Transcript Isoforms of SLC7A11-AS1 Are Associated With Varicocele-Related Male Infertility.

abstract：:We evaluated differences in gene expression in pigs from the Porcine Reproductive and Respiratory Syndrome (PRRS) Host Genetics Consortium initiative showing a range of responses to PRRS virus infection. Pigs were allocated into four phenotypic groups according to their serum viral level and weight gain. RNA obtained ...

journal_title：Frontiers in genetics

authors： Arceo ME,Ernst CW,Lunney JK,Choi I,Raney NE,Huang T,Tuggle CK,Rowland RR,Steibel JP

更新日期：2013-01-16 00:00:00

abstract：Background:Cystinuria is a rare genetic disorder characterized by defective renal reabsorption of cystine, ornithine, arginine, and lysine. The increased urinary excretion of cystine results in the development of cystine urolithiasis (CU). The mutated SLC3A1 and SLC7A9 genes are the cause of CU, a global disorder. Its ...

journal_title：Frontiers in genetics

authors： Li C,Yang Y,Zheng Y,Shen F,Liu L,Li Y,Li L,Zhao Y

更新日期：2020-02-18 00:00:00

abstract：:Mesopelagic fish are largely abundant poorly studied fish that are still intact, but which, due to their potentially great added value, will be imminently exploited by humans. Therefore, studies that provide information to anticipate the anthropogenic impact on this important resource are urgently needed. In particula...

journal_title：Frontiers in genetics

authors： Rodriguez-Ezpeleta N,Álvarez P,Irigoien X

更新日期：2017-11-28 00:00:00

abstract：:The microbiome is known to have a profound effect on the development, physiology and health of its host. Whether and how it also contributes to evolutionary diversification of the host is, however, unclear. Here we hypothesize that disruption of the microbiome by new stressful environments interferes with host-microbe...

journal_title：Frontiers in genetics

authors： Soen Y

更新日期：2014-06-20 00:00:00

abstract：:An increasing number of studies have shown that long intergenic non-coding RNAs (lincRNAs) are a very important class of non-coding RNAs that plays a vital role in many biological processes. Adipose tissue is an important place for storing energy, but few studies on lincRNAs were related to pig subcutaneous fat develo...

journal_title：Frontiers in genetics

authors： Shi G,Chen L,Chen G,Zou C,Li J,Li M,Fang C,Li C

更新日期：2019-03-04 00:00:00

abstract：:Amphibians are important vertebrates in toxicology often representing both aquatic and terrestrial forms within the life history of the same species. Of the thousands of species, only two have substantial genomics resources: the recently published genome of the Pipid, Xenopus (Silurana) tropicalis, and transcript info...

journal_title：Frontiers in genetics

authors： Helbing CC

更新日期：2012-03-14 00:00:00

abstract：:Challenges in diagnosing primary immunodeficiency are numerous and diverse, with current whole-exome and whole-genome sequencing approaches only able to reach a molecular diagnosis in 25-60% of cases. We assess these problems and discuss how RNA-focused analysis has expanded and improved in recent years and may now be...

journal_title：Frontiers in genetics

authors： Lye JJ,Williams A,Baralle D

更新日期：2019-12-11 00:00:00

abstract：:The abundance of RNA species and their response to perturbations are set by the kinetics rates of RNA synthesis, processing, and degradation. However, the visualization, interpretation, and manipulation of these data require familiarity with mathematical modeling and command line tools. INSPEcT-GUI is an R-Shiny inter...

journal_title：Frontiers in genetics

authors： de Pretis S,Furlan M,Pelizzola M

更新日期：2020-07-17 00:00:00

abstract：:While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks persist around the globe, the advent of clustered regularly interspaced short palindromic repeat (CRISPR)-based gene editing has provided exciting new opportunities for genetics-based strategies to control these diseases. In ...

journal_title：Frontiers in genetics

authors： Marshall JM,Raban RR,Kandul NP,Edula JR,León TM,Akbari OS

更新日期：2019-10-30 00:00:00

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00

abstract：Background:This study aimed to investigate the genetic causes of hypohidrotic ectodermal dysplasia (HED) in two families and elucidate the molecular pathogenesis of HED in Chinese Han patients. Methods:Whole-exome sequencing (WES) was used to screen HED-related genes in two family members, followed by confirmatory San...

journal_title：Frontiers in genetics

authors： Han Y,Wang X,Zheng L,Zhu T,Li Y,Hong J,Xu C,Wang P,Gao M

更新日期：2020-02-04 00:00:00

abstract：:Metastasis is a complex process that involved in various genetic and epigenetic alterations during the progression of breast cancer. Recent evidences have indicated that the mutation in the genome sequence may not be the key factor for increasing metastatic potential. Epigenetic changes were revealed to be important f...

journal_title：Frontiers in genetics

authors： Zhuang J,Huo Q,Yang F,Xie N

更新日期：2020-10-29 00:00:00

abstract：:Background: Sturgeons (Chondrostei: Acipenseridae) are a group of "living fossil" fishes at a basal position among Actinopteri. They have raised great public interest due to their special evolutionary position, species conservation challenges, as well as their highly-prized eggs (caviar). The sterlet, Acipenser ruthen...

journal_title：Frontiers in genetics

authors： Cheng P,Huang Y,Du H,Li C,Lv Y,Ruan R,Ye H,Bian C,You X,Xu J,Liang X,Shi Q,Wei Q

更新日期：2019-09-05 00:00:00

abstract：:The goal of any plant breeding program is to improve quality of a target crop. Crop quality is a comprehensive feature largely determined by biological background. To improve the quality parameters of crops grown for the production of fiber, a functional approach was used to search for genes suitable for the effective...

journal_title：Frontiers in genetics

authors： Galinousky D,Mokshina N,Padvitski T,Ageeva M,Bogdan V,Kilchevsky A,Gorshkova T

更新日期：2020-11-12 00:00:00

abstract：:Brugada syndrome (BrS) is a heritable disease that results in sudden cardiac death. In the exome/genomic era, certain reported pathogenic variants in some genetic diseases have been reclassified as benign owing to their high frequency in some ancestries. In the present study, we comprehensively reassessed all previous...

journal_title：Frontiers in genetics

authors： Chen CJ,Lu TP,Lin LY,Liu YB,Ho LT,Huang HC,Lai LP,Hwang JJ,Yeh SS,Wu CK,Juang JJ,Antzelevitch C

更新日期：2019-01-04 00:00:00

abstract：:The Apelin (APLN)/apelin receptor (APLNR) signaling pathway is a newly identified regulator in various cardiovascular diseases, which is considered as a candidate pathway for the occurrence of coronary heart disease (CHD), depression, and anxiety. The goal of this study was to investigate the association between APLN/...

journal_title：Frontiers in genetics

authors： Wang Y,Liu W,Xiao Y,Yuan H,Wang F,Jiang P,Luo Z

更新日期：2020-08-11 00:00:00

abstract：:History of East-Central Europe has been intertwined with the history of Turks in the past. A significant part of this region of Europe has been fallen under Ottoman control during the 150 years of Ottoman occupation in the 16-17th centuries. The presence of the Ottoman Empire affected this area not only culturally but...

journal_title：Frontiers in genetics

authors： Bánfai Z,Melegh BI,Sümegi K,Hadzsiev K,Miseta A,Kásler M,Melegh B

更新日期：2019-06-13 00:00:00

abstract：:The study of microorganisms that pervade each and every part of this planet has encountered many challenges through time such as the discovery of unknown organisms and the understanding of how they interact with their environment. The aim of this review is to take the reader along the timeline and major milestones tha...

journal_title：Frontiers in genetics

authors： Escobar-Zepeda A,Vera-Ponce de León A,Sanchez-Flores A

更新日期：2015-12-17 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:A rapidly increasing number of reports on dysregulated long intergenic non-coding RNA (lincRNA) expression across numerous types of cancers indicates that aberrant lincRNA expression may be a major contributor to tumorigenesis. Marek's disease (MD) is a T cell lymphoma of chickens induced by Marek's disease virus (MDV...

journal_title：Frontiers in genetics

authors： He Y,Han B,Ding Y,Zhang H,Chang S,Zhang L,Zhao C,Yang N,Song J

更新日期：2019-11-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC) remains hard to diagnose early and cure due to a lack of accurate biomarkers and effective treatments. Hence, it is necessary to explore the tumorigenesis and tumor progression of HCC to discover new biomarkers for clinical treatment. We performed weighted gene co-expression network anal...

journal_title：Frontiers in genetics

authors： Gu Y,Li J,Guo D,Chen B,Liu P,Xiao Y,Yang K,Liu Z,Liu Q

更新日期：2020-02-28 00:00:00

abstract：:Long intergenic non-coding RNAs (lincRNAs) are an abundant and functionally diverse class of eukaryotic transcripts. Reported lincRNA repertoires in mammals vary, but are commonly in the thousands to tens of thousands of transcripts, covering ~90% of the genome. In addition to elucidating function, there is particular...

journal_title：Frontiers in genetics

authors： Nelson ADL,Devisetty UK,Palos K,Haug-Baltzell AK,Lyons E,Beilstein MA

更新日期：2017-05-09 00:00:00

abstract：:The mammalian hearing organ is a regular array of two types of hair cells (HCs) surrounded by six types of supporting cells. Along the tonotopic axis, this conserved radial array of cell types shows longitudinal variations to enhance the tuning properties of basilar membrane. We present the current evidence supporting...

journal_title：Frontiers in genetics

authors： Booth KT,Azaiez H,Jahan I,Smith RJH,Fritzsch B

更新日期：2018-05-08 00:00:00

abstract：:High-throughput genotyping boosts genome-wide association studies (GWAS) in crop species, leading to the identification of single-nucleotide polymorphisms (SNPs) associated with economically important traits. Choosing a cost-effective genotyping method for crop GWAS requires careful examination of several aspects, nam...

journal_title：Frontiers in genetics

authors： Pavan S,Delvento C,Ricciardi L,Lotti C,Ciani E,D'Agostino N

更新日期：2020-06-05 00:00:00

abstract：:The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated an...

journal_title：Frontiers in genetics

authors： Kovina MV,Karnaukhov AV,Krasheninnikov ME,Kovin AL,Gazheev ST,Sergievich LA,Karnaukhova EV,Bogdanenko EV,Balyasin MV,Khodarovich YM,Dyuzheva TG,Lyundup AV

更新日期：2019-04-12 00:00:00

abstract：:The genetic resources available for the commercially important fish species Yellowtail kingfish (YTK) (Seriola lalandi) are relative sparse. To overcome this, we aimed (1) to develop a linkage map for this species, and (2) to identify markers/variants associated with economically important traits in kingfish (with an ...

journal_title：Frontiers in genetics

authors： Nguyen NH,Rastas PMA,Premachandra HKA,Knibb W

更新日期：2018-04-17 00:00:00

abstract：:RNase H1 is able to recognize DNA/RNA heteroduplexes and to degrade their RNA component. As a consequence, it has been implicated in different aspects of mtDNA replication such as primer formation, primer removal, and replication termination, and significant differences have been reported between control and mutant RN...

journal_title：Frontiers in genetics

authors： Reyes A,Rusecka J,Tońska K,Zeviani M

更新日期：2020-01-31 00:00:00

abstract：:Copy number changes in protein-coding genes are detrimental if the consequent changes in protein concentrations disrupt essential cellular functions. The dosage sensitivity of transcription factor (TF) genes is particularly interesting because their products are essential in regulating the expression of genetic inform...

journal_title：Frontiers in genetics

authors： Ni Z,Zhou XY,Aslam S,Niu DK

更新日期：2019-12-04 00:00:00

abstract：:Alport syndrome is a hereditary progressive chronic kidney disease caused by mutations in type IV collagen genes COL4A3/4/5. X-linked Alport syndrome (XLAS) is caused by mutations in the COL4A5 gene and is the most common form of Alport syndrome. A strong correlation between the type of COL4A5 mutation and the age dev...

journal_title：Frontiers in genetics

authors： Wang C,Liang S,Xing S,Xu K,Xiao H,Deng H,Wang X,Chen L,Ding J,Wang F

更新日期：2020-02-10 00:00:00

abstract：:Mutations in mitochondrial (mt) DNA determine important human diseases. The majority of the known pathogenic mutations are located in transfer RNA (tRNA) genes and are responsible for a wide range of currently untreatable disorders. Experimental evidence both in yeast and in human cells has shown that the detrimental ...

journal_title：Frontiers in genetics

authors： Giordano C,Morea V,Perli E,d'Amati G

更新日期：2015-03-23 00:00:00