Delayed development induced by toxicity to the host can be inherited by a bacterial-dependent, transgenerational effect.

abstract：:In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory. We propose a strategy to employ the theoretical concept of UICC TNM classification in CRC. To reveal the critical transition of CRC, the DN...

journal_title：Frontiers in genetics

authors： Tong Y,Song Y,Xia C,Deng S

更新日期：2020-10-20 00:00:00

abstract：:HFE-related Hemochromatosis is the most common genetic iron overload disease in European populations, particularly of Nordic or Celtic ancestry. It is reported that the HFE p.C282Y mutation is present in 1/10 people of northern European descent, resulting in one in two hundred people will be homozygous. However, the H...

journal_title：Frontiers in genetics

authors： Zhang W,Wang X,Duan W,Xu A,Zhao X,Huang J,You H,Brissot P,Ou X,Jia J

更新日期：2020-02-21 00:00:00

abstract：Background:Recent evidence has indicated that long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to modulate mRNAs expression by sponging microRNAs (miRNAs). However, the specific mechanism and function of lncRNA-miRNA-mRNA regulatory network in non-small cell lung cancer (NSCLC) remains ...

journal_title：Frontiers in genetics

authors： Wang M,Zheng S,Li X,Ding Y,Zhang M,Lin L,Xu H,Cheng Y,Zhang X,Xu H,Li S

更新日期：2020-09-18 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：:The adaptation of the yeast Saccharomyces cerevisiae to man-made environments for the fermentation of foodstuffs and beverages illustrates the scientific, social, and economic relevance of microbe domestication. Here we address a yet unexplored aspect of S. cerevisiae domestication, that of the emergence of lineages h...

journal_title：Frontiers in genetics

authors： Pontes A,Čadež N,Gonçalves P,Sampaio JP

更新日期：2019-05-29 00:00:00

abstract：:The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinc...

journal_title：Frontiers in genetics

authors： Palstra RJ,Grosveld F

更新日期：2012-09-28 00:00:00

abstract：:It is believed that recombination in meiosis serves to reshuffle genetic material from both parents to increase genetic variation in the progeny. At the same time, the number of crossovers is usually kept at a very low level. As a consequence, many organisms need to make the best possible use from the one or two cross...

journal_title：Frontiers in genetics

authors： Dluzewska J,Szymanska M,Ziolkowski PA

更新日期：2018-12-12 00:00:00

abstract：:Assortative mating is a universal feature of human societies, and individuals from ethnically diverse populations are known to mate assortatively based on similarities in genetic ancestry. However, little is currently known regarding the exact phenotypic cues, or their underlying genetic architecture, which inform anc...

journal_title：Frontiers in genetics

authors： Norris ET,Rishishwar L,Wang L,Conley AB,Chande AT,Dabrowski AM,Valderrama-Aguirre A,Jordan IK

更新日期：2019-04-24 00:00:00

abstract：:Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the development of biological markers. With this aim, several RNA-seq studies have been devoted to the characterization of the transcriptome of ejaculated spermatozoa in relation to sperm quality and fertility. Semen quality foll...

journal_title：Frontiers in genetics

authors： Gòdia M,Estill M,Castelló A,Balasch S,Rodríguez-Gil JE,Krawetz SA,Sánchez A,Clop A

更新日期：2019-04-16 00:00:00

abstract：:Mutations in CHD7 have been shown to be a major cause of CHARGE syndrome, which presents many symptoms and features common to other syndromes making its diagnosis difficult. Next generation sequencing (NGS) of a panel of intellectual disability related genes was performed in an adult patient without molecular diagnosi...

journal_title：Frontiers in genetics

authors： Villate O,Ibarluzea N,Fraile-Bethencourt E,Valenzuela A,Velasco EA,Grozeva D,Raymond FL,Botella MP,Tejada MI

更新日期：2018-01-26 00:00:00

abstract：:The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning properties of basilar membrane. We present the current evidence supporting...

journal_title：Frontiers in genetics

authors： Booth KT,Azaiez H,Jahan I,Smith RJH,Fritzsch B

更新日期：2018-05-08 00:00:00

abstract：:Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavor, p...

journal_title：Frontiers in genetics

authors： Walker AJ,Ressurreição M,Rothermel R

更新日期：2014-07-31 00:00:00

abstract：:MicroRNAs (miRNAs) are known to be important post-transcriptional regulators that are involved in the etiology of complex psychiatric traits. The present study aimed to incorporate miRNAs information into pathway analysis using a genome-wide association dataset to identify relevant biological pathways for bipolar diso...

journal_title：Frontiers in genetics

authors： Shih WL,Kao CF,Chuang LC,Kuo PH

更新日期：2012-12-18 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide despite the availability of diverse treatment strategies. Much research progress has been made regarding immunotherapy but the effects remain unsatisfactory, highlighting the urgent need for novel immune-related therapy target...

journal_title：Frontiers in genetics

authors： Rao J,Wu X,Zhou X,Deng R,Ma Y

更新日期：2020-10-14 00:00:00

abstract：:Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric disorders, which are...

journal_title：Frontiers in genetics

authors： Holland D,Wang Y,Thompson WK,Schork A,Chen CH,Lo MT,Witoelar A,Schizophrenia Working Group of the Psychiatric Genomics Consortium.,Enhancing Neuro Imaging Genetics through Meta Analysis Consortium.,Werge T,O'Donovan M,Andreassen OA

更新日期：2016-02-16 00:00:00

abstract：:The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver disease, is dramatically increasing. Both genetic and environmental factors are well-known contributors to the development of these diseases and therefore, the study of epigenetics can provide additional mechanistic insight. Dietar...

journal_title：Frontiers in genetics

authors： Asif S,Morrow NM,Mulvihill EE,Kim KH

更新日期：2020-10-15 00:00:00

abstract：Objective:Recessive genetic diseases impose physical and psychological impacts to both newborns and parents who may not be aware of being carriers. Expanded carrier screening (ECS) allows screening for multiple genetic conditions at the same time. Whether or not such non-targeted panethnic approach of genetic carrier s...

journal_title：Frontiers in genetics

authors： Cheng HYH,Wong GCY,Chan YK,Lee CP,Tang MHY,Ng EH,Kan AS

更新日期：2020-11-16 00:00:00

abstract：:People want to live long, healthy lives. Previous surveys suggest very limited interest in much longer lifespans, but we show that stipulating good health changes responses to favor longer lives by an order of magnitude. Advances in aging research hold out hope for greatly slowed aging with associated good health. Und...

journal_title：Frontiers in genetics

authors： Donner Y,Fortney K,Calimport SR,Pfleger K,Shah M,Betts-LaCroix J

更新日期：2016-01-20 00:00:00

abstract：:For all organisms promoting protein homeostasis is a high priority in order to optimize cellular functions and resources. However, there is accumulating evidence that aging leads to a collapse in protein homeostasis and widespread non-disease protein aggregation. This review examines these findings and discusses the p...

journal_title：Frontiers in genetics

authors： David DC

更新日期：2012-11-20 00:00:00

abstract：:Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not ye...

journal_title：Frontiers in genetics

authors： Bogucka-Kocka A,Zalewski DP,Ruszel KP,Stępniewski A,Gałkowski D,Bogucki J,Komsta Ł,Kołodziej P,Zubilewicz T,Feldo M,Kocki J

更新日期：2019-11-22 00:00:00

abstract：:Osteogenesis Imperfecta (OI) is a rare inherited bone dysplasia, which is mainly caused by mutations in genes encoding type I collagen including COL1A1 and COL1A2. It has been well established to identify the classical variants as well as consensus splicing-site-variants in these genes in our previous studies. However...

journal_title：Frontiers in genetics

authors： Li L,Cao Y,Zhao F,Mao B,Ren X,Wang Y,Guan Y,You Y,Li S,Yang T,Zhao X

更新日期：2019-10-18 00:00:00

abstract：:The castes of social insects provide outstanding opportunities to address the causes and consequences of evolution of discrete phenotypes, i.e., polymorphisms. Here we focus on recently described patterns of a positive association between the degree of caste-specific gene expression and the rate of sequence evolution....

journal_title：Frontiers in genetics

authors： Helanterä H,Uller T

更新日期：2014-08-29 00:00:00

abstract：:Specialized cell types of trophoblast cells form the placenta in which each cell type has particular properties of proliferation and invasion. The placenta sustains the growth of the fetus throughout pregnancy and any aberrant trophoblast differentiation or invasion potentially affects the future health of the child a...

journal_title：Frontiers in genetics

authors： Logan PC,Mitchell MD,Lobie PE

更新日期：2013-12-04 00:00:00

abstract：:A variety of statistical methods, such as admixture models, have been used to estimate genomic breed composition (GBC). These methods, however, tend to produce non-zero components to reference breeds that shared some genomic similarity with a test animal. These non-essential GBC components, in turn, offset the estimat...

journal_title：Frontiers in genetics

authors： Wang Y,Wu XL,Li Z,Bao Z,Tait RG Jr,Bauck S,Rosa GJM

更新日期：2020-06-11 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00

abstract：:Genome-wide association study (GWAS), exploring the historical and evolutionary recombinations at the population level, is a major method adopted to identify quantitative trait loci (QTL) for complex traits. However, to summarize GWAS results, gene structure, and linkage disequilibrium (LD) in a single view, multiple ...

journal_title：Frontiers in genetics

authors： He F,Ding S,Wang H,Qin F

更新日期：2020-03-20 00:00:00

abstract：:High-throughput analysis of the transcriptome and proteome individually are used to interrogate complex oncogenic processes in cancer. However, an outstanding challenge is how to combine these complementary, yet partially disparate data sources to accurately identify tumor-specific gene products and clinical biomarker...

journal_title：Frontiers in genetics

authors： Schwartz GW,Petrovic J,Zhou Y,Faryabi RB

更新日期：2018-06-15 00:00:00

abstract：:Predicting how species interactions evolve requires that we understand the mechanistic basis of coevolution, and thus the functional genotype-by-genotype interactions (G × G) that drive reciprocal natural selection. Theory on host-parasite coevolution provides testable hypotheses for empiricists, but depends upon mode...

journal_title：Frontiers in genetics

authors： Heath KD,Nuismer SL

更新日期：2014-04-11 00:00:00

abstract：:In this study, the genetic diversity of 115 common bean germplasm resources collected from 27 counties in Chongqing over 3 years (2015-2017) was assessed. The results showed that the genetic diversity of the common bean germplasm resources was high, with an average diversity index of 1.447. The diversity of the qualit...

journal_title：Frontiers in genetics

authors： Long J,Zhang J,Zhang X,Wu J,Chen H,Wang P,Wang Q,Du C

更新日期：2020-07-08 00:00:00

abstract：:Autism spectrum disorder (ASD) is marked by a strong genetic heterogeneity, which is underlined by the low overlap between ASD risk gene lists proposed in different studies. In this context, molecular networks can be used to analyze the results of several genome-wide studies in order to underline those network regions...

journal_title：Frontiers in genetics

authors： Mosca E,Bersanelli M,Gnocchi M,Moscatelli M,Castellani G,Milanesi L,Mezzelani A

更新日期：2017-09-25 00:00:00