Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells.

abstract：:This study examined reasons for participation in a genetic study of risk for multiple sclerosis (MS). Our sample consisted of 101 patients diagnosed with MS who were approached about enrolling in the Multiple Sclerosis Genetic Susceptibility Study. Participants were predominantly Hispanic (80%), female (80%), and well...

journal_title：Frontiers in genetics

authors： Cuccaro ML,Manrique CP,Quintero MA,Martinez R,McCauley JL

更新日期：2020-03-13 00:00:00

abstract：:The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages. A fossil pollen record spanning the last 26,000 years from an upland bog ...

journal_title：Frontiers in genetics

authors： Collins AF,Bush MB,Sachs JP

更新日期：2013-12-03 00:00:00

abstract：:Alport syndrome (AS) is a rare and inherited renal disorder with an autosomal recessive mode of inheritance. AS patients usually manifest with hematuria and progressive renal disorder also occasionally accompanied by hearing loss and ophthalmic disease. Germline variants in collagen type IV α-4 (COL4A4) gene lead to a...

journal_title：Frontiers in genetics

authors： Zhu F,Li W,Li Z,Zhu H,Xiong J

更新日期：2019-01-28 00:00:00

abstract：:The evolutionary dynamics and tissue specificity of protein-coding genes are well documented in plants. However, the evolutionary consequences of small RNAs (sRNAs) on tissue-specific functions remain poorly understood. Here, we performed integrated analysis of 195 deeply sequenced sRNA libraries of maize B73, represe...

journal_title：Frontiers in genetics

authors： Xu Y,Zhang T,Li Y,Miao Z

更新日期：2020-02-11 00:00:00

abstract：:The phenotype of carcass traits in beef cattle are affected by random genetic and non-genetic effects, which both can be modulated by an environmental variable such as Temperature-Humidity Index (THI), a key environmental factor in cattle production. In this study, a multivariate reaction norm model (MRNM) was used to...

journal_title：Frontiers in genetics

authors： Chung Y,Lee SH,Lee HK,Lim D,van der Werf J,Lee SH

更新日期：2020-12-23 00:00:00

abstract：:Lactation is a dynamic process, which evolved to meet dietary demands of growing offspring. At the same time, the mother's metabolism changes to meet the high requirements of nutrient supply to the offspring. Through strong artificial selection, the strain of milk production on dairy cows is often associated with impa...

journal_title：Frontiers in genetics

authors： Strucken EM,Laurenson YC,Brockmann GA

更新日期：2015-03-26 00:00:00

abstract：:Studies in rats and mice have established that maternal nutrition induces epigenetic modifications, sometimes permanently, that alter gene expression in the fetus, which in turn leads to phenotypic changes. However, limited data is available on the influence of maternal diet on epigenetic modifications and gene expres...

journal_title：Frontiers in genetics

authors： Lan X,Cretney EC,Kropp J,Khateeb K,Berg MA,Peñagaricano F,Magness R,Radunz AE,Khatib H

更新日期：2013-04-05 00:00:00

abstract：:Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotation of allelic imbalance and infer the existence of cis-acting transcr...

journal_title：Frontiers in genetics

authors： Salavati M,Bush SJ,Palma-Vera S,McCulloch MEB,Hume DA,Clark EL

更新日期：2019-09-19 00:00:00

abstract：:von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease and the underlying me...

journal_title：Frontiers in genetics

authors： Wang J,Peng X,Chen C,Ning X,Peng S,Li T,Liu S,Hong B,Zhou J,Ma K,Cai L,Gong K

更新日期：2019-04-24 00:00:00

abstract：:Watson for Oncology (WFO) is a artificial intelligence clinical decision-support system with evidence-based treatment options for oncologists. WFO has been gradually used in China, but limited reports on whether WFO is suitable for Chinese patients. This study aims to investigate the concordance of treatment options b...

journal_title：Frontiers in genetics

authors： Zou FW,Tang YF,Liu CY,Ma JA,Hu CH

更新日期：2020-03-24 00:00:00

abstract：:Few studies have been conducted to explore the influence of the catechol-o-methyltransferase (COMT) genotype on the severity of and treatment efficacy on auditory verbal hallucination (AVH) symptoms in healthy individuals with AVHs (Hi-AVHs). We hypothesized that the efficacy of dopamine antagonist treatment on AVHs i...

journal_title：Frontiers in genetics

authors： Zhuo C,Xu Y,Zhang L,Jing R,Zhou C

更新日期：2019-03-06 00:00:00

abstract：:A case-control study was used to explore the association between the methylation status in the promoter regions of the cGAS, MAVS, and TRAF3 genes and the diseases of cervical precancerous lesions (CPL) and cervical cancer (CC) in a Southern Chinese population, and to further explore their interaction effects with hig...

journal_title：Frontiers in genetics

authors： Huang S,Li R,Huang X,Zheng S,Wang L,Wen Z,Zou X,Wu J,Liu Y,Liu D,Wang Y,Dong S,Chen X,Zhu K,Du X,Zhou Z,Han Y,Ye X,Zeng C,Zhang B,Yang G,Jing C

更新日期：2019-11-14 00:00:00

abstract：:Primary ciliary dyskinesia (PCD), a rare genetic disorder, is mostly caused by defects in more than 40 known cilia structure-related genes. However, in approximately 20-35% of patients, it is caused by unknown genetic factors, and the inherited pathogenic factors are difficult to confirm. Kartagener syndrome (KTS) is ...

journal_title：Frontiers in genetics

authors： Yue Y,Huang Q,Zhu P,Zhao P,Tan X,Liu S,Li S,Han X,Cheng L,Li B,Fu Y

更新日期：2019-08-22 00:00:00

abstract：:Sucrose transporters (SUTs) play key roles in allocating the translocation of assimilates from source to sink tissues. Although the characteristics and biological roles of SUTs have been intensively investigated in higher plants, this gene family has not been functionally characterized in cotton. In this study, we per...

journal_title：Frontiers in genetics

authors： Li W,Sun K,Ren Z,Song C,Pei X,Liu Y,Wang Z,He K,Zhang F,Zhou X,Ma X,Yang D

更新日期：2018-10-23 00:00:00

abstract：:Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machin...

journal_title：Frontiers in genetics

authors： Bi XA,Wang Y,Shu Q,Sun Q,Xu Q

更新日期：2018-02-06 00:00:00

abstract：:Environmental exposures vary by timing, severity, and frequency and may have a number of deleterious effects throughout the life course. The period of in utero development, for example, is one of the most crucial stages of development during which adverse environmental exposures can both alter the growth and developme...

journal_title：Frontiers in genetics

authors： Maccani MA,Knopik VS

更新日期：2012-04-09 00:00:00

abstract：:Various patterns of multi-phenotype associations (MPAs) exist in the results of Genome Wide Association Studies (GWAS) involving different topologies of single nucleotide polymorphism (SNP)-phenotype associations. These can provide interesting information about the different impacts of a gene on closely related phenot...

journal_title：Frontiers in genetics

authors： Weighill D,Jones P,Bleker C,Ranjan P,Shah M,Zhao N,Martin M,DiFazio S,Macaya-Sanz D,Schmutz J,Sreedasyam A,Tschaplinski T,Tuskan G,Jacobson D

更新日期：2019-05-10 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:Extensively raised village chickens are considered a valuable source of biodiversity, with genetic variability developed over thousands of years that ought to be characterized and utilized. Surveys that can reveal a population's genetic structure and provide an insight into its demographic history will give valuable i...

journal_title：Frontiers in genetics

authors： Khanyile KS,Dzomba EF,Muchadeyi FC

更新日期：2015-02-03 00:00:00

abstract：:Rodent models have been extensively used to investigate the cause and mechanisms behind Alzheimer's disease. Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Although zebrafish lack the complexity of advanced cogn...

journal_title：Frontiers in genetics

authors： Newman M,Ebrahimie E,Lardelli M

更新日期：2014-06-30 00:00:00

abstract：:Acetaminophen (APAP) is widely used as an over-the-counter fever reducer and pain reliever. However, the current therapeutic use of APAP is not optimal. The inter-patient variability in both efficacy and toxicity limits the use of this drug. This is particularly an issue in pediatric populations, where tools for predi...

journal_title：Frontiers in genetics

authors： Krasniak AE,Knipp GT,Svensson CK,Liu W

更新日期：2014-10-14 00:00:00

abstract：:The goal of any plant breeding program is to improve quality of a target crop. Crop quality is a comprehensive feature largely determined by biological background. To improve the quality parameters of crops grown for the production of fiber, a functional approach was used to search for genes suitable for the effective...

journal_title：Frontiers in genetics

authors： Galinousky D,Mokshina N,Padvitski T,Ageeva M,Bogdan V,Kilchevsky A,Gorshkova T

更新日期：2020-11-12 00:00:00

abstract：:In Colchester, Britain's oldest recorded town, during the Roman period there were areas which were clearly used solely as cemeteries. One of the most significant is at Butt Road, which includes a late Roman probable Christian cemetery with an associated building, apparently a church, that overlies and developed from a...

journal_title：Frontiers in genetics

authors： Voong CP,Spencer PS,Navarrete CV,Turner D,Hayrabedyan SB,Crummy P,Holloway E,Wilson MT,Smith PR,Fernández N

更新日期：2017-12-05 00:00:00

abstract：:Mechanotransduction is an essential mechanism of transforming external mechanical stimulus to biochemical response. In cardiomyocytes mechanotransduction plays an important role in contraction, stretch sensing and homeostasis regulation. One of the major mechanosensitive area in cardiomyocytes, the Z-disk, consists of...

journal_title：Frontiers in genetics

authors： Knyazeva A,Krutikov A,Golovkin A,Mishanin A,Pavlov G,Smolina N,Hushkina A,Sejersen T,Sjoberg G,Galagudza M,Kostareva A

更新日期：2019-01-07 00:00:00

abstract：:Colitis-associated cancer (CAC) has been linked to microRNA (miRNA) aberrant expression elicited by inflammation. In this study, we used the AOM/DSS-induced CAC mice model to explore the ectopic expression of miRNAs in the precancerous stage of CAC. As a result, we found that miR-31-5p, miR-223-3p, and let-7f-5p were ...

journal_title：Frontiers in genetics

authors： Chen G,Feng Y,Li X,Jiang Z,Bei B,Zhang L,Han Y,Li Y,Li N

更新日期：2019-06-19 00:00:00

abstract：Background:Genetic association studies have identified single nucleotide polymorphisms (SNPs) related to chronic obstructive pulmonary disease (COPD) susceptibility. The aim of this study was to identify HHIP genetic variants associated with COPD, pulmonary function, and serum and sputum HHIP protein levels in Mexican ...

journal_title：Frontiers in genetics

authors： Ortega-Martínez A,Pérez-Rubio G,Ambrocio-Ortiz E,Nava-Quiroz KJ,Hernández-Zenteno RJ,Abarca-Rojano E,Rodríguez-Llamazares S,Hernández-Pérez A,García-Gómez L,Ramírez-Venegas A,Falfán-Valencia R

更新日期：2020-09-24 00:00:00

abstract：:Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in ...

journal_title：Frontiers in genetics

authors： Dai B,Wang F,Nie X,Du H,Zhao Y,Yin Z,Li H,Fan J,Wen Z,Wang DW,Chen C

更新日期：2020-11-20 00:00:00

abstract：:Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in re...

journal_title：Frontiers in genetics

authors： Onzima RB,Upadhyay MR,Doekes HP,Brito LF,Bosse M,Kanis E,Groenen MAM,Crooijmans RPMA

更新日期：2018-08-14 00:00:00

abstract：:Shotgun metagenomics has greatly advanced our understanding of microbial communities over the last decade. Metagenomic analyses often include assembly and genome binning, computationally daunting tasks especially for big data from complex environments such as soil and sediments. In many studies, however, only a subset...

journal_title：Frontiers in genetics

authors： Guo J,Quensen JF,Sun Y,Wang Q,Brown CT,Cole JR,Tiedje JM

更新日期：2019-10-15 00:00:00