Genomics of Developmental Plasticity in Animals.

abstract：CONTEXT:The effect of weight loss by diet alone or diet in conjunction with exercise on low-grade inflammation in non-obese (overweight) individuals is not known. OBJECTIVE:Test the hypothesis that 24 weeks of moderate calorie restriction (CR; 25%) by diet only or with aerobic exercise would reduce markers of systemic...

journal_title：Frontiers in genetics

authors： Tam CS,Covington JD,Ravussin E,Redman LM,Pennington CALERIE Team.

更新日期：2012-04-19 00:00:00

abstract：:Alzheimer's disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only...

journal_title：Frontiers in genetics

authors： Bajic VP,Essack M,Zivkovic L,Stewart A,Zafirovic S,Bajic VB,Gojobori T,Isenovic E,Spremo-Potparevic B

更新日期：2020-01-28 00:00:00

abstract：:Genetic variants can influence the expression of mRNA and protein. Genetic regulatory loci such as expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs) exist in several species. However, it remains unclear how human genetic variants regulate mRNA and protein expression. Here, we chara...

journal_title：Frontiers in genetics

authors： Wang Y,He B,Zhao Y,Reiter JL,Chen SX,Simpson E,Feng W,Liu Y

更新日期：2019-09-10 00:00:00

abstract：:The diagnosis of mesothelioma is not always straightforward, despite known immunohistochemical markers and other diagnostic techniques. One reason for the difficulty is that extrapleural tumors resembling mesothelioma may have several possible etiologies, especially in cases with no meaningful history of amphibole asb...

journal_title：Frontiers in genetics

authors： Kerger BD,James RC,Galbraith DA

更新日期：2014-05-30 00:00:00

abstract：:The goal of this work was to determine the effect of nonablative syngeneic transplantation of young bone marrow (BM) to laboratory animals (mice) of advanced age upon maximum duration of their lifespan. To do this, transplantation of 100 million nucleated cells from BM of young syngeneic donors to an old nonablated an...

journal_title：Frontiers in genetics

authors： Kovina MV,Karnaukhov AV,Krasheninnikov ME,Kovin AL,Gazheev ST,Sergievich LA,Karnaukhova EV,Bogdanenko EV,Balyasin MV,Khodarovich YM,Dyuzheva TG,Lyundup AV

更新日期：2019-04-12 00:00:00

abstract：:Mud crab, Scylla paramamosain is one of the most important crustacean species in global aquaculture. To determine the genetic basis of sex and growth-related traits in S. paramamosain, a high-density genetic linkage map with 16,701 single nucleotide polymorphisms (SNPs) was constructed using SLAF-seq and a full-sib fa...

journal_title：Frontiers in genetics

authors： Waiho K,Shi X,Fazhan H,Li S,Zhang Y,Zheng H,Liu W,Fang S,Ikhwanuddin M,Ma H

更新日期：2019-04-05 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) are a class of small RNAs that regulate gene expression. They are aberrantly expressed in many human cancers and are potential therapeutic targets and molecular biomarkers. METHODS:In this study, we for the first time validated the reported data on the entire set of published differential...

journal_title：Frontiers in genetics

authors： Zabolotneva AA,Zhavoronkov AA,Shegay PV,Gaifullin NM,Alekseev BY,Roumiantsev SA,Garazha AV,Kovalchuk O,Aravin A,Buzdin AA

更新日期：2013-11-15 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:In the world of high-throughput sequencing there are numerous challenges to effective data quality control. There are no single quality metrics which are appropriate in all conditions. Here we detail the different open source software used at the Exeter Sequencing Service to provide generic quality control information...

journal_title：Frontiers in genetics

authors： Paszkiewicz KH,Farbos A,O'Neill P,Moore K

更新日期：2014-05-27 00:00:00

abstract：Background:Recent evidence has indicated that long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to modulate mRNAs expression by sponging microRNAs (miRNAs). However, the specific mechanism and function of lncRNA-miRNA-mRNA regulatory network in non-small cell lung cancer (NSCLC) remains ...

journal_title：Frontiers in genetics

authors： Wang M,Zheng S,Li X,Ding Y,Zhang M,Lin L,Xu H,Cheng Y,Zhang X,Xu H,Li S

更新日期：2020-09-18 00:00:00

abstract：:von Hippel-Lindau (VHL) disease is a hereditary cancer syndrome with poor survival. The current recommendations have proposed uniform surveillance strategies for all patients, neglecting the obvious phenotypic varieties. In this study, we aim to confirm the phenotypic heterogeneity in VHL disease and the underlying me...

journal_title：Frontiers in genetics

authors： Wang J,Peng X,Chen C,Ning X,Peng S,Li T,Liu S,Hong B,Zhou J,Ma K,Cai L,Gong K

更新日期：2019-04-24 00:00:00

abstract：:Mixed strain infection (MSI) refers to the concurrent infection of a susceptible host with multiple strains of a single pathogenic species. Known to occur in humans and animals, MSIs deserve special consideration when studying transmission dynamics, evolution, and treatment of mycobacterial diseases, notably tuberculo...

journal_title：Frontiers in genetics

authors： Byrne AS,Goudreau A,Bissonnette N,Shamputa IC,Tahlan K

更新日期：2020-12-21 00:00:00

abstract：:The aging of the population represents one of the largest healthcare challenges facing the world today. The available scientific evidence shows that interventions are available now that can target fundamental "aging" processes or pathways. Sufficient economic evidence is available to argue convincingly that this appro...

journal_title：Frontiers in genetics

authors： Faragher RG

更新日期：2015-07-14 00:00:00

abstract：:High-throughput genotyping boosts genome-wide association studies (GWAS) in crop species, leading to the identification of single-nucleotide polymorphisms (SNPs) associated with economically important traits. Choosing a cost-effective genotyping method for crop GWAS requires careful examination of several aspects, nam...

journal_title：Frontiers in genetics

authors： Pavan S,Delvento C,Ricciardi L,Lotti C,Ciani E,D'Agostino N

更新日期：2020-06-05 00:00:00

abstract：:A considerable volume of research over the last decade has focused on understanding the fundamental mechanisms for the progression of atherosclerosis-the underlying cause for the vast majority of all cardiovascular (CVD)-related complications. Aging is the dominant risk factor for clinically significant atheroscleroti...

journal_title：Frontiers in genetics

authors： Head T,Daunert S,Goldschmidt-Clermont PJ

更新日期：2017-12-14 00:00:00

abstract：:Human pluripotent stem cells (hPSCs) are increasingly used for cell-based regenerative therapies worldwide, with embryonic and induced pluripotent stem cells as potential treatments for debilitating and chronic conditions, such as age-related macular degeneration, Parkinson's disease, spinal cord injuries, and type 1 ...

journal_title：Frontiers in genetics

authors： Henry MP,Hawkins JR,Boyle J,Bridger JM

更新日期：2019-01-21 00:00:00

abstract：:This study examined reasons for participation in a genetic study of risk for multiple sclerosis (MS). Our sample consisted of 101 patients diagnosed with MS who were approached about enrolling in the Multiple Sclerosis Genetic Susceptibility Study. Participants were predominantly Hispanic (80%), female (80%), and well...

journal_title：Frontiers in genetics

authors： Cuccaro ML,Manrique CP,Quintero MA,Martinez R,McCauley JL

更新日期：2020-03-13 00:00:00

abstract：:Bamboo is one of the fastest-growing non-timber forest plants. Moso bamboo (Phyllostachys edulis) is the most economically valuable bamboo in Asia, especially in China. With the release of the whole-genome sequence of moso bamboo, there are increasing demands for refined annotation of bamboo genes. Recently, large amo...

journal_title：Frontiers in genetics

authors： Ma X,Zhao H,Xu W,You Q,Yan H,Gao Z,Su Z

更新日期：2018-11-27 00:00:00

abstract：:The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinc...

journal_title：Frontiers in genetics

authors： Palstra RJ,Grosveld F

更新日期：2012-09-28 00:00:00

abstract：Objective:This study reports a Chinese patient with a Congenital Disorder of Glycosylation (CDG) caused by compound-heterozygous mutations in the Conserved Oligomeric Golgi 5 (COG5) gene and thereby offers concrete evidence for early diagnosis. Methods:The clinical manifestations, the results of laboratory examination...

journal_title：Frontiers in genetics

authors： Wang X,Han L,Wang XY,Wang JH,Li XM,Jin CH,Wang L

更新日期：2020-02-27 00:00:00

abstract：:Usher type 1 syndrome is a rare autosomal recessive disorder involving congenital severe-to-profound hearing loss, development of vision impairment in the first decade, and severe balance difficulties. The PCDH15 gene, one of the five genes implicated in this disease, is involved in 8-20% of cases. In this study, we a...

journal_title：Frontiers in genetics

authors： Vaché C,Puechberty J,Faugère V,Darmaisin F,Liquori A,Baux D,Blanchet C,Garcia-Garcia G,Meunier I,Pellestor F,Koenig M,Roux AF

更新日期：2020-07-02 00:00:00

abstract：:Replicative senescence of cells in vitro is often considered as counterpart for aging of the organism in vivo. In fact, both processes are associated with functional decay and similar molecular modifications. On epigenetic level, replicative senescence and aging evoke characteristic modifications in the DNA methylatio...

journal_title：Frontiers in genetics

authors： Wagner W

更新日期：2019-04-03 00:00:00

abstract：:Tools for genomic island prediction use strategies for genomic comparison analysis and sequence composition analysis. The goal of comparative analysis is to identify unique regions in the genomes of related organisms, whereas sequence composition analysis evaluates and relates the composition of specific regions with ...

journal_title：Frontiers in genetics

authors： da Silva Filho AC,Raittz RT,Guizelini D,De Pierri CR,Augusto DW,Dos Santos-Weiss ICR,Marchaukoski JN

更新日期：2018-12-12 00:00:00

abstract：:In this study, we used pan RNA-seq analysis to reveal the ubiquitous existence of both 5' and 3' end small RNAs (5' and 3' sRNAs). 5' and 3' sRNAs alone can be used to annotate nuclear non-coding and mitochondrial genes at 1-bp resolution and identify new steady RNAs, which are usually transcribed from functional gene...

journal_title：Frontiers in genetics

authors： Xu X,Ji H,Jin X,Cheng Z,Yao X,Liu Y,Zhao Q,Zhang T,Ruan J,Bu W,Chen Z,Gao S

更新日期：2019-02-14 00:00:00

abstract：Background:Myopia is a common eye disorder that is approaching epidemic proportions worldwide. A genome-wide association study identified AREG (rs12511037), GABRR1 (rs13215566), and PDE10A (rs12206610) as being associated with refractive error in Asian populations. The present study investigated the associations betwee...

journal_title：Frontiers in genetics

authors： Lin Y,Ding Y,Jiang D,Li C,Huang X,Liu L,Xiao H,Vasudevan B,Chen Y

更新日期：2020-03-25 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths worldwide and is derived from an accumulation of genetic and epigenetic changes. This study explored potential prognostic markers in CRC via the construction and in-depth analysis of a competing endogenous RNA (ceRNA) network, which was gene...

journal_title：Frontiers in genetics

authors： Guo L,Yang G,Kang Y,Li S,Duan R,Shen L,Jiang W,Qian B,Yin Z,Liang T

更新日期：2020-05-08 00:00:00

abstract：:Over the past decade, neural networks have become one of the cutting-edge methods in various research fields, outshining specifically in complex classification problems. In this paper, we propose two main contributions: first, we conduct a methodological study of neural network modeling for classifying biological trai...

journal_title：Frontiers in genetics

authors： Wilentzik Müller R,Gat-Viks I

更新日期：2020-05-15 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the world's population. The etiology of RA remains unknown. It is considered to occur in the presence of genetic and environmental factors. An increasing body of evidence pinpoints that epigenetic modifications play an important role i...

journal_title：Frontiers in genetics

authors： Nemtsova MV,Zaletaev DV,Bure IV,Mikhaylenko DS,Kuznetsova EB,Alekseeva EA,Beloukhova MI,Deviatkin AA,Lukashev AN,Zamyatnin AA Jr

更新日期：2019-06-14 00:00:00

abstract：:Although bipolar disorder (BP) is one of the most heritable psychiatric conditions, susceptibility genes for the disorder have yet to be conclusively identified. It is likely that variants in multiple genes across multiple pathways contribute to the genotype-phenotype relationship in the affected population. Recent ev...

journal_title：Frontiers in genetics

authors： Judy JT,Zandi PP

更新日期：2013-06-11 00:00:00

abstract：:Pathogenic microorganism analysis based on next-generation sequencing technology is an important tool for clinical diagnosis, public health surveillance, and outbreak investigation. However, scientific researchers without the relevant background lack the time, training, or infrastructure to use large data sets or inst...

journal_title：Frontiers in genetics

authors： Han N,Miao J,Zhang T,Qiang Y,Peng X,Li X,Zhang W

更新日期：2020-08-31 00:00:00