Abstract：
:Over the last 25 years, reforms in undergraduate biology education have transformed the way biology is taught at many institutions of higher education. This has been fueled in part by a burgeoning discipline-based education research community, which has advocated for evidence-based instructional practices based on findings from research. This perspective will review some of the changes to undergraduate biology education that have gained or are currently gaining momentum, becoming increasingly common in undergraduate biology classrooms. However, there are still areas in need of improvement. Although more underrepresented minority students are enrolling in and graduating from biology programs than in the past, there is a need to understand the experiences and broaden participation of other underserved groups in biology and ensure biology classroom learning environments are inclusive. Additionally, although understanding biology relies on understanding concepts from the physical sciences and mathematics, students still rarely connect the concepts they learn from other STEM disciplines to biology. Integrating concepts and practices across the STEM disciplines will be critical for biology graduates as they tackle the biological problems of the twenty-first century.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Aikens MLdoi
10.1007/s11538-020-00739-6subject
Has Abstractpub_date
2020-05-13 00:00:00pages
60issue
5eissn
0092-8240issn
1522-9602pii
10.1007/s11538-020-00739-6journal_volume
82pub_type
杂志文章abstract：:Synchronization and desynchronization is of great interest in the study of circadian rhythms, metabolic oscillations and time-dependent cell aggregate behaviors. Several recent studies examine synchronization and other dynamics in models of repressilators coupled by a quorum sensing mechanism that uses a diffusive sig...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-016-0187-8
更新日期：2016-06-01 00:00:00
abstract：:The multifractal analysis of binary images of DNA is studied in order to define a methodological approach to the classification of DNA sequences. This method is based on the computation of some multifractality parameters on a suitable binary image of DNA, which takes into account the nucleotide distribution. The binar...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-013-9859-9
更新日期：2013-09-01 00:00:00
abstract：:In this paper, we use multiple scale homogenisation to derive a set of averaged macroscale equations that describe the movement of nutrients in partially saturated soil that contains growing potato tubers. The soil is modelled as a poroelastic material, which is deformed by the growth of the tubers, where the growth o...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-019-00656-3
更新日期：2019-10-01 00:00:00
abstract：:We address the observation that, in some cases, patients infected with the hepatitis C virus (HCV) are cleared of HCV when super-infected with the hepatitis A virus (HAV). We hypothesise that this phenomenon can be explained by the competitive exclusion principle, including the action of the immune system, and show th...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-012-9795-0
更新日期：2013-01-01 00:00:00
abstract：:We explore the dynamics of invasive weeds by partial differential equation (PDE) modelling and applying dynamical system and phase portrait techniques. We begin by applying the method of characteristics to a preexisting PDE model of the spreading of T. fluminensis, an invasive weed which has been responsible for nativ...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-020-00825-9
更新日期：2021-01-07 00:00:00
abstract：:There is still controversy as to which characteristics of the pressure-volume relation should be used to define myocardial contractility. In the present study a mathematical model for the left ventricle as a two-dimensional cylinder contracting radially and symmetrically was used to establish a relation between a calc...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/BF02460085
更新日期：1989-01-01 00:00:00
abstract：:For epidemic models, it is shown that fatal infectious diseases cannot drive the host population into extinction if the incidence function is upper density-dependent. This finding holds even if a latency period is included and the time from infection to disease-induced death has an arbitrary length distribution. Howev...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-018-0446-y
更新日期：2018-07-01 00:00:00
abstract：:Logical modeling of biological regulatory networks gives rise to a representation of the system's dynamics as a so-called state transition graph. Analysis of such a graph in its entirety allows for a comprehensive understanding of the functionalities and behavior of the modeled system. However, the size of the vertex ...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-012-9782-5
更新日期：2013-06-01 00:00:00
abstract：:A model, based on the principles of continuum mechanics, is presented for the analysis of cell-velocity fields within wool follicles. The model requires specification of three follicle characteristics in the form of spatially varying fields: viscosity, cell density and cell production rate. The viscosity is introduced...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1006/bulm.1997.0025
更新日期：1998-01-01 00:00:00
abstract：:The insertion-deletion model developed by Thorne, Kishino and Felsenstein (1991, J. Mol. Evol., 33, 114-124; the TKF91 model) provides a statistical framework of two sequences. The statistical alignment of a set of sequences related by a star tree is a generalization of this model. The known algorithm computes the pro...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1006/bulm.2002.0300
更新日期：2002-07-01 00:00:00
abstract：:Two algorithms for the efficient identification of segment neighborhoods are presented. A segment neighborhood is a set of contiguous residues that share common features. Two procedures are developed to efficiently find estimates for the parameters of the model that describe these features and for the residues that de...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/BF02458835
更新日期：1989-01-01 00:00:00
abstract：:In this paper we formulate a multi-patch multi-species model in which the per-capita emigration rate of one species depends on the density of some other species. We then focus on Turing instability to examine if and when this cross-emigration response has crucial effects. We find that the type of interaction matters g...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1006/bulm.2002.0328
更新日期：2003-01-01 00:00:00
abstract：:Bovine Babesiosis (BB) is a tick borne parasitic disease with worldwide over 1.3 billion bovines at potential risk of being infected. The disease, also called tick fever, causes significant mortality from infection by the protozoa upon exposure to infected ticks. An important factor in the spread of the disease is the...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-013-9912-8
更新日期：2014-01-01 00:00:00
abstract：:The fluorescent dye carboxyfluorescein diacetate succinimidyl ester (CFSE) classifies proliferating cell populations into groups according to the number of divisions each cell has undergone (i.e., its division class). The pulse labeling of cells with radioactive thymidine provides a means to determine the distribution...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-007-9239-4
更新日期：2008-01-01 00:00:00
abstract：:We introduce a mesoscopic scale chemotaxis model for traveling wave phenomena which is induced by food metric. The organisms of this simplified kinetic model have two discrete velocity modes, [Formula: see text] and a constant tumbling rate. The main feature of the model is that the speed of organisms is constant [For...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-016-0235-4
更新日期：2017-02-01 00:00:00
abstract：:Recent advances in virology, gene therapy, and molecular and cell biology have provided insight into the mechanisms through which viruses can boost the anti-tumor immune response, or can infect and directly kill tumor cells. A recent experimental report (Bridle et al. in Molec. Ther. 18(8):1430-1439, 2010) showed that...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-011-9653-5
更新日期：2011-12-01 00:00:00
abstract：:The propagation of fire-diffuse-fire Ca(2+) waves through a three-dimensional rectangular domain is considered. The domain is infinite in extent in the direction of propagation but with lateral barriers to diffusion which contain Ca(2+) pumps. The Ca(2+) concentration profile due to the firing of a release site (spark...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1016/S0092-8240(03)00074-0
更新日期：2004-01-01 00:00:00
abstract：:Based on the logistic growth law for a tumour derived from enzymatic dynamics, we address from a physical point of view the phenomena of synergism, additivity and antagonism in an avascular anti-tumour system regulated externally by dual coupling periodic interventions, and propose a theoretical model to simulate the ...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-011-9693-x
更新日期：2012-02-01 00:00:00
abstract：:We develop an age-structured ODE model to investigate the role of intermittent preventive treatment (IPT) in averting malaria-induced mortality in children, and its related cost in promoting the spread of antimalarial drug resistance. IPT, a malaria control strategy in which a full curative dose of an antimalarial med...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-018-0524-1
更新日期：2019-01-01 00:00:00
abstract：:Cholera is an acute gastro-intestinal infection that affects millions of people throughout the world each year, primarily but not exclusively in developing countries. Because of its public health ramifications, considerable mathematical attention has been paid to the disease. Here we consider one neglected aspect of c...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-018-0476-5
更新日期：2018-10-01 00:00:00
abstract：:The origin of the modern genetic code and the mechanisms that have contributed to its present form raise many questions. The main goal of this work is to test two hypotheses concerning the development of the genetic code for their compatibility and complementarity and see if they could benefit from each other. On the ...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-020-00724-z
更新日期：2020-04-04 00:00:00
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journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-018-00557-x
更新日期：2019-04-01 00:00:00
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journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-013-9897-3
更新日期：2013-12-01 00:00:00
abstract：:At least four distinct lineages of CD4+ T cells play diverse roles in the immune system. Both in vivo and in vitro, naïve CD4+ T cells often differentiate into a variety of cellular phenotypes. Previously, we developed a mathematical framework to study heterogeneous differentiation of two lineages governed by a mutual...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-015-0076-6
更新日期：2015-06-01 00:00:00
abstract：:A dynamic model for cell differentiation, where cells with internal chemical reaction dynamics interact with each other and replicate was studied. It led to spontaneous differentiation of cells and determination, as discussed in the isologous diversification. The following features of the differentiation were obtained...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1006/bulm.1997.0034
更新日期：1998-07-01 00:00:00
abstract：:The apoptotic caspase-3/8 feedback loop describes the core of the extrinsic pro-apoptotic signaling pathway, an essential part of apoptosis. Latter is a prototype of the programmed cell death, which enables organisms to remove damaged or infected cells. The reaction network of the caspase-3/8 feedback loop in a single...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-013-9892-8
更新日期：2013-11-01 00:00:00
abstract：:We present an improved mathematical model of population dynamics of mosquito-borne disease transmission. Our model considers the effect of mosquito repellent use and the mosquito's behavior or attraction to the infected human, which cause mosquitoes' biased distribution around the human population. Our analysis of the...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-019-00666-1
更新日期：2019-12-01 00:00:00
abstract：:W.O. Kermack and A.G. McKendrick introduced in their fundamental paper, A Contribution to the Mathematical Theory of Epidemics, published in 1927, a deterministic model that captured the qualitative dynamic behavior of single infectious disease outbreaks. A Kermack–McKendrick discrete-time general framework, motivated...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/s11538-013-9866-x
更新日期：2013-10-01 00:00:00
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journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1016/S0092-8240(03)00007-7
更新日期：2003-05-01 00:00:00
abstract：:A model of embryo energetics was fitted to data from the literature for species as different as snails and mammals. The model is based on assumptions about energy uptake, storage and utilization. It describes the animal by two state variables: volume and energy storage. Embryo weight is taken to be proportional to vol...
journal_title：Bulletin of mathematical biology
pub_type： 杂志文章
doi：10.1007/BF02460653
更新日期：1993-05-01 00:00:00
