Gene and Protein Expression in Subjects With a Nystagmus-Associated AHR Mutation.

abstract：:Hereditary spastic paraplegias (HSPs) is a rare heterogeneous group of neurodegenerative diseases, with upper and lower limb spasticity motor neuron disintegration leading to paraplegias. NT5C2 gene (OMIM: 600417) encode a hydrolase enzyme 5'-nucleotidase, cytosolic II play an important role in maintaining the balance...

journal_title：Frontiers in genetics

authors： Naseer MI,Abdulkareem AA,Pushparaj PN,Bibi F,Chaudhary AG

更新日期：2020-02-21 00:00:00

abstract：:Staphylococcus epidermidis is one of the most commonly isolated species from human skin and the second leading cause of bloodstream infections. Here, we performed a large-scale comparative study without any pre-assigned reference to identify genomic determinants associated with the diversity and adaptation of S. epide...

journal_title：Frontiers in genetics

authors： Su F,Tian R,Yang Y,Li H,Sun G,Li Y,Han B,Xu X,Chen X,Zhao G,Cui H,Xu H

更新日期：2020-11-09 00:00:00

abstract：:An increasing number of studies have shown that long intergenic non-coding RNAs (lincRNAs) are a very important class of non-coding RNAs that plays a vital role in many biological processes. Adipose tissue is an important place for storing energy, but few studies on lincRNAs were related to pig subcutaneous fat develo...

journal_title：Frontiers in genetics

authors： Shi G,Chen L,Chen G,Zou C,Li J,Li M,Fang C,Li C

更新日期：2019-03-04 00:00:00

abstract：:Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not ye...

journal_title：Frontiers in genetics

authors： Bogucka-Kocka A,Zalewski DP,Ruszel KP,Stępniewski A,Gałkowski D,Bogucki J,Komsta Ł,Kołodziej P,Zubilewicz T,Feldo M,Kocki J

更新日期：2019-11-22 00:00:00

abstract：:Evidence from clinical and epidemiological studies indicates that asthma is associated with allergic diseases including hay fever, allergic rhinitis, and eczema. Genetic analysis demonstrated that asthma had a positive genetic correlation with allergic diseases. A Mendelian randomization (MR) analysis using the rs1696...

journal_title：Frontiers in genetics

authors： Shen M,Liu X,Li G,Li Z,Zhou H

更新日期：2020-08-04 00:00:00

abstract：:Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric disorders, which are...

journal_title：Frontiers in genetics

authors： Holland D,Wang Y,Thompson WK,Schork A,Chen CH,Lo MT,Witoelar A,Schizophrenia Working Group of the Psychiatric Genomics Consortium.,Enhancing Neuro Imaging Genetics through Meta Analysis Consortium.,Werge T,O'Donovan M,Andreassen OA

更新日期：2016-02-16 00:00:00

abstract：:This study assessed the accuracy and bias of genomic prediction (GP) in purebred Holstein (H) and Jersey (J) as well as crossbred (H and J) validation cows using different reference sets and prediction strategies. The reference sets were made up of different combinations of 36,695 H and J purebreds and crossbreds. Add...

journal_title：Frontiers in genetics

authors： Khansefid M,Goddard ME,Haile-Mariam M,Konstantinov KV,Schrooten C,de Jong G,Jewell EG,O'Connor E,Pryce JE,Daetwyler HD,MacLeod IM

更新日期：2020-12-14 00:00:00

abstract：:Inference of absolute copy numbers in tumor genomes is one of the key points in the study of tumor genesis. However, the mixture of tumor and normal cells poses a big challenge to this task. Accurate estimation of tumor purity (i.e., the fraction of tumor cells) is a necessary step to solve this problem. In this paper...

journal_title：Frontiers in genetics

authors： Yuan X,Li Z,Zhao H,Bai J,Zhang J

更新日期：2020-04-30 00:00:00

abstract：:Telomeres are essential nucleoprotein structures at linear chromosomes that maintain genome integrity by protecting chromosome ends from being recognized and processed as damaged DNA. In addition, they limit the cell's proliferative capacity, as progressive loss of telomeric DNA during successive rounds of cell divisi...

journal_title：Frontiers in genetics

authors： Yalçin Z,Selenz C,Jacobs JJL

更新日期：2017-05-23 00:00:00

abstract：Background:Myopia is a common eye disorder that is approaching epidemic proportions worldwide. A genome-wide association study identified AREG (rs12511037), GABRR1 (rs13215566), and PDE10A (rs12206610) as being associated with refractive error in Asian populations. The present study investigated the associations betwee...

journal_title：Frontiers in genetics

authors： Lin Y,Ding Y,Jiang D,Li C,Huang X,Liu L,Xiao H,Vasudevan B,Chen Y

更新日期：2020-03-25 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:[This corrects the article on p. 23 in vol. 9, PMID: 29456554.]. ...

journal_title：Frontiers in genetics

authors： Yang L,Banerjee S,Cao J,Bai X,Peng Z,Chen H,Huang H,Han P,Feng S,Yi N,Song X,Wu J

更新日期：2018-04-04 00:00:00

abstract：:The TempO-SeqTM platform allows for targeted transcriptomic analysis and is currently used by many groups to perform high-throughput gene expression analysis. Herein we performed a comparison of gene expression characteristics measured using 45 purified RNA samples from the livers of rats exposed to chemicals that fal...

journal_title：Frontiers in genetics

authors： Bushel PR,Paules RS,Auerbach SS

更新日期：2018-10-30 00:00:00

abstract：:The identification of functional modules in gene interaction networks is a key step in understanding biological processes. Network interpretation is essential for unveiling biological mechanisms, candidate biomarkers, or potential targets for drug discovery/repositioning. Plenty of biological module identification alg...

journal_title：Frontiers in genetics

authors： Nazzicari N,Vella D,Coronnello C,Di Silvestre D,Bellazzi R,Marini S

更新日期：2019-10-09 00:00:00

abstract：:Prolonged drug use causes long-lasting neuroadaptations in reward-related brain areas that contribute to addiction. Despite significant amount of research dedicated to understanding the underlying mechanisms of addiction, the molecular underpinnings remain unclear. At the same time, much of the pervasive transcription...

journal_title：Frontiers in genetics

authors： Sartor GC,St Laurent G 3rd,Wahlestedt C

更新日期：2012-06-22 00:00:00

abstract：:The arrangement of chromatin within interphase nuclei seems to be caused by topological constraints and related to gene expression depending on tissue and developmental stage. In yeast and animals it was found that homologous and heterologous chromatin association are required to realize faithful expression and DNA re...

journal_title：Frontiers in genetics

authors： Schubert V,Rudnik R,Schubert I

更新日期：2014-11-13 00:00:00

abstract：:Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen rece...

journal_title：Frontiers in genetics

authors： Holwerda S,de Laat W

更新日期：2012-10-17 00:00:00

abstract：:Autoimmune encephalitis (AE) is a severe neurological disease. The brain of the AE patient is attacked by a dysregulated immune system, which is caused by the excessive production of autoantibodies against neuronal receptors and synaptic proteins. AE is also characterized by the uncontrolled B lymphocyte infiltration ...

journal_title：Frontiers in genetics

authors： Tsai MH,Lin CH,Tsai KW,Lin MH,Ho CJ,Lu YT,Weng KP,Lin Y,Lin PH,Li SC

更新日期：2019-11-22 00:00:00

abstract：:Leukocyte telomere length is believed to measure cellular aging in humans, and short leukocyte telomere length is associated with increased risks of late onset diseases, including cardiovascular disease, dementia, etc. Many studies have shown that leukocyte telomere length is a heritable trait, and several candidate g...

journal_title：Frontiers in genetics

authors： Lee JH,Cheng R,Honig LS,Feitosa M,Kammerer CM,Kang MS,Schupf N,Lin SJ,Sanders JL,Bae H,Druley T,Perls T,Christensen K,Province M,Mayeux R

更新日期：2014-01-17 00:00:00

abstract：:Technological advances over the past decade have unraveled the remarkable complexity of RNA. The identification of small peptides encoded by long non-coding RNAs (lncRNAs) as well as regulatory functions mediated by non-coding regions of mRNAs have further complicated our understanding of the multifaceted functions of...

journal_title：Frontiers in genetics

authors： Li J,Liu C

更新日期：2019-05-22 00:00:00

abstract：:Somatic alterations in the epidermal growth factor receptor gene (EGFR) result in aberrant activation of kinase signaling and occur in ∼15% of non-small cell lung cancers (NSCLC). Patients diagnosed with EGFR-mutant NSCLC have good initial clinical response to EGFR tyrosine kinase inhibitors (EGFR TKIs), yet tumor rec...

journal_title：Frontiers in genetics

authors： Shaurova T,Zhang L,Goodrich DW,Hershberger PA

更新日期：2020-03-27 00:00:00

abstract：:Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavor, p...

journal_title：Frontiers in genetics

authors： Walker AJ,Ressurreição M,Rothermel R

更新日期：2014-07-31 00:00:00

abstract：:Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

journal_title：Frontiers in genetics

authors： Jia K,Zhou Y,Cui Q

更新日期：2020-01-21 00:00:00

abstract：:A complete and compelling evolutionary explanation for the origin of human menopause is wanting. Menopause onset is defined clinically as the final menses, confirmed after 1 year without menstruation. The theory proposed herein explains at multiple levels - ultimately genetic but involving (1) behavioral, (2) life his...

journal_title：Frontiers in genetics

authors： Takahashi M,Singh RS,Stone J

更新日期：2017-01-06 00:00:00

abstract：:Developmental plasticity refers to the property by which the same genotype produces distinct phenotypes depending on the environmental conditions under which development takes place. By allowing organisms to produce phenotypes adjusted to the conditions that adults will experience, developmental plasticity can provide...

journal_title：Frontiers in genetics

authors： Lafuente E,Beldade P

更新日期：2019-08-07 00:00:00

abstract：:Since the turn of the century, researchers have sought to diagnose cancer based on gene expression signatures measured from the blood or biopsy as biomarkers. This task, known as classification, is typically solved using a suite of algorithms that learn a mathematical rule capable of discriminating one group ("cases")...

journal_title：Frontiers in genetics

authors： Quinn TP,Nguyen T,Lee SC,Venkatesh S

更新日期：2019-07-02 00:00:00

abstract：:Undergraduate students in the biomedical sciences are often interested in future health-focused careers. This presents opportunities for instructors in genetics, molecular biology, and cancer biology to capture their attention using lab experiences built around clinically relevant data. As biomedical science in genera...

journal_title：Frontiers in genetics

authors： Hankey W,Zanghi N,Crow MM,Dow WH,Kratz A,Robinson AM,Robinson MR,Segarra VA

更新日期：2020-12-16 00:00:00

abstract：:Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population. Methods: We analyzed 279 patients with unexplained optic atrophy using next-generation sequencing. All patients underwent detailed clinical e...

journal_title：Frontiers in genetics

authors： Wang DD,Hu FY,Gao FJ,Zhang SH,Xu P,Tian GH,Wu JH

更新日期：2019-11-26 00:00:00

abstract：:The direct RNA sequencing platform offered by Oxford Nanopore Technologies allows for direct measurement of RNA molecules without the need of conversion to complementary DNA, fragmentation or amplification. As such, it is virtually capable of detecting any given RNA modification present in the molecule that is being s...

journal_title：Frontiers in genetics

authors： Cozzuto L,Liu H,Pryszcz LP,Pulido TH,Delgado-Tejedor A,Ponomarenko J,Novoa EM

更新日期：2020-03-17 00:00:00

abstract：:Oxidative stress is one of the crucial mediators of varicocele-related male infertility. Recently, roles of long noncoding RNAs (lncRNAs) in oxidative stress have begun to emerge, however, little is known about their role in male infertility. The aim of this study was to determine the role of lncRNA SLC7A11-AS1 in var...

journal_title：Frontiers in genetics

authors： Sanei-Ataabadi N,Mowla SJ,Nasr-Esfahani MH

更新日期：2020-09-11 00:00:00