Could magnetic resonance provide in vivo histology?

abstract：:In the last decades, genome-wide association studies (GWAS) have uncovered tens of thousands of associations between common genetic variants and complex diseases. However, these statistical associations can rarely be interpreted functionally and mechanistically. As the majority of the disease-associated variants are l...

journal_title：Frontiers in genetics

authors： Mariella E,Marotta F,Grassi E,Gilotto S,Provero P

更新日期：2019-08-16 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. They constitute a major, but still poorly characterized part of human transcriptome, however, evidence is growing that they are important regulatory molecules involved...

journal_title：Frontiers in genetics

authors： Yarmishyn AA,Kurochkin IV

更新日期：2015-04-23 00:00:00

abstract：:Parent-of-origin effects (POE) such as genomic imprinting influence growth and body composition in livestock, rodents, and humans. Here, we report the results of a genome scan to detect quantitative trait loci (QTL) with POE on growth and carcass traits in Angus × Brahman cattle crossbreds. We identified 24 POE-QTL on...

journal_title：Frontiers in genetics

authors： Imumorin IG,Kim EH,Lee YM,De Koning DJ,van Arendonk JA,De Donato M,Taylor JF,Kim JJ

更新日期：2011-07-12 00:00:00

abstract：:A complete and compelling evolutionary explanation for the origin of human menopause is wanting. Menopause onset is defined clinically as the final menses, confirmed after 1 year without menstruation. The theory proposed herein explains at multiple levels - ultimately genetic but involving (1) behavioral, (2) life his...

journal_title：Frontiers in genetics

authors： Takahashi M,Singh RS,Stone J

更新日期：2017-01-06 00:00:00

abstract：:A case-control study was used to explore the association between the methylation status in the promoter regions of the cGAS, MAVS, and TRAF3 genes and the diseases of cervical precancerous lesions (CPL) and cervical cancer (CC) in a Southern Chinese population, and to further explore their interaction effects with hig...

journal_title：Frontiers in genetics

authors： Huang S,Li R,Huang X,Zheng S,Wang L,Wen Z,Zou X,Wu J,Liu Y,Liu D,Wang Y,Dong S,Chen X,Zhu K,Du X,Zhou Z,Han Y,Ye X,Zeng C,Zhang B,Yang G,Jing C

更新日期：2019-11-14 00:00:00

abstract：:The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of resilience. Data used were t...

journal_title：Frontiers in genetics

authors： Putz AM,Harding JCS,Dyck MK,Fortin F,Plastow GS,Dekkers JCM,PigGen Canada.

更新日期：2019-01-08 00:00:00

abstract：:Improving grain yield in the staple food crop rice has been long sought goal of plant biotechnology. One of the traits with significant impact on rice breeding programs is peduncle elongation at the time of heading failing which leads to significant reduction in grain yield due to incomplete panicle exsertion. To deci...

journal_title：Frontiers in genetics

authors： Kandpal M,Vishwakarma C,Krishnan K,Chinnusamy V,Pareek A,Sharma MK,Sharma R

更新日期：2020-12-03 00:00:00

abstract：:Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways. Elucidating shared biologic processes and overlapping gene networks will help to bett...

journal_title：Frontiers in genetics

authors： Funderburk KM,Auerbach SS,Bushel PR

更新日期：2017-10-24 00:00:00

abstract：:Identifying driver genes that contribute to cancer progression from numerous passenger genes, although a central goal, is a major challenge. The protein-protein interaction network provides convenient and reasonable assistance for driver gene discovery. Random walk-based methods have been widely used to prioritize nod...

journal_title：Frontiers in genetics

authors： Wei PJ,Wu FX,Xia J,Su Y,Wang J,Zheng CH

更新日期：2020-04-28 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00

abstract：:Gene expression profiling has been widely used to characterize cell status to reflect the health of the body, to diagnose genetic diseases, etc. In recent years, although the cost of genome-wide expression profiling is gradually decreasing, the cost of collecting expression profiles for thousands of genes is still ver...

journal_title：Frontiers in genetics

authors： Li W,Yin Y,Quan X,Zhang H

更新日期：2019-11-12 00:00:00

abstract：:Mutations in mitochondrial (mt) DNA determine important human diseases. The majority of the known pathogenic mutations are located in transfer RNA (tRNA) genes and are responsible for a wide range of currently untreatable disorders. Experimental evidence both in yeast and in human cells has shown that the detrimental ...

journal_title：Frontiers in genetics

authors： Giordano C,Morea V,Perli E,d'Amati G

更新日期：2015-03-23 00:00:00

abstract：:The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

journal_title：Frontiers in genetics

authors： Mahal DG,Matsoukas IG

更新日期：2017-09-20 00:00:00

abstract：:Empirical evidence is limited on whether allopolyploid species combine or merge parental adaptations to broaden habitats. The allopolyploid Arabidopsis kamchatica is a hybrid of the two diploid parents Arabidopsis halleri and Arabidopsis lyrata. A. halleri is a facultative heavy metal hyperaccumulator, and may be foun...

journal_title：Frontiers in genetics

authors： Paape T,Akiyama R,Cereghetti T,Onda Y,Hirao AS,Kenta T,Shimizu KK

更新日期：2020-09-30 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:Advances in the field of sequencing techniques have resulted in the greatly accelerated production of huge sequence datasets. This presents immediate challenges in database maintenance at datacenters. It provides additional computational challenges in data mining and sequence analysis. Together these represent a signi...

journal_title：Frontiers in genetics

authors： Thakur RS,Bandopadhyay R,Chaudhary B,Chatterjee S

更新日期：2012-12-11 00:00:00

abstract：:Excessive fat deposition can cause chicken health problem, and affect production efficiency by causing great economic losses to the industry. However, the molecular underpinnings of the complex adiposity trait remain elusive. In the current study, we constructed and compared the gene co-expression networks on four tra...

journal_title：Frontiers in genetics

authors： Gao Z,Ding R,Zhai X,Wang Y,Chen Y,Yang CX,Du ZQ

更新日期：2020-05-29 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease for which it is difficult to find exact disease-related genes. Effectively identifying disease-related genes would contribute to improving the treatment and diagnosis of multiple sclerosis. Current methods for identifying disease-related genes mainly focus on the hypoth...

journal_title：Frontiers in genetics

authors： Liu H,Guan J,Li H,Bao Z,Wang Q,Luo X,Xue H

更新日期：2020-04-21 00:00:00

abstract：:The Xichuan black-bone chicken, which is a rare local chicken species in China, is an important genetic resource of black-bone chickens. Tyrosine can affect melanin production, but the molecular mechanism underlying tyrosine-induced melanin deposition in Xichuan black-bone chickens is poorly understood. Here, the blac...

journal_title：Frontiers in genetics

authors： Li D,Wang X,Fu Y,Zhang C,Cao Y,Wang J,Zhang Y,Li Y,Chen Y,Li Z,Li W,Jiang R,Sun G,Tian Y,Li G,Kang X

更新日期：2019-05-15 00:00:00

abstract：:Genetic variants can influence the expression of mRNA and protein. Genetic regulatory loci such as expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs) exist in several species. However, it remains unclear how human genetic variants regulate mRNA and protein expression. Here, we chara...

journal_title：Frontiers in genetics

authors： Wang Y,He B,Zhao Y,Reiter JL,Chen SX,Simpson E,Feng W,Liu Y

更新日期：2019-09-10 00:00:00

abstract：:Resistant Starch (RS), plays a crucial role in human health and nutrition by controlling glucose metabolism. RS or dietary fibre content in rice is low because it goes through a variety of process before it is ready for cooking and consumption. Hence, this study was carried out to develop a rice mutant with increased ...

journal_title：Frontiers in genetics

authors： Gurunathan S,Ramadoss BR,Mudili V,Siddaiah C,Kalagatur NK,Bapu JRK,Mohan CD,Alqarawi AA,Hashem A,Abd Allah EF

更新日期：2019-11-15 00:00:00

abstract：:mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mRNA-Seq data does no...

journal_title：Frontiers in genetics

authors： Bhattacharjee M,Gupta R,Davuluri RV

更新日期：2012-11-27 00:00:00

abstract：:Osteogenesis Imperfecta (OI) is a rare inherited bone dysplasia, which is mainly caused by mutations in genes encoding type I collagen including COL1A1 and COL1A2. It has been well established to identify the classical variants as well as consensus splicing-site-variants in these genes in our previous studies. However...

journal_title：Frontiers in genetics

authors： Li L,Cao Y,Zhao F,Mao B,Ren X,Wang Y,Guan Y,You Y,Li S,Yang T,Zhao X

更新日期：2019-10-18 00:00:00

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element LINE-1, MEST, P16, H19, and GNAS in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quantitative DNA methyla...

journal_title：Frontiers in genetics

authors： Zhang W,Li M,Sun F,Xu X,Zhang Z,Liu J,Sun X,Zhang A,Shen Y,Xu J,Miao M,Wu B,Yuan Y,Huang X,Shi H,Du J

更新日期：2019-10-18 00:00:00

abstract：Background/Aims:Leiomyosarcoma (LMS) is a tumor derived from malignant mesenchymal tissue associated with poor prognosis. Determining potential prognostic markers for LMS can provide clues for early diagnosis, recurrence, and treatment. Methods:RNA sequence data and clinical features of 103 LMS were obtained from the ...

journal_title：Frontiers in genetics

authors： Yang J,Li C,Zhou J,Liu X,Wang S

更新日期：2020-02-04 00:00:00

abstract：OBJECTIVES:Using a novel candidate SNP approach, we aimed to identify a possible genetic basis for the higher glioma incidence in Whites relative to East Asians and African-Americans. METHODS:  We hypothesized that genetic regions containing SNPs with extreme differences in allele frequencies across ethnicities are mo...

journal_title：Frontiers in genetics

authors： Jacobs DI,Walsh KM,Wrensch M,Wiencke J,Jenkins R,Houlston RS,Bondy M,Simon M,Sanson M,Gousias K,Schramm J,Labussière M,Di Stefano AL,Wichmann HE,Müller-Nurasyid M,Schreiber S,Franke A,Moebus S,Eisele L,Dewan AT,Du

更新日期：2012-10-12 00:00:00

abstract：:The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asb...

journal_title：Frontiers in genetics

authors： Kerger BD,James RC,Galbraith DA

更新日期：2014-05-30 00:00:00

abstract：:Searching for the Multiple Longest Common Subsequences (MLCS) of multiple sequences is a classical NP-hard problem, which has been used in many applications. One of the most effective exact approaches for the MLCS problem is based on dominant point graph, which is a kind of directed acyclic graph (DAG). However, the t...

journal_title：Frontiers in genetics

authors： Peng Z,Wang Y

更新日期：2017-08-09 00:00:00