Emerging applications of read profiles towards the functional annotation of the genome.

abstract：:Advanced castrate-resistant prostate cancer (CRPC) is a poorly prognostic disease currently lacking effective cure. Understanding the molecular mechanism that underlies the initiation and progression of CRPC will provide new strategies for treating this deadly disease. One candidate target is the fibroblast growth fac...

journal_title：Frontiers in genetics

authors： Wang C,Liu Z,Ke Y,Wang F

更新日期：2019-01-30 00:00:00

abstract：:Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and ob...

journal_title：Frontiers in genetics

authors： Cronin RM,Field JR,Bradford Y,Shaffer CM,Carroll RJ,Mosley JD,Bastarache L,Edwards TL,Hebbring SJ,Lin S,Hindorff LA,Crane PK,Pendergrass SA,Ritchie MD,Crawford DC,Pathak J,Bielinski SJ,Carrell DS,Crosslin DR,Ledbett

更新日期：2014-08-05 00:00:00

abstract：Background:Tumor stem cells play important roles in the survival, proliferation, metastasis and recurrence of tumors. We aimed to identify new prognostic biomarkers for lung squamous cell carcinoma (LUSC) based on the cancer stem cell theory. Methods:RNA-seq data and relevant clinical information were downloaded from ...

journal_title：Frontiers in genetics

authors： Liao Y,Xiao H,Cheng M,Fan X

更新日期：2020-05-13 00:00:00

abstract：:Molybdenum cofactor deficiency (MoCD) is an autosomal recessive disorder belonging to the large family of inborn errors in metabolism. Patients typically present with encephalopathy and seizures early after birth and develop severe neurodegeneration within the first few weeks of life. The main pathomechanism underlyin...

journal_title：Frontiers in genetics

authors： Mellis AT,Roeper J,Misko AL,Kohl J,Schwarz G

更新日期：2021-01-07 00:00:00

abstract：:This study examined reasons for participation in a genetic study of risk for multiple sclerosis (MS). Our sample consisted of 101 patients diagnosed with MS who were approached about enrolling in the Multiple Sclerosis Genetic Susceptibility Study. Participants were predominantly Hispanic (80%), female (80%), and well...

journal_title：Frontiers in genetics

authors： Cuccaro ML,Manrique CP,Quintero MA,Martinez R,McCauley JL

更新日期：2020-03-13 00:00:00

abstract：:Cotton (Gossypium spp.) is the most important natural fiber crop in the world. The R2R3-MYB gene family is a large gene family involved in many plant functions including cotton fiber development. Although previous studies have reported its phylogenetic relationships, gene structures, and expression patterns in tetrapl...

journal_title：Frontiers in genetics

authors： Wang N,Ma Q,Ma J,Pei W,Liu G,Cui Y,Wu M,Zang X,Zhang J,Yu S,Ma L,Yu J

更新日期：2019-08-15 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Small-Tailed Han (STH) sheep are known for their high fecundity, but the survival of lambs is compromised and influences the commercial return from farming these sheep, with this being attributed in part to starvation from insufficient milk production by the ewes. In this study, the transcriptome profiles of the mamma...

journal_title：Frontiers in genetics

authors： Wang J,Zhou H,Hickford JGH,Hao Z,Shen J,Luo Y,Hu J,Liu X,Li S

更新日期：2020-05-21 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. They are aberrantly expressed in many human cancers and are potential therapeutic targets and molecular biomarkers. METHODS:In this study, we for the first time validated the reported data on the entire set of published differential...

journal_title：Frontiers in genetics

authors： Zabolotneva AA,Zhavoronkov AA,Shegay PV,Gaifullin NM,Alekseev BY,Roumiantsev SA,Garazha AV,Kovalchuk O,Aravin A,Buzdin AA

更新日期：2013-11-15 00:00:00

abstract：:Motivation:Arabidopsis thaliana is a well-established model system for the analysis of the basic physiological and metabolic pathways of plants. Nevertheless, the system is not yet fully understood, although many mechanisms are described, and information for many processes exists. However, the combination and interpre...

journal_title：Frontiers in genetics

authors： Koch I,Nöthen J,Schleiff E

更新日期：2017-06-30 00:00:00

abstract：PURPOSE:Genetic risk assessment is becoming an important component of clinical decision-making. Genetic Risk Scores (GRSs) allow the composite assessment of genetic risk in complex traits. A technically and clinically pertinent question is how to most easily and effectively combine a GRS with an assessment of clinical ...

journal_title：Frontiers in genetics

authors： Goldstein BA,Knowles JW,Salfati E,Ioannidis JP,Assimes TL

更新日期：2014-08-01 00:00:00

abstract：:Pacu (Piaractus mesopotamicus) is a Neotropical fish of major importance for South American aquaculture. Septicemia caused by Aeromonas hydrophila bacteria is currently considered a substantial threat for pacu aquaculture that have provoked infectious disease outbreaks with high economic losses. The understanding of m...

journal_title：Frontiers in genetics

authors： Mastrochirico-Filho VA,Hata ME,Kuradomi RY,de Freitas MV,Ariede RB,Pinheiro DG,Robledo D,Houston R,Hashimoto DT

更新日期：2020-06-09 00:00:00

abstract：:Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

journal_title：Frontiers in genetics

authors： Jia K,Zhou Y,Cui Q

更新日期：2020-01-21 00:00:00

abstract：:RNA-binding proteins (RBPs) interacting with target RNAs play essential roles in RNA metabolism at the post-transcription level. Perturbations of RBPs can accelerate cancer development and cause dysregulation of the immune cell function and activity leading to evade immune destruction of cancer cells. However, few stu...

journal_title：Frontiers in genetics

authors： Hu G,Jiang Q,Liu L,Peng H,Wang Y,Li S,Tang Y,Yu J,Yang J,Liu Z

更新日期：2021-01-11 00:00:00

abstract：:It is broadly expected that next generation sequencing will ultimately generate a complete genome as is the latest goat reference genome (ARS1), which is considered to be one of the most continuous assemblies in livestock. However, the rich diversity of worldwide goat breeds indicates that a genome from one individual...

journal_title：Frontiers in genetics

authors： Li R,Fu W,Su R,Tian X,Du D,Zhao Y,Zheng Z,Chen Q,Gao S,Cai Y,Wang X,Li J,Jiang Y

更新日期：2019-11-15 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the world's population. The etiology of RA remains unknown. It is considered to occur in the presence of genetic and environmental factors. An increasing body of evidence pinpoints that epigenetic modifications play an important role i...

journal_title：Frontiers in genetics

authors： Nemtsova MV,Zaletaev DV,Bure IV,Mikhaylenko DS,Kuznetsova EB,Alekseeva EA,Beloukhova MI,Deviatkin AA,Lukashev AN,Zamyatnin AA Jr

更新日期：2019-06-14 00:00:00

abstract：:Breeding livestock that are better able to withstand the onslaught of endemic- and exotic pathogens is high on the wish list of breeders and farmers world-wide. However, the defense systems in both pathogens and their hosts are complex and the degree of genetic variation in resistance and tolerance will depend on the ...

journal_title：Frontiers in genetics

authors： Glass EJ

更新日期：2012-12-14 00:00:00

abstract：:Watson for Oncology (WFO) is a artificial intelligence clinical decision-support system with evidence-based treatment options for oncologists. WFO has been gradually used in China, but limited reports on whether WFO is suitable for Chinese patients. This study aims to investigate the concordance of treatment options b...

journal_title：Frontiers in genetics

authors： Zou FW,Tang YF,Liu CY,Ma JA,Hu CH

更新日期：2020-03-24 00:00:00

abstract：:MicroRNAs (miRNAs) crucial roles in translation repression and post-transcriptional adjustments contribute to regulate intestinal lipid metabolism. Even though their actions in different metabolic tissues have been elucidated, their intestinal activity is yet unclear. We aimed to investigate intestinal miRNA-regulated...

journal_title：Frontiers in genetics

authors： Ruiz-Roso MB,Gil-Zamorano J,López de Las Hazas MC,Tomé-Carneiro J,Crespo MC,Latasa MJ,Briand O,Sánchez-López D,Ortiz AI,Visioli F,Martínez JA,Dávalos A

更新日期：2020-07-10 00:00:00

abstract：:MicroRNAs are a class of noncoding RNAs that can be involved in the regulation of gene expression in cancers, including lung cancer. Our previous research has shown that miR-486-5p is one of the most downregulated microRNAs in tissue and serum samples of lung cancer as a good diagnostic biomarker. The objective of thi...

journal_title：Frontiers in genetics

authors： Tian F,Wang J,Ouyang T,Lu N,Lu J,Shen Y,Bai Y,Xie X,Ge Q

更新日期：2019-07-26 00:00:00

abstract：:Recent studies have revealed that the RNA N6-methyladenosine (m6A) modification plays a critical role in a variety of biological processes and associated with multiple diseases including cancers. Till this day, transcriptome-wide m6A RNA methylation sites have been identified by high-throughput sequencing technique co...

journal_title：Frontiers in genetics

authors： Tang Y,Chen K,Wu X,Wei Z,Zhang SY,Song B,Zhang SW,Huang Y,Meng J

更新日期：2019-04-03 00:00:00

abstract：:Plant basic helix-loop-helix (bHLH) transcription factors are involved in the regulation of various biological processes in plant growth, development, and stress response. However, members of this important transcription factor family have not been systematically identified and analyzed in pepper (Capsicum annuum L.)....

journal_title：Frontiers in genetics

authors： Zhang Z,Chen J,Liang C,Liu F,Hou X,Zou X

更新日期：2020-09-25 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:MicroRNAs (miRNAs) undergo high levels of regulation in skeletal muscle development and control skeletal muscle mass, function and metabolism over the lifespan. More recently, the role of long non-coding RNAs (lncRNAs) in skeletal muscle regulation has started to emerge. Following up on our recent study describing the...

journal_title：Frontiers in genetics

authors： Mikovic J,Sadler K,Butchart L,Voisin S,Gerlinger-Romero F,Della Gatta P,Grounds MD,Lamon S

更新日期：2018-11-16 00:00:00

abstract：:Systemic sclerosis-associated with pulmonary arterial hypertension (SSc-PAH) is still a major cause of SSc related deaths. Early diagnosis and prompt treatment are crucial to reduce the mortality of patients with SSc-PAH. To screen the candidate biomarkers and potential therapeutic targets for SSc-PAH, we analyzed the...

journal_title：Frontiers in genetics

authors： Zheng JN,Li Y,Yan YM,Shi H,Zou TT,Shao WQ,Wang Q

更新日期：2020-07-24 00:00:00

abstract：:Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes. The vast majority of adult CMs (ACMs) do not reenter cell...

journal_title：Frontiers in genetics

authors： Oyama K,El-Nachef D,Zhang Y,Sdek P,MacLellan WR

更新日期：2014-11-04 00:00:00

abstract：:Phomopsis longicolla T. W. Hobbs (syn. Diaporthe longicolla) is the primary cause of Phomopsis seed decay (PSD) in soybean, Glycine max (L.) Merrill. This disease results in poor seed quality and is one of the most economically important seed diseases in soybean. The objectives of this study were to infer protein-prot...

journal_title：Frontiers in genetics

authors： Li S,Musungu B,Lightfoot D,Ji P

更新日期：2018-04-03 00:00:00

abstract：:Plant Glycine-rich proteins (GRP), a superfamily with a glycine-rich domain, play an important role in various stresses such as high or low temperature stress and drought stress. GRP genes have been studied in many plants, but seldom in Chinese cabbage (Brassica rapa L. ssp. pekinensis). In this study, a total of 64 G...

journal_title：Frontiers in genetics

authors： Lu X,Cheng Y,Gao M,Li M,Xu X

更新日期：2020-07-23 00:00:00