The Endometrial Polarity Paradox: Differential Regulation of Polarity Within Secretory-Phase Human Endometrium.

abstract：:The involvement of hypothalamic histaminergic neurons in the stress-induced release of peripheral catecholamines was studied in conscious, freely moving male rats. Blood samples were obtained via a catheter in a femoral artery. Intracerebroventricular infusion of histamine (HA; 30 micrograms) increased the plasma conc...

journal_title：Endocrinology

authors： Knigge U,Matzen S,Warberg J

更新日期：1990-03-01 00:00:00

abstract：:Central administration of melanocortin 3 and 4 receptor (MC3/4-R) agonists increases energy expenditure, with the hypothalamus commonly held as the primary site of action. It is also clear, however, that MC4-R are expressed in caudal brainstem structures of relevance to the control of energy expenditure. Three experim...

journal_title：Endocrinology

authors： Williams DL,Bowers RR,Bartness TJ,Kaplan JM,Grill HJ

更新日期：2003-11-01 00:00:00

abstract：:Prostaglandin (PG) E2 (PGE(2)) plays a central role in the regulation of smooth muscle contractions. Classically, PGE(2) stimulates contractions via EP1 and EP3 receptors, whereas EP2 and EP4 maintain quiescence. Labor involves a change from myometrial quiescence to contractions with a shift from anti- to proinflammat...

journal_title：Endocrinology

authors： Kandola MK,Sykes L,Lee YS,Johnson MR,Hanyaloglu AC,Bennett PR

更新日期：2014-02-01 00:00:00

abstract：:Previous studies demonstrated the involvement of transforming growth factor-alpha (TGF alpha), a member of the epidermal growth factor (EGF) family, in the developmental regulation of hypothalamic LHRH release. Although both TGF alpha and EGF stimulate LHRH release, they do not appear to act directly on LHRH neurons, ...

journal_title：Endocrinology

authors： Ma YJ,Berg-von der Emde K,Rage F,Wetsel WC,Ojeda SR

更新日期：1997-01-01 00:00:00

abstract：:We examined whether mitogen-activated protein (MAP) kinase was activated by stimulation of the cAMP pathway and whether MAP kinase activation was involved in synthesis of PRL and GH in GH(3) cells. Treatment of the cells with a cAMP analog, 8-(4-chlorophenylthio)cAMP (CPT-cAMP), activated MAP kinase and increased PRL ...

journal_title：Endocrinology

authors： Yonehara T,Kanasaki H,Yamamoto H,Fukunaga K,Miyazaki K,Miyamoto E

更新日期：2001-07-01 00:00:00

abstract：:GH receptor (GHR) mediates the anabolic and metabolic effects of GH. We previously characterized a monoclonal antibody (anti-GHR(ext-mAb)) that reacts with subdomain 2 of the rabbit GHR extracellular domain (ECD) and is a conformation-specific inhibitor of GH signaling in cells bearing rabbit or human GHR. Notably, th...

journal_title：Endocrinology

authors： Jiang J,Wan Y,Wang X,Xu J,Harris JM,Lobie PE,Zhang Y,Zinn KR,Waters MJ,Frank SJ

更新日期：2011-12-01 00:00:00

abstract：:Orally delivered salt stimulates renal salt excretion more effectively than does iv delivered salt. Although the mechanisms that underlie this "postprandial natriuresis" are poorly understood, the peptide uroguanylin (UGn) is thought to be a key mediator. However, the lack of selective assays for UGn gene products has...

journal_title：Endocrinology

authors： Moss NG,Fellner RC,Qian X,Yu SJ,Li Z,Nakazato M,Goy MF

更新日期：2008-09-01 00:00:00

abstract：:Insulin and protein kinase B (or Akt) play critical roles in cardiomyocytic growth and survival. High concentrations of glucocorticoids antagonize insulin's action. To examine whether endogenous glucocorticoids modulate insulin's effect on Akt signaling in the protein and glycogen synthetic pathways in myocardium, we ...

journal_title：Endocrinology

authors： Wu Y,Barrett EJ,Long W,Liu Z

更新日期：2004-03-01 00:00:00

abstract：:The androgen receptor (AR) in Sertoli cells mediates the actions of testosterone on spermatogenesis. However, the transcription factors responsible for AR gene regulation in Sertoli cells remain unknown. In this study, we determined that nuclear factor-kappaB (NF-kappaB) regulates transcription of AR in primary cultur...

journal_title：Endocrinology

authors： Zhang L,Charron M,Wright WW,Chatterjee B,Song CS,Roy AK,Brown TR

更新日期：2004-02-01 00:00:00

abstract：:To examine the physiological effects of norepinephrine (NE) in the paraventricular nucleus of the hypothalamus (PVH) on CRF gene expression and CRF release, NE was microinjected bilaterally into the PVH of conscious rats, and kinetic studies were performed on the levels of POMC messenger RNA (mRNA) in the anterior pit...

journal_title：Endocrinology

authors： Itoi K,Suda T,Tozawa F,Dobashi I,Ohmori N,Sakai Y,Abe K,Demura H

更新日期：1994-11-01 00:00:00

abstract：:Hypothalamic lesions or deficient melanocortin (MC) signaling via MC4 receptor (MC4r) mutations often lead to hyperphagia and severe treatment-resistant obesity. We tested the methionine aminopeptidase 2-inhibitor beloranib (ZGN-440) in 2 male rat models of obesity, one modeling hypothalamic obesity with a combined me...

journal_title：Endocrinology

authors： Elfers CT,Roth CL

更新日期：2017-01-01 00:00:00

abstract：:The dose-dependent displacement characteristics of a biologically active 20,000 molecular weight human pituitary growth hormone variant (20K) and of human growth hormone (hGH) were compared using hGH liver plasma membrane receptors both from 20-30 day pregnant rabbits and from normal female rats and also using mammary...

journal_title：Endocrinology

authors： Sigel MB,Thorpe NA,Kobrin MS,Lewis UJ,Vanderlaan WP

更新日期：1981-04-01 00:00:00

abstract：:Hamsters injected sc with 50 mug estradiol cyclopentylpropionate (ECP) at 0900 h on day 1 (metestrus) of the cycle show the normal "postovulatory" vaginal discharge 4 days later but do not resume ovulation until 14--18 days later. After ECP injection ovarian histology reveals that the follicles normally destined to ov...

journal_title：Endocrinology

authors： Greenwald GS

更新日期：1975-10-01 00:00:00

abstract：:Estrogen receptor α (ESR1; encoded by Esr1) is a crucial nuclear transcription factor for female reproduction and is expressed throughout the female reproductive tract. To assess the function of ESR1 in reproductive tissues without confounding effects from a potential developmental defect arising from global deletion ...

journal_title：Endocrinology

authors： Herrera GGB,Lierz SL,Harris EA,Donoghue LJ,Hewitt SC,Rodriguez KF,Jefferson WN,Lydon JP,DeMayo FJ,Williams CJ,Korach KS,Winuthayanon W

更新日期：2020-02-01 00:00:00

abstract：:SH2B1 is an SH2 domain-containing adaptor protein that plays a key role in the regulation of energy and glucose metabolism in both rodents and humans. Genetic deletion of SH2B1 in mice results in obesity and type 2 diabetes. Single-nucleotide polymorphisms in the SH2B1 loci and chromosomal deletions of the SH2B1 loci ...

journal_title：Endocrinology

authors： Morris DL,Cho KW,Rui L

更新日期：2010-08-01 00:00:00

abstract：:The expression of short-chain fatty acid receptors GPR41/FFAR3 and GPR43/ free fatty acid receptor 2 (FFAR2) was studied in the gastrointestinal tract of transgenic monomeric red fluorescent protein (mRFP) reporter mice. In the stomach free fatty acid receptor 3 (FFAR3)-mRFP was expressed in a subpopulation of ghrelin...

journal_title：Endocrinology

authors： Nøhr MK,Pedersen MH,Gille A,Egerod KL,Engelstoft MS,Husted AS,Sichlau RM,Grunddal KV,Poulsen SS,Han S,Jones RM,Offermanns S,Schwartz TW

更新日期：2013-10-01 00:00:00

abstract：:With the use of rabbit anti-LH-RH serum, a system of delicate nerve fibers and terminals which contain immunoreactive LH-RH can be demonstrated in the median eminence of the rat, corresponding exactly to the tubero-infundibular tract as described earlier with the aid of classical neurophistological methods. The delica...

journal_title：Endocrinology

authors： Sétáló G,Vigh S,Schally AV,Arimura A,Flerkó B

更新日期：1975-01-01 00:00:00

abstract：:Two surges of PRL designated as nocturnal (N) and diurnal (D) are observed during early pregnancy. The present study was undertaken to determine the involvement of serotonin (5-HT) in regulating these PRL surges. On day 7 of pregnancy intracarotid catheters were implanted, and blood samples were obtained at 0200 and 0...

journal_title：Endocrinology

authors： Mistry A,Voogt JL

更新日期：1989-12-01 00:00:00

abstract：:We report here the desensitization and internalization of the relaxin receptor (RXFP1) after agonist activation in both primary human decidual cells and HEK293 cells stably transfected with RXFP1. The importance of beta-arrestin 2 in these processes has also been demonstrated. Thus, in HEK-RXFP1 cells the desensitizat...

journal_title：Endocrinology

authors： Kern A,Bryant-Greenwood GD

更新日期：2009-05-01 00:00:00

abstract：:Bone remodeling is a complex process of coordinated resorption and formation of bone, which is regulated by systemic hormones and by local factors. We have previously shown that the peptide hormone adrenomedullin is mitogenic to osteoblastic cells in vitro and that it promotes bone growth in vivo. The aim of the prese...

journal_title：Endocrinology

authors： Naot D,Callon KE,Grey A,Cooper GJ,Reid IR,Cornish J

更新日期：2001-05-01 00:00:00

abstract：:The mechanism by which xylazine raises plasma glucose but lowers insulin concentrations was examined in Holstein cows. Intravenous injection of xylazine (15-150 micrograms/kg) induced a dose-dependent hyperglycemia and hypoinsulinemia for 3-4 h. An alpha 2-adrenergic blocking agent, yohimbine, and an alpha 1- and alph...

journal_title：Endocrinology

authors： Hsu WH,Hummel SK

更新日期：1981-09-01 00:00:00

abstract：:Prolactinomas are the most prevalent functional pituitary adenomas. Dopamine D2 receptor (D2R) agonists, such as bromocriptine are the first line of therapy; however, drug intolerance/resistance to D2R agonists exists. Apart from D2R agonists, there is no established medical therapy for prolactinomas; therefore, ident...

journal_title：Endocrinology

authors： Miller M,Chen S,Woodliff J,Kansra S

更新日期：2008-08-01 00:00:00

abstract：:Activators of protein kinase C, such as phorbol myristate acetate (PMA) and the synthetic diacylglycerol dioctanoylglycerol (diC8), either stimulate or inhibit PTH release depending on the extracellular Ca2+ concentration. By increasing PTH release at high extracellular Ca2+, these agents, in effect, block high Ca2(+)...

journal_title：Endocrinology

authors： Shoback DM,Chen TH

更新日期：1990-07-01 00:00:00

abstract：:Androgens play a critical role in the development and progression of prostate cancer (PCa), and androgen deprivation therapy via surgical or medical castration is front-line therapy for patients with advanced PCa. However, intratumoral testosterone levels are elevated in metastases from patients with castration-resist...

journal_title：Endocrinology

authors： Cho E,Montgomery RB,Mostaghel EA

更新日期：2014-11-01 00:00:00

abstract：:GH promptly increases cytosolic free calcium ([Ca2+]i) in freshly isolated rat adipocytes. Adipocytes deprived of GH for 3 h or longer are incapable of increasing [Ca2+]i in response to GH, but instead respond in an insulin-like manner. Insulin blocks the GH-induced increase in [Ca2+]i in GH-replete cells and stimulat...

journal_title：Endocrinology

authors： Gaur S,Yamaguchi H,Goodman HM

更新日期：2000-02-01 00:00:00

abstract：:Administration of ovine or rat PRL to animals, including man, has resulted in decreased urine volume and increased urine osmolality. Contamination of PRL preparations with vasopressin is the most likely explanation for the apparent antidiuretic effect. In this study, diabetes insipidus rats lacking vasopressin(homozyg...

journal_title：Endocrinology

authors： Adler RA,Dolphin S,Szefler M,Sokol HW

更新日期：1979-10-01 00:00:00

abstract：:To further characterize the effect of TSH administration on thyroid iodothyronine monodeiodinating activity, we have evaluated the in vitro conversion of T4 to T3 (outer ring deiodination) and T3 to 3,3'-diiodothyronine (T2; inner ring deiodination) by mouse thyroid, liver, and kidney homogenates, comparing tissues fr...

journal_title：Endocrinology

authors： Wu SY,Reggio R,Florsheim WH

更新日期：1985-03-01 00:00:00

abstract：:Circulating levels of the pancreatic beta-cell peptide hormone amylin and the gut peptide PYY[3-36] increase after nutrient ingestion. Both have been implicated as short-term signals of meal termination with anorexigenic and weight-reducing effects. However, their combined effects are unknown. We report that the combi...

journal_title：Endocrinology

authors： Roth JD,Coffey T,Jodka CM,Maier H,Athanacio JR,Mack CM,Weyer C,Parkes DG

更新日期：2007-12-01 00:00:00

abstract：:The maximum amounts of angiotensins II and III that were confined to the kidney during intrarenal arterial administration in conscious dogs were determined to be 2 and 12 pmol/kg X min, respectively. These doses were infused chronically intrarenally to uninephrectomized dogs. A significant reduction in urinary volume ...

journal_title：Endocrinology

authors： Dickstein GM,Woodson JF,Lamb NE,Rose CE Jr,Peach MJ,Carey RM

更新日期：1985-11-01 00:00:00

abstract：:We have found that microwave (MW) stabilization greatly improves detection of the estrogen receptor (ER) in frozen sections of rhesus monkey oviduct by immunocytochemistry (ICC). Fresh samples of fimbriae were MW-irradiated, frozen, and then cryosectioned. The frozen sections were also MW-treated and then fixed in a p...

journal_title：Endocrinology

authors： Slayden OD,Koji T,Brenner RM

更新日期：1995-09-01 00:00:00