Comparative and Phylogenetic Analysis of the Complete Chloroplast Genomes of Three Paeonia Section Moutan Species (Paeoniaceae).

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes. This study explored potential prognostic markers in CRC via the construction and in-depth analysis of a competing endogenous RNA (ceRNA) network, which was gene...

journal_title：Frontiers in genetics

authors： Guo L,Yang G,Kang Y,Li S,Duan R,Shen L,Jiang W,Qian B,Yin Z,Liang T

更新日期：2020-05-08 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:Commensal gut bacteria in many species including flies are integral part of their host, and are known to influence its development and homeostasis within generation. Here we report an unexpected impact of host-microbe interactions, which mediates multi-generational, non-Mendelian inheritance of a stress-induced phenot...

journal_title：Frontiers in genetics

authors： Fridmann-Sirkis Y,Stern S,Elgart M,Galili M,Zeisel A,Shental N,Soen Y

更新日期：2014-02-25 00:00:00

abstract：:The extent to which genetic gain achieved from selection programs under strictly controlled environments in the nucleus that can be expressed in commercial production systems is not well-documented in aquaculture species. The main aim of this paper was to assess the effects of genotype by environment interaction on ge...

journal_title：Frontiers in genetics

authors： Nguyen NH,Hamzah A,Thoa NP

更新日期：2017-06-13 00:00:00

abstract：:p73 transcription factor belongs to one of the most important gene families in vertebrate biology, the p53-family. Trp73 gene, like the other family members, generates multiple isoforms named TA and DNp73, with different and, sometimes, antagonist functions. Although p73 shares many biological functions with p53, it a...

journal_title：Frontiers in genetics

authors： Marques MM,Villoch-Fernandez J,Maeso-Alonso L,Fuertes-Alvarez S,Marin MC

更新日期：2019-03-15 00:00:00

abstract：:The genetic predisposition to chronic kidney disease (CKD) has been widely evaluated especially using the genome-wide association studies, which highlighted some novel genetic susceptibility variants in many genes, and estimated glomerular filtration rate to diagnose and stage CKD. Of these variants, rs7805747 in PRKA...

journal_title：Frontiers in genetics

authors： Wang E,Zhao H,Zhao D,Li L,Du L

更新日期：2018-12-03 00:00:00

abstract：:The factors behind genome size evolution have been of great interest, considering that eukaryotic genomes vary in size by more than three orders of magnitude. Using a model of two wild peanut relatives, Arachis duranensis and Arachis ipaensis, in which one genome experienced large rearrangements, we find that the main...

journal_title：Frontiers in genetics

authors： Ren L,Huang W,Cannon EKS,Bertioli DJ,Cannon SB

更新日期：2018-10-09 00:00:00

abstract：:Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks due to the shared genetics of their haplotype block. Therefore, ...

journal_title：Frontiers in genetics

authors： Joslin SEK,Durbin-Johnson BP,Britton M,Settles ML,Korf I,Lemay DG

更新日期：2020-10-29 00:00:00

abstract：:Glioblastoma (GBM) is characterized by rapid and lethal infiltration of brain tissue, which is the primary cause of treatment failure and deaths for GBM. Therefore, understanding the molecular mechanisms of tumor cell invasion is crucial for the treatment of GBM. In this study, we dissected the single-cell RNA-seq dat...

journal_title：Frontiers in genetics

authors： Pang B,Quan F,Ping Y,Hu J,Lan Y,Pang L

更新日期：2021-01-11 00:00:00

abstract：Background:This study aimed to investigate the genetic causes of hypohidrotic ectodermal dysplasia (HED) in two families and elucidate the molecular pathogenesis of HED in Chinese Han patients. Methods:Whole-exome sequencing (WES) was used to screen HED-related genes in two family members, followed by confirmatory San...

journal_title：Frontiers in genetics

authors： Han Y,Wang X,Zheng L,Zhu T,Li Y,Hong J,Xu C,Wang P,Gao M

更新日期：2020-02-04 00:00:00

abstract：:Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population. Methods: We analyzed 279 patients with unexplained optic atrophy using next-generation sequencing. All patients underwent detailed clinical e...

journal_title：Frontiers in genetics

authors： Wang DD,Hu FY,Gao FJ,Zhang SH,Xu P,Tian GH,Wu JH

更新日期：2019-11-26 00:00:00

abstract：:The emerald ash borer (EAB), Agrilus planipennis, is a highly destructive quarantine pest. The olfactory and visual systems of A. planipennis play different but critical roles at newly emerged and sexually mature stages; however, the molecular basis underlying these differences remain unclear. Consequently, based on d...

journal_title：Frontiers in genetics

authors： Shen S,Fan Z,Zhang X,Kong X,Liu F,Zhang Z,Zhang X,Hu X,Zhang S

更新日期：2021-01-15 00:00:00

abstract：:Assortative mating is a universal feature of human societies, and individuals from ethnically diverse populations are known to mate assortatively based on similarities in genetic ancestry. However, little is currently known regarding the exact phenotypic cues, or their underlying genetic architecture, which inform anc...

journal_title：Frontiers in genetics

authors： Norris ET,Rishishwar L,Wang L,Conley AB,Chande AT,Dabrowski AM,Valderrama-Aguirre A,Jordan IK

更新日期：2019-04-24 00:00:00

abstract：:Pharmacogenomics is the study of how genes affect a person's response to drugs. Thus, understanding the effect of drug at the molecular level can be helpful in both drug discovery and personalized medicine. Over the years, transcriptome data upon drug treatment has been collected and several databases compiled before ...

journal_title：Frontiers in genetics

authors： Oh M,Park S,Lee S,Lee D,Lim S,Jeong D,Jo K,Jung I,Kim S

更新日期：2020-11-12 00:00:00

abstract：:Searching for the Multiple Longest Common Subsequences (MLCS) of multiple sequences is a classical NP-hard problem, which has been used in many applications. One of the most effective exact approaches for the MLCS problem is based on dominant point graph, which is a kind of directed acyclic graph (DAG). However, the t...

journal_title：Frontiers in genetics

authors： Peng Z,Wang Y

更新日期：2017-08-09 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common histological subtypes of renal cancer, with a poor prognosis. Our study aimed to identify a biomarker that is significantly associated with ccRCC prognosis and novel immunotherapeutic targets, as well as some novel molecular drugs for ccRCC. Based on th...

journal_title：Frontiers in genetics

authors： Xiao GF,Yan X,Chen Z,Zhang RJ,Liu TZ,Hu WL

更新日期：2020-08-18 00:00:00

abstract：:At the time of translation, nascent proteins are thought to be sorted into their final subcellular localization sites, based on the part of their amino acid sequences (i.e., sorting or targeting signals). Thus, it is interesting to computationally recognize these signals from the amino acid sequences of any given prot...

journal_title：Frontiers in genetics

authors： Imai K,Nakai K

更新日期：2020-11-25 00:00:00

abstract：:Primary ciliary dyskinesia (PCD), a rare genetic disorder, is mostly caused by defects in more than 40 known cilia structure-related genes. However, in approximately 20-35% of patients, it is caused by unknown genetic factors, and the inherited pathogenic factors are difficult to confirm. Kartagener syndrome (KTS) is ...

journal_title：Frontiers in genetics

authors： Yue Y,Huang Q,Zhu P,Zhao P,Tan X,Liu S,Li S,Han X,Cheng L,Li B,Fu Y

更新日期：2019-08-22 00:00:00

abstract：:Production animals are constantly subjected to early adverse environmental conditions that influence the adult phenotype and produce epigenetic effects. CpG dinucleotide methylation in red blood cells (RBC) could be a useful epigenetic biomarker to identify animals subjected to chronic stress in the production environ...

journal_title：Frontiers in genetics

authors： Pértille F,Ibelli AMG,Sharif ME,Poleti MD,Fröhlich AS,Rezaei S,Ledur MC,Jensen P,Guerrero-Bosagna C,Coutinho LL

更新日期：2020-11-02 00:00:00

abstract：:The Galway sheep population is the only native Irish sheep breed and this livestock genetic resource is currently categorised as 'at-risk'. In the present study, comparative population genomics analyses of Galway sheep and other sheep populations of European origin were used to investigate the microevolution and recen...

journal_title：Frontiers in genetics

authors： McHugo GP,Browett S,Randhawa IAS,Howard DJ,Mullen MP,Richardson IW,Park SDE,Magee DA,Scraggs E,Dover MJ,Correia CN,Hanrahan JP,MacHugh DE

更新日期：2019-10-08 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is one of the malignancies in women, which has the highest mortality. However, the microlevel mechanism has not been discussed in detail. The expression profiles GSE27651, GSE38666, GSE40595, and GSE66957 including 188 tumor and 52 nontumor samples were downloaded from the Gene Expressi...

journal_title：Frontiers in genetics

authors： Liu J,Meng H,Li S,Shen Y,Wang H,Shan W,Qiu J,Zhang J,Cheng W

更新日期：2019-10-24 00:00:00

abstract：:Muscle weakness is a common consequence of both aging (sarcopenia) and neuromuscular disorders (NMD). Whilst genome-wide association (GWA) studies have identified genetic variants associated with grip strength (GS; measure of muscle strength/weakness) and NMDs, including multiple sclerosis (MS), myasthenia gravis (MG)...

journal_title：Frontiers in genetics

authors： Gokuladhas S,Schierding W,Cameron-Smith D,Wake M,Scotter EL,O'Sullivan J

更新日期：2020-04-24 00:00:00

abstract：:A livestock population can be characterized by different population genetic parameters, such as linkage disequilibrium and recombination rate between pairs of genetic markers. The population structure, which may be caused by family stratification, has an influence on the estimates of these parameters. An expectation m...

journal_title：Frontiers in genetics

authors： Hampel A,Teuscher F,Gomez-Raya L,Doschoris M,Wittenburg D

更新日期：2018-06-05 00:00:00

abstract：:Genotype imputation is a powerful tool for increasing statistical power in an association analysis. Meta-analysis of multiple study datasets also requires a substantial overlap of SNPs for a successful association analysis, which can be achieved by imputation. Quality of imputed datasets is largely dependent on the so...

journal_title：Frontiers in genetics

authors： Schurz H,Müller SJ,van Helden PD,Tromp G,Hoal EG,Kinnear CJ,Möller M

更新日期：2019-02-05 00:00:00

abstract：:Lin28 is a developmentally regulated RNA-binding protein that plays important roles in diverse physiological and pathological processes including oncogenesis and brain synaptic function. These pleiotropic roles of Lin28 are mechanistically linked both to its ability to directly stimulate translation of genes involved ...

journal_title：Frontiers in genetics

authors： Kallen AN,Ma J,Huang Y

更新日期：2012-11-16 00:00:00

abstract：:Fragile X-associated primary ovarian insufficiency (FXPOI) occurs in about 20% of women who carry a premutation allele (55-200 CGG repeats). These women develop hypergonadotropic hypogonadism and have secondary amenorrhea before age 40. A non-linear association with repeat size and risk for FXPOI has been seen in mult...

journal_title：Frontiers in genetics

authors： Allen EG,Glicksman A,Tortora N,Charen K,He W,Amin A,Hipp H,Shubeck L,Nolin SL,Sherman SL

更新日期：2018-08-03 00:00:00

abstract：:Taproot skin color is a crucial visual and nutritional quality trait of radish, and purple skin is most attractive to consumers. However, the genetic mechanism underlying this character is unknown. Herein, F2 segregating populations were constructed to investigate radish genomic regions with purple skin genes. Segrega...

journal_title：Frontiers in genetics

authors： Liu T,Wang J,Wu C,Zhang Y,Zhang X,Li X,Wang H,Song J,Li X

更新日期：2019-09-20 00:00:00

abstract：:In genome wide association studies (GWAS), family-based studies tend to have less power to detect genetic associations than population-based studies, such as case-control studies. This can be an issue when testing if genes in a family-based GWAS have a direct effect on the phenotype of interest over and above their po...

journal_title：Frontiers in genetics

authors： Lutz SM,Vansteelandt S,Lange C

更新日期：2013-11-21 00:00:00

abstract：:Extracellular vesicles (EVs) are abundant in most biological fluids and considered promising biomarker candidates, but the development of EV biomarker assays is hindered, in part, by their requirement for prior EV purification and the lack of standardized and reproducible EV isolation methods. We now describe a far-fi...

journal_title：Frontiers in genetics

authors： Amrollahi P,Rodrigues M,Lyon CJ,Goel A,Han H,Hu TY

更新日期：2019-12-17 00:00:00

abstract：:Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 ...

journal_title：Frontiers in genetics

authors： Sebastiani P,Gurinovich A,Bae H,Andersen SL,Perls TT

更新日期：2017-11-21 00:00:00