Lost in Translation: Ribosome-Associated mRNA and Protein Quality Controls.

abstract：:Motivation:Arabidopsis thaliana is a well-established model system for the analysis of the basic physiological and metabolic pathways of plants. Nevertheless, the system is not yet fully understood, although many mechanisms are described, and information for many processes exists. However, the combination and interpre...

journal_title：Frontiers in genetics

authors： Koch I,Nöthen J,Schleiff E

更新日期：2017-06-30 00:00:00

abstract：:Glioblastoma (GBM) is characterized by rapid and lethal infiltration of brain tissue, which is the primary cause of treatment failure and deaths for GBM. Therefore, understanding the molecular mechanisms of tumor cell invasion is crucial for the treatment of GBM. In this study, we dissected the single-cell RNA-seq dat...

journal_title：Frontiers in genetics

authors： Pang B,Quan F,Ping Y,Hu J,Lan Y,Pang L

更新日期：2021-01-11 00:00:00

abstract：:Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks due to the shared genetics of their haplotype block. Therefore, ...

journal_title：Frontiers in genetics

authors： Joslin SEK,Durbin-Johnson BP,Britton M,Settles ML,Korf I,Lemay DG

更新日期：2020-10-29 00:00:00

abstract：:Phenome-wide association studies (PheWAS) have demonstrated utility in validating genetic associations derived from traditional genetic studies as well as identifying novel genetic associations. Here we used an electronic health record (EHR)-based PheWAS to explore pleiotropy of genetic variants in the fat mass and ob...

journal_title：Frontiers in genetics

authors： Cronin RM,Field JR,Bradford Y,Shaffer CM,Carroll RJ,Mosley JD,Bastarache L,Edwards TL,Hebbring SJ,Lin S,Hindorff LA,Crane PK,Pendergrass SA,Ritchie MD,Crawford DC,Pathak J,Bielinski SJ,Carrell DS,Crosslin DR,Ledbett

更新日期：2014-08-05 00:00:00

abstract：:Selective breeding programs aiming to increase the productivity and profitability of the sheep meat industry use elite, progeny tested sires. The broad genetic traits of primary interest in the progeny of these sires include skeletal muscle yield, fat content, eating quality, and reproductive efficiency. Natural mutat...

journal_title：Frontiers in genetics

authors： Tellam RL,Cockett NE,Vuocolo T,Bidwell CA

更新日期：2012-08-29 00:00:00

abstract：:Pervasive allelic variation at both gene and single nucleotide level (SNV) between individuals is commonly associated with complex traits in humans and animals. Allele-specific expression (ASE) analysis, using RNA-Seq, can provide a detailed annotation of allelic imbalance and infer the existence of cis-acting transcr...

journal_title：Frontiers in genetics

authors： Salavati M,Bush SJ,Palma-Vera S,McCulloch MEB,Hume DA,Clark EL

更新日期：2019-09-19 00:00:00

abstract：:Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is...

journal_title：Frontiers in genetics

authors： Zaghi M,Broccoli V,Sessa A

更新日期：2020-01-09 00:00:00

abstract：:Telomeres are essential nucleoprotein structures at linear chromosomes that maintain genome integrity by protecting chromosome ends from being recognized and processed as damaged DNA. In addition, they limit the cell's proliferative capacity, as progressive loss of telomeric DNA during successive rounds of cell divisi...

journal_title：Frontiers in genetics

authors： Yalçin Z,Selenz C,Jacobs JJL

更新日期：2017-05-23 00:00:00

abstract：:The switch to a modern lifestyle in recent decades has coincided with a rapid increase in prevalence of obesity and other diseases. These shifts in prevalence could be explained by the release of genetic susceptibility for disease in the form of gene-by-environment (GxE) interactions. Yet, the detection of interaction...

journal_title：Frontiers in genetics

authors： Marigorta UM,Gibson G

更新日期：2014-07-21 00:00:00

abstract：:Liver is the main organ of lipid metabolism in chicken, especially for laying hens. To explore the molecular mechanism of lipid metabolism in chicken, five novel genes discovered in chicken liver tissue were systematically studied. Bioinformatic analysis was used to analyze the gene characteristics. The expression pat...

journal_title：Frontiers in genetics

authors： Li H,Li Y,Yang L,Zhang D,Liu Z,Wang Y,Han R,Li G,Li Z,Tian Y,Kang X,Liu X

更新日期：2020-03-31 00:00:00

abstract：:RNA binding proteins (RBPs) play a key role in post-transcriptional gene regulation. They have been shown to be dysfunctional in a variety of cancers and are closely related to the occurrence and progression of cancers. However, the biological function and clinical significance of RBPs in clear cell renal carcinoma (c...

journal_title：Frontiers in genetics

authors： Wu Y,Wei X,Feng H,Hu B,Liu B,Luan Y,Ruan Y,Liu X,Liu Z,Wang S,Liu J,Wang T

更新日期：2021-01-07 00:00:00

abstract：:Successful seedling establishment depends on the optimum depth of seed placement especially in drought-prone conditions, providing an opportunity to exploit subsoil water and increase winter survival in winter wheat. Coleoptile length is a key determinant for the appropriate depth at which seed can be sown. Thus, unde...

journal_title：Frontiers in genetics

authors： Sidhu JS,Singh D,Gill HS,Brar NK,Qiu Y,Halder J,Al Tameemi R,Turnipseed B,Sehgal SK

更新日期：2020-02-05 00:00:00

abstract：:Human CYP3A enzymes (including CYP3A4 and CYP4A5) metabolize about 40% of all drugs and numerous other environmental and endogenous substances. CYP3A activity is highly variable within and between humans. As a consequence, therapy with standard doses often results in too low or too high blood and tissue concentrations...

journal_title：Frontiers in genetics

authors： Matthaei J,Bonat WH,Kerb R,Tzvetkov MV,Strube J,Brunke S,Sachse-Seeboth C,Sehrt D,Hofmann U,von Bornemann Hjelmborg J,Schwab M,Brockmöller J

更新日期：2020-08-21 00:00:00

abstract：:Analysis of the relationships among wild species of section Moutan in the plant genus Paeonia has traditionally been problematic. Interspecies relationships cannot be effectively determined using phenotypic traits alone or through analysis of nuclear or chloroplast DNA fragments. Elucidation of complete chloroplast ge...

journal_title：Frontiers in genetics

authors： Wu L,Nie L,Xu Z,Li P,Wang Y,He C,Song J,Yao H

更新日期：2020-09-18 00:00:00

abstract：:Recent work shows strong evidence of ancestry-based assortative mating in spouse pairs of the older generation of the Framingham Heart Study. Here, we extend this analysis to two studies of human longevity: the Long Life Family Study (LLFS), and the New England Centenarian Study (NECS). In the LLFS, we identified 890 ...

journal_title：Frontiers in genetics

authors： Sebastiani P,Gurinovich A,Bae H,Andersen SL,Perls TT

更新日期：2017-11-21 00:00:00

abstract：:Sorting of individual chromosomes by Flow Cytometry (flow-sorting) is an enrichment method to potentially simplify genome assembly by isolating chromosomes from the context of the genome. We have recently developed a workflow to sequence native, unamplified DNA and applied it to the smallest human chromosome, the Y ch...

journal_title：Frontiers in genetics

authors： Kuderna LFK,Solís-Moruno M,Batlle-Masó L,Julià E,Lizano E,Anglada R,Ramírez E,Bote A,Tormo M,Marquès-Bonet T,Fornas Ò,Casals F

更新日期：2020-01-09 00:00:00

abstract：:Human exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic ...

journal_title：Frontiers in genetics

authors： Arrifano GPF,Martín-Doimeadios RCR,Jiménez-Moreno M,Fernández-Trujillo S,Augusto-Oliveira M,Souza-Monteiro JR,Macchi BM,Alvarez-Leite JI,do Nascimento JLM,Amador MT,Santos S,Ribeiro-Dos-Santos Â,Silva-Pereira LC,Oriá RB,Cresp

更新日期：2018-07-27 00:00:00

abstract：:Ionizing radiation (IR) is a high-energy radiation whose biological effects depend on the irradiation doses. Low-dose radiation (LDR) is delivered during medical diagnoses or by an exposure to radioactive elements and has been linked to the occurrence of chronic diseases, such as leukemia and cardiovascular diseases. ...

journal_title：Frontiers in genetics

authors： Shin E,Lee S,Kang H,Kim J,Kim K,Youn H,Jin YW,Seo S,Youn B

更新日期：2020-10-02 00:00:00

abstract：:Single variant analysis in genome-wide association studies (GWAS) has been proven to be successful in identifying thousands of genetic variants associated with hundreds of complex diseases. However, these identified variants only explain a small fraction of inheritable variability in many diseases, suggesting that oth...

journal_title：Frontiers in genetics

authors： He T,Zhong PS,Cui Y

更新日期：2014-11-12 00:00:00

abstract：:The prevalence of obesity continues to increase particularly in developed countries. To establish the primary mechanisms involved, relevant animal models which track the developmental pathway to obesity are required. This need is emphasized by the substantial rise in the number of overweight and obese children, of whi...

journal_title：Frontiers in genetics

authors： Symonds ME,Sebert S,Budge H

更新日期：2011-05-31 00:00:00

abstract：:p73 transcription factor belongs to one of the most important gene families in vertebrate biology, the p53-family. Trp73 gene, like the other family members, generates multiple isoforms named TA and DNp73, with different and, sometimes, antagonist functions. Although p73 shares many biological functions with p53, it a...

journal_title：Frontiers in genetics

authors： Marques MM,Villoch-Fernandez J,Maeso-Alonso L,Fuertes-Alvarez S,Marin MC

更新日期：2019-03-15 00:00:00

abstract：:The southern muriqui (Brachyteles arachnoides) is the largest neotropical primate. This species is endemic to Brazil and is currently critically endangered due to its habitat destruction. The genetic basis underlying adaptive traits of New World monkeys has been a subject of interest to several investigators, with sig...

journal_title：Frontiers in genetics

authors： Moreira DA,Lamarca AP,Soares RF,Coelho AMA,Furtado C,Scherer NM,Moreira MAM,Seuánez HN,Boroni M

更新日期：2020-07-31 00:00:00

abstract：:Inverted repeat (IR) regions in the plastomes from land plants induce homologous recombination, generating isomeric plastomes. While the plastomes of Taxaceae species often lose one of the IR regions, considerable isomeric plastomes were created in Taxaceae species with a hitherto unclarified mechanism. To investigate...

journal_title：Frontiers in genetics

authors： Zhang Y,Xu Y,Chen H,Wang L,Yin K,Du FK

更新日期：2020-01-14 00:00:00

abstract：:Cardiac myocytes (CMs) proliferate robustly during fetal life but withdraw permanently from the cell cycle soon after birth and undergo terminal differentiation. This cell cycle exit is associated with the upregulation of a host of adult cardiac-specific genes. The vast majority of adult CMs (ACMs) do not reenter cell...

journal_title：Frontiers in genetics

authors： Oyama K,El-Nachef D,Zhang Y,Sdek P,MacLellan WR

更新日期：2014-11-04 00:00:00

abstract：:The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease (CVD), and have also been associated with longevity. We sought to identify novel loci for HDL that could potentially provide new insights into biological regulation of...

journal_title：Frontiers in genetics

authors： Feitosa MF,Wojczynski MK,Straka R,Kammerer CM,Lee JH,Kraja AT,Christensen K,Newman AB,Province MA,Borecki IB

更新日期：2014-06-03 00:00:00

abstract：:Primary ciliary dyskinesia (PCD), a rare genetic disorder, is mostly caused by defects in more than 40 known cilia structure-related genes. However, in approximately 20-35% of patients, it is caused by unknown genetic factors, and the inherited pathogenic factors are difficult to confirm. Kartagener syndrome (KTS) is ...

journal_title：Frontiers in genetics

authors： Yue Y,Huang Q,Zhu P,Zhao P,Tan X,Liu S,Li S,Han X,Cheng L,Li B,Fu Y

更新日期：2019-08-22 00:00:00

abstract：:mRNA-Seq is a precise and highly reproducible technique for measurement of transcripts levels and yields sequence information of a transcriptome at a single nucleotide base-level thus enabling us to determine splice junctions and alternative splicing events with high confidence. Often analysis of mRNA-Seq data does no...

journal_title：Frontiers in genetics

authors： Bhattacharjee M,Gupta R,Davuluri RV

更新日期：2012-11-27 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:Several authors have acknowledged that testing mediational hypotheses between treatments, genes, physiological measures, and behaviors may substantially advance our understanding of how these associations operate. In psychiatric research, the costs of measuring the putative mediator or the outcome can be prohibitive. ...

journal_title：Frontiers in genetics

authors： Makowsky R,Beasley TM,Gadbury GL,Albert JM,Kennedy RE,Allison DB

更新日期：2011-10-31 00:00:00

abstract：PURPOSE:The multifactorial pathogenesis of coronary atherosclerotic lesion formation has been investigated in a swine model of high cholesterol diet induced atherogenesis and data processed by a systems approach. METHODS:Farm pigs were fed on standard or high cholesterol diet of 8 and 16 weeks duration. Plasma assessm...

journal_title：Frontiers in genetics

authors： Pelosi G,Rocchiccioli S,Cecchettini A,Viglione F,Puntoni M,Parodi O,Capobianco E,Trivella MG

更新日期：2014-04-07 00:00:00