Ubiquitination and SUMOylation in Telomere Maintenance and Dysfunction.

abstract：Background:Lung disease phenotype varies widely even in the F508del (homozygous) genotype. Leukocyte-driven inflammation is important for pulmonary disease pathogenesis in cystic fibrosis (CF). Blood cytokines correlate negatively with pulmonary function in F508del homozygous patients, and gap junction proteins (GJA) m...

journal_title：Frontiers in genetics

authors： Horn T,Ludwig M,Eickmeier O,Neerinex AH,Maitland-van der Zee AH,Smaczny C,Wagner TOF,Schubert R,Zielen S,Majoor C,Bos LD,Schmitt-Grohé S

更新日期：2020-10-28 00:00:00

abstract：:The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinc...

journal_title：Frontiers in genetics

authors： Palstra RJ,Grosveld F

更新日期：2012-09-28 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:High-throughput analysis of the transcriptome and proteome individually are used to interrogate complex oncogenic processes in cancer. However, an outstanding challenge is how to combine these complementary, yet partially disparate data sources to accurately identify tumor-specific gene products and clinical biomarker...

journal_title：Frontiers in genetics

authors： Schwartz GW,Petrovic J,Zhou Y,Faryabi RB

更新日期：2018-06-15 00:00:00

abstract：:The principles and function of chromatin and nuclear architecture have been extensively studied in model organisms, such as Drosophila melanogaster. However, little is known about the role of these epigenetic processes in transcriptional regulation in other insects including mosquitoes, which are major disease vectors...

journal_title：Frontiers in genetics

authors： Lezcano ÓM,Sánchez-Polo M,Ruiz JL,Gómez-Díaz E

更新日期：2020-12-07 00:00:00

abstract：:[This corrects the article on p. 102 in vol. 6, PMID: 25852744.]. ...

journal_title：Frontiers in genetics

authors： Brito S,Thompson K,Campistol J,Colomer J,Hardy SA,He L,Fernández-Marmiesse A,Palacios L,Jou C,Jiménez-Mallebrera C,Armstrong J,Montero R,Artuch R,Tischner C,Wenz T,McFarland R,Taylor RW

更新日期：2015-07-28 00:00:00

abstract：:The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth....

journal_title：Frontiers in genetics

authors： Fritz MA,Rosa S,Sicard A

更新日期：2018-10-24 00:00:00

abstract：Background:Genetic association studies have identified single nucleotide polymorphisms (SNPs) related to chronic obstructive pulmonary disease (COPD) susceptibility. The aim of this study was to identify HHIP genetic variants associated with COPD, pulmonary function, and serum and sputum HHIP protein levels in Mexican ...

journal_title：Frontiers in genetics

authors： Ortega-Martínez A,Pérez-Rubio G,Ambrocio-Ortiz E,Nava-Quiroz KJ,Hernández-Zenteno RJ,Abarca-Rojano E,Rodríguez-Llamazares S,Hernández-Pérez A,García-Gómez L,Ramírez-Venegas A,Falfán-Valencia R

更新日期：2020-09-24 00:00:00

abstract：:Sucrose transporters (SUTs) play key roles in allocating the translocation of assimilates from source to sink tissues. Although the characteristics and biological roles of SUTs have been intensively investigated in higher plants, this gene family has not been functionally characterized in cotton. In this study, we per...

journal_title：Frontiers in genetics

authors： Li W,Sun K,Ren Z,Song C,Pei X,Liu Y,Wang Z,He K,Zhang F,Zhou X,Ma X,Yang D

更新日期：2018-10-23 00:00:00

abstract：:Behavioral and cognitive traits have a genetic component even though contributions from individual genes and genomic loci are in many cases modest. Changes in the environment can alter genotype-phenotype relationships. Space travel, which includes exposure to ionizing radiation, constitutes environmental challenges an...

journal_title：Frontiers in genetics

authors： Iancu OD,Boutros SW,Olsen RHJ,Davis MJ,Stewart B,Eiwaz M,Marzulla T,Belknap J,Fallgren CM,Edmondson EF,Weil MM,Raber J

更新日期：2018-10-09 00:00:00

abstract：:Multiple sclerosis (MS) is an autoimmune disease for which it is difficult to find exact disease-related genes. Effectively identifying disease-related genes would contribute to improving the treatment and diagnosis of multiple sclerosis. Current methods for identifying disease-related genes mainly focus on the hypoth...

journal_title：Frontiers in genetics

authors： Liu H,Guan J,Li H,Bao Z,Wang Q,Luo X,Xue H

更新日期：2020-04-21 00:00:00

abstract：:The Jats represent a large ethnic community that has inhabited the northwest region of India and Pakistan for several thousand years. It is estimated the community has a population of over 123 million people. Many historians and academics have asserted that the Jats are descendants of Aryans, Scythians, or other ancie...

journal_title：Frontiers in genetics

authors： Mahal DG,Matsoukas IG

更新日期：2017-09-20 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) play a regulatory role and influence various biological activities, such as cell proliferation, differentiation, and survival. Our group has demonstrated through functional studies that Schistosoma mansoni c-Jun N-terminal kinase (SmJNK) MAPK is involved in the parasite's deve...

journal_title：Frontiers in genetics

authors： Gava SG,Tavares NC,Falcone FH,Oliveira G,Mourão MM

更新日期：2019-10-18 00:00:00

abstract：:Network propagation is a central tool in biological research. While a number of variants and normalizations have been proposed for this method, each has its own shortcomings and no large scale assessment of those variants is available. Here we propose a novel normalization method for network propagation that is based ...

journal_title：Frontiers in genetics

authors： Biran H,Kupiec M,Sharan R

更新日期：2019-01-22 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterized by a...

journal_title：Frontiers in genetics

authors： Kim JE,Leung E,Baguley BC,Finlay GJ

更新日期：2013-05-31 00:00:00

abstract：:Most cell functions are carried out by interacting factors, thus underlying the functional importance of genetic interactions between genes, termed epistasis. Epistasis could be under strong selective pressures especially in conditions where the mutation rate of one of the interacting partners notably differs from the...

journal_title：Frontiers in genetics

authors： Levin L,Blumberg A,Barshad G,Mishmar D

更新日期：2014-12-23 00:00:00

abstract：:A variety of statistical methods, such as admixture models, have been used to estimate genomic breed composition (GBC). These methods, however, tend to produce non-zero components to reference breeds that shared some genomic similarity with a test animal. These non-essential GBC components, in turn, offset the estimat...

journal_title：Frontiers in genetics

authors： Wang Y,Wu XL,Li Z,Bao Z,Tait RG Jr,Bauck S,Rosa GJM

更新日期：2020-06-11 00:00:00

abstract：:Myiopsitta monachus is a small Neotropical parrot (Psittaciformes: Arini Tribe) from subtropical and temperate regions of South America. It has a diploid chromosome number 2n = 48, different from other members of the Arini Tribe that have usually 70 chromosomes. The species has the lowest 2n within the Arini Tribe. In...

journal_title：Frontiers in genetics

authors： Furo IO,Kretschmer R,O'Brien PC,Pereira JC,Garnero ADV,Gunski RJ,O'Connor RE,Griffin DK,Gomes AJB,Ferguson-Smith MA,de Oliveira EHC

更新日期：2020-07-10 00:00:00

abstract：:The aging brain undergoes a range of changes varying from subtle structural and physiological changes causing only minor functional decline under healthy normal aging conditions, to severe cognitive or neurological impairment associated with extensive loss of neurons and circuits due to age-associated neurodegenerativ...

journal_title：Frontiers in genetics

authors： Hermann PM,Watson SN,Wildering WC

更新日期：2014-12-04 00:00:00

abstract：:Satellite ncRNAs are emerging as key players in cell and cancer pathways. Cancer-linked satellite DNA hypomethylation seems to be responsible for the overexpression of satellite non-coding DNAs in several tumors. FA-SAT is the major satellite DNA of Felis catus and recently, its presence and transcription was describe...

journal_title：Frontiers in genetics

authors： Ferreira D,Escudeiro A,Adega F,Chaves R

更新日期：2019-02-12 00:00:00

abstract：:There are associations between DNA methylation and the expression of long non-coding RNA (lncRNA), also known as lncRNA expression quantitative trait methylations (lnc-eQTMs). Lnc-eQTMs may induce a wide range of carcinogenesis pathways. However, lnc-eQTMs have not been globally identified and studied, and their roles...

journal_title：Frontiers in genetics

authors： Wu X,Gao Y,Bu J,Deng L,Zhang P,Chi M,Jiang L,Shi X,Ning S,Wang G

更新日期：2020-12-09 00:00:00

abstract：:At the end of introns, the polypyrimidine tract (Py) is often close to the 3' AG in a consensus (Y)20NCAGgt in humans. Interestingly, we have found that they could also be separated by purine-rich elements including G tracts in thousands of human genes. These regulatory elements between the Py and 3' AG (REPA) mainly ...

journal_title：Frontiers in genetics

authors： Nguyen H,Xie J

更新日期：2019-01-14 00:00:00

abstract：:Organ size and architecture of plants are important traits affecting crop yield and agronomic practices. An induced mutant, multiple-organ gigantism (MOG), of black gram (Vigna mungo) has been obtained, which shows gigantic leaves, fruit, seed, and architecture (plant height) but lower number of pods per plant. These ...

journal_title：Frontiers in genetics

authors： Somta P,Chen J,Yimram T,Yundaeng C,Yuan X,Tomooka N,Chen X

更新日期：2020-06-30 00:00:00

abstract：:A case-control study was used to explore the association between the methylation status in the promoter regions of the cGAS, MAVS, and TRAF3 genes and the diseases of cervical precancerous lesions (CPL) and cervical cancer (CC) in a Southern Chinese population, and to further explore their interaction effects with hig...

journal_title：Frontiers in genetics

authors： Huang S,Li R,Huang X,Zheng S,Wang L,Wen Z,Zou X,Wu J,Liu Y,Liu D,Wang Y,Dong S,Chen X,Zhu K,Du X,Zhou Z,Han Y,Ye X,Zeng C,Zhang B,Yang G,Jing C

更新日期：2019-11-14 00:00:00

abstract：:There is a paradigm shift from the traditional focus on the "average" individual towards the definition and analysis of trait variation within individual life-history and among individuals in populations. This is a result of increasing availability of individual phenotypic data. The shift allows the use of genetic and...

journal_title：Frontiers in genetics

authors： Filipe JAN,Kyriazakis I

更新日期：2019-09-20 00:00:00

abstract：:The emerald ash borer (EAB), Agrilus planipennis, is a highly destructive quarantine pest. The olfactory and visual systems of A. planipennis play different but critical roles at newly emerged and sexually mature stages; however, the molecular basis underlying these differences remain unclear. Consequently, based on d...

journal_title：Frontiers in genetics

authors： Shen S,Fan Z,Zhang X,Kong X,Liu F,Zhang Z,Zhang X,Hu X,Zhang S

更新日期：2021-01-15 00:00:00

abstract：:Anther extrusion (AE) is the most important male floral trait for hybrid wheat seed production. AE is a complex quantitative trait that is difficult to phenotype reliably in field experiments not only due to high genotype-by-environment effects but also due to the short expression window in the field condition. In thi...

journal_title：Frontiers in genetics

authors： Adhikari A,Basnet BR,Crossa J,Dreisigacker S,Camarillo F,Bhati PK,Jarquin D,Manes Y,Ibrahim AMH

更新日期：2020-12-08 00:00:00

abstract：:Alport syndrome is a hereditary progressive chronic kidney disease caused by mutations in type IV collagen genes COL4A3/4/5. X-linked Alport syndrome (XLAS) is caused by mutations in the COL4A5 gene and is the most common form of Alport syndrome. A strong correlation between the type of COL4A5 mutation and the age dev...

journal_title：Frontiers in genetics

authors： Wang C,Liang S,Xing S,Xu K,Xiao H,Deng H,Wang X,Chen L,Ding J,Wang F

更新日期：2020-02-10 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00