Linc-GALMD1 Regulates Viral Gene Expression in the Chicken.

Abstract:

:A rapidly increasing number of reports on dysregulated long intergenic non-coding RNA (lincRNA) expression across numerous types of cancers indicates that aberrant lincRNA expression may be a major contributor to tumorigenesis. Marek's disease (MD) is a T cell lymphoma of chickens induced by Marek's disease virus (MDV). Although we have investigated the roles of lincRNAs in bursa tissue of MDV-infected chickens in previous studies, the molecular mechanisms of lincRNA functions in T cells remain poorly understood. In the present study, Linc-GALMD1 was identified from CD4+ T cells and MSB1 cells, and its expression was significantly downregulated in MD-resistant line of birds in response to MDV challenge. Furthermore, loss-of-function experiments indicated that linc-GALMD1 significantly affected the expression of 290 genes in trans. Through integrated analysis of differentially expressed genes (DEGs) induced by MDV and linc-GALMD1, we found that IGLL1 gene expression levels had a positive correlation with the degree of MD infection and could potentially serve as an indicator for clinical diagnosis of MD. Moreover, an interaction between MDV and linc-GALMD1 was also observed. Accordingly, chicken embryonic fibroblast cells were inoculated with MDV with and without the linc-GALMD1 knockdown, and the data showed that linc-GALMD1 could repress MDV gene expression during the course of MDV infection. These findings uncovered a role of linc-GALMD1 as a viral gene regulator and suggested a function of linc-GALMD1 contributing to tumor suppression by coordinating expression of MDV genes and tumor-related genes and regulating immune responses to MDV infection.

journal_name

Front Genet

journal_title

Frontiers in genetics

authors

He Y,Han B,Ding Y,Zhang H,Chang S,Zhang L,Zhao C,Yang N,Song J

doi

10.3389/fgene.2019.01122

subject

Has Abstract

pub_date

2019-11-14 00:00:00

pages

1122

issn

1664-8021

journal_volume

10

pub_type

杂志文章
  • Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans.

    abstract::Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and tissue concentrations...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2020.00944

    authors: Matthaei J,Bonat WH,Kerb R,Tzvetkov MV,Strube J,Brunke S,Sachse-Seeboth C,Sehrt D,Hofmann U,von Bornemann Hjelmborg J,Schwab M,Brockmöller J

    更新日期:2020-08-21 00:00:00

  • THI Modulation of Genetic and Non-genetic Variance Components for Carcass Traits in Hanwoo Cattle.

    abstract::The phenotype of carcass traits in beef cattle are affected by random genetic and non-genetic effects, which both can be modulated by an environmental variable such as Temperature-Humidity Index (THI), a key environmental factor in cattle production. In this study, a multivariate reaction norm model (MRNM) was used to...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2020.576377

    authors: Chung Y,Lee SH,Lee HK,Lim D,van der Werf J,Lee SH

    更新日期:2020-12-23 00:00:00

  • Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation.

    abstract::Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age. Inflammation of blood vessels...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2014.00422

    authors: Cheng HS,Njock MS,Khyzha N,Dang LT,Fish JE

    更新日期:2014-12-10 00:00:00

  • Cancer as a Tissue Anomaly: Classifying Tumor Transcriptomes Based Only on Healthy Data.

    abstract::Since the turn of the century, researchers have sought to diagnose cancer based on gene expression signatures measured from the blood or biopsy as biomarkers. This task, known as classification, is typically solved using a suite of algorithms that learn a mathematical rule capable of discriminating one group ("cases")...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2019.00599

    authors: Quinn TP,Nguyen T,Lee SC,Venkatesh S

    更新日期:2019-07-02 00:00:00

  • Evolutionary diversifications of plants on the Qinghai-Tibetan Plateau.

    abstract::The Qinghai-Tibetan Plateau (QTP) is the highest and one of the most extensive plateaus in the world. Phylogenetic, phylogeographic, and ecological studies support plant diversifications on the QTP through multiple mechanisms such as allopatric speciation via geographic isolation, climatic oscillations and divergences...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2014.00004

    authors: Wen J,Zhang JQ,Nie ZL,Zhong Y,Sun H

    更新日期:2014-02-12 00:00:00

  • Y-STR Haplogroup Diversity in the Jat Population Reveals Several Different Ancient Origins.

    abstract::The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2017.00121

    authors: Mahal DG,Matsoukas IG

    更新日期:2017-09-20 00:00:00

  • Testing for direct genetic effects using a screening step in family-based association studies.

    abstract::In genome wide association studies (GWAS), family-based studies tend to have less power to detect genetic associations than population-based studies, such as case-control studies. This can be an issue when testing if genes in a family-based GWAS have a direct effect on the phenotype of interest over and above their po...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2013.00243

    authors: Lutz SM,Vansteelandt S,Lange C

    更新日期:2013-11-21 00:00:00

  • Multi-model inference in comparative phylogeography: an integrative approach based on multiple lines of evidence.

    abstract::Comparative phylogeography has its roots in classical biogeography and, historically, relies on a pattern-based approach. Here, we present a model-based framework for comparative phylogeography. Our framework was initially developed for statistical phylogeography based on a multi-model inference approach, by coupling ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2015.00031

    authors: Collevatti RG,Terribile LC,Diniz-Filho JA,Lima-Ribeiro MS

    更新日期:2015-02-17 00:00:00

  • Phylogeography and Population Genetics of Vicugna vicugna: Evolution in the Arid Andean High Plateau.

    abstract::The vicuña (Vicugna vicugna) is the most representative wild ungulate of the high Andes of South America with two recognized morphological subspecies, V. v. mensalis in the north and V. v. vicugna in the south of its distribution. Current vicuña population size (460,000-520,000 animals) is the result of population rec...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2019.00445

    authors: González BA,Vásquez JP,Gómez-Uchida D,Cortés J,Rivera R,Aravena N,Chero AM,Agapito AM,Varas V,Wheleer JC,Orozco-terWengel P,Marín JC

    更新日期:2019-06-06 00:00:00

  • Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans.

    abstract::Neurodegenerative diseases share pathogenic mechanisms at the cellular level including protein misfolding, excitotoxicity and altered RNA homeostasis among others. Recent advances have shown that the genetic causes underlying these pathologies overlap, hinting at the existence of a genetic network for neurodegeneratio...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2014.00085

    authors: Therrien M,Parker JA

    更新日期:2014-04-17 00:00:00

  • Lifetime Smoking and Asthma: A Mendelian Randomization Study.

    abstract::Evidence from clinical and epidemiological studies indicates that asthma is associated with allergic diseases including hay fever, allergic rhinitis, and eczema. Genetic analysis demonstrated that asthma had a positive genetic correlation with allergic diseases. A Mendelian randomization (MR) analysis using the rs1696...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2020.00769

    authors: Shen M,Liu X,Li G,Li Z,Zhou H

    更新日期:2020-08-04 00:00:00

  • Go with the flow-biology and genetics of the lactation cycle.

    abstract::Lactation is a dynamic process, which evolved to meet dietary demands of growing offspring. At the same time, the mother's metabolism changes to meet the high requirements of nutrient supply to the offspring. Through strong artificial selection, the strain of milk production on dairy cows is often associated with impa...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2015.00118

    authors: Strucken EM,Laurenson YC,Brockmann GA

    更新日期:2015-03-26 00:00:00

  • Functional evaluation of DNA repair in human biopsies and their relation to other cellular biomarkers.

    abstract::Thousands of DNA lesions are estimated to occur in each cell every day and almost all are recognized and repaired. DNA repair is an essential system that prevents accumulation of mutations which can lead to serious cellular malfunctions. Phenotypic evaluation of DNA repair activity of individuals is a relatively new a...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2014.00116

    authors: Slyskova J,Langie SA,Collins AR,Vodicka P

    更新日期:2014-05-23 00:00:00

  • Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models.

    abstract::The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2014.00088

    authors: Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

    更新日期:2014-04-23 00:00:00

  • Corrigendum: Exposing the Causal Effect of C-Reactive Protein on the Risk of Type 2 Diabetes Mellitus: A Mendelian Randomization Study.

    abstract::[This corrects the article DOI: 10.3389/fgene.2018.00657.]. ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,已发布勘误

    doi:10.3389/fgene.2019.00085

    authors: Cheng L,Zhuang H,Yang S,Jiang H,Wang S,Zhang J

    更新日期:2019-02-18 00:00:00

  • The Emerging Role of Non-Coding RNAs in Drug Addiction.

    abstract::Prolonged drug use causes long-lasting neuroadaptations in reward-related brain areas that contribute to addiction. Despite significant amount of research dedicated to understanding the underlying mechanisms of addiction, the molecular underpinnings remain unclear. At the same time, much of the pervasive transcription...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2012.00106

    authors: Sartor GC,St Laurent G 3rd,Wahlestedt C

    更新日期:2012-06-22 00:00:00

  • Heterogeneity of expression of epithelial-mesenchymal transition markers in melanocytes and melanoma cell lines.

    abstract::The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterized by a...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2013.00097

    authors: Kim JE,Leung E,Baguley BC,Finlay GJ

    更新日期:2013-05-31 00:00:00

  • Twenty Years Later: A Comprehensive Review of the X Chromosome Use in Forensic Genetics.

    abstract::The unique structure of the X chromosome shaped by evolution has led to the present gender-specific genetic differences, which are not shared by its counterpart, the Y chromosome, and neither by the autosomes. In males, recombination between the X and Y chromosomes is limited to the pseudoautosomal regions, PAR1 and P...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2020.00926

    authors: Gomes I,Pinto N,Antão-Sousa S,Gomes V,Gusmão L,Amorim A

    更新日期:2020-09-17 00:00:00

  • Evidence for the multiple hits genetic theory for inherited language impairment: a case study.

    abstract::Communication disorders have complex genetic origins, with constellations of relevant gene markers that vary across individuals. Some genetic variants are present in healthy individuals as well as those affected by developmental disorders. Growing evidence suggests that some variants may increase susceptibility to the...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2015.00272

    authors: Centanni TM,Green JR,Iuzzini-Seigel J,Bartlett CW,Hogan TP

    更新日期:2015-08-24 00:00:00

  • Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction.

    abstract::Telomeres are essential nucleoprotein structures at linear chromosomes that maintain genome integrity by protecting chromosome ends from being recognized and processed as damaged DNA. In addition, they limit the cell's proliferative capacity, as progressive loss of telomeric DNA during successive rounds of cell divisi...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2017.00067

    authors: Yalçin Z,Selenz C,Jacobs JJL

    更新日期:2017-05-23 00:00:00

  • Whole Genome Scan Reveals Molecular Signatures of Divergence and Selection Related to Important Traits in Durum Wheat Germplasm.

    abstract::The first breeding program in the world for durum wheat was conceived in Italy in the early 1900s. Over the decades, pressure exerted by natural and artificial selection could have progressively reduced the genetic diversity of the durum wheat germplasm. In the present study, a large panel of Italian durum wheat acces...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2020.00217

    authors: Taranto F,D'Agostino N,Rodriguez M,Pavan S,Minervini AP,Pecchioni N,Papa R,De Vita P

    更新日期:2020-04-21 00:00:00

  • Identification of an Immune-Related Gene Signature to Improve Prognosis Prediction in Colorectal Cancer Patients.

    abstract:Background:Despite recent advance in immune therapy, great heterogeneity exists in the outcomes of colorectal cancer (CRC) patients. In this study, we aimed to analyze the immune-related gene (IRG) expression profiles from three independent public databases and develop an effective signature to forecast patient's progn...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2020.607009

    authors: Dai S,Xu S,Ye Y,Ding K

    更新日期:2020-12-04 00:00:00

  • A Novel Loss-of-Function Variant in Transmembrane Protein 263 (TMEM263) of Autosomal Dwarfism in Chicken.

    abstract::Autosomal dwarfism (adw) in chickens is a growth deficiency caused by a recessive mutation. Characteristic for adw is an approximately 30% growth reduction with short shank. The adw variant was first recognized in the Cornell K-strain of White Leghorns, but the genetic causal variant remained unknown. To identify the ...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2018.00193

    authors: Wu Z,Derks MFL,Dibbits B,Megens HJ,Groenen MAM,Crooijmans RPMA

    更新日期:2018-06-07 00:00:00

  • Recommendations for Choosing the Genotyping Method and Best Practices for Quality Control in Crop Genome-Wide Association Studies.

    abstract::High-throughput genotyping boosts genome-wide association studies (GWAS) in crop species, leading to the identification of single-nucleotide polymorphisms (SNPs) associated with economically important traits. Choosing a cost-effective genotyping method for crop GWAS requires careful examination of several aspects, nam...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2020.00447

    authors: Pavan S,Delvento C,Ricciardi L,Lotti C,Ciani E,D'Agostino N

    更新日期:2020-06-05 00:00:00

  • Population Structure and Implications on the Genetic Architecture of HIV-1 Phenotypes Within Southern Africa.

    abstract::The interesting history of Southern Africa has put the region in the spotlight for population medical genetics. Major events including the Bantu expansion and European colonialism have imprinted unique genetic signatures within autochthonous populations of Southern Africa, this resulting in differential allele frequen...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2019.00905

    authors: Thami PK,Chimusa ER

    更新日期:2019-09-27 00:00:00

  • Identification and interrogation of combinatorial histone modifications.

    abstract::Histone proteins are dynamically modified to mediate a variety of cellular processes including gene transcription, DNA damage repair, and apoptosis. Regulation of these processes occurs through the recruitment of non-histone proteins to chromatin by specific combinations of histone post-translational modifications (PT...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2013.00264

    authors: Karch KR,Denizio JE,Black BE,Garcia BA

    更新日期:2013-12-20 00:00:00

  • Mechanisms Underlying the Environmentally Induced Plasticity of Leaf Morphology.

    abstract::The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth....

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2018.00478

    authors: Fritz MA,Rosa S,Sicard A

    更新日期:2018-10-24 00:00:00

  • Comparative Genomic Analysis Reveals the Mechanism Driving the Diversification of Plastomic Structure in Taxaceae Species.

    abstract::Inverted repeat (IR) regions in the plastomes from land plants induce homologous recombination, generating isomeric plastomes. While the plastomes of Taxaceae species often lose one of the IR regions, considerable isomeric plastomes were created in Taxaceae species with a hitherto unclarified mechanism. To investigate...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2019.01295

    authors: Zhang Y,Xu Y,Chen H,Wang L,Yin K,Du FK

    更新日期:2020-01-14 00:00:00

  • Analysis of Transcriptome and Epitranscriptome in Plants Using PacBio Iso-Seq and Nanopore-Based Direct RNA Sequencing.

    abstract::Nanopore sequencing from Oxford Nanopore Technologies (ONT) and Pacific BioSciences (PacBio) single-molecule real-time (SMRT) long-read isoform sequencing (Iso-Seq) are revolutionizing the way transcriptomes are analyzed. These methods offer many advantages over most widely used high-throughput short-read RNA sequenci...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章,评审

    doi:10.3389/fgene.2019.00253

    authors: Zhao L,Zhang H,Kohnen MV,Prasad KVSK,Gu L,Reddy ASN

    更新日期:2019-03-21 00:00:00

  • Improved measurements of RNA structure conservation with generalized centroid estimators.

    abstract::Identification of non-protein-coding RNAs (ncRNAs) in genomes is a crucial task for not only molecular cell biology but also bioinformatics. Secondary structures of ncRNAs are employed as a key feature of ncRNA analysis since biological functions of ncRNAs are deeply related to their secondary structures. Although the...

    journal_title:Frontiers in genetics

    pub_type: 杂志文章

    doi:10.3389/fgene.2011.00054

    authors: Okada Y,Saito Y,Sato K,Sakakibara Y

    更新日期:2011-08-31 00:00:00