： Funderburk KM,Auerbach SS,Bushel PR

更新日期：2017-10-24 00:00:00

abstract：:Respiratory burst oxidase homologs (Rbohs) play a predominant role in reactive oxygen species (ROS) production, which is crucial in plant growth, differentiation, as well as their responses to biotic and abiotic stresses. To date, however, there is little knowledge about the function of cotton Rboh genes. Here, we ide...

journal_title：Frontiers in genetics

authors： Chang Y,Li B,Shi Q,Geng R,Geng S,Liu J,Zhang Y,Cai Y

更新日期：2020-09-11 00:00:00

abstract：:Production animals are constantly subjected to early adverse environmental conditions that influence the adult phenotype and produce epigenetic effects. CpG dinucleotide methylation in red blood cells (RBC) could be a useful epigenetic biomarker to identify animals subjected to chronic stress in the production environ...

journal_title：Frontiers in genetics

authors： Pértille F,Ibelli AMG,Sharif ME,Poleti MD,Fröhlich AS,Rezaei S,Ledur MC,Jensen P,Guerrero-Bosagna C,Coutinho LL

更新日期：2020-11-02 00:00:00

abstract：UNLABELLED:The PIMMS (Pragmatic Insertional Mutation Mapping System) pipeline has been developed for simple conditionally essential genome discovery experiments in bacteria. Capable of using raw sequence data files alongside a FASTA sequence of the reference genome and GFF file, PIMMS will generate a tabulated output o...

journal_title：Frontiers in genetics

authors： Blanchard AM,Leigh JA,Egan SA,Emes RD

更新日期：2015-04-09 00:00:00

abstract：:Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child a...

journal_title：Frontiers in genetics

authors： Logan PC,Mitchell MD,Lobie PE

更新日期：2013-12-04 00:00:00

abstract：:Commensal gut bacteria in many species including flies are integral part of their host, and are known to influence its development and homeostasis within generation. Here we report an unexpected impact of host-microbe interactions, which mediates multi-generational, non-Mendelian inheritance of a stress-induced phenot...

journal_title：Frontiers in genetics

authors： Fridmann-Sirkis Y,Stern S,Elgart M,Galili M,Zeisel A,Shental N,Soen Y

更新日期：2014-02-25 00:00:00

abstract：:Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a single network, which results in important temporal- or context-re...

journal_title：Frontiers in genetics

authors： Yu L,Yao S,Gao L,Zha Y

更新日期：2019-01-18 00:00:00

abstract：:Quantitative traits are usually controlled by numerous genomic variants with small individual effects, and variances associated with those traits are explained in a continuous manner. However, the relative contributions of genomic regions to observed genetic variations have not been well explored using sequence level ...

journal_title：Frontiers in genetics

authors： Bhuiyan MSA,Lim D,Park M,Lee S,Kim Y,Gondro C,Park B,Lee S

更新日期：2018-06-22 00:00:00

abstract：:Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotation of allelic imbalance and infer the existence of cis-acting transcr...

journal_title：Frontiers in genetics

authors： Salavati M,Bush SJ,Palma-Vera S,McCulloch MEB,Hume DA,Clark EL

更新日期：2019-09-19 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:Late blight of potato (Solanum tuberosum L.) caused by the oomycete Phytophthora infestans (Mont.) de Bary, is one of the most important bottlenecks of potato production worldwide. Cultivars with high levels of durable, race unspecific, quantitative resistance are part of a solution to this problem. However, breeding ...

journal_title：Frontiers in genetics

authors： Muktar MS,Lübeck J,Strahwald J,Gebhardt C

更新日期：2015-09-23 00:00:00

abstract：:RNA is a unique bio-macromolecule that can both record genetic information and perform biological functions in a variety of molecular processes, including transcription, splicing, translation, and even regulating protein function. RNAs adopt specific three-dimensional conformations to enable their functions. Experimen...

journal_title：Frontiers in genetics

authors： Li B,Cao Y,Westhof E,Miao Z

更新日期：2020-10-26 00:00:00

abstract：:Understanding the processes that cause speciation is a key aim of evolutionary biology. Lineages or biomes that exhibit recent and rapid diversification are ideal model systems for determining these processes. Species rich biomes reported to be of relatively recent origin, i.e., since the beginning of the Miocene, inc...

journal_title：Frontiers in genetics

authors： Madriñán S,Cortés AJ,Richardson JE

更新日期：2013-10-09 00:00:00

abstract：:Recent studies have revealed that the RNA N6-methyladenosine (m6A) modification plays a critical role in a variety of biological processes and associated with multiple diseases including cancers. Till this day, transcriptome-wide m6A RNA methylation sites have been identified by high-throughput sequencing technique co...

journal_title：Frontiers in genetics

authors： Tang Y,Chen K,Wu X,Wei Z,Zhang SY,Song B,Zhang SW,Huang Y,Meng J

更新日期：2019-04-03 00:00:00

abstract：:Human exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic ...

journal_title：Frontiers in genetics

authors： Arrifano GPF,Martín-Doimeadios RCR,Jiménez-Moreno M,Fernández-Trujillo S,Augusto-Oliveira M,Souza-Monteiro JR,Macchi BM,Alvarez-Leite JI,do Nascimento JLM,Amador MT,Santos S,Ribeiro-Dos-Santos Â,Silva-Pereira LC,Oriá RB,Cresp

更新日期：2018-07-27 00:00:00

abstract：:Several cyanobacterial species are dominant primary producers in hot spring microbial mats. To date, hot spring cyanobacterial taxonomy, as well as the evolution of their genomic adaptations to high temperatures, are poorly understood, with genomic information currently available for only a few dominant genera, includ...

journal_title：Frontiers in genetics

authors： Alcorta J,Alarcón-Schumacher T,Salgado O,Díez B

更新日期：2020-11-05 00:00:00

abstract：:Background: The aim of this study was to explore the Human Papillomavirus (HPV) genotype composition and intra-genotype variants within individual samples of low- and high-grade cervical cytology by deep sequencing. Clinical, cytological, sequencing, and functional/structural data were forged into an integrated varian...

journal_title：Frontiers in genetics

authors： Shen-Gunther J,Cai H,Zhang H,Wang Y

更新日期：2019-05-24 00:00:00

abstract：:The Apelin (APLN)/apelin receptor (APLNR) signaling pathway is a newly identified regulator in various cardiovascular diseases, which is considered as a candidate pathway for the occurrence of coronary heart disease (CHD), depression, and anxiety. The goal of this study was to investigate the association between APLN/...

journal_title：Frontiers in genetics

authors： Wang Y,Liu W,Xiao Y,Yuan H,Wang F,Jiang P,Luo Z

更新日期：2020-08-11 00:00:00

abstract：:The increased feasibility of whole-genome (or whole-exome) sequencing has led to renewed interest in using family data to find disease mutations. For clinical phenotypes that lend themselves to study in large families, this approach can be particularly effective, because it may be possible to obtain strong evidence of...

journal_title：Frontiers in genetics

authors： Huang Y,Thomas A,Vieland VJ

更新日期：2013-04-19 00:00:00

abstract：:Sufficient genetic variation in livestock populations is necessary both for adaptation to future changes in climate and consumer demand, and for continual genetic improvement of economically important traits. Unfortunately, the current trend is for reduced genetic variation, both within and across breeds. The latter o...

journal_title：Frontiers in genetics

authors： Biscarini F,Nicolazzi EL,Stella A,Boettcher PJ,Gandini G

更新日期：2015-02-25 00:00:00

abstract：:Usher type 1 syndrome is a rare autosomal recessive disorder involving congenital severe-to-profound hearing loss, development of vision impairment in the first decade, and severe balance difficulties. The PCDH15 gene, one of the five genes implicated in this disease, is involved in 8-20% of cases. In this study, we a...

journal_title：Frontiers in genetics

authors： Vaché C,Puechberty J,Faugère V,Darmaisin F,Liquori A,Baux D,Blanchet C,Garcia-Garcia G,Meunier I,Pellestor F,Koenig M,Roux AF

更新日期：2020-07-02 00:00:00