The Length of the Expressed 3' UTR Is an Intermediate Molecular Phenotype Linking Genetic Variants to Complex Diseases.

abstract：:Functional annotation of the genome is important to understand the phenotypic complexity of various species. The road toward functional annotation involves several challenges ranging from experiments on individual molecules to large-scale analysis of high-throughput sequencing (HTS) data. HTS data is typically a resul...

journal_title：Frontiers in genetics

authors： Pundhir S,Poirazi P,Gorodkin J

更新日期：2015-05-19 00:00:00

abstract：:Sufficient genetic variation in livestock populations is necessary both for adaptation to future changes in climate and consumer demand, and for continual genetic improvement of economically important traits. Unfortunately, the current trend is for reduced genetic variation, both within and across breeds. The latter o...

journal_title：Frontiers in genetics

authors： Biscarini F,Nicolazzi EL,Stella A,Boettcher PJ,Gandini G

更新日期：2015-02-25 00:00:00

abstract：:Understanding the molecular basis of cell function and ultimate phenotypes is crucial for the development of biological markers. With this aim, several RNA-seq studies have been devoted to the characterization of the transcriptome of ejaculated spermatozoa in relation to sperm quality and fertility. Semen quality foll...

journal_title：Frontiers in genetics

authors： Gòdia M,Estill M,Castelló A,Balasch S,Rodríguez-Gil JE,Krawetz SA,Sánchez A,Clop A

更新日期：2019-04-16 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00

abstract：:Erythropoiesis of human hematopoietic stem cells (HSCs) maintains generation of red blood cells throughout life. However, little is known how human erythropoiesis is regulated by long non-coding RNAs (lncRNAs). By using ChIRP-seq, we report here that the lncRNA steroid receptor RNA activator (SRA) occupies chromatin, ...

journal_title：Frontiers in genetics

authors： Sawaengdee W,Cui K,Zhao K,Hongeng S,Fucharoen S,Wongtrakoongate P

更新日期：2020-08-11 00:00:00

abstract：:Trauma is a leading cause of morbidity and mortality. It is unclear why some trauma victims follow a complicated clinical course and die, while others, with apparently similar injury characteristics, do not. Interpatient genomic differences, in the form of single nucleotide polymorphisms (SNPs), have been associated p...

journal_title：Frontiers in genetics

authors： Schimunek L,Namas RA,Yin J,Barclay D,Liu D,El-Dehaibi F,Abboud A,Cohen M,Zamora R,Billiar TR,Vodovotz Y

更新日期：2019-11-08 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition. The function of the DNA helicase encoded by WRN, the gene responsible for WS, has been studied extensively. WRN helicase is in...

journal_title：Frontiers in genetics

authors： Shimamoto A,Yokote K,Tahara H

更新日期：2015-01-29 00:00:00

abstract：:The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease (CVD), and have also been associated with longevity. We sought to identify novel loci for HDL that could potentially provide new insights into biological regulation of...

journal_title：Frontiers in genetics

authors： Feitosa MF,Wojczynski MK,Straka R,Kammerer CM,Lee JH,Kraja AT,Christensen K,Newman AB,Province MA,Borecki IB

更新日期：2014-06-03 00:00:00

abstract：:Reliable phenotypes are paramount for meaningful quantification of genetic variation and for estimating individual breeding values on which genetic selection is based. In this paper, we assert that genetic improvement of host tolerance to disease, although desirable, may be first of all handicapped by the ability to o...

journal_title：Frontiers in genetics

authors： Doeschl-Wilson AB,Villanueva B,Kyriazakis I

更新日期：2012-12-14 00:00:00

abstract：Background:Myopia is a common eye disorder that is approaching epidemic proportions worldwide. A genome-wide association study identified AREG (rs12511037), GABRR1 (rs13215566), and PDE10A (rs12206610) as being associated with refractive error in Asian populations. The present study investigated the associations betwee...

journal_title：Frontiers in genetics

authors： Lin Y,Ding Y,Jiang D,Li C,Huang X,Liu L,Xiao H,Vasudevan B,Chen Y

更新日期：2020-03-25 00:00:00

abstract：:The red junglefowl Gallus gallus is the main progenitor of domestic chicken, the commonest livestock species, outnumbering humans by an approximate ratio of six to one. The genetic control for production traits have been well studied in commercial chicken, but the selection pressures underlying unique adaptation and p...

journal_title：Frontiers in genetics

authors： Lawal RA,Al-Atiyat RM,Aljumaah RS,Silva P,Mwacharo JM,Hanotte O

更新日期：2018-07-20 00:00:00

abstract：:Rodent models have been extensively used to investigate the cause and mechanisms behind Alzheimer's disease. Despite many years of intensive research using these models we still lack a detailed understanding of the molecular events that lead to neurodegeneration. Although zebrafish lack the complexity of advanced cogn...

journal_title：Frontiers in genetics

authors： Newman M,Ebrahimie E,Lardelli M

更新日期：2014-06-30 00:00:00

abstract：:This study tests in a genetically informative design whether exercise behavior causally influences subjective wellbeing (SWB) and internalizing problems (INT). If exercise causally influences SWB and INT, genetic and environmental factors influencing exercise behavior will also influence SWB and INT. Furthermore, with...

journal_title：Frontiers in genetics

authors： Bartels M,de Moor MH,van der Aa N,Boomsma DI,de Geus EJ

更新日期：2012-01-19 00:00:00

abstract：:Genome-wide association study (GWAS), exploring the historical and evolutionary recombinations at the population level, is a major method adopted to identify quantitative trait loci (QTL) for complex traits. However, to summarize GWAS results, gene structure, and linkage disequilibrium (LD) in a single view, multiple ...

journal_title：Frontiers in genetics

authors： He F,Ding S,Wang H,Qin F

更新日期：2020-03-20 00:00:00

abstract：:Tools for genomic island prediction use strategies for genomic comparison analysis and sequence composition analysis. The goal of comparative analysis is to identify unique regions in the genomes of related organisms, whereas sequence composition analysis evaluates and relates the composition of specific regions with ...

journal_title：Frontiers in genetics

authors： da Silva Filho AC,Raittz RT,Guizelini D,De Pierri CR,Augusto DW,Dos Santos-Weiss ICR,Marchaukoski JN

更新日期：2018-12-12 00:00:00

abstract：:Analysis of the relationships among wild species of section Moutan in the plant genus Paeonia has traditionally been problematic. Interspecies relationships cannot be effectively determined using phenotypic traits alone or through analysis of nuclear or chloroplast DNA fragments. Elucidation of complete chloroplast ge...

journal_title：Frontiers in genetics

authors： Wu L,Nie L,Xu Z,Li P,Wang Y,He C,Song J,Yao H

更新日期：2020-09-18 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:MicroRNAs (miRNAs) crucial roles in translation repression and post-transcriptional adjustments contribute to regulate intestinal lipid metabolism. Even though their actions in different metabolic tissues have been elucidated, their intestinal activity is yet unclear. We aimed to investigate intestinal miRNA-regulated...

journal_title：Frontiers in genetics

authors： Ruiz-Roso MB,Gil-Zamorano J,López de Las Hazas MC,Tomé-Carneiro J,Crespo MC,Latasa MJ,Briand O,Sánchez-López D,Ortiz AI,Visioli F,Martínez JA,Dávalos A

更新日期：2020-07-10 00:00:00

abstract：:Cotton (Gossypium spp.) is the most important natural fiber crop in the world. The R2R3-MYB gene family is a large gene family involved in many plant functions including cotton fiber development. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in tetrapl...

journal_title：Frontiers in genetics

authors： Wang N,Ma Q,Ma J,Pei W,Liu G,Cui Y,Wu M,Zang X,Zhang J,Yu S,Ma L,Yu J

更新日期：2019-08-15 00:00:00

abstract：:The interesting history of Southern Africa has put the region in the spotlight for population medical genetics. Major events including the Bantu expansion and European colonialism have imprinted unique genetic signatures within autochthonous populations of Southern Africa, this resulting in differential allele frequen...

journal_title：Frontiers in genetics

authors： Thami PK,Chimusa ER

更新日期：2019-09-27 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common histological subtypes of renal cancer, with a poor prognosis. Our study aimed to identify a biomarker that is significantly associated with ccRCC prognosis and novel immunotherapeutic targets, as well as some novel molecular drugs for ccRCC. Based on th...

journal_title：Frontiers in genetics

authors： Xiao GF,Yan X,Chen Z,Zhang RJ,Liu TZ,Hu WL

更新日期：2020-08-18 00:00:00

abstract：:Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications. On epigenetic level, replicative senescence and aging evoke characteristic modifications in the DNA methylatio...

journal_title：Frontiers in genetics

authors： Wagner W

更新日期：2019-04-03 00:00:00

abstract：:The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

journal_title：Frontiers in genetics

authors： Mahal DG,Matsoukas IG

更新日期：2017-09-20 00:00:00

abstract：:The concept of Developmental Origins of Health and Diseases (DOHaD) recognizes that an unfavorable maternal environment alters the developmental trajectory of the fetus and can lead to long-term risk of developing chronic noncommunicable diseases. More recently, the concept of a paternal transmission [Paternal Origins...

journal_title：Frontiers in genetics

authors： Dupont C,Kappeler L,Saget S,Grandjean V,Lévy R

更新日期：2019-04-18 00:00:00

abstract：:Motivation:Arabidopsis thaliana is a well-established model system for the analysis of the basic physiological and metabolic pathways of plants. Nevertheless, the system is not yet fully understood, although many mechanisms are described, and information for many processes exists. However, the combination and interpre...

journal_title：Frontiers in genetics

authors： Koch I,Nöthen J,Schleiff E

更新日期：2017-06-30 00:00:00

abstract：:Variability of the comet assay is a serious issue, whether it occurs from experiment to experiment in the same laboratory, or between different laboratories analysing identical samples. Do we have to live with high variability, just because the comet assay is a biological assay rather than analytical chemistry? Numero...

journal_title：Frontiers in genetics

authors： Collins AR,El Yamani N,Lorenzo Y,Shaposhnikov S,Brunborg G,Azqueta A

更新日期：2014-10-20 00:00:00

abstract：:In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element LINE-1, MEST, P16, H19, and GNAS in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quantitative DNA methyla...

journal_title：Frontiers in genetics

authors： Zhang W,Li M,Sun F,Xu X,Zhang Z,Liu J,Sun X,Zhang A,Shen Y,Xu J,Miao M,Wu B,Yuan Y,Huang X,Shi H,Du J

更新日期：2019-10-18 00:00:00

abstract：:Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expression of genetic inform...

journal_title：Frontiers in genetics

authors： Ni Z,Zhou XY,Aslam S,Niu DK

更新日期：2019-12-04 00:00:00

abstract：:Staphylococcus epidermidis is one of the most commonly isolated species from human skin and the second leading cause of bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic determinants associated with the diversity and adaptation of S. epide...

journal_title：Frontiers in genetics

authors： Su F,Tian R,Yang Y,Li H,Sun G,Li Y,Han B,Xu X,Chen X,Zhao G,Cui H,Xu H

更新日期：2020-11-09 00:00:00