The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice.

abstract：:Ionic mechanisms play an important role in the regulation of hormone secretion. The GHRH-induced GH release by human GH-secreting cells is transmitted through protein kinase A (PKA), which activates nonselective cation current (NSCC) and induces membrane depolarization, intracellular Ca2+ increase, and GH secretion. T...

journal_title：Endocrinology

authors： Yasufuku-Takano J,Takano K,Takei T,Fukumoto S,Teramoto A,Takakura K,Yamashita N,Fujita T

更新日期：1999-05-01 00:00:00

abstract：:Diets lacking soy and alpha-alpha derivatives that are considered to be estrogen-free by standard bioassays (uterotrophic assay and vaginal opening) have been revealed to contain considerable amounts of compounds able to transcriptionally activate the estrogen receptors (ERs) and stimulate luciferase expression in sev...

journal_title：Endocrinology

authors： Ciana P,Brena A,Sparaciari P,Bonetti E,Di Lorenzo D,Maggi A

更新日期：2005-12-01 00:00:00

abstract：:Neuropeptide Y (NPY), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. Because both genetic (e.g. in obese ob/ob mice) and acquired leptin deficiency (e.g. fasting in normal mice) increase hypothalamic NPY accumulation, and as leptin ad...

journal_title：Endocrinology

authors： Schwartz MW,Erickson JC,Baskin DG,Palmiter RD

更新日期：1998-05-01 00:00:00

abstract：:The synthesis of androgens by theca-interstitial cells is stimulated by LH and the insulin/insulin-like growth factor I (IGF-I) system. An essential element of the steroidogenesis is the uptake of plasma cholesterol and transformation to steroid hormones. In the rat, the uptake of cholesterol by the theca-interstitial...

journal_title：Endocrinology

authors： Li X,Peegel H,Menon KM

更新日期：2001-01-01 00:00:00

abstract：:Adiposity is regulated in a sexually divergent manner. This is partly due to sex steroids, but the differential effects of androgens in males and females are unclear. We investigated effects of testosterone on energy balance in castrated male (n = 6) and female sheep (n = 4), which received 3 × 200 mg testosterone imp...

journal_title：Endocrinology

authors： Clarke SD,Clarke IJ,Rao A,Cowley MA,Henry BA

更新日期：2012-01-01 00:00:00

abstract：:The establishment of dominant ovarian follicles that are capable of ovulating fertilizable oocytes is a fundamental determinant of female fertility. This process is governed by pituitary gonadotropins as well as local ovarian factors. Within the follicle, estrogen acts in an autocrine/paracrine manner to enhance FSH a...

journal_title：Endocrinology

authors： Otsuka F,Moore RK,Wang X,Sharma S,Miyoshi T,Shimasaki S

更新日期：2005-08-01 00:00:00

abstract：:Fetal pancreatic islets (21.5 days old) were cultured in RPMI 1640 containing either 2.8 or 11.1 mM glucose for 7 days. After the 7-day culture period, islets cultured in 2.8 mM glucose demonstrated a minimal first phase of insulin secretion in response to acute glucose stimulation, whereas islets cultured in 11.1 mM ...

journal_title：Endocrinology

authors： Dudek RW,Kawabe T,Brinn JE,O'Brien K,Poole MC,Morgan CR

更新日期：1984-02-01 00:00:00

abstract：:17 beta-Estradiol (E2; 100 micrograms/kg X day) was infused iv for 6 days into three chronically catheterized ovine fetuses beginning at 105-106 days of gestation (term, 147 days) and into four younger fetuses for 3 days commencing at 87-92 days. Control studies were performed on three fetuses at each age. At 90 days,...

journal_title：Endocrinology

authors： Gluckman PD,Marti-Henneberg C,Kaplan SL,Grumbach MM

更新日期：1983-05-01 00:00:00

abstract：:Hyperandrogenism is the central feature of polycystic ovary syndrome (PCOS). Due to the intricate relationship between hyperandrogenism and insulin resistance in PCOS, 50%-70% of these patients also present with hyperinsulinemia. Metformin, an insulin sensitizer, has been used to reduce insulin resistance and improve ...

journal_title：Endocrinology

authors： Lee BH,Indran IR,Tan HM,Li Y,Zhang Z,Li J,Yong EL

更新日期：2016-01-01 00:00:00

abstract：:Although kisspeptin is the primary stimulator of gonadotropin-releasing hormone secretion and therefore the hypothalamic-pituitary-gonadal axis, recent findings suggest kisspeptin can also regulate additional neuroendocrine processes including release of growth hormone (GH). Here we show that central delivery of kissp...

journal_title：Endocrinology

authors： Foradori CD,Whitlock BK,Daniel JA,Zimmerman AD,Jones MA,Read CC,Steele BP,Smith JT,Clarke IJ,Elsasser TH,Keisler DH,Sartin JL

更新日期：2017-10-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11betaHSDs) catalyze interconversion of 11-hydroxy-glucocorticoids with inactive 11-keto metabolites. In blood vessel walls, loss of 11betaHSD1 is thought to reduce local glucocorticoid concentrations, reducing the progression of atheroma and enhancing angiogenesis. Conversely, on...

journal_title：Endocrinology

authors： Dover AR,Hadoke PW,Macdonald LJ,Miller E,Newby DE,Walker BR

更新日期：2007-01-01 00:00:00

abstract：:A major cause of infertility in normal and assisted reproduction cycles is failure of the endometrium to undergo appropriate changes during the secretory phase of the menstrual cycle as it acquires receptivity for an implanting blastocyst. Current dogma states that loss of epithelial polarity in the luminal epithelial...

journal_title：Endocrinology

authors： Whitby S,Salamonsen LA,Evans J

更新日期：2018-01-01 00:00:00

abstract：:To analyze the roles of insulin receptor substrate (IRS) proteins in insulin-stimulated cell cycle progression, we examined the functions of rat IRS-1 and IRS-3 in Chinese hamster ovary cells overexpressing the human insulin receptor. In this type of cell overexpressing IRS-1 or IRS-3, we showed that: 1) overexpressio...

journal_title：Endocrinology

authors： Kaburagi Y,Yamashita R,Ito Y,Okochi H,Yamamoto-Honda R,Yasuda K,Sekihara H,Sasazuki T,Kadowaki T,Yazaki Y

更新日期：2004-12-01 00:00:00

abstract：:The existence of a vasoactive molecule released in response to hCG is believed to be the main feature in the development of ovarian hyperstimulation syndrome (OHSS) in women, and vascular endothelial growth factor (VEGF) is the main candidate as the human chorionic gonadotropin (hCG) mediator. This study was conducted...

journal_title：Endocrinology

authors： Gómez R,Simón C,Remohí J,Pellicer A

更新日期：2002-11-01 00:00:00

abstract：:Indwelling, exteriorized, jugular vein catheters were placed in five thyroidectomized ewes at a time when myxedema was manifested clinically and chemically and three euthyroid sheep were used as controls. Post-operatively, tracer doses of [125I]-iodovasopressin were injected and serial blood specimens were obtained fo...

journal_title：Endocrinology

authors： Skowsky WR,Fisher DA

更新日期：1977-04-01 00:00:00

abstract：:Kisspeptin (encoded by the Kiss1 gene) is an important regulator of reproduction. In rodents, Kiss1 is expressed in two hypothalamic regions, the arcuate nucleus and anteroventral periventricular/ periventricular continuum, where it is regulated by sex steroids. However, the distribution, regulation, and functional si...

journal_title：Endocrinology

authors： Kim J,Semaan SJ,Clifton DK,Steiner RA,Dhamija S,Kauffman AS

更新日期：2011-05-01 00:00:00

abstract：:Metastasis of various malignant cells is inversely related to the abundance of the Nm23-H1 protein. The role of estrogens in tumor metastasis has now been investigated by examining the effect of E2 on the expression of the Nm23-H1 gene. Three human breast carcinoma cell lines, in which endogenous ERalpha is expressed ...

journal_title：Endocrinology

authors： Lin KH,Wang WJ,Wu YH,Cheng SY

更新日期：2002-02-01 00:00:00

abstract：:The present study was designed to characterize the interaction of calcium and PTH in the control of renin release in isolated rat kidneys perfused in a closed circuit at constant flow. Kidneys were rendered nonfiltering using low perfusion pressures (70 mm Hg) and a hyperoncotic perfusate (100 g/liter BSA). Under thes...

journal_title：Endocrinology

authors： Helwig JJ,Musso MJ,Judes C,Nickols GA

更新日期：1991-09-01 00:00:00

abstract：:TGF-beta is a multifunctional factor involved in regulating a variety of cellular activities. In mammals, TGF-beta is known to regulate reproduction, including ovarian functions. The role of TGF-beta in lower vertebrates, such as fish, is poorly understood. To examine the role of TGF-beta in fish reproduction, cDNAs e...

journal_title：Endocrinology

authors： Kohli G,Hu S,Clelland E,Di Muccio T,Rothenstein J,Peng C

更新日期：2003-05-01 00:00:00

abstract：:Prolonged exposure to elevated glucocorticoid levels is known to produce insulin resistance (IR), a hallmark of diabetes mellitus. Although not fully elucidated, the underlying molecular mechanisms by which glucocorticoids induce IR may provide potential targets for pharmacological interventions. Here we characterized...

journal_title：Endocrinology

authors： Gounarides JS,Korach-André M,Killary K,Argentieri G,Turner O,Laurent D

更新日期：2008-02-01 00:00:00

abstract：:We have studied the changes in thyroid hormone economy that occur in normal pregnant rats between 17-22 days of gestation. T4 and T3 decreased in all extrathyroidal tissues studied, namely plasma, liver, kidney, lung, heart, and skeletal muscle. The exception is the concentration of T3 in cerebral cortex, which remain...

journal_title：Endocrinology

authors： Calvo R,Obregon MJ,Ruiz de Oña C,Ferreiro B,Escobar Del Rey E,Morreale de Escobar G

更新日期：1990-07-01 00:00:00

abstract：:Some 17 alpha-alkylated androgens used as anabolic agents, such as stanozolol (ST) and danazol (DA), have specific effects on the liver that are not exerted by testosterone. This gives rise to the possibility that a steroid-binding protein, other than the androgen receptor, could modulate the intracellular actions of ...

journal_title：Endocrinology

authors： Fernández L,Chirino R,Boada LD,Navarro D,Cabrera N,del Rio I,Díaz-Chico BN

更新日期：1994-03-01 00:00:00

abstract：:The activity of hepatic NADPH cytochrome c reductase, an enzyme important in drug and steroid metabolism, increases rapidly during the perinatal period in rats. However, the regulation of this increase is not well understood. To investigate the role of hormones in the development of NADPH cytochrome c reductase activi...

journal_title：Endocrinology

authors： Kriz BM,Gates JA,Read FE,Fong BB

更新日期：1982-06-01 00:00:00

abstract：:In teleosts, the pituitary contains a single glycoprotein gonadotropic hormone (GTH) composed of two dissimilar alpha- and beta-subunits. The European eel, Anguilla anguilla L, is sexually immature at the silver stage due to a deficiency in GTH synthesis and secretion. In previous studies we (S.D., YA.F.) have demonst...

journal_title：Endocrinology

authors： Counis R,Dufour S,Ribot G,Quérat B,Fontaine YA,Jutisz M

更新日期：1987-09-01 00:00:00

abstract：:Although the main role of prolactin (PRL) in pregnant rodents is to sustain progesterone production by the corpus luteum, progesterone treatment of PRL or PRL receptor (PRL-R) null mice is unable to prevent fetal loss. We have previously shown that the rat decidua is a site of PRL production and action. In this report...

journal_title：Endocrinology

authors： Bao L,Tessier C,Prigent-Tessier A,Li F,Buzzio OL,Callegari EA,Horseman ND,Gibori G

更新日期：2007-05-01 00:00:00

abstract：:Somatostatin-like immunoreactivity (SRIF-LI) has previously been demonstrated immunohistochemically in rat thyroid parafollicular cells. Studies were therefore performed to determine whether SRIF-LI was present in a transplantable medullary carcinoma of the thyroid (MCT) in the WAG/Rij strain of rat. SRIF-LI was found...

journal_title：Endocrinology

authors： Berelowitz M,Cibelius M,Szabo M,Frohman LA,Epstein S,Bell NH

更新日期：1980-11-01 00:00:00

abstract：:In cultured granulosa cells, interleukin-1 beta (IL-1 beta) induced a time-dependent (16-72 h) and dose-related (0.3-30 ng/ml) stimulation of nitric oxide (NO) synthase (NOS) activity, as determined by the catalytic conversion of [3H]arginine to [3H]citrulline and NO2- accumulation in the culture medium. Although FSH ...

journal_title：Endocrinology

authors： Tabraue C,Diaz Peñate R,Gallardo G,Hernandez I,Quintana J,Lopez Blanco F,Gonzalez Reyes J,Fanjul LF,Ruiz de Galarreta CM

更新日期：1997-01-01 00:00:00

abstract：:The existence of renin in a number of extrarenal tissues has been well documented, but the physiological role of extrarenal renin remains unknown. To study the physiological role of adrenal renin, we developed a serum-free culture system for adrenal capsular/zona glomrulosa explants. Explants showed good viability in ...

journal_title：Endocrinology

authors： Shier DN,Kusano E,Stoner GD,Franco-Saenz R,Mulrow PJ

更新日期：1989-07-01 00:00:00

abstract：:The rate of internalization and degradation of radioiodinated hCG and ovine LH (oLH) as well as homologous and heterologous recombinants of their subunits was studied in suspensions of ovine luteal cells. Hormone bound to the plasma membrane was quantified by treating the cells with acidic buffer (pH 3.0) and quantifi...

journal_title：Endocrinology

authors： Mock EJ,Papkoff H,Niswender GD

更新日期：1983-07-01 00:00:00

abstract：:Nuclear entry of proteins the size of the glucocorticoid and thyroid hormone receptors appears to be mediated by an interaction of nuclear localization signals (NLSs) within the proteins and specific NLS-binding proteins. NLSs have been identified in the hinge region of both receptors. We have identified the cellular ...

journal_title：Endocrinology

authors： LaCasse EC,Lochnan HA,Walker P,Lefebvre YA

更新日期：1993-03-01 00:00:00