The X Files: "The Mystery of X Chromosome Instability in Alzheimer's Disease".

abstract：:A within-breed genome-wide association study (GWAS) is useful when identifying the QTL that segregates in a breed. However, an across-breed meta-analysis can be used to increase the power of identification and precise localization of QTL that segregate in multiple breeds. Precise localization will allow including QTL ...

journal_title：Frontiers in genetics

authors： Marete AG,Guldbrandtsen B,Lund MS,Fritz S,Sahana G,Boichard D

更新日期：2018-11-06 00:00:00

abstract：:In this study, we used pan RNA-seq analysis to reveal the ubiquitous existence of both 5' and 3' end small RNAs (5' and 3' sRNAs). 5' and 3' sRNAs alone can be used to annotate nuclear non-coding and mitochondrial genes at 1-bp resolution and identify new steady RNAs, which are usually transcribed from functional gene...

journal_title：Frontiers in genetics

authors： Xu X,Ji H,Jin X,Cheng Z,Yao X,Liu Y,Zhao Q,Zhang T,Ruan J,Bu W,Chen Z,Gao S

更新日期：2019-02-14 00:00:00

abstract：:Technological advances over the past decade have unraveled the remarkable complexity of RNA. The identification of small peptides encoded by long non-coding RNAs (lncRNAs) as well as regulatory functions mediated by non-coding regions of mRNAs have further complicated our understanding of the multifaceted functions of...

journal_title：Frontiers in genetics

authors： Li J,Liu C

更新日期：2019-05-22 00:00:00

abstract：:Using genomic information, local ruminant populations can be better characterized and compared to selected ones. Genetic relationships between animals can be established even without systematic pedigree recording, provided a budget is available for genotyping. Genomic selection (GS) can rely on a subset of the total p...

journal_title：Frontiers in genetics

authors： Ducrocq V,Laloe D,Swaminathan M,Rognon X,Tixier-Boichard M,Zerjal T

更新日期：2018-07-13 00:00:00

abstract：:Lactation is a dynamic process, which evolved to meet dietary demands of growing offspring. At the same time, the mother's metabolism changes to meet the high requirements of nutrient supply to the offspring. Through strong artificial selection, the strain of milk production on dairy cows is often associated with impa...

journal_title：Frontiers in genetics

authors： Strucken EM,Laurenson YC,Brockmann GA

更新日期：2015-03-26 00:00:00

abstract：:Sufficient genetic variation in livestock populations is necessary both for adaptation to future changes in climate and consumer demand, and for continual genetic improvement of economically important traits. Unfortunately, the current trend is for reduced genetic variation, both within and across breeds. The latter o...

journal_title：Frontiers in genetics

authors： Biscarini F,Nicolazzi EL,Stella A,Boettcher PJ,Gandini G

更新日期：2015-02-25 00:00:00

abstract：:Recently, an increasing number of studies sequence multiple biopsies of primary tumors, and even paired metastatic tumors to understand heterogeneity and the evolutionary trajectory of cancer progression. Although several algorithms are available to infer the phylogeny, most tools rely on accurate measurements of muta...

journal_title：Frontiers in genetics

authors： Wu P,Hou L,Zhang Y,Zhang L

更新日期：2020-02-07 00:00:00

abstract：:The Apelin (APLN)/apelin receptor (APLNR) signaling pathway is a newly identified regulator in various cardiovascular diseases, which is considered as a candidate pathway for the occurrence of coronary heart disease (CHD), depression, and anxiety. The goal of this study was to investigate the association between APLN/...

journal_title：Frontiers in genetics

authors： Wang Y,Liu W,Xiao Y,Yuan H,Wang F,Jiang P,Luo Z

更新日期：2020-08-11 00:00:00

abstract：:Satellite ncRNAs are emerging as key players in cell and cancer pathways. Cancer-linked satellite DNA hypomethylation seems to be responsible for the overexpression of satellite non-coding DNAs in several tumors. FA-SAT is the major satellite DNA of Felis catus and recently, its presence and transcription was describe...

journal_title：Frontiers in genetics

authors： Ferreira D,Escudeiro A,Adega F,Chaves R

更新日期：2019-02-12 00:00:00

abstract：:Aberrant, misfolded, and mislocalized proteins are often toxic to cells and result in many human diseases. All proteins and their mRNA templates are subject to quality control. There are several distinct mechanisms that control the quality of mRNAs and proteins during translation at the ribosome. mRNA quality control ...

journal_title：Frontiers in genetics

authors： Karamyshev AL,Karamysheva ZN

更新日期：2018-10-04 00:00:00

abstract：:Background: Papillary renal cell carcinoma (PRCC), although the second-most common type of renal cell carcinoma, still lacks specific biomarkers for diagnosis, treatment, and prognosis. TopBP1-interacting checkpoint and replication regulator (TICRR) is a DNA replication initiation regulator upregulated in various canc...

journal_title：Frontiers in genetics

authors： Xia S,Lin Y,Lin J,Li X,Tan X,Huang Z

更新日期：2021-01-11 00:00:00

abstract：:In recent years, studies have shown that phytopathogenic fungi possess the ability of cross-kingdom regulation of host plants through small RNAs (sRNAs). Magnaporthe oryzae, a causative agent of rice blast, introduces disease by penetrating the rice tissues through appressoria. However, little is known about the trans...

journal_title：Frontiers in genetics

authors： Zhang H,Liu S,Chang H,Zhan M,Qin QM,Zhang B,Li Z,Liu Y

更新日期：2019-03-29 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are a novel class of RNA molecules defined as transcripts longer than 200 nucleotides that lack protein coding potential. They constitute a major, but still poorly characterized part of human transcriptome, however, evidence is growing that they are important regulatory molecules involved...

journal_title：Frontiers in genetics

authors： Yarmishyn AA,Kurochkin IV

更新日期：2015-04-23 00:00:00

abstract：:In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory. We propose a strategy to employ the theoretical concept of UICC TNM classification in CRC. To reveal the critical transition of CRC, the DN...

journal_title：Frontiers in genetics

authors： Tong Y,Song Y,Xia C,Deng S

更新日期：2020-10-20 00:00:00

abstract：:Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immu...

journal_title：Frontiers in genetics

authors： Wertheim B

更新日期：2015-06-19 00:00:00

abstract：:The principles and function of chromatin and nuclear architecture have been extensively studied in model organisms, such as Drosophila melanogaster. However, little is known about the role of these epigenetic processes in transcriptional regulation in other insects including mosquitoes, which are major disease vectors...

journal_title：Frontiers in genetics

authors： Lezcano ÓM,Sánchez-Polo M,Ruiz JL,Gómez-Díaz E

更新日期：2020-12-07 00:00:00

abstract：:Plants are subjected to strong fluctuations in light intensity in their natural growth environment, caused both by unpredictable changes due to weather conditions and movement of clouds and upper canopy leaves and predictable changes during day-night cycle. The mechanisms of long-term acclimation to fluctuating light ...

journal_title：Frontiers in genetics

authors： Niedermaier S,Schneider T,Bahl MO,Matsubara S,Huesgen PF

更新日期：2020-03-05 00:00:00

abstract：:Selection for improved host response to infectious disease offers a desirable alternative to chemical treatment but has proven difficult in practice, due to low heritability estimates of disease traits. Disease data from field studies is often binary, indicating whether an individual has become infected or not followi...

journal_title：Frontiers in genetics

authors： Lipschutz-Powell D,Woolliams JA,Bijma P,Pong-Wong R,Bermingham ML,Doeschl-Wilson AB

更新日期：2012-10-22 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:Chemicals, toxicants, and environmental stressors mediate their biologic effect through specific modes of action (MOAs). These encompass key molecular events that lead to changes in the expression of genes within regulatory pathways. Elucidating shared biologic processes and overlapping gene networks will help to bett...

journal_title：Frontiers in genetics

authors： Funderburk KM,Auerbach SS,Bushel PR

更新日期：2017-10-24 00:00:00

abstract：:Production animals are constantly subjected to early adverse environmental conditions that influence the adult phenotype and produce epigenetic effects. CpG dinucleotide methylation in red blood cells (RBC) could be a useful epigenetic biomarker to identify animals subjected to chronic stress in the production environ...

journal_title：Frontiers in genetics

authors： Pértille F,Ibelli AMG,Sharif ME,Poleti MD,Fröhlich AS,Rezaei S,Ledur MC,Jensen P,Guerrero-Bosagna C,Coutinho LL

更新日期：2020-11-02 00:00:00

abstract：:Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor with the ability to bind to a CCAAT box in nearly all eukaryotes. However, the function of NF-Y in the life-history traits of insects is unclear. Here, we identified three NF-Y subunits, NlNF-YA, NlNF-YB, and NlNF-YC, in the wing-dimorphic brown planthop...

journal_title：Frontiers in genetics

authors： Chen HH,Liu YL,Liu XY,Zhang JL,Xu HJ

更新日期：2020-11-03 00:00:00

abstract：:Inference of copy number variation presents a technical challenge because variant callers typically require the copy number of a genome or genomic region to be known a priori. Here we present a method to infer copy number that uses variant call format (VCF) data as input and is implemented in the R package vcfR. This ...

journal_title：Frontiers in genetics

authors： Knaus BJ,Grünwald NJ

更新日期：2018-04-13 00:00:00

abstract：:The mammalian genome is packed tightly in the nucleus of the cell. This packing is primarily facilitated by histone proteins and results in an ordered organization of the genome in chromosome territories that can be roughly divided in heterochromatic and euchromatic domains. On top of this organization several distinc...

journal_title：Frontiers in genetics

authors： Palstra RJ,Grosveld F

更新日期：2012-09-28 00:00:00

abstract：:Reliable phenotypes are paramount for meaningful quantification of genetic variation and for estimating individual breeding values on which genetic selection is based. In this paper, we assert that genetic improvement of host tolerance to disease, although desirable, may be first of all handicapped by the ability to o...

journal_title：Frontiers in genetics

authors： Doeschl-Wilson AB,Villanueva B,Kyriazakis I

更新日期：2012-12-14 00:00:00

abstract：:Functional annotation of the genome is important to understand the phenotypic complexity of various species. The road toward functional annotation involves several challenges ranging from experiments on individual molecules to large-scale analysis of high-throughput sequencing (HTS) data. HTS data is typically a resul...

journal_title：Frontiers in genetics

authors： Pundhir S,Poirazi P,Gorodkin J

更新日期：2015-05-19 00:00:00

abstract：:Measuring facial traits by quantitative means is a prerequisite to investigate epidemiological, clinical, and forensic questions. This measurement process has received intense attention in recent years. We divided this process into the registration of the face, landmarking, morphometric quantification, and dimension r...

journal_title：Frontiers in genetics

authors： Böhringer S,de Jong MA

更新日期：2019-05-24 00:00:00

abstract：:Classification of DNA sequences is an important issue in the bioinformatics study, yet most existing methods for phylogenetic analysis including Multiple Sequence Alignment (MSA) are time-consuming and computationally expensive. The alignment-free methods are popular nowadays, whereas the manual intervention in those ...

journal_title：Frontiers in genetics

authors： Dong R,He L,He RL,Yau SS

更新日期：2019-04-09 00:00:00

abstract：:Organ size and architecture of plants are important traits affecting crop yield and agronomic practices. An induced mutant, multiple-organ gigantism (MOG), of black gram (Vigna mungo) has been obtained, which shows gigantic leaves, fruit, seed, and architecture (plant height) but lower number of pods per plant. These ...

journal_title：Frontiers in genetics

authors： Somta P,Chen J,Yimram T,Yundaeng C,Yuan X,Tomooka N,Chen X

更新日期：2020-06-30 00:00:00

abstract：:Leukemia, specifically acute myeloid leukemia (AML), is a common malignancy that can be differentiated into multiple subtypes based on leukemogenic history and etiology. Although genetic aberrations, particularly cytogenetic abnormalities and mutations in known oncogenes, play an integral role in AML development, epig...

journal_title：Frontiers in genetics

authors： Goldman SL,Hassan C,Khunte M,Soldatenko A,Jong Y,Afshinnekoo E,Mason CE

更新日期：2019-03-01 00:00:00