Cocarcinogenesis in vitro using Balb/3T3 cells and aromatic hydrocarbon cocarcinogens.

abstract：:Interactions between microtubules and filamentous actin (F-actin) are essential to many cellular processes, but their mechanisms are poorly understood. We investigated possible roles of the myosin family of proteins in the interactions between filamentous actin (F-actin) and microtubules of budding yeast Saccharomyces...

journal_title：Cell biology and toxicology

authors： Chon K,Hwang HS,Lee JH,Song K

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Endoplasmic reticulum (ER) stress is a growing concern for drug-induced toxicity which causes several side effects. Ritonavir, a potent HIV protease inhibitor, induces both ER and mitochondrial stress; however, the missing link between ER stress and mitochondrial damage has been unknown. In the pres...

journal_title：Cell biology and toxicology

authors： Ganta KK,Chaubey B

更新日期：2019-06-01 00:00:00

abstract：:Cellular accumulation of mono(2-ethylhexyl)phthalate (MEHP) has been recently demonstrated to disturb fat cell energy metabolism; however, the underlying mechanism remained unclear. The study aimed to determine how MEHP influenced fat cell transcriptome and how the changes might contribute to bioenergetics. Because of...

journal_title：Cell biology and toxicology

authors： Chiang HC,Wang CH,Yeh SC,Lin YH,Kuo YT,Liao CW,Tsai FY,Lin WY,Chuang WH,Tsou TC

更新日期：2017-12-01 00:00:00

abstract：:Cholestatic liver injury, a group of diseases characterized with dysregulated bile acid (BA) homeostasis, was partly resulted from BA circulation disorders, which is commonly associated with the damage of hepatocyte barrier function. However, the underlying hepatocyte barrier-protective molecular mechanisms of cholest...

journal_title：Cell biology and toxicology

authors： Yang T,Wang X,Zhou Y,Yu Q,Heng C,Yang H,Yuan Z,Miao Y,Chai Y,Wu Z,Sun L,Huang X,Liu B,Jiang Z,Zhang L

更新日期：2021-01-05 00:00:00

abstract：:During the last decade, the unbound glutathione content of cultured adherent cells has become a very important biological marker for many pharmacological and toxicological in vitro studies with regard to the protective role of the tripeptide in its reduced form (GSH). However, the literature does not provide extensive...

journal_title：Cell biology and toxicology

authors： Thioudellet C,Oster T,Leroy P,Nicolas A,Wellman M

更新日期：1995-04-01 00:00:00

abstract：:Pulmonary alveolar macrophages exposed to very short chrysotile asbestos fibers present a typical cytotoxic response: extracellular releases of lactate dehydrogenase and beta-galactosidase, and a decrease in cellular ATP content. The objective of this study was to determine if nicotinamide and 3-aminobenzamide, two in...

journal_title：Cell biology and toxicology

authors： Nadeau D,Lane DA

更新日期：1988-03-01 00:00:00

abstract：:Sensitivity of baker's yeast to disulfiram (DSF) and hypersensitivity of a mutant devoid of Cu, Zn-superoxide dismutase to this compound is reported, demonstrating that yeast may be a simple convenient eukaryotic model to study the mechanism of DSF toxicity. DSF was found to induce oxidative stress in yeast cells demo...

journal_title：Cell biology and toxicology

authors： Kwolek-Mirek M,Zadrag-Tecza R,Bartosz G

更新日期：2012-02-01 00:00:00

abstract：:Ten compounds representative of diverse classes of chemicals were evaluated for their cytotoxicity and transforming ability to human skin fibroblasts in vitro. Only five of the ten compounds were highly cytotoxic in the 0-100 micrograms/ml range and their order of cytotoxicity was: 2,5-bis(1-aziridinyl)-3,6-bis(carboe...

journal_title：Cell biology and toxicology

authors： Kurian P,Nesnow S,Milo GE

更新日期：1990-04-01 00:00:00

abstract：:The effect of noncytotoxic doses of argemone oil (AO) and butter yellow (BY), the common adulterants in edible oil, on free radical generation and signaling pathway for cell proliferation in primary cells of gall bladder (GB) was undertaken. AO and BY showed no cytotoxicity at 0.1 μl/ml and 0.1 μg/ml concentration, re...

journal_title：Cell biology and toxicology

authors： Mishra V,Ansari KM,Khanna R,Das M

更新日期：2012-06-01 00:00:00

abstract：:Clinical tests of gene sequence, structure, and function are to predict, diagnose, monitor, and prognose human disease-specific phenomes, characters severities, durations, stages, and responses to therapy. The concept and content of gene tests for clinical application mainly include chromosome/chromatins, DNA, and RNA...

journal_title：Cell biology and toxicology

authors： Wu D,Cheng Y,Wang X,CSGT group.

更新日期：2019-04-01 00:00:00

abstract：:We have previously synthesized various diazenecarboxamides (subsequently referred to as diazenes) that were cytotoxic to several tumor cell lines. To increase their biological activity, the structure has been modified appropriately. In the present study we examined the effects of N(1)-phenyl-N(2)-(2-pyridinylmethyl)di...

journal_title：Cell biology and toxicology

authors： Jakopec S,Dubravcic K,Brozovic A,Polanc S,Osmak M

更新日期：2006-01-01 00:00:00

abstract：:Aging, injuries, and diseases can be considered as the result of malfunctioning or damaged cells. Regenerative medicine aims to restore tissue homeostasis by repairing or replacing cells, tissues, or damaged organs, by linking and combining different disciplines including engineering, technology, biology, and medicine...

journal_title：Cell biology and toxicology

authors： Mora C,Serzanti M,Consiglio A,Memo M,Dell'Era P

更新日期：2017-08-01 00:00:00

abstract：:In pharmaceutical research, in vitro toxicity tests, for assessing the potential toxicity of new chemical entities are necessary in the early stages of the developmental process, when no information is available about the metabolism or even the target organ toxicity of the compounds to be tested. In vitro specific org...

journal_title：Cell biology and toxicology

authors： Negro GD,Bonato M,Gribaldo L

更新日期：2001-01-01 00:00:00

abstract：:Human tumor cells have properties in vitro or in surrogate hosts that are distinct from those of normal cells, such as immortality, anchorage independence, and tumor formation in nude mice. However, different cells from individual tumors may exhibit some, but not all of these features. In previous years, human tumor c...

journal_title：Cell biology and toxicology

authors： Lee H,Li D,Prior T,Casto BC,Weghorst CM,Shuler CF,Milo GE

更新日期：1997-10-01 00:00:00

abstract：:The nephrotoxic fungal toxins ochratoxin A (OA), ochratoxin B (OB) and citrinin (CIT) are natural contaminants of foods and feeds. While cytotoxicity assays have proven useful for establishing relative toxicity and structure function relationships within groups of fungal toxins, a drawback of in vitro bioassays is the...

journal_title：Cell biology and toxicology

authors： Bondy GS,Armstrong CL

更新日期：1998-10-01 00:00:00

abstract：:The activity of chemical-induced unscheduled DNA synthesis was evaluated in hepatocyte primary cultures from Fischer 344 and Sprague-Dawley rats over a period of two years. In this two-year study hepatocytes from both sexes and strains were prepared from animals 2, 8, 14, 20 and 25 months of age and UDS was measured b...

journal_title：Cell biology and toxicology

authors： Probst GS,Hill LE

更新日期：1987-06-01 00:00:00

abstract：:Adverse effect of nanoparticles may include impairment of phagocyte function. To identify the effect of nanoparticle size on uptake, cytotoxicity, chemotaxis, cytokine secretion, phagocytosis, oxidative burst, nitric oxide production and myeloperoxidase release, leukocytes isolated from human peripheral blood, monocyt...

journal_title：Cell biology and toxicology

authors： Prietl B,Meindl C,Roblegg E,Pieber TR,Lanzer G,Fröhlich E

更新日期：2014-02-01 00:00:00

abstract：:2,2'-Dichlorodiethyl sulfide (sulfur mustard, HD, 1,1'-thiobis [2-chloroethane]) is a potent vesicant which can cause severe lesions to skin, lung, and eyes. Due to the high number of debilitating exposures during the Iran-Iraq war to the alkylating agent, HD, there is an increased interest in its mechanism of action ...

journal_title：Cell biology and toxicology

authors： Meier HL

更新日期：1996-06-01 00:00:00

abstract：:A method for the primary culture of rat liver cells on collagen-coated dextran microcarriers is described. Ethoxycoumarin deethylase (EOD) activity 24 hr after inoculation was comparable for liver cells cultured on microcarriers and on collagen-coated dishes. Cells were cultured on microcarriers for up to 48 hr and re...

journal_title：Cell biology and toxicology

authors： Voss JU,Seibert H

更新日期：1991-10-01 00:00:00

abstract：:In vitro directional migration of 10T1/2 fibroblasts is partially inhibited by TPA but not by its non-promoting analogues. Other tumor promoters, e.g., phenobarbital, saccharin, and benzoylperoxide had no measurable effect when added in concentrations known to affect in vitro two-step transformation or intercellular c...

journal_title：Cell biology and toxicology

authors： Verschueren H

更新日期：1985-06-01 00:00:00

abstract：:Recent findings suggest a functional interaction of the drug resistance enzyme glutathione S-transferase P (GSTP) with the transcription factor Nrf2, a master regulator of the adaptive stress response to cellular electrophiles. The effect of this interaction on the metabolism and redox of cellular thiols was investiga...

journal_title：Cell biology and toxicology

authors： Bartolini D,Giustarini D,Pietrella D,Rossi R,Galli F

更新日期：2020-08-01 00:00:00

abstract：:We assessed the in vitro toxicity of various particles on three murine macrophage cell lines, (J774A.1, WR19M.1, RAW264.7). The cells were exposed to aqueous suspensions (0-100 microg/30 mm2 well) of urban particulate matter (SRM-1648, SRM-1649, EHC-93), fine particulate matter (PM2.5), titanium dioxide (SRM-154b), an...

journal_title：Cell biology and toxicology

authors： Chauhan V,Breznan D,Goegan P,Nadeau D,Karthikeyan S,Brook JR,Vincent R

更新日期：2004-07-01 00:00:00

abstract：:We investigated mitogen-activated protein kinase (MAPK) pathways as well as reactive oxygen species (ROS) in olaquindox-induced apoptosis. Exposure of HepG2 cells to olaquindox resulted in the phosphorylation of p38 MAPK and c-Jun N-terminal kinases (JNK). To confirm the role of p38 MAPK and JNK, HepG2 cells were pret...

journal_title：Cell biology and toxicology

authors： Zhao WX,Tang SS,Jin X,Zhang CM,Zhang T,Wang CC,Sun Y,Xiao XL

更新日期：2013-08-01 00:00:00

abstract：:An in vitro human nasal model was developed as a tool to study the local tolerability of nasal powder forms using excised nasal mucosa in a diffusion chamber. The suitability of this model was tested using Sandostatin (SMS) an octapeptide analog of somatostatin, as a reference drug enhanced by Avicel (microcrystalline...

journal_title：Cell biology and toxicology

authors： de Fraissinette A,Kolopp M,Schiller I,Fricker G,Gammert C,Pospischil A,Vonderscher J,Richter F

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Heat shock proteins (HSP) are induced during cellular stress. Their role is to chaperone cellular proteins giving protection from denaturation and ultimately preventing cell death. Monocytes are key cells involved in atherosclerosis and are highly responsive to HSP induction. Therefore, we wished to examine ...

journal_title：Cell biology and toxicology

authors： Madden J,Coward JC,Shearman CP,Grimble RF,Calder PC

更新日期：2010-06-01 00:00:00

abstract：:The ubiquitin proteasome-proteolytic pathway has emerged as one of the most significant pathways in modulating protein homeostasis under both normal and disease states. The use of proteasome inhibitors (PI) has played a pivotal role in understanding protein turn over. The main objective of this work was to develop a c...

journal_title：Cell biology and toxicology

authors： Keyomarsi K,Efuet ET,Bui TN

更新日期：2011-04-01 00:00:00

abstract：:Microfilaments and microtubules are components of the cytoskeleton which could be implicated in neoplastic transformation. We studied the effect of two hepatic tumor promoters, phenobarbital (PB) and biliverdin (BV), on microfilaments and microtubules of non-transformed (Cl3) and transformed (FV) hepatic epithelial ce...

journal_title：Cell biology and toxicology

authors： Decloitre F,Lafarge-Frayssinet C,Martin M,Frayssinet C

更新日期：1990-01-01 00:00:00

abstract：:It has been well documented in in vitro studies that ambient airborne particulate matter (PM) with an aerodynamic diameter less than 2.5 μm (PM(2.5)) is capable of inducing oxidative stress, which plays a key role in PM(2.5)-mediated cytotoxicity. Although nuclear factor erythroid-2-related factor 2 (Nrf2) has been sh...

journal_title：Cell biology and toxicology

authors： Deng X,Rui W,Zhang F,Ding W

更新日期：2013-06-01 00:00:00

abstract：:The effectiveness of some chelating agents to mobilize cadmium from Chinese hamster ovary cells after chronic exposure (20 hr), as well as from cytosolic metallothionein, was studied. In the first protocol, the most effective substance was 2,3-dimercaptopropanol, followed by 2,3-dimercaptopropane-1-sulfonate and 2,3-d...

journal_title：Cell biology and toxicology

authors： Rau W,Planas-Bohne F,Taylor DM

更新日期：1989-01-01 00:00:00

abstract：:Recent studies have demonstrated that the insecticide DDT is a tumor promoting agent. Similar to many other tumor promoting agents, DDT has been shown to inhibit gap junctional intercellular communication (GJIC) between cells in culture, and it has been suggested that DDT-induced loss of communication between adjacent...

journal_title：Cell biology and toxicology

authors： Fransson R,Nicotera P,Wärngård L,Ahlborg UG

更新日期：1990-04-01 00:00:00