The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis.

abstract：:Satellite DNA is a class of repetitive sequences that are organized in long arrays of tandemly repeated units in most eukaryotes. Long considered as selfish DNA, satellite sequences are now proposed to contribute to genome integrity. Despite their potential impact on the architecture and evolution of the genome, satel...

journal_title：Frontiers in genetics

authors： Panabières F,Rancurel C,da Rocha M,Kuhn ML

更新日期：2020-06-05 00:00:00

abstract：:Cytotoxicity assays of immortalized lymphoblastoid cell lines (LCLs) represent a promising new in vitro approach in pharmacogenomics research. However, previous studies employing LCLs in gene mapping have used simple association methods, which may not adequately capture the true differences in non-linear response prof...

journal_title：Frontiers in genetics

authors： Brown C,Havener TM,Everitt L,McLeod H,Motsinger-Reif AA

更新日期：2011-12-14 00:00:00

abstract：:The Galápagos Islands are known to have experienced significant drought during the Quaternary. The loss of mesophytic upland habitats has been suggested to underlie the relatively lower endemism of upland compared with lowland plant assemblages. A fossil pollen record spanning the last 26,000 years from an upland bog ...

journal_title：Frontiers in genetics

authors： Collins AF,Bush MB,Sachs JP

更新日期：2013-12-03 00:00:00

abstract：Objective:Extensive literature put forward the link between sleep and type 2 diabetes mellitus (T2DM), however, little is known about the underlying causality of the associations. Here we aim to assess the causal relationships between five major sleep-related traits and T2DM. Design Setting and Participants:Two-sample...

journal_title：Frontiers in genetics

authors： Gao X,Sun H,Zhang Y,Liu L,Wang J,Wang T

更新日期：2020-12-15 00:00:00

abstract：:In this study, we used pan RNA-seq analysis to reveal the ubiquitous existence of both 5' and 3' end small RNAs (5' and 3' sRNAs). 5' and 3' sRNAs alone can be used to annotate nuclear non-coding and mitochondrial genes at 1-bp resolution and identify new steady RNAs, which are usually transcribed from functional gene...

journal_title：Frontiers in genetics

authors： Xu X,Ji H,Jin X,Cheng Z,Yao X,Liu Y,Zhao Q,Zhang T,Ruan J,Bu W,Chen Z,Gao S

更新日期：2019-02-14 00:00:00

abstract：:Inverted repeat (IR) regions in the plastomes from land plants induce homologous recombination, generating isomeric plastomes. While the plastomes of Taxaceae species often lose one of the IR regions, considerable isomeric plastomes were created in Taxaceae species with a hitherto unclarified mechanism. To investigate...

journal_title：Frontiers in genetics

authors： Zhang Y,Xu Y,Chen H,Wang L,Yin K,Du FK

更新日期：2020-01-14 00:00:00

abstract：:Organ size and architecture of plants are important traits affecting crop yield and agronomic practices. An induced mutant, multiple-organ gigantism (MOG), of black gram (Vigna mungo) has been obtained, which shows gigantic leaves, fruit, seed, and architecture (plant height) but lower number of pods per plant. These ...

journal_title：Frontiers in genetics

authors： Somta P,Chen J,Yimram T,Yundaeng C,Yuan X,Tomooka N,Chen X

更新日期：2020-06-30 00:00:00

abstract：:For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate the effectiveness of therapeutic interventions is still a major challe...

journal_title：Frontiers in genetics

authors： Mamoshina P,Volosnikova M,Ozerov IV,Putin E,Skibina E,Cortese F,Zhavoronkov A

更新日期：2018-07-12 00:00:00

abstract：:Apomixis, an asexual mode of reproduction through seeds, has immense scope for crop improvement due to its ability to fix hybrid vigor. In C. ciliaris, a predominantly apomictically reproducing range grass, apomixis is genetically controlled by an apospory-specific-genomic-region (ASGR) which is enriched with retrotra...

journal_title：Frontiers in genetics

authors： Rathore P,Raina SN,Kumar S,Bhat V

更新日期：2020-07-22 00:00:00

abstract：:Taproot skin color is a crucial visual and nutritional quality trait of radish, and purple skin is most attractive to consumers. However, the genetic mechanism underlying this character is unknown. Herein, F2 segregating populations were constructed to investigate radish genomic regions with purple skin genes. Segrega...

journal_title：Frontiers in genetics

authors： Liu T,Wang J,Wu C,Zhang Y,Zhang X,Li X,Wang H,Song J,Li X

更新日期：2019-09-20 00:00:00

abstract：:A biochemical activity, that is, enzymatic reaction or molecular interaction, frequently involves a molecule, for example, an enzyme, capable of interacting with numerous substrates or partners. Specificity is a fundamental property of biochemical activities, and relative specificity refers to the situation whereby a ...

journal_title：Frontiers in genetics

authors： Zeng Y

更新日期：2011-09-20 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:In the last 40 years, the Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the...

journal_title：Frontiers in genetics

authors： Battaglia V,Gabrieli P,Brandini S,Capodiferro MR,Javier PA,Chen XG,Achilli A,Semino O,Gomulski LM,Malacrida AR,Gasperi G,Torroni A,Olivieri A

更新日期：2016-11-23 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are an emerging class of RNA species that may play a critical regulatory role in gene expression. However, the association between lncRNAs and atrial fibrillation (AF) is still not fully understood. In this study, we used RNA sequencing data to identify and quantify the both protein codi...

journal_title：Frontiers in genetics

authors： Wu DM,Zhou ZK,Fan SH,Zheng ZH,Wen X,Han XR,Wang S,Wang YJ,Zhang ZF,Shan Q,Li MQ,Hu B,Lu J,Chen GQ,Hong XW,Zheng YL

更新日期：2019-10-02 00:00:00

abstract：Background:Tumor stem cells play important roles in the survival, proliferation, metastasis and recurrence of tumors. We aimed to identify new prognostic biomarkers for lung squamous cell carcinoma (LUSC) based on the cancer stem cell theory. Methods:RNA-seq data and relevant clinical information were downloaded from ...

journal_title：Frontiers in genetics

authors： Liao Y,Xiao H,Cheng M,Fan X

更新日期：2020-05-13 00:00:00

abstract：:Analysis of bulk RNA sequencing (RNA-Seq) data is a valuable tool to understand transcription at the genome scale. Targeted sequencing of RNA has emerged as a practical means of assessing the majority of the transcriptomic space with less reliance on large resources for consumables and bioinformatics. TempO-Seq is a t...

journal_title：Frontiers in genetics

authors： Bushel PR,Ferguson SS,Ramaiahgari SC,Paules RS,Auerbach SS

更新日期：2020-06-23 00:00:00

abstract：:Plant basic helix-loop-helix (bHLH) transcription factors are involved in the regulation of various biological processes in plant growth, development, and stress response. However, members of this important transcription factor family have not been systematically identified and analyzed in pepper (Capsicum annuum L.)....

journal_title：Frontiers in genetics

authors： Zhang Z,Chen J,Liang C,Liu F,Hou X,Zou X

更新日期：2020-09-25 00:00:00

abstract：:Two chaperonopathies have been linked to mutations in the human hsp60 (hHsp60; HSPD1) gene, but other existing variants might cause diseases, even if there is no comprehensive information about this possibility. To fill this vacuum, which might be at the basis of misdiagnoses or simply ignorance of chaperonopathies in...

journal_title：Frontiers in genetics

authors： Vitale AM,Conway de Macario E,Alessandro R,Cappello F,Macario AJL,Marino Gammazza A

更新日期：2020-08-18 00:00:00

abstract：:Adult adipose tissue-derived mesenchymal stem cells (ASCs) constitute a vital population of multipotent cells capable of differentiating into numerous end-organ phenotypes. However, scientific and translational endeavors to harness the regenerative potential of ASCs are currently limited by an incomplete understanding...

journal_title：Frontiers in genetics

authors： Pepin ME,Infante T,Benincasa G,Schiano C,Miceli M,Ceccarelli S,Megiorni F,Anastasiadou E,Della Valle G,Fatone G,Faenza M,Docimo L,Nicoletti GF,Marchese C,Wende AR,Napoli C

更新日期：2020-04-15 00:00:00

abstract：:High-throughput analysis of the transcriptome and proteome individually are used to interrogate complex oncogenic processes in cancer. However, an outstanding challenge is how to combine these complementary, yet partially disparate data sources to accurately identify tumor-specific gene products and clinical biomarker...

journal_title：Frontiers in genetics

authors： Schwartz GW,Petrovic J,Zhou Y,Faryabi RB

更新日期：2018-06-15 00:00:00

abstract：:Background: The aim of this study was to explore the Human Papillomavirus (HPV) genotype composition and intra-genotype variants within individual samples of low- and high-grade cervical cytology by deep sequencing. Clinical, cytological, sequencing, and functional/structural data were forged into an integrated varian...

journal_title：Frontiers in genetics

authors： Shen-Gunther J,Cai H,Zhang H,Wang Y

更新日期：2019-05-24 00:00:00

abstract：:Eukaryotic protein kinases are well conserved through evolution. The genome of Schistosoma mansoni, which causes intestinal schistosomiasis, encodes over 250 putative protein kinases with all of the main eukaryotic groups represented. However, unraveling functional roles for these kinases is a considerable endeavor, p...

journal_title：Frontiers in genetics

authors： Walker AJ,Ressurreição M,Rothermel R

更新日期：2014-07-31 00:00:00

abstract：:Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age. Inflammation of blood vessels...

journal_title：Frontiers in genetics

authors： Cheng HS,Njock MS,Khyzha N,Dang LT,Fish JE

更新日期：2014-12-10 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide despite the availability of diverse treatment strategies. Much research progress has been made regarding immunotherapy but the effects remain unsatisfactory, highlighting the urgent need for novel immune-related therapy target...

journal_title：Frontiers in genetics

authors： Rao J,Wu X,Zhou X,Deng R,Ma Y

更新日期：2020-10-14 00:00:00

abstract：:Some candidate genes have been robustly reported to be associated with complex traits, such as the fat mass and obesity-associated (FTO) gene on body mass index (BMI), and the fibroblast growth factor 5 (FGF5) gene on blood pressure levels. It is of interest to know whether an environmental factor (E) can attenuate or...

journal_title：Frontiers in genetics

authors： Lin WY,Lin YS,Chan CC,Liu YL,Tsai SJ,Kuo PH

更新日期：2020-05-08 00:00:00

abstract：:The first breeding program in the world for durum wheat was conceived in Italy in the early 1900s. Over the decades, pressure exerted by natural and artificial selection could have progressively reduced the genetic diversity of the durum wheat germplasm. In the present study, a large panel of Italian durum wheat acces...

journal_title：Frontiers in genetics

authors： Taranto F,D'Agostino N,Rodriguez M,Pavan S,Minervini AP,Pecchioni N,Papa R,De Vita P

更新日期：2020-04-21 00:00:00

abstract：:Molecular epidemiological studies have identified several risk factors linking to the genes and external factors in the pathogenesis of breast cancer. In this sense, genetic instability caused by DNA damage and DNA repair inefficiencies are important molecular events for the diagnosis and prognosis of therapies. There...

journal_title：Frontiers in genetics

authors： Paz MFCJ,de Alencar MVOB,Gomes Junior AL,da Conceição Machado K,Islam MT,Ali ES,Shill MC,Ahmed MI,Uddin SJ,da Mata AMOF,de Carvalho RM,da Conceição Machado K,Sobral ALP,da Silva FCC,de Castro E Souza JM,Arcanjo DDR,Ferrei

更新日期：2018-02-16 00:00:00

abstract：:Werner syndrome (WS) is a rare human autosomal recessive premature aging disorder characterized by early onset of aging-associated diseases, chromosomal instability, and cancer predisposition. The function of the DNA helicase encoded by WRN, the gene responsible for WS, has been studied extensively. WRN helicase is in...

journal_title：Frontiers in genetics

authors： Shimamoto A,Yokote K,Tahara H

更新日期：2015-01-29 00:00:00

abstract：:This review attempts to collate all the studies performed in India or comprising a population originating from India and to find out if there is an association between the HLA (human leucocyte antigen) type of individual and development of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) subsequent to med...

journal_title：Frontiers in genetics

authors： Shanbhag SS,Koduri MA,Kannabiran C,Donthineni PR,Singh V,Basu S

更新日期：2021-01-12 00:00:00

abstract：:In the last decade, several studies have been focused on revealing the microRNA (miRNA) repertoire and determining their functions in farm animals such as poultry, pigs, cattle, and fish. These small non-protein coding RNA molecules (18-25 nucleotides) are capable of controlling gene expression by binding to messenger...

journal_title：Frontiers in genetics

authors： Herkenhoff ME,Oliveira AC,Nachtigall PG,Costa JM,Campos VF,Hilsdorf AWS,Pinhal D

更新日期：2018-03-19 00:00:00