Abstract:
:S-(chloroethyl)-cysteine (CEC) and S-(1,2-dichlorovinyl)-cysteine (DCVC) have been proposed as intermediates in the metabolic transformation of the carcinogens 1,2-dichloroethane and 1,1,2-trichloroethylene. We have tested the ability of CEC and DCVC to induce DNA repair and genotoxic effects at the chromosomal level by comparative assessment of unscheduled DNA synthesis induction and micronucleus formation in Syrian hamster embryo fibroblasts. CEC induced a potent and dose-dependent response in both assays, whereas DCVC treatment resulted in a comparatively weak induction of DNA repair and failed to raise micronucleus formation above control rates. Inhibition of cysteine conjugate beta-lyase diminished the effect of DCVC, but had no influence on the genotoxicity of CEC either in the unscheduled DNA synthesis or micronucleus assay.
journal_name
Cell Biol Toxicoljournal_title
Cell biology and toxicologyauthors
Vamvakas S,Dekant W,Schiffmann D,Henschler Ddoi
10.1007/BF00117768subject
Has Abstractpub_date
1988-12-01 00:00:00pages
393-403issue
4eissn
0742-2091issn
1573-6822journal_volume
4pub_type
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