The metamorphosis of amphibian toxicogenomics.

abstract：:Excessive fat deposition can cause chicken health problem, and affect production efficiency by causing great economic losses to the industry. However, the molecular underpinnings of the complex adiposity trait remain elusive. In the current study, we constructed and compared the gene co-expression networks on four tra...

journal_title：Frontiers in genetics

authors： Gao Z,Ding R,Zhai X,Wang Y,Chen Y,Yang CX,Du ZQ

更新日期：2020-05-29 00:00:00

abstract：:Objective: Adrenocortical carcinoma (ACC) is a rare but aggressive malignant cancer that has been attracting growing attention over recent decades. This study aims to integrate protein interaction networks with gene expression profiles to identify potential biomarkers with prognostic value in silico. Methods: Three mi...

journal_title：Frontiers in genetics

authors： Xu WH,Wu J,Wang J,Wan FN,Wang HK,Cao DL,Qu YY,Zhang HL,Ye DW

更新日期：2019-09-11 00:00:00

abstract：:Accurate inference of causal gene regulatory networks from gene expression data is an open bioinformatics challenge. Gene interactions are dynamical processes and consequently we can expect that the effect of any regulation action occurs after a certain temporal lag. However such lag is unknown a priori and temporal a...

journal_title：Frontiers in genetics

authors： Lopes M,Bontempi G

更新日期：2013-12-24 00:00:00

abstract：:Technological developments and intense research over the last years have led to a better understanding of the 3D structure of the genome and its influence on genome function inside the cell nucleus. We will summarize topological studies performed on four model gene loci: the α- and β-globin gene loci, the antigen rece...

journal_title：Frontiers in genetics

authors： Holwerda S,de Laat W

更新日期：2012-10-17 00:00:00

abstract：:The ability to sense and respond to stressful conditions is essential to maintain organismal homeostasis. It has long been recognized that stress response factors that improve survival in changing conditions can also influence longevity. In this review, we discuss different strategies used by animals in response to de...

journal_title：Frontiers in genetics

authors： Iranon NN,Miller DL

更新日期：2012-11-27 00:00:00

abstract：:Germline variants of PIP4K2A impact susceptibility of acute lymphoblastic leukemia (ALL) through inducing its overexpression. Although limited reports suggested the oncogenic role of PIP4K2A in cancers, regulatory network and prognostic effect of this gene remains poorly understood in tumorigenesis and leukemogenesis....

journal_title：Frontiers in genetics

authors： Zhang S,Li Z,Yan X,Bao L,Deng Y,Zeng F,Wang P,Zhu J,Yin D,Liao F,Zhou X,Zhang D,Xia X,Wang H,Yang X,Zhang W,Gao H,Zhang W,Yang L,Hou Q,Xu H,Zhang Y,Shu Y,Wang Y

更新日期：2019-01-15 00:00:00

abstract：:Resistant Starch (RS), plays a crucial role in human health and nutrition by controlling glucose metabolism. RS or dietary fibre content in rice is low because it goes through a variety of process before it is ready for cooking and consumption. Hence, this study was carried out to develop a rice mutant with increased ...

journal_title：Frontiers in genetics

authors： Gurunathan S,Ramadoss BR,Mudili V,Siddaiah C,Kalagatur NK,Bapu JRK,Mohan CD,Alqarawi AA,Hashem A,Abd Allah EF

更新日期：2019-11-15 00:00:00

abstract：:Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological p...

journal_title：Frontiers in genetics

authors： Cirillo E,Parnell LD,Evelo CT

更新日期：2017-11-07 00:00:00

abstract：:Alport syndrome (AS) is a rare and inherited renal disorder with an autosomal recessive mode of inheritance. AS patients usually manifest with hematuria and progressive renal disorder also occasionally accompanied by hearing loss and ophthalmic disease. Germline variants in collagen type IV α-4 (COL4A4) gene lead to a...

journal_title：Frontiers in genetics

authors： Zhu F,Li W,Li Z,Zhu H,Xiong J

更新日期：2019-01-28 00:00:00

abstract：:Telomeres are important for maintaining genomic stability. Telomere length has been associated with aging, disease, and mortality and is highly heritable (∼82%). In this study, we aimed to identify rare genetic variants associated with telomere length using whole-exome sequence data. We studied 1,303 participants of t...

journal_title：Frontiers in genetics

authors： van der Spek A,Warner SC,Broer L,Nelson CP,Vojinovic D,Ahmad S,Arp PP,Brouwer RWW,Denniff M,van den Hout MCGN,van Rooij JGJ,Kraaij R,van IJcken WFJ,Samani NJ,Ikram MA,Uitterlinden AG,Codd V,Amin N,van Duijn CM

更新日期：2020-04-30 00:00:00

abstract：:Over millions of years, vertebrate species populated vast environments spanning the globe. Among the most challenging habitats encountered were those with limited availability of oxygen, yet many animal and human populations inhabit and perform life cycle functions and/or daily activities in varying degrees of hypoxia...

journal_title：Frontiers in genetics

authors： Pamenter ME,Hall JE,Tanabe Y,Simonson TS

更新日期：2020-07-22 00:00:00

abstract：:Atherosclerosis and its comorbidities are the major contributors to the global burden of death worldwide. Lower extremities arterial disease (LEAD) is a common manifestation of atherosclerotic disease of arteries of lower extremities. MicroRNAs belong to epigenetic factors that regulate gene expression and have not ye...

journal_title：Frontiers in genetics

authors： Bogucka-Kocka A,Zalewski DP,Ruszel KP,Stępniewski A,Gałkowski D,Bogucki J,Komsta Ł,Kołodziej P,Zubilewicz T,Feldo M,Kocki J

更新日期：2019-11-22 00:00:00

abstract：:It is critical for patients who cannot undergo eradicable surgery to predict the risk of lung cancer recurrence and metastasis; therefore, the physicians can design the appropriate adjuvant therapy plan. However, traditional circulating tumor cell (CTC) detection or next-generation sequencing (NGS)-based methods are u...

journal_title：Frontiers in genetics

authors： Wu Z,Wang L,Li C,Cai Y,Liang Y,Mo X,Lu Q,Dong L,Liu Y

更新日期：2020-08-25 00:00:00

abstract：:Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications. On epigenetic level, replicative senescence and aging evoke characteristic modifications in the DNA methylatio...

journal_title：Frontiers in genetics

authors： Wagner W

更新日期：2019-04-03 00:00:00

abstract：:Autism spectrum disorder (ASD) is mainly reflected in the communication and language barriers, difficulties in social communication, and it is a kind of neurological developmental disorder. Most researches have used the machine learning method to classify patients and normal controls, among which support vector machin...

journal_title：Frontiers in genetics

authors： Bi XA,Wang Y,Shu Q,Sun Q,Xu Q

更新日期：2018-02-06 00:00:00

abstract：:Extracting inherent valuable knowledge from omics big data remains as a daunting problem in bioinformatics and computational biology. Deep learning, as an emerging branch from machine learning, has exhibited unprecedented performance in quite a few applications from academia and industry. We highlight the difference a...

journal_title：Frontiers in genetics

authors： Tang B,Pan Z,Yin K,Khateeb A

更新日期：2019-03-26 00:00:00

abstract：:People want to live long, healthy lives. Previous surveys suggest very limited interest in much longer lifespans, but we show that stipulating good health changes responses to favor longer lives by an order of magnitude. Advances in aging research hold out hope for greatly slowed aging with associated good health. Und...

journal_title：Frontiers in genetics

authors： Donner Y,Fortney K,Calimport SR,Pfleger K,Shah M,Betts-LaCroix J

更新日期：2016-01-20 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：:Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgen...

journal_title：Frontiers in genetics

authors： Huang W,Wang S,Jacobs-Lorena M

更新日期：2020-03-10 00:00:00

abstract：:RNA-binding proteins (RBPs) are a kind of gene regulatory factor that presents a significant biological effect in the initiation and development of various tumors, including bladder cancer (BLCA). However, the RBP-based prognosis signature for BLCA has not been investigated. In this study, we attempted to develop an R...

journal_title：Frontiers in genetics

authors： Wu Y,Liu Y,He A,Guan B,He S,Zhang C,Kang Z,Gong Y,Li X,Zhou L

更新日期：2020-08-28 00:00:00

abstract：:Software which simulates, infers, or analyzes ancestral recombination graphs (ARGs) faces the problem of communicating them. Existing formats omit information either about the location of recombinations along the chromosome or the position of recombinations relative to the branching topology. We present a specializati...

journal_title：Frontiers in genetics

authors： McGill JR,Walkup EA,Kuhner MK

更新日期：2013-08-07 00:00:00

abstract：:The sustainable development of aquaculture has been impeded by infectious diseases worldwide. However, the genomic architecture and the genetic basis underlying the disease resistance remain poorly understood, which severely hampers both the understanding of the evolution of fish disease resistance traits and the prev...

journal_title：Frontiers in genetics

authors： Zhou Q,Su Z,Li Y,Liu Y,Wang L,Lu S,Wang S,Gan T,Liu F,Zhou X,Wei M,Liu G,Chen S

更新日期：2019-11-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) remains hard to diagnose early and cure due to a lack of accurate biomarkers and effective treatments. Hence, it is necessary to explore the tumorigenesis and tumor progression of HCC to discover new biomarkers for clinical treatment. We performed weighted gene co-expression network anal...

journal_title：Frontiers in genetics

authors： Gu Y,Li J,Guo D,Chen B,Liu P,Xiao Y,Yang K,Liu Z,Liu Q

更新日期：2020-02-28 00:00:00

abstract：:Severe hypercholesterolemia (HC) is defined as an elevation of total cholesterol (TC) due to the increase in LDL cholesterol (LDL-C) >95th percentile or 190 mg/dl. The high values of LDL-C, especially when it is maintained over time, is considered a risk factor for the development of atherosclerotic cardiovascular dis...

journal_title：Frontiers in genetics

authors： Jarauta E,Bea-Sanz AM,Marco-Benedi V,Lamiquiz-Moneo I

更新日期：2020-12-03 00:00:00

abstract：:ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale. Although it is ubiqu...

journal_title：Frontiers in genetics

authors： Ye B,Yang G,Li Y,Zhang C,Wang Q,Yu G

更新日期：2020-04-07 00:00:00

abstract：:In this study, we examined whether smoking and drinking affect sperm quality and the DNA methylation of the repetitive element LINE-1, MEST, P16, H19, and GNAS in sperm. Semen samples were obtained from 143 male residents in a minority-inhabited district of Guizhou province in southwest China. Quantitative DNA methyla...

journal_title：Frontiers in genetics

authors： Zhang W,Li M,Sun F,Xu X,Zhang Z,Liu J,Sun X,Zhang A,Shen Y,Xu J,Miao M,Wu B,Yuan Y,Huang X,Shi H,Du J

更新日期：2019-10-18 00:00:00

abstract：Background:Despite recent advance in immune therapy, great heterogeneity exists in the outcomes of colorectal cancer (CRC) patients. In this study, we aimed to analyze the immune-related gene (IRG) expression profiles from three independent public databases and develop an effective signature to forecast patient's progn...

journal_title：Frontiers in genetics

authors： Dai S,Xu S,Ye Y,Ding K

更新日期：2020-12-04 00:00:00

abstract：:Over the past decade, neural networks have become one of the cutting-edge methods in various research fields, outshining specifically in complex classification problems. In this paper, we propose two main contributions: first, we conduct a methodological study of neural network modeling for classifying biological trai...

journal_title：Frontiers in genetics

authors： Wilentzik Müller R,Gat-Viks I

更新日期：2020-05-15 00:00:00

abstract：:Alternative splicing (AS) can enhance transcript diversity dramatically and play an important role in stress adaptation. Limited researches of AS have been reported in the Pacific white shrimp (Litopenaeus vannamei), which is an important aquaculture species in the world. Here, we performed a genome-wide identificatio...

journal_title：Frontiers in genetics

authors： Zhang X,Yuan J,Zhang X,Liu C,Xiang J,Li F

更新日期：2019-09-12 00:00:00

abstract：:Since its emergence, CRISPR/Cas9-mediated base editors (BEs) with cytosine deaminase activity have been used to precisely and efficiently introduce single-base mutations in genomes, including those of human cells, mice, and crop species. Most production traits in livestock are induced by point mutations, and genome ed...

journal_title：Frontiers in genetics

authors： Zhou S,Cai B,He C,Wang Y,Ding Q,Liu J,Liu Y,Ding Y,Zhao X,Li G,Li C,Yu H,Kou Q,Niu W,Petersen B,Sonstegard T,Ma B,Chen Y,Wang X

更新日期：2019-03-15 00:00:00